CA2677679A1 - Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations - Google Patents
Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations Download PDFInfo
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- CA2677679A1 CA2677679A1 CA002677679A CA2677679A CA2677679A1 CA 2677679 A1 CA2677679 A1 CA 2677679A1 CA 002677679 A CA002677679 A CA 002677679A CA 2677679 A CA2677679 A CA 2677679A CA 2677679 A1 CA2677679 A1 CA 2677679A1
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| EP2316463B1 (en) | 2001-02-14 | 2017-04-12 | Anthrogenesis Corporation | Tissue matrices comprising placental stem cells, and methods of making them |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| BR0316695A (pt) * | 2002-11-26 | 2005-10-18 | Anthrogenesis Corp | Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente |
| EP1738253A4 (en) * | 2004-03-26 | 2009-07-22 | Celgene Corp | SYSTEMS AND METHOD FOR PROVIDING A STEM CELL BENCH |
| AU2006304274B2 (en) * | 2005-10-13 | 2012-08-16 | Celularity Inc. | Production of oligodendrocytes from placenta-derived stem cells |
| PL1957633T3 (pl) * | 2005-10-13 | 2014-05-30 | Anthrogenesis Corp | Immunomodulacja z zastosowaniem komórek macierzystych łożyska |
| EP2471904B1 (en) | 2005-12-29 | 2018-10-24 | Celularity, Inc. | Placental stem cell populations |
| CN101374941A (zh) * | 2005-12-29 | 2009-02-25 | 人类起源公司 | 采集和保存胎盘干细胞的改良组合物及其使用方法 |
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| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| CA2667359C (en) | 2006-10-23 | 2014-07-22 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| CA2677679A1 (en) | 2007-02-12 | 2008-08-21 | Anthrogenesis Corporation | Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations |
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| WO2008157594A2 (en) | 2007-06-18 | 2008-12-24 | New Jersey Institute Of Technology | Electrospun ceramic-polymer composite as a scaffold for tissue repair |
| US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
| US20090104164A1 (en) * | 2007-09-26 | 2009-04-23 | Celgene Cellular Therapeutics | Angiogenic cells from human placental perfusate |
| RU2536242C2 (ru) | 2007-09-28 | 2014-12-20 | Антродженезис Корпорейшн | Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров |
| WO2009058983A2 (en) * | 2007-10-30 | 2009-05-07 | University Of Louisville Research Foundation, Inc. | Subpopulations of bone marrow-derived adherent stem cells and methods of use therefor |
| US20090325296A1 (en) * | 2008-03-25 | 2009-12-31 | New Jersey Institute Of Technology | Electrospun electroactive polymers for regenerative medicine applications |
| KR20110050521A (ko) | 2008-08-20 | 2011-05-13 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
| US8828376B2 (en) | 2008-08-20 | 2014-09-09 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| AU2009283161A1 (en) * | 2008-08-22 | 2010-02-25 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| US8008075B2 (en) * | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| WO2010053472A1 (en) * | 2008-11-04 | 2010-05-14 | Novocell, Inc. | Stem cell aggregate suspension compositions and methods for differentiation thereof |
| WO2010057110A1 (en) * | 2008-11-14 | 2010-05-20 | University Of Louisville Research Foundation, Inc. | Methods and compositions for long term hematopoietic repopulation |
| WO2010059828A1 (en) | 2008-11-19 | 2010-05-27 | Anthrogenesis Corporation | Amnion derived adherent cells |
| US9476026B2 (en) | 2009-03-12 | 2016-10-25 | New Jersey Institute Of Technology | Method of tissue repair using a piezoelectric scaffold |
| US9192655B2 (en) | 2009-03-12 | 2015-11-24 | New Jersey Institute Of Technology | System and method for a hydrogel and hydrogel composite for cartilage repair applications |
| US9334476B2 (en) * | 2009-03-12 | 2016-05-10 | New Jersey Institute Of Technology | Method for nerve growth and repair using a piezoelectric scaffold |
| US9771557B2 (en) | 2009-03-12 | 2017-09-26 | New Jersey Institute Of Technology | Piezoelectric scaffold for nerve growth and repair |
| AU2010266016B2 (en) * | 2009-06-25 | 2016-05-26 | Asterias Biotherapeutics, Inc. | Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes |
| WO2011002959A1 (en) | 2009-07-02 | 2011-01-06 | Anthrogenesis Corporation | Method of producing erythrocytes without feeder cells |
| JP2013518108A (ja) | 2010-01-26 | 2013-05-20 | アントフロゲネシス コーポレーション | 胎盤幹細胞を用いる骨関連癌の治療 |
| US9180166B2 (en) | 2010-03-12 | 2015-11-10 | New Jersey Institute Of Technology | Cartilage repair systems and applications utilizing a glycosaminoglycan mimic |
| CN102933703A (zh) | 2010-04-07 | 2013-02-13 | 人类起源公司 | 使用胎盘干细胞的血管生成 |
| AU2011237743A1 (en) | 2010-04-08 | 2012-11-01 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US20120020931A1 (en) * | 2010-06-02 | 2012-01-26 | Rutgers, The State University Of New Jersey | Therapeutic encapsulated embryonic stem cells and mesenchymal stromal cells |
| JP5996533B2 (ja) | 2010-07-13 | 2016-09-21 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞を生成させる方法 |
| CA2815097A1 (en) | 2010-10-18 | 2012-04-26 | Sunshine Biotech Inc. | Human multipotent embryonic stem cell-like progenitor cells |
| CN102028970A (zh) * | 2010-12-27 | 2011-04-27 | 协和干细胞基因工程有限公司 | 一种用于治疗肝硬化的干细胞制剂 |
| EP2658556A4 (en) * | 2010-12-30 | 2015-03-04 | Anthrogenesis Corp | PROCESS FOR CRYOCONIZING AND CELLULARIZATION OF CELLS |
| AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
| WO2012142533A1 (en) | 2011-04-13 | 2012-10-18 | New Jersey Institute Of Technology | System and method for electrospun biodegradable scaffold for bone repair |
| KR101637895B1 (ko) * | 2011-05-13 | 2016-07-11 | 고려대학교 산학협력단 | Ｂ 세포 분리를 위한 특이적 결합분자-나노섬유 복합체 및 그를 이용한 분리 방법 |
| PT2714059T (pt) | 2011-06-01 | 2019-02-04 | Celularity Inc | Tratamento da dor utilizando células estaminais da placenta |
| US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
| TWI614340B (zh) * | 2011-09-28 | 2018-02-11 | 幹細胞生物科技股份有限公司 | 體幹細胞及其製備方法 |
| GB201119335D0 (en) * | 2011-11-09 | 2011-12-21 | Univ Leuven Kath | Hepatitis virus infectable stem cells |
| WO2013082417A1 (en) * | 2011-11-30 | 2013-06-06 | Anthrogenesis Corporation | Treatment using placental stem cells |
| GB201202138D0 (en) * | 2012-02-07 | 2012-03-21 | Electrospinning Company The Ltd | Multi-well plate |
| CN107449923B (zh) * | 2012-03-18 | 2020-07-24 | 株式会社资生堂 | 疾病样品分析装置、分析系统及分析方法 |
| SG11201502753YA (en) * | 2012-10-09 | 2015-05-28 | Sanbio Inc | Methods and compositions for treatment of retinal degeneration |
| TWI687519B (zh) | 2012-12-06 | 2020-03-11 | 美商幹細胞生物科技股份有限公司 | Ｌｇｒ５＋體幹細胞 |
| AU2014215458A1 (en) | 2013-02-05 | 2015-08-13 | Anthrogenesis Corporation | Natural killer cells from placenta |
| WO2014138793A1 (en) * | 2013-03-13 | 2014-09-18 | The University Of Queensland | A method of isolating cells for therapy and prophylaxis |
| KR20210121277A (ko) * | 2013-11-15 | 2021-10-07 | 안트로제네시스 코포레이션 | 사람 태반 관류액 세포를 포함하는 조성물, 상기 세포의 부분모집단 및 이의 용도 |
| GB201406716D0 (en) * | 2014-04-15 | 2014-05-28 | Insphero Ag | Method of preparing cells for 3D tissue culture |
| SG11201703487TA (en) | 2014-10-31 | 2017-06-29 | Nat Univ Corp Tokyo Univ Agriculture & Tech | Cell isolation method and cell trapping filter |
| WO2016081553A1 (en) * | 2014-11-19 | 2016-05-26 | StemBios Technologies, Inc. | Somatic stem cells for treating bone defects |
| ES3036772T3 (en) | 2015-02-09 | 2025-09-24 | Slingshot Biosciences Inc | Hydrogel particles with tunable optical properties and methods for using the same |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| EP3302065A4 (en) * | 2015-05-28 | 2019-04-10 | Celularity, Inc. | PLACENTIAL STEM CELLS FOR RECOVERING THE REGENERATIVE MOTOR, CORRECTING PROTEOMIC DEFECTS AND EXTENDING THE LIFE |
| WO2017039251A1 (ko) * | 2015-08-28 | 2017-03-09 | 주식회사 차바이오텍 | 향상된 산후 부착형 세포 및 그의 용도 |
| US11312940B2 (en) | 2015-08-31 | 2022-04-26 | University Of Louisville Research Foundation, Inc. | Progenitor cells and methods for preparing and using the same |
| WO2017152073A1 (en) | 2016-03-04 | 2017-09-08 | University Of Louisville Research Foundation, Inc. | Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (vsels) |
| AU2017296175B2 (en) * | 2016-07-11 | 2023-11-02 | Bonus Therapeutics Ltd. | Cell compositions for tissue regeneration |
| WO2018093069A1 (ko) * | 2016-11-15 | 2018-05-24 | 광주과학기술원 | 세포 3d 배양 방법 |
| CN108721707B (zh) * | 2017-04-25 | 2021-04-09 | 北京纳米能源与系统研究所 | 可降解导线及其制备方法 |
| KR101952762B1 (ko) * | 2017-05-08 | 2019-02-27 | 강원대학교산학협력단 | 알긴산과 콜라겐의 조합으로 생성된 줄기세포를 캡슐화하는 미세캡슐 조성물 및 그 제조방법 |
| JP7291217B2 (ja) * | 2018-11-08 | 2023-06-14 | イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッド | 足場非依存性細胞およびその使用 |
| WO2021042015A1 (en) * | 2019-08-30 | 2021-03-04 | Northwestern University | Biodegradable soft elastomers for regenerative engineering |
| KR102141641B1 (ko) * | 2020-01-31 | 2020-08-06 | 주식회사 래디안 | 인간지방 유래 중간엽 줄기세포로부터 모유두세포로의 분화방법 |
| KR102307115B1 (ko) * | 2021-05-12 | 2021-10-01 | 주식회사 스마트셀랩 | 시프로플록사신에 의한 줄기세포의 연골전구세포로의 유도 및 연골세포로의 분화 |
| JP2025516304A (ja) | 2022-05-05 | 2025-05-27 | スリングショット バイオサイエンシーズ， インコーポレイテッド | 血液学のための赤血球模倣物としての作出された粒子およびそれらを含有する組成物 |
| WO2024254494A2 (en) * | 2023-06-09 | 2024-12-12 | Kanzo Biomedicines, Inc. | Liver support systems and methods of use |
| WO2025049609A1 (en) * | 2023-08-29 | 2025-03-06 | Slingshot Biosciences, Inc. | Cd34 stem cell mimics |
Family Cites Families (167)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862002A (en) | 1962-05-08 | 1975-01-21 | Sanfar Lab Inc | Production of physiologically active placental substances |
| US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| GB8803697D0 (en) | 1988-02-17 | 1988-03-16 | Deltanine Research Ltd | Clinical developments using amniotic membrane cells |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5605822A (en) | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| US5763266A (en) | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| US5399493A (en) | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5733542A (en) | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US5190556A (en) | 1991-03-19 | 1993-03-02 | O.B. Tech, Inc. | Cord cutter sampler |
| US5744361A (en) | 1991-04-09 | 1998-04-28 | Indiana University | Expansion of human hematopoietic progenitor cells in a liquid medium |
| US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| WO1993003139A1 (fr) | 1991-08-08 | 1993-02-18 | Kao Corporation | Support pour la culture de cellules, production de ce support et production d'un amas de cellules au moyen de ce support |
| EP0529751A1 (en) | 1991-08-09 | 1993-03-03 | W.R. Grace & Co.-Conn. | Cell culture substrate, test material for cell culture and preparations thereof |
| EP0590156A4 (en) | 1992-03-31 | 1994-07-13 | Toray Industries | Novel, physiologically active protein and hemopoietic stem cell growth promoter |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| US5552267A (en) | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
| WO1994000484A1 (en) | 1992-06-22 | 1994-01-06 | Young Henry E | Scar inhibitory factor and use thereof |
| US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
| WO1994011493A1 (en) | 1992-11-16 | 1994-05-26 | Applied Immune Sciences, Inc. | Pluripotential quiescent stem cell population |
| US5654186A (en) | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
| US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| US5698579A (en) | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
| US5372581A (en) | 1993-07-21 | 1994-12-13 | Minneapolis Children's Services Corporation | Method and apparatus for placental blood collection |
| IL107483A0 (en) | 1993-11-03 | 1994-02-27 | Yeda Res & Dev | Bone marrow transplantation |
| US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| AU1931495A (en) | 1994-03-14 | 1995-10-03 | Cryolife, Inc. | Treated tissue for implantation and preparation methods |
| DE4422667A1 (de) | 1994-06-30 | 1996-01-04 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Züchtung hämatopoetischer Vorläuferzellen |
| US6103522A (en) | 1994-07-20 | 2000-08-15 | Fred Hutchinson Cancer Research Center | Human marrow stromal cell lines which sustain hematopoiesis |
| US5516532A (en) | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
| US5827742A (en) | 1994-09-01 | 1998-10-27 | Beth Israel Deaconess Medical Center, Inc. | Method of selecting pluripotent hematopioetic progenitor cells |
| US5665557A (en) | 1994-11-14 | 1997-09-09 | Systemix, Inc. | Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof |
| PT793714E (pt) | 1994-11-16 | 2002-12-31 | Amgen Inc | Utilizacao do factor de celulas estaminais e do receptor de interleucina 6 soluvel para a expansao ex vivo de celulas hematopoieticas multipotentes |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
| US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US5716616A (en) | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| US5733541A (en) | 1995-04-21 | 1998-03-31 | The Regent Of The University Of Michigan | Hematopoietic cells: compositions and methods |
| US5830708A (en) | 1995-06-06 | 1998-11-03 | Advanced Tissue Sciences, Inc. | Methods for production of a naturally secreted extracellular matrix |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5654381A (en) | 1995-06-16 | 1997-08-05 | Massachusetts Institute Of Technology | Functionalized polyester graft copolymers |
| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US5858782A (en) | 1995-11-13 | 1999-01-12 | Regents Of The University Of Michigan | Functional human hematopoietic cells |
| US5716794A (en) | 1996-03-29 | 1998-02-10 | Xybernaut Corporation | Celiac antigen |
| US5919176A (en) | 1996-05-14 | 1999-07-06 | Children's Hospital Medical Center Of Northern California | Apparatus and method for collecting blood from an umbilical cord |
| HU228769B1 (en) | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US5798368A (en) | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| KR100539030B1 (ko) | 1996-08-12 | 2005-12-27 | 셀진 코포레이션 | 면역치료제 및 이를 이용하여 사이토카인 농도를 감소시키는 방법 |
| US5851984A (en) | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| US5916202A (en) | 1996-08-30 | 1999-06-29 | Haswell; John N. | Umbilical cord blood collection |
| US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| US5879318A (en) | 1997-08-18 | 1999-03-09 | Npbi International B.V. | Method of and closed system for collecting and processing umbilical cord blood |
| US5874448A (en) | 1997-11-18 | 1999-02-23 | Celgene Corporation | Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels |
| US5955476A (en) | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
| US6059968A (en) | 1998-01-20 | 2000-05-09 | Baxter International Inc. | Systems for processing and storing placenta/umbilical cord blood |
| KR20060036124A (ko) | 1998-03-16 | 2006-04-27 | 셀진 코포레이션 | 염증성 사이토카인 억제제용2-(2,6-디옥소피페리딘-3-일)이소인돌린 유도체, 그제조방법 및 그 용도 |
| JP4526186B2 (ja) | 1998-06-08 | 2010-08-18 | オシリス セラピューティクス，インコーポレイテッド | 造血幹細胞を試験管内で維持する方法と組成物 |
| PT1084230E (pt) | 1998-06-08 | 2008-01-25 | Osiris Therapeutics Inc | Regulação da diferenciação de células estaminais hematopoiéticas através da utilização de células estaminais mesenquimatosas humanas |
| US6361998B1 (en) | 1998-06-25 | 2002-03-26 | Hemosol Inc. | Efficient culture of stem cells for the production of hemoglobin |
| CA2345397A1 (en) | 1998-09-23 | 2000-03-30 | Mount Sinai Hospital | Trophoblast cell preparations |
| JP2002532493A (ja) | 1998-12-17 | 2002-10-02 | エフ．ホフマン−ラ ロシュ アーゲー | Ｊｎｋプロテインキナーゼ阻害剤としての４−アリールオキシインドール |
| US6288089B1 (en) | 1998-12-21 | 2001-09-11 | Michael Zawada | Use of kinase inhibitors for treating neurodegenerative diseases |
| AU771015B2 (en) | 1999-03-18 | 2004-03-11 | Celgene Corporation | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
| US6233476B1 (en) | 1999-05-18 | 2001-05-15 | Mediguide Ltd. | Medical positioning system |
| AU4860900A (en) | 1999-06-02 | 2000-12-18 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
| AU7611500A (en) | 1999-09-24 | 2001-04-24 | Abt Holding Company | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
| EP1110957A1 (en) | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazole derivatives and their use as JNK modulators |
| ATE271691T1 (de) | 2000-01-12 | 2004-08-15 | Ventana Med Syst Inc | Verfahren zum nachweis der effektivität einer krebstherapie |
| EP1263930A4 (en) | 2000-03-09 | 2004-07-21 | Saneron Ccel Therapeutics Inc | HUMAN CORD BLOOD BLOOD AS A SOURCE FOR NEURAL TISSUE FOR HEALING THE BRAIN AND BACK MARK |
| WO2001075094A1 (en) | 2000-04-04 | 2001-10-11 | Thomas Jefferson University | Application of myeloid-origin cells to the nervous system |
| US7282366B2 (en) | 2000-04-27 | 2007-10-16 | Geron Corporation | Hepatocytes for therapy and drug screening made from embryonic stem cells |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| WO2002044343A2 (en) | 2000-11-22 | 2002-06-06 | Geron Corporation | Tolerizing allografts of pluripotent stem cells |
| MXPA03005014A (es) | 2000-12-06 | 2004-09-10 | Robert J Hariri | Metodo para recolectar celulas madres de la placenta. |
| US20080152629A1 (en) | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| EP2316463B1 (en) | 2001-02-14 | 2017-04-12 | Anthrogenesis Corporation | Tissue matrices comprising placental stem cells, and methods of making them |
| EP2314673B1 (en) | 2001-02-14 | 2013-07-24 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| US20020132343A1 (en) | 2001-03-19 | 2002-09-19 | Clark Lum | System and method for delivering umbilical cord-derived tissue-matched stem cells for transplantation |
| DE10139783C1 (de) | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
| US20030044976A1 (en) | 2001-08-27 | 2003-03-06 | Advanced Cell Technology | De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| EP1288293A1 (en) | 2001-08-30 | 2003-03-05 | Norio Sakuragawa | Human neural stem cells originated from human amniotic mesenchymal cell layer |
| CN1195055C (zh) | 2001-09-06 | 2005-03-30 | 周胜利 | 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法 |
| CA2468171C (en) | 2001-11-15 | 2015-10-06 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
| US7799324B2 (en) | 2001-12-07 | 2010-09-21 | Geron Corporation | Using undifferentiated embryonic stem cells to control the immune system |
| NZ534643A (en) * | 2002-02-13 | 2010-06-25 | Anthrogenesis Corp | Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| JP2003274973A (ja) | 2002-03-27 | 2003-09-30 | Nara Institute Of Science & Technology | キサントシンメチル化酵素およびその用途 |
| MXPA04009997A (es) | 2002-04-12 | 2004-12-13 | Celgene Corp | Modulacion de la diferenciacion de celulas madre y progenitoras, ensayos y usos de las mismas. |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| AU2003237078C1 (en) | 2002-04-12 | 2009-10-08 | Celgene Corporation | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| JP2005528105A (ja) | 2002-05-30 | 2005-09-22 | セルジーン・コーポレーション | 細胞分化をモジュレートするため、並びに骨髄増殖性疾患及び骨髄異形成症候群を治療するためのｊｎｋ又はｍｋｋ阻害剤の使用方法 |
| US7422736B2 (en) | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| BR0316695A (pt) | 2002-11-26 | 2005-10-18 | Anthrogenesis Corp | Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente |
| CN1770976A (zh) | 2003-02-13 | 2006-05-10 | 人类起源公司 | 利用脐带血治疗患有疾病、紊乱或状况的个体的用途 |
| CN1548529A (zh) | 2003-05-09 | 2004-11-24 | 中国人民解放军军事医学科学院基础医 | 一种人胎盘间充质干细胞的分离方法 |
| US7510873B2 (en) * | 2003-06-27 | 2009-03-31 | Ethicon, Incorporated | Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same |
| EP1694328A4 (en) | 2003-12-02 | 2010-02-17 | Celgene Corp | METHOD AND COMPOSITIONS FOR THE TREATMENT AND SUPPLY OF HEMOGLOBINOPATHY AND ANEMIA |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| US20050239897A1 (en) | 2004-03-22 | 2005-10-27 | Pittenger Mark F | Mesenchymal stem cells and uses therefor |
| EP1738253A4 (en) | 2004-03-26 | 2009-07-22 | Celgene Corp | SYSTEMS AND METHOD FOR PROVIDING A STEM CELL BENCH |
| US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US7909806B2 (en) | 2004-09-23 | 2011-03-22 | Anthrogenesis Corporation | Cord blood and placenta collection kit |
| CA2596957C (en) * | 2004-12-03 | 2015-04-14 | New Jersey Institute Of Technology | Substrate recognition by differentiable human mesenchymal stem cells |
| WO2006071773A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incoporated | Treatment of osteochondral diseases using postpartum-derived cells and products thereof |
| US20060182724A1 (en) * | 2005-02-15 | 2006-08-17 | Riordan Neil H | Method for expansion of stem cells |
| WO2006122147A2 (en) * | 2005-05-10 | 2006-11-16 | Rutgers, The State University Of New Jersey | Alginate poly-l-lysine encapsulation as a technology for controlled differentiation of embryonic stem cells |
| KR20080031735A (ko) | 2005-06-10 | 2008-04-10 | 셀진 코포레이션 | 인간 태반 콜라겐 조성물, 그의 제조 방법, 그의 사용 방법및 상기 조성물을 포함하는 키트 |
| JP2008544818A (ja) | 2005-06-30 | 2008-12-11 | アントフロゲネシス コーポレーション | 胎盤由来コラーゲンバイオ線維を用いた鼓膜の修復 |
| US20070021762A1 (en) | 2005-07-13 | 2007-01-25 | Qing Liu | Ocular plug formed from placenta derived collagen biofabric |
| EP1919500A2 (en) | 2005-07-13 | 2008-05-14 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
| AU2006304274B2 (en) | 2005-10-13 | 2012-08-16 | Celularity Inc. | Production of oligodendrocytes from placenta-derived stem cells |
| PL1957633T3 (pl) | 2005-10-13 | 2014-05-30 | Anthrogenesis Corp | Immunomodulacja z zastosowaniem komórek macierzystych łożyska |
| CN100344757C (zh) | 2005-10-18 | 2007-10-24 | 天津昂赛细胞基因工程有限公司 | 人胎盘、脐带间充质干细胞库及其构建方法 |
| EP2471904B1 (en) * | 2005-12-29 | 2018-10-24 | Celularity, Inc. | Placental stem cell populations |
| AU2006332679A1 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| CN101374941A (zh) | 2005-12-29 | 2009-02-25 | 人类起源公司 | 采集和保存胎盘干细胞的改良组合物及其使用方法 |
| AU2007238660C1 (en) | 2006-04-14 | 2013-11-07 | Astellas Institute For Regenerative Medicine | Hemangio-colony forming cells |
| JP2009539378A (ja) | 2006-06-09 | 2009-11-19 | アントフロゲネシス コーポレーション | 胎盤環境及び幹細胞を培養するためのその使用 |
| EP2089510B1 (en) * | 2006-06-28 | 2021-02-24 | The University of Medicine and Dentistry of New Jersey | Amnion-derived stem cells and uses thereof |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| US8105634B2 (en) | 2006-08-15 | 2012-01-31 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
| US8122763B2 (en) | 2006-09-01 | 2012-02-28 | Avair, Llc | Breathing gas supply visual broadcast apparatus |
| WO2008036374A2 (en) | 2006-09-21 | 2008-03-27 | Medistem Laboratories, Inc. | Allogeneic stem cell transplants in non-conditioned recipients |
| WO2008042441A1 (en) | 2006-10-03 | 2008-04-10 | Anthrogenesis Corporation | Use of umbilical cord biomaterial for ocular surgery |
| US8071135B2 (en) | 2006-10-04 | 2011-12-06 | Anthrogenesis Corporation | Placental tissue compositions |
| KR101595108B1 (ko) | 2006-10-06 | 2016-02-18 | 안트로제네시스 코포레이션 | 천연(텔로펩티드) 태반 콜라겐 조성물 |
| CA2667359C (en) | 2006-10-23 | 2014-07-22 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| EP2687220A3 (en) | 2007-02-12 | 2014-05-14 | Anthrogenesis Corporation | Treatment of inflammatory diseases using placental stem cells |
| CA2677679A1 (en) | 2007-02-12 | 2008-08-21 | Anthrogenesis Corporation | Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations |
| US20100172830A1 (en) | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
| US20090104164A1 (en) | 2007-09-26 | 2009-04-23 | Celgene Cellular Therapeutics | Angiogenic cells from human placental perfusate |
| RU2536242C2 (ru) | 2007-09-28 | 2014-12-20 | Антродженезис Корпорейшн | Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров |
| WO2009061447A2 (en) | 2007-11-07 | 2009-05-14 | Anthrogenesis Corporation | Treatment of premature birth complications |
| KR20110050521A (ko) | 2008-08-20 | 2011-05-13 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
| US8828376B2 (en) | 2008-08-20 | 2014-09-09 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| AU2009283161A1 (en) | 2008-08-22 | 2010-02-25 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| WO2010059828A1 (en) | 2008-11-19 | 2010-05-27 | Anthrogenesis Corporation | Amnion derived adherent cells |
| RU2570550C2 (ru) | 2008-11-21 | 2015-12-10 | Антродженезис Корпорейшн | Лечение заболеваний, расстройств или патологических состояний легких с использованием плацентарных клеток |
| US20100323446A1 (en) | 2009-06-05 | 2010-12-23 | Jill Renee Barnett | Method of collecting placental cells |
| WO2011002959A1 (en) | 2009-07-02 | 2011-01-06 | Anthrogenesis Corporation | Method of producing erythrocytes without feeder cells |
| JP2013518108A (ja) | 2010-01-26 | 2013-05-20 | アントフロゲネシス コーポレーション | 胎盤幹細胞を用いる骨関連癌の治療 |
| US20110280849A1 (en) | 2010-03-26 | 2011-11-17 | Anthrogenesis Corporation | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
| CN102933703A (zh) | 2010-04-07 | 2013-02-13 | 人类起源公司 | 使用胎盘干细胞的血管生成 |
| AU2011237743A1 (en) | 2010-04-08 | 2012-11-01 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
| JP5996533B2 (ja) | 2010-07-13 | 2016-09-21 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞を生成させる方法 |
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- 2008-02-12 MX MX2009008559A patent/MX2009008559A/es not_active Application Discontinuation
- 2008-02-12 KR KR1020097018748A patent/KR20090109127A/ko not_active Withdrawn
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- 2008-02-12 WO PCT/US2008/001830 patent/WO2008100497A1/en not_active Ceased
- 2008-02-12 AU AU2008216748A patent/AU2008216748A1/en not_active Abandoned
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- 2008-02-12 EP EP08725457A patent/EP2129775A1/en not_active Withdrawn
- 2008-02-12 CN CN200880011764A patent/CN101688177A/zh active Pending
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| IL200336A0 (en) | 2010-04-29 |
| US10494607B2 (en) | 2019-12-03 |
| AU2008216748A1 (en) | 2008-08-21 |
| EP2129775A1 (en) | 2009-12-09 |
| US20080206343A1 (en) | 2008-08-28 |
| KR20090109127A (ko) | 2009-10-19 |
| ZA200905374B (en) | 2011-03-30 |
| MX2009008559A (es) | 2009-08-21 |
| CN101688177A (zh) | 2010-03-31 |
| US20200048603A1 (en) | 2020-02-13 |
| ZA201008539B (en) | 2012-09-26 |
| JP2010518812A (ja) | 2010-06-03 |
| WO2008100497A1 (en) | 2008-08-21 |
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