CA2674111A1 - Defined cell culturing surfaces and methods of use - Google Patents
Defined cell culturing surfaces and methods of use Download PDFInfo
- Publication number
- CA2674111A1 CA2674111A1 CA2674111A CA2674111A CA2674111A1 CA 2674111 A1 CA2674111 A1 CA 2674111A1 CA 2674111 A CA2674111 A CA 2674111A CA 2674111 A CA2674111 A CA 2674111A CA 2674111 A1 CA2674111 A1 CA 2674111A1
- Authority
- CA
- Canada
- Prior art keywords
- cell culturing
- stem cells
- culturing substrate
- substrate
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000012258 culturing Methods 0.000 title claims abstract 25
- 238000000034 method Methods 0.000 title claims 7
- 239000000758 substrate Substances 0.000 claims abstract 27
- 210000004027 cell Anatomy 0.000 claims abstract 25
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims abstract 12
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims abstract 12
- 239000011248 coating agent Substances 0.000 claims abstract 11
- 238000000576 coating method Methods 0.000 claims abstract 11
- 238000004113 cell culture Methods 0.000 claims abstract 7
- 239000000178 monomer Substances 0.000 claims abstract 7
- 239000003125 aqueous solvent Substances 0.000 claims abstract 3
- 210000000130 stem cell Anatomy 0.000 claims 12
- 239000008199 coating composition Substances 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 239000006143 cell culture medium Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 2
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 claims 2
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 2
- 108090000054 Syndecan-2 Proteins 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- 230000000379 polymerizing effect Effects 0.000 claims 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- WJYIASZWHGOTOU-UHFFFAOYSA-N Heptylamine Chemical compound CCCCCCCN WJYIASZWHGOTOU-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 102100037369 Nidogen-1 Human genes 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical group 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- PVEOYINWKBTPIZ-UHFFFAOYSA-N but-3-enoic acid Chemical compound OC(=O)CC=C PVEOYINWKBTPIZ-UHFFFAOYSA-N 0.000 claims 1
- 150000001993 dienes Chemical class 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 108010008217 nidogen Proteins 0.000 claims 1
- ZNZJJSYHZBXQSM-UHFFFAOYSA-N propane-2,2-diamine Chemical compound CC(C)(N)N ZNZJJSYHZBXQSM-UHFFFAOYSA-N 0.000 claims 1
- 150000003440 styrenes Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0666—Mesenchymal stem cells from hair follicles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8357008P | 2008-07-25 | 2008-07-25 | |
| US61/083,570 | 2008-07-25 | ||
| US8504408P | 2008-08-13 | 2008-08-13 | |
| US61/085,044 | 2008-08-13 | ||
| US12/508,661 US8288513B2 (en) | 2008-07-25 | 2009-07-24 | Defined cell culturing surfaces and methods of use |
| US12/508,661 | 2009-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2674111A1 true CA2674111A1 (en) | 2010-01-25 |
Family
ID=41320258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2674111A Abandoned CA2674111A1 (en) | 2008-07-25 | 2009-07-27 | Defined cell culturing surfaces and methods of use |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8288513B2 (https=) |
| EP (3) | EP2213728B1 (https=) |
| JP (1) | JP5784266B2 (https=) |
| CN (2) | CN101705186A (https=) |
| AU (1) | AU2009203051A1 (https=) |
| CA (1) | CA2674111A1 (https=) |
| PL (1) | PL3323883T3 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8288513B2 (en) | 2008-07-25 | 2012-10-16 | Becton, Dickinson And Company | Defined cell culturing surfaces and methods of use |
| WO2013170052A1 (en) | 2012-05-09 | 2013-11-14 | Sio2 Medical Products, Inc. | Saccharide protective coating for pharmaceutical package |
| MX350703B (es) | 2009-05-13 | 2017-09-14 | Sio2 Medical Products Inc | Metodo de gasificacion para inspeccionar una superficie revestida. |
| US9458536B2 (en) | 2009-07-02 | 2016-10-04 | Sio2 Medical Products, Inc. | PECVD coating methods for capped syringes, cartridges and other articles |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| WO2011159684A2 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US9272095B2 (en) | 2011-04-01 | 2016-03-01 | Sio2 Medical Products, Inc. | Vessels, contact surfaces, and coating and inspection apparatus and methods |
| EP2695934B1 (en) | 2011-04-05 | 2019-01-09 | Hiroshima University | Animal cell culture kit, method for culturing animal cells, method for selective culture of animal cells and cell differentiation method |
| EP2776603B1 (en) | 2011-11-11 | 2019-03-06 | SiO2 Medical Products, Inc. | PASSIVATION, pH PROTECTIVE OR LUBRICITY COATING FOR PHARMACEUTICAL PACKAGE, COATING PROCESS AND APPARATUS |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| CN104271593B (zh) | 2012-05-01 | 2018-01-16 | 富士胶片株式会社 | 多能干细胞的培养方法及该方法中使用的多肽 |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| US9193779B2 (en) * | 2012-10-26 | 2015-11-24 | Corning Incorporated | Recombinant human fibronectin fragment for cell culture |
| CA2890066C (en) | 2012-11-01 | 2021-11-09 | Sio2 Medical Products, Inc. | Coating inspection method |
| US9903782B2 (en) | 2012-11-16 | 2018-02-27 | Sio2 Medical Products, Inc. | Method and apparatus for detecting rapid barrier coating integrity characteristics |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| JP6382830B2 (ja) | 2012-11-30 | 2018-08-29 | エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド | 医療シリンジ、カートリッジ等上でのｐｅｃｖｄ堆積の均一性制御 |
| US9662450B2 (en) | 2013-03-01 | 2017-05-30 | Sio2 Medical Products, Inc. | Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus |
| US9937099B2 (en) | 2013-03-11 | 2018-04-10 | Sio2 Medical Products, Inc. | Trilayer coated pharmaceutical packaging with low oxygen transmission rate |
| EP2971228B1 (en) | 2013-03-11 | 2023-06-21 | Si02 Medical Products, Inc. | Coated packaging |
| US20160017490A1 (en) | 2013-03-15 | 2016-01-21 | Sio2 Medical Products, Inc. | Coating method |
| WO2014201154A1 (en) * | 2013-06-14 | 2014-12-18 | Microstem, Inc. | Matrix combinations support hematopoietic stem cell in vitro culturing |
| JP6169710B2 (ja) * | 2013-09-10 | 2017-07-26 | 富士フイルム株式会社 | 多能性幹細胞の培養方法、培養用キット及び多能性幹細胞培養用培地 |
| WO2015037623A1 (ja) | 2013-09-10 | 2015-03-19 | 富士フイルム株式会社 | 多能性幹細胞の培養方法ならびにこれに用いる多能性幹細胞の培養用キットおよび培地 |
| WO2015064661A1 (ja) | 2013-10-31 | 2015-05-07 | 富士フイルム株式会社 | ポリペプチド組成物およびこれを用いた多能性幹細胞の培養方法 |
| GB201403558D0 (en) | 2014-02-28 | 2014-04-16 | P2I Ltd | Coating |
| WO2015148471A1 (en) | 2014-03-28 | 2015-10-01 | Sio2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| WO2015187241A1 (en) * | 2014-06-02 | 2015-12-10 | Sikorsky Aircraft Corporation | Diagnosis of drive shaft disc couplings |
| US10625234B2 (en) | 2014-08-28 | 2020-04-21 | StemoniX Inc. | Method of fabricating cell arrays and uses thereof |
| US9721081B2 (en) | 2015-05-14 | 2017-08-01 | Alclear, Llc | Physical token-less security screening using biometrics |
| US11220669B2 (en) * | 2015-06-05 | 2022-01-11 | Amolifescience Co., Ltd. | Defined three dimensional microenvironment for cell culture |
| WO2016198857A1 (en) | 2015-06-09 | 2016-12-15 | P2I Ltd | Coatings |
| US11248212B2 (en) | 2015-06-30 | 2022-02-15 | StemoniX Inc. | Surface energy directed cell self assembly |
| EP3337915B1 (en) | 2015-08-18 | 2021-11-03 | SiO2 Medical Products, Inc. | Pharmaceutical and other packaging with low oxygen transmission rate |
| US10760053B2 (en) * | 2015-10-15 | 2020-09-01 | StemoniX Inc. | Method of manufacturing or differentiating mammalian pluripotent stem cells or progenitor cells using a hollow fiber bioreactor |
| US20200392460A1 (en) * | 2017-11-10 | 2020-12-17 | Toppan Printing Co., Ltd. | Artificial fat tissue and method for producing same, method for producing artificial skin and agent for fat cell culture |
| US10296048B1 (en) * | 2018-03-14 | 2019-05-21 | Htc Corporation | Portable electronic device with dual displays and a hinge structure |
| WO2022076639A2 (en) * | 2020-10-09 | 2022-04-14 | Corning Incorporated | Surface-modified cell culture substrates and methods of modifying cell culture substrates |
| JP7700843B2 (ja) * | 2021-03-26 | 2025-07-01 | 東ソー株式会社 | 温度応答性高分子表面処理剤 |
| US20240287430A1 (en) * | 2021-06-02 | 2024-08-29 | The Regents Of The University Of California | Systems and Methods for Cellular Lumen Formation and Cellular Differentiation |
| CN114058504B (zh) * | 2021-11-04 | 2023-10-20 | 南京艾尔普再生医学科技有限公司 | 一种拟胚体生产方式、容器以及装置 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1989011500A1 (en) | 1988-05-17 | 1989-11-30 | Commonwealth Scientific And Industrial Research Or | Hydrophilic non-swelling multilayer polymeric materials and process for their manufacture |
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- 2009-07-27 CN CN200910205733A patent/CN101705186A/zh active Pending
- 2009-07-27 JP JP2009174472A patent/JP5784266B2/ja active Active
- 2009-07-27 PL PL18150504T patent/PL3323883T3/pl unknown
- 2009-07-27 CA CA2674111A patent/CA2674111A1/en not_active Abandoned
- 2009-07-27 EP EP10155353.5A patent/EP2213728B1/en active Active
- 2009-07-27 EP EP09166478.9A patent/EP2147971B1/en active Active
- 2009-07-27 CN CN201610324432.7A patent/CN106148189A/zh active Pending
- 2009-07-27 EP EP18150504.1A patent/EP3323883B1/en active Active
- 2009-07-27 AU AU2009203051A patent/AU2009203051A1/en not_active Abandoned
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2012
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2014
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- 2014-10-09 US US14/510,260 patent/US9157059B2/en active Active
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| Publication number | Publication date |
|---|---|
| EP2147971B1 (en) | 2018-04-11 |
| US8728818B2 (en) | 2014-05-20 |
| US8916382B2 (en) | 2014-12-23 |
| EP2147971A2 (en) | 2010-01-27 |
| CN101705186A (zh) | 2010-05-12 |
| US8288513B2 (en) | 2012-10-16 |
| EP2147971A3 (en) | 2010-04-28 |
| EP3323883B1 (en) | 2020-03-04 |
| US20150024494A1 (en) | 2015-01-22 |
| US20130280803A1 (en) | 2013-10-24 |
| AU2009203051A1 (en) | 2010-02-11 |
| US9157059B2 (en) | 2015-10-13 |
| JP5784266B2 (ja) | 2015-09-24 |
| EP2213728B1 (en) | 2016-01-06 |
| PL3323883T3 (pl) | 2020-07-13 |
| EP3323883A1 (en) | 2018-05-23 |
| CN106148189A (zh) | 2016-11-23 |
| JP2010029186A (ja) | 2010-02-12 |
| US20100021998A1 (en) | 2010-01-28 |
| US20140287506A1 (en) | 2014-09-25 |
| EP2213728A1 (en) | 2010-08-04 |
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