CA2671976C - Methods of inducing terminal differentiation - Google Patents

Methods of inducing terminal differentiation Download PDF

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Publication number
CA2671976C
CA2671976C CA2671976A CA2671976A CA2671976C CA 2671976 C CA2671976 C CA 2671976C CA 2671976 A CA2671976 A CA 2671976A CA 2671976 A CA2671976 A CA 2671976A CA 2671976 C CA2671976 C CA 2671976C
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CA
Canada
Prior art keywords
saha
pharmaceutically acceptable
hdac
hydrate
oral
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Expired - Lifetime
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CA2671976A
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English (en)
French (fr)
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CA2671976A1 (en
Inventor
Victoria M. Richon
W. Kevin Kelly
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Sloan Kettering Institute for Cancer Research
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Sloan Kettering Institute for Cancer Research
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Application filed by Sloan Kettering Institute for Cancer Research filed Critical Sloan Kettering Institute for Cancer Research
Publication of CA2671976A1 publication Critical patent/CA2671976A1/en
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    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
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    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
CA2671976A 2002-03-04 2003-03-04 Methods of inducing terminal differentiation Expired - Lifetime CA2671976C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36175902P 2002-03-04 2002-03-04
US60/361,759 2002-03-04
CA 2478094 CA2478094C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA 2478094 Division CA2478094C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

Publications (2)

Publication Number Publication Date
CA2671976A1 CA2671976A1 (en) 2003-09-18
CA2671976C true CA2671976C (en) 2016-05-10

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CA2671976A Expired - Lifetime CA2671976C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation
CA 2478094 Expired - Lifetime CA2478094C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation
CA 2632078 Expired - Lifetime CA2632078C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

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CA 2632078 Expired - Lifetime CA2632078C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

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EP (4) EP2082737B1 (US20040072735A1-20040415-C00078.png)
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KR (2) KR100868813B1 (US20040072735A1-20040415-C00078.png)
CN (3) CN101259120B (US20040072735A1-20040415-C00078.png)
AU (1) AU2003213684C1 (US20040072735A1-20040415-C00078.png)
BR (1) BR0308250A (US20040072735A1-20040415-C00078.png)
CA (3) CA2671976C (US20040072735A1-20040415-C00078.png)
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US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US20040087657A1 (en) * 2001-10-16 2004-05-06 Richon Victoria M. Treatment of neurodegenerative diseases and cancer of the brain using histone deacetylase inhibitors
CA2476434A1 (en) * 2002-02-15 2003-08-28 Sloan-Kettering Institute For Cancer Research Method of treating trx mediated diseases
US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
NZ567758A (en) * 2002-03-04 2009-07-31 Merck Hdac Res Llc Methods of inducing terminal differentiation using suberoylanilide hydrozmic acid (SAHA)
US20040132825A1 (en) * 2002-03-04 2004-07-08 Bacopoulos Nicholas G. Methods of treating cancer with HDAC inhibitors
US20060276547A1 (en) * 2002-03-04 2006-12-07 Bacopoulos Nicholas G Methods of treating cancer with HDAC inhibitors
US20070060614A1 (en) * 2002-03-04 2007-03-15 Bacopoulos Nicholas G Methods of treating cancer with hdac inhibitors
US7148257B2 (en) * 2002-03-04 2006-12-12 Merck Hdac Research, Llc Methods of treating mesothelioma with suberoylanilide hydroxamic acid
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