CA2661012C - Method of treating stroke with thrombolytic agent - Google Patents

Method of treating stroke with thrombolytic agent Download PDF

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Publication number
CA2661012C
CA2661012C CA2661012A CA2661012A CA2661012C CA 2661012 C CA2661012 C CA 2661012C CA 2661012 A CA2661012 A CA 2661012A CA 2661012 A CA2661012 A CA 2661012A CA 2661012 C CA2661012 C CA 2661012C
Authority
CA
Canada
Prior art keywords
tenecteplase
dose
infusion
ischemic stroke
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2661012A
Other languages
English (en)
French (fr)
Other versions
CA2661012A1 (en
Inventor
Peter Kuebler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38835003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2661012(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CA2661012A1 publication Critical patent/CA2661012A1/en
Application granted granted Critical
Publication of CA2661012C publication Critical patent/CA2661012C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2661012A 2006-08-29 2007-08-01 Method of treating stroke with thrombolytic agent Expired - Fee Related CA2661012C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82386806P 2006-08-29 2006-08-29
US60/823,868 2006-08-29
PCT/US2007/074997 WO2008027687A2 (en) 2006-08-29 2007-08-01 Use of tenecteplase for treating acute ischemic stroke

Publications (2)

Publication Number Publication Date
CA2661012A1 CA2661012A1 (en) 2008-03-06
CA2661012C true CA2661012C (en) 2019-03-19

Family

ID=38835003

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2661012A Expired - Fee Related CA2661012C (en) 2006-08-29 2007-08-01 Method of treating stroke with thrombolytic agent

Country Status (21)

Country Link
US (2) US20080107641A1 (cg-RX-API-DMAC10.html)
EP (1) EP2056856B1 (cg-RX-API-DMAC10.html)
JP (1) JP5785687B2 (cg-RX-API-DMAC10.html)
KR (1) KR20090045405A (cg-RX-API-DMAC10.html)
CN (1) CN101505785A (cg-RX-API-DMAC10.html)
AU (1) AU2007290277B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0716143A2 (cg-RX-API-DMAC10.html)
CA (1) CA2661012C (cg-RX-API-DMAC10.html)
CO (1) CO6150188A2 (cg-RX-API-DMAC10.html)
EA (1) EA015573B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP099178A (cg-RX-API-DMAC10.html)
IL (2) IL196987A (cg-RX-API-DMAC10.html)
MX (1) MX2009001918A (cg-RX-API-DMAC10.html)
MY (1) MY163119A (cg-RX-API-DMAC10.html)
NO (1) NO342302B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ574767A (cg-RX-API-DMAC10.html)
SG (3) SG10201501498VA (cg-RX-API-DMAC10.html)
TW (1) TWI439282B (cg-RX-API-DMAC10.html)
UA (1) UA97486C2 (cg-RX-API-DMAC10.html)
WO (1) WO2008027687A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200900957B (cg-RX-API-DMAC10.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
UA95903C2 (ru) 2005-02-24 2011-09-26 Дифьюжен Фармасьютикалз Ллк Транс-каротиноиды, их синтез, лекарственная форма и применение
TWI439282B (zh) 2006-08-29 2014-06-01 Genentech Inc 以血栓溶解劑治療中風之方法
EP3483140A1 (en) 2007-04-13 2019-05-15 Diffusion Pharmaceuticals LLC Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
US9034007B2 (en) 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
EP2384141A1 (en) * 2008-12-24 2011-11-09 Koninklijke Philips Electronics N.V. System, method and apparatus for cardiac intervention with mr stroke detection and treatment
KR101875843B1 (ko) 2009-06-22 2018-07-06 디퓨젼 파마슈티컬즈 엘엘씨 확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도
CA2772097C (en) * 2009-08-24 2019-04-30 Hough Ear Institute Methods for treating acute acoustic trauma
CN105287473A (zh) 2010-06-02 2016-02-03 扩散药品有限公司 包含双极性反式类胡萝卜素的组合物及其应用
EP2654770B1 (en) * 2010-12-23 2018-07-11 Gennova Biopharmaceuticals Ltd. Pharmaceutical compositions of tenecteplase
WO2014062888A1 (en) * 2012-10-18 2014-04-24 University Of South Florida Compositions and methods for treating stroke
US8679150B1 (en) 2013-03-15 2014-03-25 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy methods
US8715314B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment measurement methods
CA2901443A1 (en) 2013-03-15 2014-09-25 Insera Therapeutics, Inc. Vascular treatment devices and methods
US8715315B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment systems
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders
DK3209767T3 (da) * 2014-10-21 2020-11-02 Gennova Biopharmaceuticals Ltd Hidtil ukendt oprensningsfremgangsmåde til isolering og kommerciel fremstilling af rekombinant tnk-tpa (tenecteplase)
EP3416568A4 (en) 2016-02-16 2019-10-16 Insera Therapeutics, Inc. SUCTION DEVICES AND ANCHORED FLOW REVERSING DEVICES
WO2017165667A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
US12458379B2 (en) * 2017-01-24 2025-11-04 Boston Scientific Scimed, Inc. Method for the treatment of thromboembolism
WO2018210860A1 (en) * 2017-05-16 2018-11-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of acute ischemic stroke
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
WO2021158799A1 (en) * 2020-02-04 2021-08-12 The Regents Of The University Of Colorado, A Body Corporate Prophylactic uses of annexin a2
CA3171307A1 (en) * 2020-02-19 2021-08-26 Nono Inc. Combination treatment of stroke with plasmin-cleavable psd-95 inhibitor and reperfusion
CN114984197A (zh) * 2022-07-01 2022-09-02 江苏丰华生物制药有限公司 替奈普酶在制备用于治疗急性缺血性卒中的药物组合物中的应用
CN115487294A (zh) * 2022-07-12 2022-12-20 上海丰华天力通生物医药有限公司 替奈普酶在制备用于治疗轻型缺血性卒中的药物组合物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JP3559559B2 (ja) 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
JP2002173447A (ja) * 2000-09-29 2002-06-21 Yamanouchi Pharmaceut Co Ltd 脳塞栓症治療用医薬組成物
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
US20030180282A1 (en) * 2002-03-25 2003-09-25 Victor Serebruany Method of treatment of thrombotic events
US20070014779A1 (en) * 2002-11-14 2007-01-18 Genentech, Inc. Plasminogen activator variant formulations
WO2006094120A2 (en) * 2005-03-02 2006-09-08 The Regents Of The University Of California Treatment for embolic stroke
TWI439282B (zh) 2006-08-29 2014-06-01 Genentech Inc 以血栓溶解劑治療中風之方法

Also Published As

Publication number Publication date
CN101505785A (zh) 2009-08-12
IL248176A0 (en) 2016-11-30
TW200817033A (en) 2008-04-16
US9023346B2 (en) 2015-05-05
CO6150188A2 (es) 2010-04-20
US20120164157A1 (en) 2012-06-28
EP2056856A2 (en) 2009-05-13
KR20090045405A (ko) 2009-05-07
SG174753A1 (en) 2011-10-28
MX2009001918A (es) 2009-03-06
TWI439282B (zh) 2014-06-01
BRPI0716143A2 (pt) 2013-11-26
EA015573B1 (ru) 2011-10-31
IL196987A0 (en) 2011-08-01
WO2008027687A2 (en) 2008-03-06
AU2007290277A1 (en) 2008-03-06
WO2008027687A3 (en) 2008-05-22
SG10201501498VA (en) 2015-04-29
JP2010502629A (ja) 2010-01-28
ZA200900957B (en) 2010-05-26
AU2007290277B2 (en) 2013-04-11
ECSP099178A (es) 2009-06-30
IL196987A (en) 2016-10-31
MY163119A (en) 2017-08-15
US20080107641A1 (en) 2008-05-08
CA2661012A1 (en) 2008-03-06
JP5785687B2 (ja) 2015-09-30
SG10201804944XA (en) 2018-07-30
UA97486C2 (ru) 2012-02-27
NO342302B1 (no) 2018-04-30
HK1131054A1 (en) 2010-01-15
NO20091296L (no) 2009-05-28
EP2056856B1 (en) 2015-01-14
EA200970237A1 (ru) 2009-08-28
NZ574767A (en) 2012-02-24

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EEER Examination request
MKLA Lapsed

Effective date: 20210803