CA2652205A1 - Composition d'heparine de bas poids moleculaire et utilisations de celle-ci - Google Patents

Composition d'heparine de bas poids moleculaire et utilisations de celle-ci Download PDF

Info

Publication number
CA2652205A1
CA2652205A1 CA002652205A CA2652205A CA2652205A1 CA 2652205 A1 CA2652205 A1 CA 2652205A1 CA 002652205 A CA002652205 A CA 002652205A CA 2652205 A CA2652205 A CA 2652205A CA 2652205 A1 CA2652205 A1 CA 2652205A1
Authority
CA
Canada
Prior art keywords
lmwh
composition
activity
reh
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002652205A
Other languages
English (en)
Inventor
Mallik Sundaram
Ganesh Venkataraman
Patricia Oliver
Yiming Yao
Zainab Sirajbhai Mamuwala
Ian Fier
Yi Wei Qi
Zachary Shriver
Ishan Capila
Nur Sibel Gunay
Daniela Beccati
Cuihua Liu
Corinne Bauer
Ying Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Momenta Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2652205A1 publication Critical patent/CA2652205A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078Degradation products
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002652205A 2006-05-25 2007-05-24 Composition d'heparine de bas poids moleculaire et utilisations de celle-ci Abandoned CA2652205A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US80913606P 2006-05-25 2006-05-25
US60/809,136 2006-05-25
US84957806P 2006-10-04 2006-10-04
US60/849,578 2006-10-04
US84962806P 2006-10-05 2006-10-05
US60/849,628 2006-10-05
PCT/US2007/069626 WO2007140231A2 (fr) 2006-05-25 2007-05-24 Composition d'héparine de bas poids moléculaire et utilisations de celle-ci

Publications (1)

Publication Number Publication Date
CA2652205A1 true CA2652205A1 (fr) 2007-12-06

Family

ID=38722686

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002652205A Abandoned CA2652205A1 (fr) 2006-05-25 2007-05-24 Composition d'heparine de bas poids moleculaire et utilisations de celle-ci

Country Status (7)

Country Link
US (2) US8609632B2 (fr)
EP (3) EP2404939A3 (fr)
JP (1) JP2009538386A (fr)
CN (1) CN101495517B (fr)
AU (1) AU2007267561B2 (fr)
CA (1) CA2652205A1 (fr)
WO (1) WO2007140231A2 (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2402753A1 (fr) 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analyse de polysaccharides sulfatés
CA2652205A1 (fr) 2006-05-25 2007-12-06 Mallik Sundaram Composition d'heparine de bas poids moleculaire et utilisations de celle-ci
US7790466B1 (en) * 2007-01-26 2010-09-07 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2205642B1 (fr) 2007-11-02 2016-01-27 Momenta Pharmaceuticals, Inc. Compositions de polysaccharides non anticoagulants
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US20110076729A1 (en) * 2008-02-20 2011-03-31 Momenta Pharmaceuticals, Inc. Methods of making low molecular weight heparin compositions
US20100036310A1 (en) * 2008-08-05 2010-02-11 Hillman Robert S Integrated patient management and control system for medication delivery
CN101711771B (zh) * 2008-10-07 2015-12-09 上海喜恩医药科技发展有限公司 一种肝素衍生的多糖混合物及其制法和药物组合物
EP2256139A1 (fr) * 2009-05-05 2010-12-01 Sanofi-Aventis Nouvel octosaccharide sulfaté et son utilisation en tant qu'agent antithrombotique
EP2256136A1 (fr) * 2009-05-05 2010-12-01 Sanofi-Aventis Nouveau decasaccharide acylé et son utilisation en tant qu'agent antithrombotique
EP2256137A1 (fr) * 2009-05-05 2010-12-01 Sanofi-Aventis Nouvel octosaccharide sulfaté et son utilisation en tant qu'agent antithrombotique
EP2256138A1 (fr) * 2009-05-05 2010-12-01 Sanofi-Aventis Nouveau dérivé 1,6-anhydro decasaccharide acylé et son utilisation comme agent antithrombotique
US8834807B2 (en) * 2009-08-12 2014-09-16 Caliper Life Sciences, Inc. Device and method for improving sample injection and stacking
FR2949114B1 (fr) * 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
WO2011031299A1 (fr) * 2009-08-28 2011-03-17 Mount Sinai School Of Medicine Of New York University Injections intrapéricardiques
EP2480237A1 (fr) * 2009-09-23 2012-08-01 Momenta Pharmaceuticals, Inc. Méthodes de traitement par une composition d'héparine de bas poids moléculaire
RU2576033C2 (ru) 2009-12-03 2016-02-27 Опко Хелс, Инк. Составы на основе гиперсулфатированных дисахаридов
EP2526122B1 (fr) * 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Évaluation de préparations d'héparine
CN102985443B (zh) * 2010-04-16 2017-05-10 动量制药公司 组织靶向
BR112012031906A2 (pt) 2010-06-17 2016-08-23 Momenta Pharmaceuticals Inc métodos e composições para modular o crescimento de cabelo e pelos.
US11203772B2 (en) 2010-12-23 2021-12-21 The University Of North Carolina At Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
WO2012100733A1 (fr) * 2011-01-28 2012-08-02 杭州九源基因工程有限公司 Procédé de détermination d'une structure fine d'énoxaparine sodique par électrophorèse capillaire
WO2012115952A1 (fr) * 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Évaluation de préparations d'héparine
WO2013095215A1 (fr) * 2011-12-19 2013-06-27 Dilaforette Ab Héparines anticoagulantes de faible poids moléculaire
RS56874B1 (sr) * 2011-12-19 2018-04-30 Dilafor Ab Glikozaminoglikani koji nisu antikoagulanti koji sadrže ponavljajuću jedinicu disaharida i njihova medicinska upotreba
CN103059165B (zh) * 2012-12-26 2015-04-29 安徽丰原药业股份有限公司 一种多糖酰化物及其制备方法
CN103204958B (zh) * 2013-04-24 2015-04-01 深圳赛保尔生物药业有限公司 一种低乙醇残留的那曲肝素钙生产工艺
WO2014193818A1 (fr) 2013-05-28 2014-12-04 Momenta Pharmaceuticals, Inc. Compositions pharmaceutiques
CN105452479B (zh) 2013-06-17 2021-05-18 北卡罗来纳大学查珀尔希尔分校 可逆肝素分子
CN103788232A (zh) * 2013-12-23 2014-05-14 深圳市海普瑞药业股份有限公司 一种硫酸乙酰肝素十糖及其制备方法和应用
CN104193849B (zh) * 2014-08-13 2016-08-17 南京健友生化制药股份有限公司 一种依诺肝素钠的生产方法
US10688249B2 (en) * 2015-06-11 2020-06-23 Virchow Biotech Pvt. Ltd. Multiple dose pharmaceutical compositions containing heparin and/or heparin-like compounds and devices and methods for delivering the same
CN105504097B (zh) * 2015-12-30 2018-07-03 深圳市海普瑞药业集团股份有限公司 一种硫酸化肝素寡糖及其制备方法和应用
EP3398971A4 (fr) * 2015-12-30 2019-09-25 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. Oligosaccharide d'héparine sulfaté et procédé de préparation et application de celui-ci
JP6844890B2 (ja) * 2016-01-07 2021-03-17 藤森工業株式会社 採血管、試薬及びそれらを利用した血液性状分析方法
CN105461831A (zh) * 2016-01-08 2016-04-06 东营天东制药有限公司 一种快速分离快速移动肝素与硫酸皮肤素的方法
RU2641058C1 (ru) * 2016-11-17 2018-01-15 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Способ профилактики венозной тромбоэмболии у больных раком шейки матки
CN108117614B (zh) * 2016-11-29 2020-09-04 北京碧澄生物科技有限公司 低分子量肝素
US11840565B2 (en) 2016-12-29 2023-12-12 University Of Miami Methods and compositions for treating virus-associated inflammation
JP7330893B2 (ja) 2017-03-10 2023-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
WO2019090203A1 (fr) 2017-11-03 2019-05-09 The University Of North Carolina At Chapel Hill Oligosaccharides sulfatés présentant une activité anti-inflammatoire
JP7538724B2 (ja) 2018-06-20 2024-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 細胞保護の方法と組成物
WO2022015794A1 (fr) 2020-07-14 2022-01-20 Optimvia, Llc Procédés de synthèse de sulfate d'héparane non anticoagulant
WO2021007429A1 (fr) 2019-07-09 2021-01-14 Optimvia Llc Procédés de synthèse de polysaccharides anticoagulants
WO2021253008A1 (fr) * 2020-06-12 2021-12-16 Ihp Therapeutics Inc. Héparine partiellement désulfatée pour le traitement d'infections coronavirales
AU2022273722A1 (en) * 2021-05-12 2023-11-02 NexEos Diagnostics, Inc. Methods of manufacturing a high molecular weight heparin compound

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
FR2663639B1 (fr) 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
US5707973A (en) 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
FR2687158B1 (fr) 1992-02-07 1995-06-30 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
US5849721A (en) * 1992-02-07 1998-12-15 Rhone-Poulenc Rorer S.A. Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
US5681733A (en) 1994-06-10 1997-10-28 Ibex Technologies Nucleic acid sequences and expression systems for heparinase II and heparinase III derived from Flavobacterium heparinum
FR2723847A1 (fr) * 1994-08-29 1996-03-01 Debiopharm Sa Compositions antithrombotiques et non hemorragiques a base d'heparine, procede pour leur preparation et applications therapeutiques.
US5744457A (en) 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US20010046974A1 (en) 1997-06-06 2001-11-29 Hamilton Civic Hospitals Res Dev., Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
EP0986581A1 (fr) 1997-06-06 2000-03-22 Hamilton Civic Hospitals Research Development, Inc. Heparine de faible poids moleculaire modifiee inhibant les facteurs de coagulation associes au caillot
US5896789A (en) 1997-10-09 1999-04-27 Chicago Pneumatic Tool Company Ratchet wrench head
JP4226101B2 (ja) 1998-05-12 2009-02-18 株式会社アルバック 静電チャックプレート表面からの基板離脱方法
US20020009782A1 (en) 1999-06-03 2002-01-24 Daphna Miron Heparin and heparan sulfate derived oligosaccharides and a method for their manufacture
MXPA02000142A (es) * 1999-06-30 2003-07-21 Hamilton Civic Hospitals Res Composiciones de heparina que inhiben los factores de coagulacion asociados con el coagulo.
ES2231303T3 (es) 2000-01-10 2005-05-16 Dieter Welzel Heparina con masa molecular media.
WO2001066772A2 (fr) 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii et ses utilisations
US6608042B2 (en) * 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
CA2422059C (fr) 2000-09-12 2012-05-15 Massachusetts Institute Of Technology Procedes et produits apparentes a l'heparine de faible poids moleculaire
CA2423469A1 (fr) 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Procedes et produits associes a l'administration pulmonaires de polysaccharides
WO2003017166A1 (fr) 2001-04-03 2003-02-27 Rx-Connect, Inc. Service medical et systeme de gestion des prescriptions
WO2003018032A1 (fr) 2001-08-28 2003-03-06 Leo Pharma A/S Compositions antithrombotiques comportant de l'heparine de faible poids molecule et du dermatane sulfate de poids moleculaire
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
EP2402753A1 (fr) * 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analyse de polysaccharides sulfatés
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
FR2857971B1 (fr) * 2003-07-24 2005-08-26 Aventis Pharma Sa Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US7662928B2 (en) 2003-08-08 2010-02-16 The Research Foundation Of State University Of New York Anti-FcRn antibodies for treatment of auto/allo immune conditions
CN1268650C (zh) * 2003-12-24 2006-08-09 兆科药业(合肥)有限公司 一种低亚硝酸盐含量的低分子肝素钙的制备方法
RU2295538C2 (ru) 2005-03-01 2007-03-20 Гематологический научный центр РАМН Способ получения гепаринов с низкой молекулярной массой
ES2351623T3 (es) 2006-04-24 2011-02-08 Critical Care Diagnostics, Inc. Predicción de la mortalidad y detección de una enfermedad grave.
CA2652205A1 (fr) 2006-05-25 2007-12-06 Mallik Sundaram Composition d'heparine de bas poids moleculaire et utilisations de celle-ci

Also Published As

Publication number Publication date
AU2007267561A1 (en) 2007-12-06
WO2007140231A3 (fr) 2008-12-04
AU2007267561B2 (en) 2012-05-17
EP2404939A3 (fr) 2012-03-21
EP2447285A3 (fr) 2013-01-16
JP2009538386A (ja) 2009-11-05
EP2019843A2 (fr) 2009-02-04
EP2404939A2 (fr) 2012-01-11
US20070287683A1 (en) 2007-12-13
CN101495517B (zh) 2012-10-10
US20100305022A1 (en) 2010-12-02
US8609632B2 (en) 2013-12-17
CN101495517A (zh) 2009-07-29
WO2007140231A2 (fr) 2007-12-06
EP2447285A2 (fr) 2012-05-02

Similar Documents

Publication Publication Date Title
AU2007267561B2 (en) Low molecular weight heparin composition and uses thereof
JP4828795B2 (ja) 硫酸化多糖類の分析
US9351992B2 (en) Non-anticoagulant polysaccharide compositions
Millet et al. Antithrombotic and anticoagulant activities of a low molecular weight fucoidan by the subcutaneous route
Fareed et al. Chemical and biological heterogeneity in low molecular weight heparins: implications for clinical use and standardization
JP5351770B2 (ja) ビオチンまたはビオチン誘導体との少なくとも1つの共有結合を含む低分子量ヘパリン、これらの作製方法およびそれらの使用。
IE66341B1 (en) Mixtures of low molecular weight polysaccharides and their preparation and use
US20110076729A1 (en) Methods of making low molecular weight heparin compositions
Fareed et al. Biochemical and pharmacologic heterogeneity in low molecular weight heparins. Impact on the therapeutic profile
US5721357A (en) Preparation of sulfated polysaccharides for treatment or prevention of thromboses
US20120322760A1 (en) Methods of treatment with a low molecular weight heparin composition
AU671817B2 (en) Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof
US20100075922A1 (en) Heparins including at least one covalent bond with biotin or a biotin derivative, method for preparing same and use thereof
Yan et al. Fucosylated Chondroitin Sulfate 9–18 Oligomers Exhibit Molecular Size-Independent Antithrombotic Activity while Circulating in the Blood
RU2451515C2 (ru) Композиции гепарина низкой молекулярной массы и их применение
Fareed et al. Low molecular weight heparins: a developmental perspective
Jeske et al. Pharmacologic profile of a low-molecular-weight heparin depolymerized by γ-irradiation
Kouta Comparative Studies on Biochemical and Pharmacological Profiles of Unfractionated Heparins & Their Depolymerized Derivatives from Bovine, Ovine and Porcine Origins
Green The heparins: Basic and clinical aspects
Lee Dalteparin sodium in the management of thromboembolic disorders
Saivin et al. Antithrombotic activity, bleeding effect and pharmacodynamics of a succinyl derivative of dermatan sulphate in rabbits
JP2002080371A (ja) プラスミノーゲンアクチベーター活性促進剤

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20141118