CA2649324A1 - Tetrahydropteridines useful as inhibitors of protein kinases - Google Patents
Tetrahydropteridines useful as inhibitors of protein kinases Download PDFInfo
- Publication number
- CA2649324A1 CA2649324A1 CA002649324A CA2649324A CA2649324A1 CA 2649324 A1 CA2649324 A1 CA 2649324A1 CA 002649324 A CA002649324 A CA 002649324A CA 2649324 A CA2649324 A CA 2649324A CA 2649324 A1 CA2649324 A1 CA 2649324A1
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- Prior art keywords
- compound
- aliphatic
- optionally substituted
- independently
- cycloaliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Diabetes (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Obesity (AREA)
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- Emergency Medicine (AREA)
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- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US79132706P | 2006-04-12 | 2006-04-12 | |
| US60/791,327 | 2006-04-12 | ||
| US83872006P | 2006-08-18 | 2006-08-18 | |
| US60/838,720 | 2006-08-18 | ||
| PCT/US2007/009006 WO2007120752A2 (en) | 2006-04-12 | 2007-04-12 | 4, 5-dihydro- [1, 2, 4] triazolo [4, 3-f] pteridines as protein kinase plk1 inhibitors for the treatment of proliferative disorders |
Publications (1)
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| CA2649324A1 true CA2649324A1 (en) | 2007-10-25 |
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Family Applications (1)
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| CA002649324A Abandoned CA2649324A1 (en) | 2006-04-12 | 2007-04-12 | Tetrahydropteridines useful as inhibitors of protein kinases |
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| EP (1) | EP2010542B1 (enExample) |
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| AT (1) | ATE542823T1 (enExample) |
| AU (1) | AU2007238690B2 (enExample) |
| CA (1) | CA2649324A1 (enExample) |
| ES (1) | ES2381212T3 (enExample) |
| IL (1) | IL194699A (enExample) |
| MX (1) | MX2008013110A (enExample) |
| NO (1) | NO20084747L (enExample) |
| NZ (1) | NZ571969A (enExample) |
| RU (1) | RU2441006C2 (enExample) |
| TW (1) | TW200808805A (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2008287339A1 (en) * | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases |
| AU2008343932B2 (en) | 2007-12-19 | 2013-08-15 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
| ATE531372T1 (de) | 2008-04-07 | 2011-11-15 | Amgen Inc | Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren |
| EP2318412B1 (en) * | 2008-06-23 | 2013-08-14 | Vertex Pharmceuticals Incorporated | Protein kinase inhibitors |
| CA2728729C (en) * | 2008-06-23 | 2016-09-27 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| MX2012003484A (es) | 2009-09-25 | 2012-04-20 | Vertex Pharma | Metodos para preparar derivados de pirimidina utiles como inhibidores de proteina cinasa. |
| SG179207A1 (en) | 2009-09-25 | 2012-04-27 | Vertex Pharma | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| CN102762568A (zh) | 2009-12-23 | 2012-10-31 | 伊兰药品公司 | 作为polo样激酶的抑制剂的蝶啶酮 |
| EP2535059A4 (en) * | 2010-02-10 | 2014-03-12 | Public Univ Corp Yokohama City | USE OF A MSIN3B BINDING COMPOUND FOR SPECIFIC BINDING TO THE NEURONIC RESTRICTIVE SILENCER FACTOR (NRSF) |
| CA2803446C (en) | 2010-07-02 | 2019-06-04 | University Health Network | Use of plk4 antagonists for treating pten mutant diseases |
| BR112013008526A2 (pt) | 2010-10-08 | 2016-07-12 | Elan Pharm Inc | inibidores de quinase do tipo polo |
| WO2012061342A2 (en) | 2010-11-01 | 2012-05-10 | Arqule, Inc. | Substituted benzo-imidazo-pyrido-diazepine compounds |
| KR101606250B1 (ko) | 2011-03-23 | 2016-03-24 | 암젠 인크 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
| MD4300C1 (ro) * | 2012-12-28 | 2015-03-31 | Государственный Университет Молд0 | Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
| WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
| TWI828027B (zh) | 2016-03-28 | 2024-01-01 | 美商英塞特公司 | 作為tam抑制劑之吡咯并三嗪化合物 |
| US10633387B2 (en) | 2017-09-27 | 2020-04-28 | Incyte Corporation | Salts of TAM inhibitors |
| ES3031110T3 (en) | 2018-06-29 | 2025-07-04 | Incyte Corp | Formulations of an axl/mer inhibitor |
| CN109734809A (zh) * | 2019-02-27 | 2019-05-10 | 南方科技大学 | 治疗性的人Plk1蛋白单克隆抗体及其制备方法 |
| PH12022552347A1 (en) | 2020-03-06 | 2024-01-29 | Incyte Corp | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| US12577253B2 (en) | 2021-02-08 | 2026-03-17 | Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. | 5,6-dihydrothieno[3,4-h]quinazoline compound |
| JP7555155B2 (ja) * | 2021-08-10 | 2024-09-24 | オップテラ インコーポレイテッド | 新規ｐｌｋ１分解誘導化合物 |
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| ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| JP2003509425A (ja) * | 1999-09-15 | 2003-03-11 | ワーナー−ランバート・カンパニー | キナーゼ阻害剤としてのプテリジノン |
| WO2002076985A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| RU2351586C2 (ru) * | 2002-10-03 | 2009-04-10 | Таргеджен, Инк. | Васкулостатические агенты и способы их применения |
| MXPA05003477A (es) * | 2002-10-03 | 2005-07-22 | Targegen Inc | Agentes vasculo-estaticos y metodos de uso de los mismos. |
| CA2528975A1 (en) | 2003-06-10 | 2004-12-16 | Pfizer Inc. | Therapeutic combinations comprising pde inhibitors and vasopressin receptor antagonists for the treatment of dysmenorrhoea |
| GB0315966D0 (en) * | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| GB0412874D0 (en) | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
| DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
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- 2007-04-12 TW TW096112918A patent/TW200808805A/zh unknown
- 2007-04-12 AT AT07755318T patent/ATE542823T1/de active
- 2007-04-12 JP JP2009505472A patent/JP5313875B2/ja not_active Expired - Fee Related
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2010
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2011
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Also Published As
| Publication number | Publication date |
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| JP5313875B2 (ja) | 2013-10-09 |
| ATE542823T1 (de) | 2012-02-15 |
| KR101432316B1 (ko) | 2014-08-29 |
| AU2007238690A1 (en) | 2007-10-25 |
| RU2008144584A (ru) | 2010-05-20 |
| HK1134486A1 (en) | 2010-04-30 |
| JP2009536155A (ja) | 2009-10-08 |
| IL194699A0 (en) | 2009-08-03 |
| RU2441006C2 (ru) | 2012-01-27 |
| US20110021519A1 (en) | 2011-01-27 |
| EP2010542B1 (en) | 2012-01-25 |
| US20120277425A1 (en) | 2012-11-01 |
| AU2007238690B2 (en) | 2013-05-02 |
| MX2008013110A (es) | 2009-03-06 |
| EP2010542A2 (en) | 2009-01-07 |
| TW200808805A (en) | 2008-02-16 |
| KR20080109919A (ko) | 2008-12-17 |
| IL194699A (en) | 2014-07-31 |
| AR060432A1 (es) | 2008-06-18 |
| US20090062292A1 (en) | 2009-03-05 |
| NO20084747L (no) | 2008-11-25 |
| NZ571969A (en) | 2011-10-28 |
| WO2007120752A2 (en) | 2007-10-25 |
| WO2007120752A3 (en) | 2008-05-08 |
| US8067417B2 (en) | 2011-11-29 |
| US7763629B2 (en) | 2010-07-27 |
| US8524902B2 (en) | 2013-09-03 |
| ES2381212T3 (es) | 2012-05-24 |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20160324 |