CA2649324A1 - Tetrahydropteridines useful as inhibitors of protein kinases - Google Patents
Tetrahydropteridines useful as inhibitors of protein kinases Download PDFInfo
- Publication number
- CA2649324A1 CA2649324A1 CA002649324A CA2649324A CA2649324A1 CA 2649324 A1 CA2649324 A1 CA 2649324A1 CA 002649324 A CA002649324 A CA 002649324A CA 2649324 A CA2649324 A CA 2649324A CA 2649324 A1 CA2649324 A1 CA 2649324A1
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- Prior art keywords
- compound
- aliphatic
- optionally substituted
- independently
- cycloaliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 235000011178 triphosphate Nutrition 0.000 description 1
- JLEXUIVKURIPFI-UHFFFAOYSA-N tris phosphate Chemical compound OP(O)(O)=O.OCC(N)(CO)CO JLEXUIVKURIPFI-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
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- Pulmonology (AREA)
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- Endocrinology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
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- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79132706P | 2006-04-12 | 2006-04-12 | |
| US60/791,327 | 2006-04-12 | ||
| US83872006P | 2006-08-18 | 2006-08-18 | |
| US60/838,720 | 2006-08-18 | ||
| PCT/US2007/009006 WO2007120752A2 (en) | 2006-04-12 | 2007-04-12 | 4, 5-dihydro- [1, 2, 4] triazolo [4, 3-f] pteridines as protein kinase plk1 inhibitors for the treatment of proliferative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2649324A1 true CA2649324A1 (en) | 2007-10-25 |
Family
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Family Applications (1)
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| CA002649324A Abandoned CA2649324A1 (en) | 2006-04-12 | 2007-04-12 | Tetrahydropteridines useful as inhibitors of protein kinases |
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| US (3) | US7763629B2 (enExample) |
| EP (1) | EP2010542B1 (enExample) |
| JP (1) | JP5313875B2 (enExample) |
| KR (1) | KR101432316B1 (enExample) |
| AR (1) | AR060432A1 (enExample) |
| AT (1) | ATE542823T1 (enExample) |
| AU (1) | AU2007238690B2 (enExample) |
| CA (1) | CA2649324A1 (enExample) |
| ES (1) | ES2381212T3 (enExample) |
| IL (1) | IL194699A (enExample) |
| MX (1) | MX2008013110A (enExample) |
| NO (1) | NO20084747L (enExample) |
| NZ (1) | NZ571969A (enExample) |
| RU (1) | RU2441006C2 (enExample) |
| TW (1) | TW200808805A (enExample) |
| WO (1) | WO2007120752A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2008287339A1 (en) * | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases |
| AU2008343932B2 (en) | 2007-12-19 | 2013-08-15 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
| ATE531372T1 (de) | 2008-04-07 | 2011-11-15 | Amgen Inc | Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren |
| AU2009271663B2 (en) * | 2008-06-23 | 2014-04-17 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| JP5869338B2 (ja) * | 2008-06-23 | 2016-02-24 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | タンパク質キナーゼ阻害剤 |
| JP2013505927A (ja) | 2009-09-25 | 2013-02-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼ阻害剤として有用なピリミジン誘導体の調製方法 |
| JP2013512860A (ja) | 2009-09-25 | 2013-04-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼ阻害剤として有用なピリミジン誘導体の調製方法 |
| EP2516441B1 (en) | 2009-12-23 | 2015-01-21 | Elan Pharmaceuticals Inc. | Pteridinones as inhibitors of polo-like kinase |
| JP5850321B2 (ja) * | 2010-02-10 | 2016-02-03 | 公立大学法人横浜市立大学 | 神経選択的転写抑制因子ＮＲＳＦに特異的に結合するｍＳｉｎ３Ｂに結合する化合物の利用 |
| US8933070B2 (en) | 2010-07-02 | 2015-01-13 | University Health Network | Methods of targeting PTEN mutant diseases and compositions therefor |
| EP2661268A2 (en) * | 2010-10-08 | 2013-11-13 | Elan Pharmaceuticals Inc. | Inhibitors of polo-like kinase |
| TW201307347A (zh) | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並－咪唑並－吡啶並－二氮呯化合物 |
| WO2012129344A1 (en) | 2011-03-23 | 2012-09-27 | Amgen Inc. | Fused tricyclic dual inhibitors of cdk 4/6 and flt3 |
| MD4300C1 (ro) * | 2012-12-28 | 2015-03-31 | Государственный Университет Молд0 | Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
| US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
| KR102558066B1 (ko) | 2016-03-28 | 2023-07-25 | 인사이트 코포레이션 | Tam 억제제로서 피롤로트리아진 화합물 |
| IL273579B2 (en) | 2017-09-27 | 2025-10-01 | Incyte Corp | Salts of pyrrolizidine derivatives used as Tm inhibitors. |
| HRP20250676T1 (hr) | 2018-06-29 | 2025-08-01 | Incyte Corporation | Formulacije inhibitora axl/mer |
| CN109734809A (zh) * | 2019-02-27 | 2019-05-10 | 南方科技大学 | 治疗性的人Plk1蛋白单克隆抗体及其制备方法 |
| CN115697343A (zh) | 2020-03-06 | 2023-02-03 | 因赛特公司 | 包含axl/mer和pd-1/pd-l1抑制剂的组合疗法 |
| EP4157849A4 (en) * | 2021-08-10 | 2024-12-11 | Uppthera, Inc. | Novel plk1 degradation inducing compound |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| JP2003509425A (ja) * | 1999-09-15 | 2003-03-11 | ワーナー−ランバート・カンパニー | キナーゼ阻害剤としてのプテリジノン |
| WO2002076985A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| RU2351586C2 (ru) * | 2002-10-03 | 2009-04-10 | Таргеджен, Инк. | Васкулостатические агенты и способы их применения |
| BR0315053A (pt) | 2002-10-03 | 2005-08-09 | Targegen Inc | Agentes vasculostáticos , composição, artigo e processo de preparação dos mesmos |
| MXPA05013478A (es) | 2003-06-10 | 2006-03-09 | Pfizer | Combinaciones terapeuticas. |
| GB0315966D0 (en) * | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| GB0412874D0 (en) | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
| DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
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2011
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| WO2007120752A3 (en) | 2008-05-08 |
| NO20084747L (no) | 2008-11-25 |
| IL194699A0 (en) | 2009-08-03 |
| JP2009536155A (ja) | 2009-10-08 |
| MX2008013110A (es) | 2009-03-06 |
| KR101432316B1 (ko) | 2014-08-29 |
| ATE542823T1 (de) | 2012-02-15 |
| RU2441006C2 (ru) | 2012-01-27 |
| US20110021519A1 (en) | 2011-01-27 |
| HK1134486A1 (en) | 2010-04-30 |
| US7763629B2 (en) | 2010-07-27 |
| NZ571969A (en) | 2011-10-28 |
| WO2007120752A2 (en) | 2007-10-25 |
| AU2007238690B2 (en) | 2013-05-02 |
| RU2008144584A (ru) | 2010-05-20 |
| EP2010542A2 (en) | 2009-01-07 |
| AU2007238690A1 (en) | 2007-10-25 |
| TW200808805A (en) | 2008-02-16 |
| US8524902B2 (en) | 2013-09-03 |
| JP5313875B2 (ja) | 2013-10-09 |
| KR20080109919A (ko) | 2008-12-17 |
| IL194699A (en) | 2014-07-31 |
| ES2381212T3 (es) | 2012-05-24 |
| EP2010542B1 (en) | 2012-01-25 |
| US20090062292A1 (en) | 2009-03-05 |
| US20120277425A1 (en) | 2012-11-01 |
| AR060432A1 (es) | 2008-06-18 |
| US8067417B2 (en) | 2011-11-29 |
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| FZDE | Discontinued |
Effective date: 20160324 |