RU2441006C2 - 4, 5-ДИГИДРО-[1, 2, 4]ТРИАЗОЛО[4, 3-F]ПТЕРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗЫ Plk1 ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ - Google Patents
4, 5-ДИГИДРО-[1, 2, 4]ТРИАЗОЛО[4, 3-F]ПТЕРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗЫ Plk1 ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ Download PDFInfo
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- RU2441006C2 RU2441006C2 RU2008144584/04A RU2008144584A RU2441006C2 RU 2441006 C2 RU2441006 C2 RU 2441006C2 RU 2008144584/04 A RU2008144584/04 A RU 2008144584/04A RU 2008144584 A RU2008144584 A RU 2008144584A RU 2441006 C2 RU2441006 C2 RU 2441006C2
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- C07—ORGANIC CHEMISTRY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
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| AU2008287339A1 (en) * | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases |
| AU2008343932B2 (en) | 2007-12-19 | 2013-08-15 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
| ATE531372T1 (de) | 2008-04-07 | 2011-11-15 | Amgen Inc | Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren |
| EP2318412B1 (en) * | 2008-06-23 | 2013-08-14 | Vertex Pharmceuticals Incorporated | Protein kinase inhibitors |
| CA2728729C (en) * | 2008-06-23 | 2016-09-27 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| MX2012003484A (es) | 2009-09-25 | 2012-04-20 | Vertex Pharma | Metodos para preparar derivados de pirimidina utiles como inhibidores de proteina cinasa. |
| SG179207A1 (en) | 2009-09-25 | 2012-04-27 | Vertex Pharma | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| CN102762568A (zh) | 2009-12-23 | 2012-10-31 | 伊兰药品公司 | 作为polo样激酶的抑制剂的蝶啶酮 |
| EP2535059A4 (en) * | 2010-02-10 | 2014-03-12 | Public Univ Corp Yokohama City | USE OF A MSIN3B BINDING COMPOUND FOR SPECIFIC BINDING TO THE NEURONIC RESTRICTIVE SILENCER FACTOR (NRSF) |
| CA2803446C (en) | 2010-07-02 | 2019-06-04 | University Health Network | Use of plk4 antagonists for treating pten mutant diseases |
| BR112013008526A2 (pt) | 2010-10-08 | 2016-07-12 | Elan Pharm Inc | inibidores de quinase do tipo polo |
| WO2012061342A2 (en) | 2010-11-01 | 2012-05-10 | Arqule, Inc. | Substituted benzo-imidazo-pyrido-diazepine compounds |
| KR101606250B1 (ko) | 2011-03-23 | 2016-03-24 | 암젠 인크 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
| MD4300C1 (ro) * | 2012-12-28 | 2015-03-31 | Государственный Университет Молд0 | Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
| WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
| TWI828027B (zh) | 2016-03-28 | 2024-01-01 | 美商英塞特公司 | 作為tam抑制劑之吡咯并三嗪化合物 |
| US10633387B2 (en) | 2017-09-27 | 2020-04-28 | Incyte Corporation | Salts of TAM inhibitors |
| ES3031110T3 (en) | 2018-06-29 | 2025-07-04 | Incyte Corp | Formulations of an axl/mer inhibitor |
| CN109734809A (zh) * | 2019-02-27 | 2019-05-10 | 南方科技大学 | 治疗性的人Plk1蛋白单克隆抗体及其制备方法 |
| PH12022552347A1 (en) | 2020-03-06 | 2024-01-29 | Incyte Corp | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| US12577253B2 (en) | 2021-02-08 | 2026-03-17 | Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. | 5,6-dihydrothieno[3,4-h]quinazoline compound |
| JP7555155B2 (ja) * | 2021-08-10 | 2024-09-24 | オップテラ インコーポレイテッド | 新規ｐｌｋ１分解誘導化合物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EA005287B1 (ru) * | 1999-09-15 | 2004-12-30 | Уорнер-Ламберт Компани | Птеридиноны в качестве ингибиторов киназ |
| RU2005113978A (ru) * | 2002-10-03 | 2005-11-20 | Таргеджен, Инк. (US) | Васкулостатические агенты и способы их применения |
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| ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| WO2002076985A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| MXPA05003477A (es) * | 2002-10-03 | 2005-07-22 | Targegen Inc | Agentes vasculo-estaticos y metodos de uso de los mismos. |
| CA2528975A1 (en) | 2003-06-10 | 2004-12-16 | Pfizer Inc. | Therapeutic combinations comprising pde inhibitors and vasopressin receptor antagonists for the treatment of dysmenorrhoea |
| GB0315966D0 (en) * | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| GB0412874D0 (en) | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
| DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA005287B1 (ru) * | 1999-09-15 | 2004-12-30 | Уорнер-Ламберт Компани | Птеридиноны в качестве ингибиторов киназ |
| RU2005113978A (ru) * | 2002-10-03 | 2005-11-20 | Таргеджен, Инк. (US) | Васкулостатические агенты и способы их применения |
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| JP5313875B2 (ja) | 2013-10-09 |
| ATE542823T1 (de) | 2012-02-15 |
| KR101432316B1 (ko) | 2014-08-29 |
| AU2007238690A1 (en) | 2007-10-25 |
| RU2008144584A (ru) | 2010-05-20 |
| HK1134486A1 (en) | 2010-04-30 |
| JP2009536155A (ja) | 2009-10-08 |
| CA2649324A1 (en) | 2007-10-25 |
| IL194699A0 (en) | 2009-08-03 |
| US20110021519A1 (en) | 2011-01-27 |
| EP2010542B1 (en) | 2012-01-25 |
| US20120277425A1 (en) | 2012-11-01 |
| AU2007238690B2 (en) | 2013-05-02 |
| MX2008013110A (es) | 2009-03-06 |
| EP2010542A2 (en) | 2009-01-07 |
| TW200808805A (en) | 2008-02-16 |
| KR20080109919A (ko) | 2008-12-17 |
| IL194699A (en) | 2014-07-31 |
| AR060432A1 (es) | 2008-06-18 |
| US20090062292A1 (en) | 2009-03-05 |
| NO20084747L (no) | 2008-11-25 |
| NZ571969A (en) | 2011-10-28 |
| WO2007120752A2 (en) | 2007-10-25 |
| WO2007120752A3 (en) | 2008-05-08 |
| US8067417B2 (en) | 2011-11-29 |
| US7763629B2 (en) | 2010-07-27 |
| US8524902B2 (en) | 2013-09-03 |
| ES2381212T3 (es) | 2012-05-24 |
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