CA2648371A1 - Combination therapy of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4-yl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide - Google Patents
Combination therapy of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4-yl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide Download PDFInfo
- Publication number
- CA2648371A1 CA2648371A1 CA002648371A CA2648371A CA2648371A1 CA 2648371 A1 CA2648371 A1 CA 2648371A1 CA 002648371 A CA002648371 A CA 002648371A CA 2648371 A CA2648371 A CA 2648371A CA 2648371 A1 CA2648371 A1 CA 2648371A1
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- CA
- Canada
- Prior art keywords
- cancer
- agent
- pyrazol
- acetamide
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78927606P | 2006-04-04 | 2006-04-04 | |
| US60/789,276 | 2006-04-04 | ||
| PCT/IB2007/000928 WO2007113671A1 (en) | 2006-04-04 | 2007-03-26 | Combination therapy of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4-yl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide |
Publications (1)
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|---|---|
| CA2648371A1 true CA2648371A1 (en) | 2007-10-11 |
Family
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Family Applications (1)
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|---|---|---|---|
| CA002648371A Abandoned CA2648371A1 (en) | 2006-04-04 | 2007-03-26 | Combination therapy of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4-yl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide |
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| US (1) | US20090312280A1 (enExample) |
| EP (1) | EP2007375A1 (enExample) |
| JP (1) | JP2007277240A (enExample) |
| KR (1) | KR20080100838A (enExample) |
| CN (1) | CN101415417A (enExample) |
| AR (1) | AR060284A1 (enExample) |
| AU (1) | AU2007232279B2 (enExample) |
| BR (1) | BRPI0709731A2 (enExample) |
| CA (1) | CA2648371A1 (enExample) |
| IL (1) | IL194340A0 (enExample) |
| MX (1) | MX2008012791A (enExample) |
| RU (1) | RU2409361C2 (enExample) |
| TW (1) | TW200806301A (enExample) |
| WO (1) | WO2007113671A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009113436A1 (ja) * | 2008-03-14 | 2009-09-17 | 国立大学法人千葉大学 | Ｆｇｆｒ３遺伝子阻害剤の放射線照射併用による放射線の抗癌作用増強法および副作用軽減法 |
| SG189699A1 (en) * | 2008-03-27 | 2013-05-31 | Taiho Pharmaceutical Co Ltd | Anti-tumor agent comprising cytidine derivative and carboplatin |
| EP2416773B1 (en) * | 2009-04-11 | 2016-09-28 | Array Biopharma, Inc. | Checkpoint kinase 1 inhibitors for potentiating dna damaging agents |
| US8481557B2 (en) | 2009-04-11 | 2013-07-09 | Array Biopharma Inc. | Method of treatment using checkpoint kinase 1 inhibitors |
| EP2640386B1 (en) | 2010-11-16 | 2017-01-18 | Array Biopharma Inc. | Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors |
| EP2797919B1 (en) | 2011-12-31 | 2017-03-29 | BeiGene, Ltd. | Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors |
| MX353578B (es) | 2011-12-31 | 2018-01-19 | Beigene Ltd | Dihidrodiazpinocarbazolonas tetra o penta-ciclicas fusionadas como inhibidores de poli (adp-ribosa) polimerasa (parp). |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
Family Cites Families (2)
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|---|---|---|---|---|
| SE9704545D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| SI1585749T1 (sl) * | 2003-01-09 | 2008-10-31 | Pfizer | Derivati diazepinoindola kot inhibitorji kinaze |
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2007
- 2007-03-26 MX MX2008012791A patent/MX2008012791A/es unknown
- 2007-03-26 BR BRPI0709731-0A patent/BRPI0709731A2/pt not_active IP Right Cessation
- 2007-03-26 CA CA002648371A patent/CA2648371A1/en not_active Abandoned
- 2007-03-26 AU AU2007232279A patent/AU2007232279B2/en not_active Ceased
- 2007-03-26 EP EP07734247A patent/EP2007375A1/en not_active Withdrawn
- 2007-03-26 US US12/295,986 patent/US20090312280A1/en not_active Abandoned
- 2007-03-26 RU RU2008139406/15A patent/RU2409361C2/ru not_active IP Right Cessation
- 2007-03-26 KR KR1020087024155A patent/KR20080100838A/ko not_active Ceased
- 2007-03-26 WO PCT/IB2007/000928 patent/WO2007113671A1/en not_active Ceased
- 2007-03-26 CN CNA2007800121818A patent/CN101415417A/zh active Pending
- 2007-04-03 TW TW096111825A patent/TW200806301A/zh unknown
- 2007-04-03 AR ARP070101414A patent/AR060284A1/es not_active Application Discontinuation
- 2007-04-04 JP JP2007097995A patent/JP2007277240A/ja not_active Withdrawn
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2008
- 2008-09-25 IL IL194340A patent/IL194340A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007277240A (ja) | 2007-10-25 |
| AU2007232279B2 (en) | 2010-05-06 |
| KR20080100838A (ko) | 2008-11-19 |
| CN101415417A (zh) | 2009-04-22 |
| US20090312280A1 (en) | 2009-12-17 |
| RU2008139406A (ru) | 2010-04-10 |
| IL194340A0 (en) | 2009-08-03 |
| EP2007375A1 (en) | 2008-12-31 |
| WO2007113671A1 (en) | 2007-10-11 |
| TW200806301A (en) | 2008-02-01 |
| MX2008012791A (es) | 2008-10-15 |
| AU2007232279A1 (en) | 2007-10-11 |
| AR060284A1 (es) | 2008-06-04 |
| RU2409361C2 (ru) | 2011-01-20 |
| BRPI0709731A2 (pt) | 2011-07-26 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20121012 |