AU2007232279B2 - Combination therapy of (2R)-2-amino-2-cyclohexyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-6- oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide - Google Patents
Combination therapy of (2R)-2-amino-2-cyclohexyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-6- oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide Download PDFInfo
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- AU2007232279B2 AU2007232279B2 AU2007232279A AU2007232279A AU2007232279B2 AU 2007232279 B2 AU2007232279 B2 AU 2007232279B2 AU 2007232279 A AU2007232279 A AU 2007232279A AU 2007232279 A AU2007232279 A AU 2007232279A AU 2007232279 B2 AU2007232279 B2 AU 2007232279B2
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78927606P | 2006-04-04 | 2006-04-04 | |
| US60/789,276 | 2006-04-04 | ||
| PCT/IB2007/000928 WO2007113671A1 (en) | 2006-04-04 | 2007-03-26 | Combination therapy of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4-yl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide |
Publications (2)
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| AU2007232279A1 AU2007232279A1 (en) | 2007-10-11 |
| AU2007232279B2 true AU2007232279B2 (en) | 2010-05-06 |
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|---|---|---|---|
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| EP (1) | EP2007375A1 (enExample) |
| JP (1) | JP2007277240A (enExample) |
| KR (1) | KR20080100838A (enExample) |
| CN (1) | CN101415417A (enExample) |
| AR (1) | AR060284A1 (enExample) |
| AU (1) | AU2007232279B2 (enExample) |
| BR (1) | BRPI0709731A2 (enExample) |
| CA (1) | CA2648371A1 (enExample) |
| IL (1) | IL194340A0 (enExample) |
| MX (1) | MX2008012791A (enExample) |
| RU (1) | RU2409361C2 (enExample) |
| TW (1) | TW200806301A (enExample) |
| WO (1) | WO2007113671A1 (enExample) |
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| WO2009113436A1 (ja) * | 2008-03-14 | 2009-09-17 | 国立大学法人千葉大学 | Ｆｇｆｒ３遺伝子阻害剤の放射線照射併用による放射線の抗癌作用増強法および副作用軽減法 |
| SG189699A1 (en) * | 2008-03-27 | 2013-05-31 | Taiho Pharmaceutical Co Ltd | Anti-tumor agent comprising cytidine derivative and carboplatin |
| EP2416773B1 (en) * | 2009-04-11 | 2016-09-28 | Array Biopharma, Inc. | Checkpoint kinase 1 inhibitors for potentiating dna damaging agents |
| US8481557B2 (en) | 2009-04-11 | 2013-07-09 | Array Biopharma Inc. | Method of treatment using checkpoint kinase 1 inhibitors |
| EP2640386B1 (en) | 2010-11-16 | 2017-01-18 | Array Biopharma Inc. | Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors |
| EP2797919B1 (en) | 2011-12-31 | 2017-03-29 | BeiGene, Ltd. | Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors |
| MX353578B (es) | 2011-12-31 | 2018-01-19 | Beigene Ltd | Dihidrodiazpinocarbazolonas tetra o penta-ciclicas fusionadas como inhibidores de poli (adp-ribosa) polimerasa (parp). |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050075499A1 (en) * | 2003-01-09 | 2005-04-07 | Agouron Pharmaceuticals, Inc. | Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9704545D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
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2007
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- 2007-03-26 AU AU2007232279A patent/AU2007232279B2/en not_active Ceased
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- 2007-03-26 US US12/295,986 patent/US20090312280A1/en not_active Abandoned
- 2007-03-26 RU RU2008139406/15A patent/RU2409361C2/ru not_active IP Right Cessation
- 2007-03-26 KR KR1020087024155A patent/KR20080100838A/ko not_active Ceased
- 2007-03-26 WO PCT/IB2007/000928 patent/WO2007113671A1/en not_active Ceased
- 2007-03-26 CN CNA2007800121818A patent/CN101415417A/zh active Pending
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- 2007-04-03 AR ARP070101414A patent/AR060284A1/es not_active Application Discontinuation
- 2007-04-04 JP JP2007097995A patent/JP2007277240A/ja not_active Withdrawn
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2008
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050075499A1 (en) * | 2003-01-09 | 2005-04-07 | Agouron Pharmaceuticals, Inc. | Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007277240A (ja) | 2007-10-25 |
| KR20080100838A (ko) | 2008-11-19 |
| CA2648371A1 (en) | 2007-10-11 |
| CN101415417A (zh) | 2009-04-22 |
| US20090312280A1 (en) | 2009-12-17 |
| RU2008139406A (ru) | 2010-04-10 |
| IL194340A0 (en) | 2009-08-03 |
| EP2007375A1 (en) | 2008-12-31 |
| WO2007113671A1 (en) | 2007-10-11 |
| TW200806301A (en) | 2008-02-01 |
| MX2008012791A (es) | 2008-10-15 |
| AU2007232279A1 (en) | 2007-10-11 |
| AR060284A1 (es) | 2008-06-04 |
| RU2409361C2 (ru) | 2011-01-20 |
| BRPI0709731A2 (pt) | 2011-07-26 |
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| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ COMBINATION THERAPY OF (2R)-2-AMINO-2-CYCLOHEXYL-N-(2-(1-METHYL-1H-PYRAZOL-4-YL)-6-OXO-5,6-DI HYDRO-1H-[1,2]DIAZEPINO[4,5,6-CD]INDOL-8-YL)ACETAMIDE |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |