CA2645053A1 - Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines - Google Patents

Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines Download PDF

Info

Publication number
CA2645053A1
CA2645053A1 CA002645053A CA2645053A CA2645053A1 CA 2645053 A1 CA2645053 A1 CA 2645053A1 CA 002645053 A CA002645053 A CA 002645053A CA 2645053 A CA2645053 A CA 2645053A CA 2645053 A1 CA2645053 A1 CA 2645053A1
Authority
CA
Canada
Prior art keywords
integer
cooh
amino
alkanoyloxy
configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002645053A
Other languages
English (en)
French (fr)
Inventor
Jacques Bauer
Carlo Chiavaroli
Stephane Moutel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OM Pharma SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2645053A1 publication Critical patent/CA2645053A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002645053A 2006-03-09 2007-03-09 Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines Abandoned CA2645053A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2006/050748 2006-03-09
IBPCT/IB2006/050748 2006-03-09
PCT/IB2007/000567 WO2007102081A2 (en) 2006-03-09 2007-03-09 Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines

Publications (1)

Publication Number Publication Date
CA2645053A1 true CA2645053A1 (en) 2007-09-13

Family

ID=38475231

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002645053A Abandoned CA2645053A1 (en) 2006-03-09 2007-03-09 Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines

Country Status (14)

Country Link
US (3) US7915240B2 (enExample)
EP (1) EP2051728A4 (enExample)
JP (1) JP5341526B2 (enExample)
KR (1) KR20080105048A (enExample)
CN (1) CN101511379A (enExample)
AU (1) AU2007222135B2 (enExample)
BR (1) BRPI0708363A2 (enExample)
CA (1) CA2645053A1 (enExample)
IL (1) IL192837A (enExample)
MX (1) MX2008011360A (enExample)
NO (1) NO20084195L (enExample)
RU (1) RU2498813C2 (enExample)
WO (1) WO2007102081A2 (enExample)
ZA (1) ZA200806266B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2645053A1 (en) * 2006-03-09 2007-09-13 Om Pharma Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
KR101108161B1 (ko) 2009-12-24 2012-01-31 삼성모바일디스플레이주식회사 유기 발광 표시 장치 및 그 제조방법
US10065978B2 (en) 2015-11-24 2018-09-04 University Of South Carolina Cysteine-modifying substrate analogue inhibitors of ribose 5-phosphate isomerase for parasitic diseases, along with methods of their formation and use
US10682359B2 (en) 2017-03-31 2020-06-16 University Of South Carolina Inhibitors of glucose kinases, along with methods of their formation and use
US11059842B2 (en) 2019-04-29 2021-07-13 University Of South Carolina Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
US11555047B2 (en) 2019-10-31 2023-01-17 University Of South Carolina One-step synthesis of phosphate-based inhibitors and applications thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT879056E (pt) * 1996-01-23 2002-10-31 Ribapharm Inc Modulacao da expressao das citocinas th1/th2 atraves de ribavirina em linfocitos t activados
JP4305662B2 (ja) * 1996-09-30 2009-07-29 大塚製薬株式会社 サイトカイン産生抑制剤及び接着抑制剤
AU738170B2 (en) * 1996-10-16 2001-09-13 Icn Pharmaceuticals, Inc. Monocyclic L-nucleosides, analogs and uses thereof
KR20010021789A (ko) 1997-08-04 2001-03-15 야스이 쇼사꾸 촉매 및 방향족 카보네이트의 제조방법
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
CA2332946A1 (en) 1998-05-22 1999-12-02 Welfide Corporation Hydroxamic acid derivative and pharmaceutical use thereof
US7157092B1 (en) * 1998-06-30 2007-01-02 Om Pharma Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same
US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
AU1581400A (en) * 1999-12-22 2001-07-03 Om Pharma Acyl pseudopeptides bearing a functionalised auxiliary spacer
AU2001234582A1 (en) * 2000-01-25 2001-08-14 Nuvelo, Inc. Methods and materials relating to preadipocyte factor-1-like (pref-1-like) polypeptides and polynucleotides
JP2001316260A (ja) * 2000-02-29 2001-11-13 Meiji Milk Prod Co Ltd カバラクトン類を有効成分とするTNF−α産生抑制剤
DE20220947U1 (de) * 2001-02-28 2004-09-30 Ribapharm, Inc., Costa Mesa Pyrrolo2,3-dpyrimidin-Nucleosidanaloga
RU2190422C1 (ru) * 2001-04-25 2002-10-10 Кожемякин Леонид Андреевич Аэрозоль для ингаляций фармацевтической композиции глутовент и способ лечения с его использованием
JP4902913B2 (ja) * 2001-07-11 2012-03-21 森下仁丹株式会社 TNF−α産生抑制剤
JP2004107220A (ja) * 2002-09-13 2004-04-08 Mitsubishi Pharma Corp TNF−α産生抑制剤
JP2004256403A (ja) * 2003-02-25 2004-09-16 Kyowa Hakko Kogyo Co Ltd TNF−α産生抑制剤
EP1602655A4 (en) * 2003-03-07 2010-06-09 Kowa Co benzofuran
CA2645053A1 (en) 2006-03-09 2007-09-13 Om Pharma Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines

Also Published As

Publication number Publication date
AU2007222135A1 (en) 2007-09-13
RU2008139985A (ru) 2010-04-20
WO2007102081A3 (en) 2009-04-23
WO2007102081A2 (en) 2007-09-13
AU2007222135B2 (en) 2012-02-02
BRPI0708363A2 (pt) 2011-05-24
JP2009529523A (ja) 2009-08-20
US20140086960A1 (en) 2014-03-27
NO20084195L (no) 2008-10-07
RU2498813C2 (ru) 2013-11-20
JP5341526B2 (ja) 2013-11-13
US7915240B2 (en) 2011-03-29
KR20080105048A (ko) 2008-12-03
IL192837A (en) 2013-12-31
US20090054378A1 (en) 2009-02-26
CN101511379A (zh) 2009-08-19
US20120178721A1 (en) 2012-07-12
EP2051728A2 (en) 2009-04-29
EP2051728A4 (en) 2010-03-31
ZA200806266B (en) 2010-05-26
MX2008011360A (es) 2009-03-03
US8618080B2 (en) 2013-12-31

Similar Documents

Publication Publication Date Title
KR102809631B1 (ko) 융합된-바이사이클릭 C5aR 길항제의 프로드러그
US10941115B2 (en) Kinase inhibitors
JP6764396B2 (ja) 二糖合成脂質化合物およびその使用
AU2017273771B2 (en) Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
CA2337807C (fr) Nouveaux pseudodipeptides acyles, leur mode de preparation et les compositions pharmaceutiques en renfermant
AU707779B2 (en) Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US8618080B2 (en) Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
KR20150073942A (ko) 유기 화합물
EP3880668B1 (en) Pyridin-sulfonamide compounds for the treatment of conditions related to interleukin 1 beta
KR20260046445A (ko) 이미다조[4,5-d]피리다진 화합물 및 이의 접합체, 이의 제조 및 이의 치료적 적용
AU2012202597A1 (en) Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
RU2803242C2 (ru) Соединения пиридинсульфонамида для лечения состояний, связанных с интерлейкином 1 бета
US12115161B2 (en) Prophylactic and/or therapeutic agent for inflammatory diseases which contains pyrrolopyrimidine compound as active ingredient
RU2794327C2 (ru) ПРОЛЕКАРСТВА СОПРЯЖЕННО-БИЦИКЛИЧЕСКИХ АНТАГОНИСТОВ C5aR
EA043820B1 (ru) Лиганды toll-подобных рецепторов
BR112018074919B1 (pt) Uso de indazóis 2-substituídos para preparação de medicamento para tratamento e profilaxia de doenças autoimunes

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20150310