CA2632939C - Antimicrobial composition - Google Patents
Antimicrobial composition Download PDFInfo
- Publication number
- CA2632939C CA2632939C CA2632939A CA2632939A CA2632939C CA 2632939 C CA2632939 C CA 2632939C CA 2632939 A CA2632939 A CA 2632939A CA 2632939 A CA2632939 A CA 2632939A CA 2632939 C CA2632939 C CA 2632939C
- Authority
- CA
- Canada
- Prior art keywords
- edta
- composition
- iodine
- antiseptic
- antimicrobial agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 64
- 230000000845 anti-microbial effect Effects 0.000 title description 18
- 239000004599 antimicrobial Substances 0.000 claims abstract description 29
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 29
- 229910052740 iodine Inorganic materials 0.000 claims description 29
- 239000011630 iodine Substances 0.000 claims description 29
- 229910052709 silver Inorganic materials 0.000 claims description 22
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- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/11—Peroxy compounds, peroxides, e.g. hydrogen peroxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/212—Peroxy acids, peracids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
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- Wood Science & Technology (AREA)
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0525504.7A GB0525504D0 (en) | 2005-12-14 | 2005-12-14 | Antimicrobial composition |
| GB0525504.7 | 2005-12-14 | ||
| PCT/GB2006/004691 WO2007068938A2 (en) | 2005-12-14 | 2006-12-14 | Antimicrobial composition |
Publications (2)
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| CA2632939A1 CA2632939A1 (en) | 2007-06-21 |
| CA2632939C true CA2632939C (en) | 2016-06-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2632939A Active CA2632939C (en) | 2005-12-14 | 2006-12-14 | Antimicrobial composition |
Country Status (14)
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| US (3) | US9149035B2 (enExample) |
| EP (2) | EP3241439B1 (enExample) |
| JP (4) | JP5340741B2 (enExample) |
| CA (1) | CA2632939C (enExample) |
| DK (1) | DK1959739T3 (enExample) |
| ES (1) | ES2622827T3 (enExample) |
| GB (1) | GB0525504D0 (enExample) |
| HK (1) | HK1246086A1 (enExample) |
| HU (1) | HUE032810T2 (enExample) |
| LT (1) | LT1959739T (enExample) |
| NZ (1) | NZ568999A (enExample) |
| PL (1) | PL1959739T3 (enExample) |
| PT (1) | PT1959739T (enExample) |
| WO (1) | WO2007068938A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0525504D0 (en) * | 2005-12-14 | 2006-01-25 | Bristol Myers Squibb Co | Antimicrobial composition |
| DE102007030931A1 (de) * | 2007-07-03 | 2009-01-08 | Birgit Riesinger | Zusammensetzung, enthaltend mindestens einen nutritiven, mindestens einen desinfizierenden bzw. dekontaminierenden und/oder mindestens einen Proteasen hemmend wirkenden Wirkstoff und/oder Wirkstoffkomplex |
| GB0714338D0 (en) * | 2007-07-23 | 2007-09-05 | Sinclair Pharmaceuticals Ltd | method |
| AU2009260414A1 (en) * | 2008-05-30 | 2009-12-23 | University Of Cincinnati | Use of zinc chelators to inhibit biofilm formation |
| US20100009009A1 (en) * | 2008-07-10 | 2010-01-14 | Micropure, Inc. | Method and composition for prevention and treatment of oral fungal infections |
| US20100233101A1 (en) | 2009-02-13 | 2010-09-16 | Micropure, Inc. | Composition and method for the oxidative consumption of salivary biomolecules |
| US8778387B2 (en) | 2009-09-02 | 2014-07-15 | Hyprotek, Inc. | Antimicrobial medical dressings and protecting wounds and catheter sites |
| KR101785130B1 (ko) | 2010-01-22 | 2017-10-12 | 히프로테크, 인크. | 퍼록시드, 알코올 및 킬레이트화제를 포함하는 항균제 |
| KR101352795B1 (ko) * | 2010-02-26 | 2014-02-17 | 주식회사 나이벡 | 치아의 접합능을 향상시키기 위한 치과용 클린저 조성물 |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| GB201105829D0 (en) * | 2011-04-06 | 2011-05-18 | Convatec Technologies Inc | Antimicrobial compositions |
| US8829053B2 (en) * | 2011-12-07 | 2014-09-09 | Rochal Industries Llp | Biocidal compositions and methods of using the same |
| US10617472B2 (en) | 2012-02-06 | 2020-04-14 | Hyprotek, Inc. | Adhesive patch with antimicrobial composition |
| EP2941128B1 (en) * | 2012-12-20 | 2023-06-28 | Rajiv Bhushan | Antimicrobial compositions |
| CN105008611A (zh) | 2012-12-20 | 2015-10-28 | 康沃特克科技公司 | 化学改性的纤维素纤维的处理 |
| US10357470B2 (en) * | 2013-03-07 | 2019-07-23 | Kane Biotech Inc. | Antimicrobial-antibiofilm compositions and methods of use thereof |
| WO2014134731A1 (en) * | 2013-03-07 | 2014-09-12 | Kane Biotech Inc. | Antimicrobial-antibiofilm compositions and methods of use thereof |
| GB201308770D0 (en) * | 2013-05-15 | 2013-06-26 | Convatec Technologies Inc | Wound Dressing Comprising an Antimicrobial Composition |
| MX386702B (es) | 2014-02-10 | 2025-03-19 | Fred Hutchinson Cancer Center | Tratamiento con halogeno de ataque cardiaco y lesion isquemica. |
| US20150272124A1 (en) | 2014-03-25 | 2015-10-01 | Ecolab Usa Inc. | Antimicrobial compositions containing cationic active ingredients |
| CA2964765A1 (en) * | 2014-10-15 | 2016-04-21 | Biocide Pharma, Inc. | Methods and apparatus for treating sites of infection |
| GB2533975A (en) * | 2014-12-30 | 2016-07-13 | Trio Healthcare Ltd | Antibiofilm compositions |
| SE1650162A1 (en) * | 2016-02-09 | 2017-08-10 | Karladani Abbas | Antimicrobial and cleansing composition comprising a polymeric biguanide, EDTA, and surfactants. |
| US10124067B2 (en) | 2016-04-13 | 2018-11-13 | Sage Products, Llc | CHG-compatible composition and method |
| GB201607814D0 (en) * | 2016-05-04 | 2016-06-15 | 5D Health Prot Group Ltd | Anti-microbial compositions |
| JP6456897B2 (ja) | 2016-10-05 | 2019-01-23 | マルハニチロ株式会社 | 抗菌性及び創傷治癒促進性を有する創傷治癒剤 |
| RU2675628C2 (ru) * | 2016-12-23 | 2018-12-21 | Общество с ограниченной ответственностью "Технофарм" | Композиция, содержащая протеинат серебра, и способ ее производства |
| CA3020197C (en) | 2017-09-01 | 2024-06-04 | Micropure, Inc. | Aliphatic anionic compounds and oxidative compounds with improved stability and efficacy for use in pharmaceutical compositions |
| WO2019049150A1 (en) * | 2017-09-07 | 2019-03-14 | Technion Research & Development Foundation Limited | KITS AND TOPICAL COMPOSITIONS AND THEIR USE |
| HUE067442T2 (hu) | 2017-11-09 | 2024-10-28 | Convatec Technologies Inc | Sztómafigyelõ rendszer |
| JP2021527130A (ja) * | 2018-06-08 | 2021-10-11 | ファラデイ ファーマシューティカルズ， インコーポレイテッド | 組織傷害および集中治療後症候群の処置および予防のためのハロゲン化合物の使用 |
| USD893514S1 (en) | 2018-11-08 | 2020-08-18 | 11 Health And Technologies Limited | Display screen or portion thereof with graphical user interface |
| US12295923B2 (en) | 2018-12-27 | 2025-05-13 | Solventum Intellectual Properties Company | Antimicrobial compositions with 1,2-alkanediols |
| WO2021019336A1 (en) * | 2019-07-29 | 2021-02-04 | 3M Innovative Properties Company | Antimicrobial compositions and articles comprising the same |
| US20220046927A1 (en) * | 2020-08-13 | 2022-02-17 | Tom Johnson | Disinfectant compositions and methods of making and using the same |
| JP2023545504A (ja) | 2020-10-15 | 2023-10-30 | コンバテック・テクノロジーズ・インコーポレイテッド | オストミーシステムおよび方法 |
| WO2022244013A1 (en) * | 2021-05-21 | 2022-11-24 | Prerna Goradia | Light stable silver containing near neutral ph disinfectant and method of preparation |
| WO2024030261A1 (en) * | 2022-08-04 | 2024-02-08 | Seifert Kevin J | Antimicrobial formulations and their methods for use |
Family Cites Families (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396514A (en) | 1943-03-20 | 1946-03-12 | Ludwig Jekels | Sterilizing materials and methods for making the same |
| GB735462A (en) * | 1951-12-20 | 1955-08-24 | Dow Chemical Co | Improvements in or relating to iodine-containing ethylenediaminetetraacetic acid compounds and methods of making same |
| US2785106A (en) | 1952-08-16 | 1957-03-12 | Ions Exchange And Chemical Cor | Process for making antiseptic article |
| US3092552A (en) | 1958-05-19 | 1963-06-04 | Albert C Nolte | Oligodynamic silver compositions and uses |
| US3061469A (en) | 1959-11-05 | 1962-10-30 | Givaudan Corp | Antibacterial textile fabrics |
| US3246624A (en) | 1965-02-05 | 1966-04-19 | Novo Ind Corp | Pressure indicating device |
| US4258056A (en) | 1978-12-18 | 1981-03-24 | Economics Laboratory, Inc. | Control of mastitis and compositions therefor |
| JPS6015641B2 (ja) | 1981-03-18 | 1985-04-20 | 花王株式会社 | 繊維状カルボキシメチルセルロ−スの製造方法 |
| EP0124536A4 (en) | 1982-11-05 | 1985-06-06 | Baxter Travenol Lab | ANTIMICROBIAL COMPOSITIONS. |
| US4655758A (en) | 1982-12-16 | 1987-04-07 | Johnson & Johnson Products, Inc. | Microbial polysaccharide articles and methods of production |
| US4889654A (en) | 1984-07-31 | 1989-12-26 | Rio Linda Chemical Company, Inc. | Aqueous foam disinfectant containing chlorine dixoide and preparation and use thereof |
| US4612337A (en) | 1985-05-30 | 1986-09-16 | The Trustees Of Columbia University In The City Of New York | Method for preparing infection-resistant materials |
| US4728323A (en) | 1986-07-24 | 1988-03-01 | Minnesota Mining And Manufacturing Company | Antimicrobial wound dressings |
| FR2604900B1 (fr) * | 1986-10-08 | 1989-01-13 | Blomet Marie Claude | Solution physiologique pour le lavage des parties du corps humain ayant ete mises en contact avec un acide fluorhydrique et concentre pour sa preparation |
| GB8709498D0 (en) | 1987-04-22 | 1987-05-28 | Bay M | Wound dressing |
| US4829129A (en) | 1987-05-29 | 1989-05-09 | International Dioxcide, Inc. | Reaction product of polymer with chlorine dioxide |
| GB2220881B (en) | 1988-04-28 | 1992-07-08 | Toyo Boseki | Improvements in or relating to superabsorbent materials |
| US4906100A (en) | 1988-05-13 | 1990-03-06 | University Of Cincinnati | Method of detecting adriamycin (doxorubicin) or daunomycin in the environment |
| RU2092180C1 (ru) | 1988-06-22 | 1997-10-10 | Эпплаид Микробиолоджи Инк. | Антимикробная композиция |
| US4973848A (en) | 1989-07-28 | 1990-11-27 | J. Mccaughan | Laser apparatus for concurrent analysis and treatment |
| US5340924A (en) | 1990-01-18 | 1994-08-23 | Morinaga Milk Industry Co., Ltd. | Method for heat treatment of lactoferrin without losing physiological activities thereof |
| US6066469A (en) | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
| US5662913A (en) | 1991-04-10 | 1997-09-02 | Capelli; Christopher C. | Antimicrobial compositions useful for medical applications |
| JPH06506694A (ja) | 1991-04-10 | 1994-07-28 | カペリ，クリストフアー・シー | 医療用に有用な抗微生物組成物 |
| GB9126193D0 (en) | 1991-12-10 | 1992-02-12 | Courtaulds Plc | Cellulosic fibres |
| US5407656A (en) | 1992-03-04 | 1995-04-18 | Arco Research Co., Inc. | Method and compositions for the production of chlorine dioxide |
| AU669163B2 (en) | 1992-03-20 | 1996-05-30 | Unilever Plc | Aqueous cleaning composition containing protein binding dye |
| US5762620A (en) | 1992-04-02 | 1998-06-09 | Ndm Acquisition Corp. | Wound dressing containing a partially dehydrated hydrogel |
| SK6495A3 (en) | 1992-07-22 | 1995-07-11 | Unilever Nv | Method of microorganism killing |
| DE69332954D1 (de) | 1992-10-21 | 2003-06-12 | Gynetech Lab Inc | Abgabesystem bestehend aus einem vaginaschwamm |
| KR100320636B1 (ko) | 1993-01-22 | 2002-07-27 | 아코디스 스페셜리티 파이버스 리미티드 | 환부보호대 |
| GB9301258D0 (en) | 1993-01-22 | 1993-03-17 | Courtaulds Plc | Use of absorbent fibre |
| US5848995A (en) | 1993-04-09 | 1998-12-15 | Walder; Anthony J. | Anti-infective medical article and method for its preparation |
| US5567495A (en) | 1993-08-06 | 1996-10-22 | The Trustees Of Columbia University In The City Of New York | Infection resistant medical devices |
| US5744155A (en) | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| JP3121503B2 (ja) | 1994-10-18 | 2001-01-09 | レンゴー株式会社 | 抗菌剤 |
| JP3297969B2 (ja) | 1994-12-26 | 2002-07-02 | ライオン株式会社 | 点眼剤 |
| US5616347A (en) | 1995-02-14 | 1997-04-01 | Alliger; Howard | Chlorine dioxide skin medicating compositions for preventing irritation |
| SE506869C2 (sv) | 1995-06-30 | 1998-02-23 | Inst Polymerutveckling Ab | Metod för laminering genom fotoympning, laminat framställt enligt metoden samt dess användning |
| US5744151A (en) | 1995-06-30 | 1998-04-28 | Capelli; Christopher C. | Silver-based pharmaceutical compositions |
| DE19609143C1 (de) | 1996-03-08 | 1997-11-13 | Rhodia Ag Rhone Poulenc | Melt-blown-Vlies, Verfahren zu dessen Herstellung und dessen Verwendungen |
| US5820918A (en) | 1996-07-11 | 1998-10-13 | Hercules Incorporated | Medical devices containing in-situ generated medical compounds |
| CA2263473C (en) | 1996-08-16 | 2003-04-22 | Christopher C. Capelli | Silver-based antimicrobial compositions |
| US20030104018A1 (en) * | 1996-12-31 | 2003-06-05 | Griscom Bettle | Skin product having micro-spheres, and processes for the production thereof |
| DE69721547T2 (de) | 1997-04-11 | 2004-03-18 | Bristol-Myers Squibb Co. | Gestrickter wundverbund |
| KR20010013377A (ko) | 1997-06-04 | 2001-02-26 | 데이비드 엠 모이어 | 마일드한 잔류성 항균 조성물 |
| US5993864A (en) * | 1997-07-11 | 1999-11-30 | Kross; Robert D. | Chlorine dioxide chelate compositions and method of use |
| US5860947A (en) | 1997-08-20 | 1999-01-19 | Stamler; Keith D. | Wound irrigation device and method |
| US6605751B1 (en) | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
| US6753063B1 (en) | 1997-11-19 | 2004-06-22 | The Procter & Gamble Company | Personal cleansing wipe articles having superior softness |
| IL123437A0 (en) | 1998-02-24 | 1998-09-24 | Shalev Pinchas | Apparatus and method for photothermal destruction of oral bacteria |
| AU757461B2 (en) | 1998-07-01 | 2003-02-20 | Acordis Speciality Fibres Limited | Wound dressings and materials suitable for use therein |
| US6413556B1 (en) | 1999-01-08 | 2002-07-02 | Sky High, Llc | Aqueous anti-apoptotic compositions |
| DE19909214A1 (de) | 1999-03-03 | 2000-09-07 | Basf Ag | Wasserabsorbierende, schaumförmige, vernetzte Polymerisate mit verbesserter Verteilungswirkung, Verfahren zu ihrer Herstellung und ihre Verwendung |
| GB9905663D0 (en) * | 1999-03-12 | 1999-05-05 | Bristol Myers Squibb Co | Iodine preparation composition |
| US6172040B1 (en) | 1999-05-28 | 2001-01-09 | A. Satyanarayan Naidu | Immobilized lactoferrin antimicrobial agents and the use thereof |
| DE60009727T2 (de) | 1999-09-27 | 2004-08-12 | Bhk Holding Ltd. | Absorbierender stoff |
| AU7989100A (en) | 1999-10-01 | 2001-05-10 | Acrymed | Silver-containing compositions, devices and methods for making |
| US6592890B1 (en) | 1999-10-20 | 2003-07-15 | Oxibio, Inc. | Conveyance of anti-infective activity to wound dressings |
| US6555508B1 (en) | 2000-02-17 | 2003-04-29 | Leonard Paul | Liquid foaming soap compositions |
| AU2001239835A1 (en) | 2000-02-26 | 2001-09-03 | Advanced Photodynamic Technologies, Inc. | Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant |
| AU2000265516A1 (en) | 2000-08-11 | 2002-02-25 | The Lawson Health Research Institute | Compositions and methods for inhibiting islet dysfunction and autoimmune disorders |
| US20020091074A1 (en) * | 2000-09-20 | 2002-07-11 | Wooley Richard E. | Medical compositions, dressings and methods for treating microbial infections of skin lesions |
| US20070003508A1 (en) * | 2005-07-01 | 2007-01-04 | Wooley Richard E | Methods and compositions for promoting wound healing |
| GB2370226A (en) | 2000-09-21 | 2002-06-26 | Acordis Speciality Fibres Ltd | Wound dressing |
| NZ526039A (en) | 2000-11-29 | 2004-11-26 | Bristol Myers Squibb Co | A method of preparing light stabilized antimicrobial materials from an organic solvent and a source of silver |
| US20020172709A1 (en) | 2001-03-30 | 2002-11-21 | Brian Nielsen | Medical dressing comprising an antimicrobial silver compound and a method for enhancing wound healing |
| BR0212432A (pt) | 2001-09-12 | 2004-08-17 | Acordis Speciality Fibres Ltd | Curativo de ferimento antibacteriano e processo para a produção de fibras prateadas para uso em curativos de ferimento antibacterianos |
| GB2382527A (en) | 2001-12-03 | 2003-06-04 | Acordis Speciality Fibres Ltd | Wound dressings |
| US8541472B2 (en) * | 2001-12-05 | 2013-09-24 | Aseptica, Inc. | Antiseptic compositions, methods and systems |
| US20040047763A1 (en) | 2001-12-05 | 2004-03-11 | Peter Kite | Anti-microbial systems and methods |
| SK3313U (sk) * | 2002-02-11 | 2002-10-08 | Unimed Pharma Spol Sro | Očná instilácia na báze jódového aniónu |
| US6468965B1 (en) | 2002-04-22 | 2002-10-22 | Paul Cutler | Pharmaceutical composition for oral administration of a mixture of chelating agents |
| US20040033916A1 (en) | 2002-06-28 | 2004-02-19 | Kuzmin Vladimir Semenovich | Disinfecting composition |
| GB0215023D0 (en) * | 2002-06-28 | 2002-08-07 | Bristol Myers Squibb Co | Wound dressing |
| CA2500461C (en) | 2002-09-25 | 2013-04-16 | Edwin Odell Miner | Antiseptic solutions containing silver chelated with polypectate and edta |
| WO2004035718A2 (de) * | 2002-10-14 | 2004-04-29 | Arconia Gmbh | Zusammensetzung |
| WO2004056346A1 (en) * | 2002-12-19 | 2004-07-08 | University Of Georgia Research Foundation, Inc. | Methods and compositions for wound management |
| US7629000B2 (en) | 2003-05-13 | 2009-12-08 | E.I. Du Pont De Nemours And Company | Method for making antimicrobial polyester-containing articles with improved wash durability and articles made thereby |
| EP1667601A4 (en) | 2003-08-28 | 2010-11-10 | Pure Bioscience | SILVER DIHYDROGENCITRATE COMPOSITIONS WITH A SECOND ANTIMICROBIAL AGENT |
| US20050059731A1 (en) | 2003-09-16 | 2005-03-17 | Ceramoptec Industries, Inc. | Erythrosin-based antimicrobial photodynamic therapy compound and its use |
| US7033511B2 (en) | 2004-01-20 | 2006-04-25 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| EP1720411A1 (en) * | 2004-02-24 | 2006-11-15 | Campina B.V. | Antimicrobial lactoferrin compositions for surfaces, cavities, and foodstuff |
| KR101226665B1 (ko) | 2004-04-16 | 2013-01-25 | 브레덴트 메디칼 게엠베하 운트 코. 카게 | 미생물의 광역학적 제어를 위한 제제 및 상기 제제의 사용 |
| EP1765376B1 (en) | 2004-06-12 | 2013-04-10 | Signum Biosciences, Inc. | Topical compositions and use thereof for the treatment of epithelial-related conditions |
| GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
| ATE410535T1 (de) | 2004-07-09 | 2008-10-15 | Johnson & Johnson Gmbh | Kosmetischer und/oder dermatologischer absorbierender körperpflegeartikel mit mindestens einer absorbierenden schicht |
| US20060019220A1 (en) | 2004-07-22 | 2006-01-26 | Ondine International Ltd. | Sonophotodynamic therapy for dental applications |
| CN102783499A (zh) | 2004-07-30 | 2012-11-21 | 金伯利-克拉克环球有限公司 | 抗微生物的装置和组合物 |
| US20060115440A1 (en) | 2004-09-07 | 2006-06-01 | Arata Andrew B | Silver dihydrogen citrate compositions |
| US20060051430A1 (en) | 2004-09-07 | 2006-03-09 | Arata Andrew B | Silver dihydrogen citrate compositions |
| US9028852B2 (en) * | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
| GB0424833D0 (en) | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
| CA2593482A1 (en) | 2005-01-14 | 2006-07-20 | Neurogen Corporation | Heteroaryl substituted quinolin-4-ylamine analogues |
| US20060234959A1 (en) | 2005-04-14 | 2006-10-19 | Advanced Photodynamic Technologies, Inc. | Photodynamic therapy utilizing multiple duty cycle light modulation |
| FR2884422B1 (fr) | 2005-04-18 | 2008-04-11 | Roquette Freres | Composition anti-inflammatoire de l'intestin comprenant des maltodextrines branchees |
| US20060254988A1 (en) | 2005-05-10 | 2006-11-16 | Confirm Monitoring Systems, Inc. | Methods and compositions for the treatment of water |
| GB0513552D0 (en) | 2005-07-01 | 2005-08-10 | Bristol Myers Squibb Co | Bandage |
| JP3877174B1 (ja) | 2005-09-13 | 2007-02-07 | 株式会社オーバル | 弾性連結部材及び台座を有する三次モード振動の直管式コリオリ流量計 |
| GB0525504D0 (en) | 2005-12-14 | 2006-01-25 | Bristol Myers Squibb Co | Antimicrobial composition |
| JP2007167266A (ja) | 2005-12-21 | 2007-07-05 | Lion Corp | 歯垢検出システムおよび歯垢検出方法 |
| US20070166399A1 (en) | 2006-01-13 | 2007-07-19 | 3M Innovative Properties Company | Silver-containing antimicrobial articles and methods of manufacture |
| MX2008012573A (es) | 2006-04-11 | 2008-10-14 | Tyco Healthcare | Vendajes para heridas con agentes anti-microbianos y quelantes. |
| JP4826382B2 (ja) | 2006-08-08 | 2011-11-30 | アルケア株式会社 | 抗菌性セルロース繊維及び皮膚接触用繊維製品 |
| JP4915530B2 (ja) | 2006-09-21 | 2012-04-11 | アルケア株式会社 | 抗菌性繊維及びその製造方法並びに抗菌性繊維を含有してなる抗菌性繊維製品、その製造方法及び再生方法 |
| US9034352B2 (en) | 2006-11-14 | 2015-05-19 | Rohm And Haas Company | Microbicide combinations containing silver |
| WO2008088922A2 (en) | 2007-01-19 | 2008-07-24 | Genentech, Inc. | Prevention of hydrogel viscosity loss |
| GB0710846D0 (en) | 2007-06-06 | 2007-07-18 | Bristol Myers Squibb Co | A wound dressing |
| GB0805162D0 (en) | 2008-03-19 | 2008-04-23 | Bristol Myers Squibb Co | Antibacterial wound dressing |
| WO2009130608A2 (en) | 2008-04-24 | 2009-10-29 | Uti Limited Partnership | Combination of copper cations with peroxides or quaternary ammonium compounds for the treatment of biofilms |
| DK2291640T3 (en) | 2008-05-20 | 2019-03-11 | Univ Health Network | Device and method for fluorescence-based imaging and monitoring |
| US9221963B2 (en) | 2008-11-27 | 2015-12-29 | Speciality Fibres And Materials Ltd. | Absorbent material |
| GB0823265D0 (en) | 2008-12-20 | 2009-01-28 | Convatec Technologies Inc | Antimicrobial Composition |
| US20100310845A1 (en) | 2009-06-03 | 2010-12-09 | Eric Bryan Bond | Fluid permeable structured fibrous web |
| GB2474694B (en) | 2009-10-23 | 2011-11-02 | Innovia Films Ltd | Biodegradable composites |
| US20110237994A1 (en) | 2010-03-25 | 2011-09-29 | Combat Medical Systems, Llc | Void-filling wound dressing |
| CN108486261A (zh) | 2010-11-01 | 2018-09-04 | 贝克顿·迪金森公司 | 阴道加特纳菌测定 |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| GB201105829D0 (en) | 2011-04-06 | 2011-05-18 | Convatec Technologies Inc | Antimicrobial compositions |
| GB201308770D0 (en) | 2013-05-15 | 2013-06-26 | Convatec Technologies Inc | Wound Dressing Comprising an Antimicrobial Composition |
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2005
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2017214386A (ja) | 2017-12-07 |
| NZ568999A (en) | 2011-12-22 |
| JP6348892B2 (ja) | 2018-06-27 |
| US10493101B2 (en) | 2019-12-03 |
| ES2622827T3 (es) | 2017-07-07 |
| HK1246086A1 (en) | 2018-09-07 |
| AU2006325408A1 (en) | 2007-06-21 |
| EP1959739B1 (en) | 2017-03-29 |
| JP2009519312A (ja) | 2009-05-14 |
| GB0525504D0 (en) | 2006-01-25 |
| EP1959739A2 (en) | 2008-08-27 |
| US9149035B2 (en) | 2015-10-06 |
| WO2007068938A3 (en) | 2008-09-18 |
| JP2016040294A (ja) | 2016-03-24 |
| US20170079276A1 (en) | 2017-03-23 |
| LT1959739T (lt) | 2017-04-25 |
| CA2632939A1 (en) | 2007-06-21 |
| JP6509948B2 (ja) | 2019-05-08 |
| EP3241439A1 (en) | 2017-11-08 |
| US20150306055A1 (en) | 2015-10-29 |
| JP2013209385A (ja) | 2013-10-10 |
| EP3241439B1 (en) | 2020-12-02 |
| WO2007068938A2 (en) | 2007-06-21 |
| US9545390B2 (en) | 2017-01-17 |
| JP5340741B2 (ja) | 2013-11-13 |
| HUE032810T2 (en) | 2017-11-28 |
| PL1959739T3 (pl) | 2017-07-31 |
| PT1959739T (pt) | 2017-04-24 |
| DK1959739T3 (en) | 2017-05-01 |
| US20070190176A1 (en) | 2007-08-16 |
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