CA2631289C - The use of bacillus pb6 for the prophylaxis or treatment of gastrointestinal and immuno-related diseases - Google Patents
The use of bacillus pb6 for the prophylaxis or treatment of gastrointestinal and immuno-related diseases Download PDFInfo
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- CA2631289C CA2631289C CA2631289A CA2631289A CA2631289C CA 2631289 C CA2631289 C CA 2631289C CA 2631289 A CA2631289 A CA 2631289A CA 2631289 A CA2631289 A CA 2631289A CA 2631289 C CA2631289 C CA 2631289C
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- UCRLQOPRDMGYOA-DFTDUNEMSA-L zinc;(4r)-4-[[(2s)-2-[[(4r)-2-[(1s,2s)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2s,3s)-1-[[(3s,6r,9s,12r,15s,18r,21s)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2s)-butan-2-yl]-6-(carbox Chemical compound [Zn+2].C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@H](CC([O-])=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 UCRLQOPRDMGYOA-DFTDUNEMSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74051805P | 2005-11-29 | 2005-11-29 | |
| US60/740,518 | 2005-11-29 | ||
| PCT/US2006/045755 WO2007064741A2 (en) | 2005-11-29 | 2006-11-29 | The use of bacillus pb6 for the prophylaxis or treatment of gastrointestinal and immuno-related diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2631289A1 CA2631289A1 (en) | 2007-06-07 |
| CA2631289C true CA2631289C (en) | 2015-01-06 |
Family
ID=38092773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2631289A Expired - Fee Related CA2631289C (en) | 2005-11-29 | 2006-11-29 | The use of bacillus pb6 for the prophylaxis or treatment of gastrointestinal and immuno-related diseases |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080057047A1 (enExample) |
| EP (1) | EP1956914B1 (enExample) |
| JP (2) | JP5280854B2 (enExample) |
| KR (1) | KR101470352B1 (enExample) |
| CN (1) | CN101448398B (enExample) |
| AU (1) | AU2006320613B2 (enExample) |
| BR (1) | BRPI0619364A2 (enExample) |
| CA (1) | CA2631289C (enExample) |
| IL (1) | IL191795A (enExample) |
| NZ (1) | NZ569244A (enExample) |
| RU (1) | RU2412241C2 (enExample) |
| WO (1) | WO2007064741A2 (enExample) |
| ZA (1) | ZA200804646B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2489659T3 (pl) | 2004-06-24 | 2018-06-29 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą atp |
| PT1993360T (pt) | 2005-12-28 | 2017-05-25 | Vertex Pharma | Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| PE20120074A1 (es) * | 2008-09-17 | 2012-02-26 | Agraquest Inc | Composicion que comprende cepa de bacillus subtilis para alimentar animales |
| MX348019B (es) * | 2008-09-24 | 2017-05-23 | Resilux | Incorporacion en materiales de organismos termo-resistentes y/o resistentes a la presión. |
| EP3330255B1 (en) | 2009-03-20 | 2020-12-09 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US20130004475A1 (en) * | 2010-03-12 | 2013-01-03 | Misaki Hatanaka | Agent for increasing bifidobacteria and reducing the decrease of bifidobacteria in large intestine |
| DK2547348T3 (da) | 2010-03-17 | 2015-08-24 | Bayer Cropscience Lp | Fremgangsmåde til anvendelse af en bacillus subtilis-stamme til profylakse og behandling af mave-tarm-tilstande |
| WO2012009712A2 (en) | 2010-07-16 | 2012-01-19 | The Board Of Trustees Of The University Of Arkansas | Methods and compositions including spore-forming bacteria for increasing the health of animals |
| WO2012044984A1 (en) | 2010-09-30 | 2012-04-05 | The Board Of Trustees Of The University Of Arkansas | Methods of selecting and using therapeutic and prophylactic probiotic cultures to reduce bacterial pathogen loads |
| CA2834402A1 (en) * | 2010-12-29 | 2012-07-05 | Cangene Corporation | Clostridium difficile antigens |
| IL311180A (en) | 2012-02-27 | 2024-04-01 | Vertex Pharma | Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof |
| US9393275B2 (en) | 2012-08-01 | 2016-07-19 | Novozymes A/S | Probiotic for amelioration of coccidiosis vaccine reaction |
| RU2534356C2 (ru) * | 2012-10-04 | 2014-11-27 | Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Россельхозакадемии (ГНУ ИЭВСиДВ Россельхозакадемии) | Способ контроля качества дезинфекции птицеводческих помещений |
| FR2999191B1 (fr) * | 2012-12-12 | 2016-02-05 | Lesaffre & Cie | Souches probiotiques pour le traitement et/ou la prevention de la diarrhee |
| FR3007655B1 (fr) * | 2013-06-28 | 2016-12-23 | Lesaffre & Cie | Souche bacillus subtilis pour le traitement et/ou la prevention de maladies inflammatoires chroniques |
| EP2923710A1 (en) * | 2014-03-27 | 2015-09-30 | Universitätsklinikum Heidelberg | Bacterial phospholipase inhibitors as modulator of colonic bacterial flora |
| WO2016011511A1 (en) * | 2014-07-25 | 2016-01-28 | The University Of Queensland | Bacillus amyloliquefaciens probiotic compositions, methods of production, and methods of use |
| ES2835731T3 (es) | 2014-09-30 | 2021-06-23 | Univ Auburn | Uso de pectina o sacáridos relacionados con la pectina para mejorar la eficacia de las cepas de rizobacterias que promueven el crecimiento de las plantas (PGPR) para promover el crecimiento y la salud en las plantas |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| JP6595761B2 (ja) * | 2014-12-19 | 2019-10-23 | 東亜薬品工業株式会社 | バチルスアミロリキファシエンス菌株及び該菌株を含む抗菌組成物 |
| ES2954455T3 (es) | 2015-01-23 | 2023-11-22 | Novozymes As | Cepas de Bacillus que mejoran la salud y el rendimiento de animales de producción |
| BR112017015623B1 (pt) | 2015-01-23 | 2022-05-31 | Novozymes A/S | Ração animal ou aditivo de ração animal ou pré-mistura de ração, método para melhora de um ou mais parâmetros de desempenho de um animal e para alimentação de um animal, e, uso de uma cepa de bacillus |
| WO2016118850A1 (en) | 2015-01-23 | 2016-07-28 | Novozymes A/S | Bacillus subtilis subspecies |
| WO2016194427A1 (ja) * | 2015-05-30 | 2016-12-08 | 日環科学株式会社 | プロバイオティクス、あるいはプレバイオティクス、並びにその製造方法、微生物製剤、健康食品並びに医薬品 |
| US10857190B2 (en) | 2015-10-06 | 2020-12-08 | Albert Einstein College Of Medicine | Microbial hyperswarmers and uses thereof |
| JP6759337B2 (ja) * | 2015-10-26 | 2020-09-23 | シージェー チェイルジェダン コーポレーション | 酵素生産能が優秀である伝統発酵食品由来の新たな菌株及びこれを用いた穀物発酵酵素食品の製造方法 |
| RU2641979C1 (ru) * | 2016-10-24 | 2018-01-23 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московская государственная академия ветеринарной медицины и биотехнологии - МВА имени К.И. Скрябина" (ФГБОУ ВО МГАВМиБ - МВА имени К.И. Скрябина) | Способ морфологической оценки влияния различных лекарственных форм железа для энтерального применения на тонкий отдел кишечника у экспериментальных животных |
| EP3645751A1 (en) * | 2017-06-30 | 2020-05-06 | Evonik Operations GmbH | Bacillus subtilis |
| US20190289878A1 (en) * | 2018-03-23 | 2019-09-26 | Purina Animal Nutrition Llc | Methods of feeding animals feed products containing direct-fed microbials |
| BR122023002250B1 (pt) * | 2018-06-07 | 2024-01-09 | Artugen Therapeutics Ltd | Composição para o tratamento de c. difficile |
| US20220160794A1 (en) * | 2019-05-14 | 2022-05-26 | Ormendes Sa | Use of bacillus amyloliquefaciens and/or bacillus subtilis for the enhancement of active probiotic compositions or for the activation of inactive probiotic compositions, compositions thus obtained, and related method |
| WO2020257769A1 (en) * | 2019-06-21 | 2020-12-24 | The Board Of Trustees Of The University Of Arkansas | Bacillus isolate compositions and methods of using and producing the same |
| GB201911925D0 (en) * | 2019-08-20 | 2019-10-02 | Sporegen Ltd | Formulations for prevention or reduction of c. difficile infections |
| WO2021116983A1 (en) * | 2019-12-11 | 2021-06-17 | Artugen Therapeutics, Ltd. | Edible products comprising bacterial strains and methods of use |
| US20210283199A1 (en) * | 2020-03-13 | 2021-09-16 | Kemin Industries, Inc. | Method for controlling clostridium infection in animals |
| GB202013874D0 (en) * | 2020-09-03 | 2020-10-21 | Sporegen Ltd | Treatment and prevention of viral infections |
| US12317906B2 (en) | 2020-12-09 | 2025-06-03 | Purina Animal Nutrition Llc | Feed compositions and methods for inhibiting focal ulcerative dermatitis |
| CN113151069B (zh) * | 2021-04-01 | 2022-07-26 | 安杰利(重庆)生物科技有限公司 | 一种枯草芽孢杆菌及其在制备抗菌肽、饲料中的应用 |
| KR102546973B1 (ko) * | 2021-10-20 | 2023-06-26 | 주식회사 리빙진 | 바실러스 밸레젠시스 Kh2-2 균주를 포함하는 면역증강용 조성물 |
| WO2023220279A1 (en) * | 2022-05-12 | 2023-11-16 | Can Technologies, Inc. | Compositions and methods for the treatment and prevention of campylobacter infection |
| CN115725461B (zh) * | 2022-11-03 | 2024-03-19 | 东北农业大学 | 一株具有抗幽门螺杆菌作用的解淀粉芽孢杆菌及其应用 |
| FR3158224A1 (fr) * | 2024-01-12 | 2025-07-18 | Lesaffre Et Compagnie | Effet bénéfique d’une bactérie probiotique Bacillus subtilis dans la lutte contre les infections |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968493A (en) * | 1986-06-30 | 1990-11-06 | American Cyanamid Company | Method for controlling chronic respiratory disease, fowl cholera and necrotic enteritis in avian species |
| US5352586A (en) * | 1987-05-01 | 1994-10-04 | Biogaia Ab | Method of determining the presence of an antibiotic produced by Lactobacillus reuteri |
| ZA926834B (en) * | 1991-09-09 | 1993-03-15 | American Cyanamid Co | Antibiotic LL-E19020 Gamma. |
| TW455591B (en) * | 1993-06-08 | 2001-09-21 | Hoechst Ag | Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof |
| DE4411025A1 (de) * | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JP2879321B2 (ja) * | 1996-03-14 | 1999-04-05 | 久保田 豊秋 | 動物用経口組成物 |
| EP0862863B9 (en) * | 1997-01-09 | 2009-08-12 | Societe Des Produits Nestle S.A. | Cereal product containing probiotics |
| US6461607B1 (en) * | 1998-08-24 | 2002-10-08 | Ganeden Biotech, Inc. | Probiotic, lactic acid-producing bacteria and uses thereof |
| FI110668B (fi) * | 2000-06-20 | 2003-03-14 | Aboatech Ab Oy | Probioottien käyttö atooppisten sairauksien primaariseen ehkäisyyn |
| RU2246537C2 (ru) * | 2002-11-11 | 2005-02-20 | Закрытое акционерное общество "КУЛ" | Штамм бактерий bacillus subtilis, используемый для получения пробиотического препарата, предназначенного для профилактики и лечения желудочно-кишечных заболеваний сельскохозяйственных животных, птицы и рыбы |
| US7247299B2 (en) * | 2002-11-27 | 2007-07-24 | Kemin Industries, Inc. | Antimicrobial compounds from Bacillus subtilis for use against animal and human pathogens |
| JP4189224B2 (ja) * | 2003-01-14 | 2008-12-03 | 株式会社カンサイ | バチルス属に属する微生物及びそれを用いる防除剤 |
| KR100535912B1 (ko) * | 2003-12-17 | 2005-12-09 | 주식회사 케이티앤지 | 신규한 미생물 바실러스 아밀로리쿼페이션스 케이티지비0202 및 이를 이용한 식물병원균의 방제방법 |
| JP2005198518A (ja) * | 2004-01-13 | 2005-07-28 | Asahi Business Support Co Ltd | 海苔屑分解処理法及び微生物 |
| RU2270858C2 (ru) * | 2004-03-30 | 2006-02-27 | Институт биологии Уфимского научного центра РАН | Штамм бактерий b. subtilis - продуцент сурфактина |
| US7854927B2 (en) * | 2004-05-11 | 2010-12-21 | Ganeden Biotech, Inc. | Methods and compositions for the dietary management of autoimmune disorders |
-
2006
- 2006-11-28 US US11/605,736 patent/US20080057047A1/en not_active Abandoned
- 2006-11-29 NZ NZ569244A patent/NZ569244A/en not_active IP Right Cessation
- 2006-11-29 CN CN2006800519498A patent/CN101448398B/zh not_active Expired - Fee Related
- 2006-11-29 WO PCT/US2006/045755 patent/WO2007064741A2/en not_active Ceased
- 2006-11-29 CA CA2631289A patent/CA2631289C/en not_active Expired - Fee Related
- 2006-11-29 RU RU2008121602/10A patent/RU2412241C2/ru active
- 2006-11-29 BR BRPI0619364-1A patent/BRPI0619364A2/pt not_active IP Right Cessation
- 2006-11-29 JP JP2008543436A patent/JP5280854B2/ja not_active Expired - Fee Related
- 2006-11-29 AU AU2006320613A patent/AU2006320613B2/en not_active Ceased
- 2006-11-29 EP EP06838624.2A patent/EP1956914B1/en not_active Not-in-force
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- 2008-06-27 KR KR1020087015832A patent/KR101470352B1/ko not_active Expired - Fee Related
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2013
- 2013-03-28 JP JP2013069311A patent/JP2013173750A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013173750A (ja) | 2013-09-05 |
| US20080057047A1 (en) | 2008-03-06 |
| EP1956914B1 (en) | 2014-01-08 |
| CN101448398A (zh) | 2009-06-03 |
| RU2008121602A (ru) | 2009-12-10 |
| CN101448398B (zh) | 2013-05-08 |
| CA2631289A1 (en) | 2007-06-07 |
| BRPI0619364A2 (pt) | 2011-09-27 |
| JP5280854B2 (ja) | 2013-09-04 |
| NZ569244A (en) | 2012-07-27 |
| IL191795A (en) | 2013-07-31 |
| ZA200804646B (en) | 2011-11-30 |
| WO2007064741A3 (en) | 2008-05-08 |
| AU2006320613B2 (en) | 2012-08-16 |
| EP1956914A4 (en) | 2011-12-21 |
| RU2412241C2 (ru) | 2011-02-20 |
| WO2007064741A2 (en) | 2007-06-07 |
| EP1956914A2 (en) | 2008-08-20 |
| IL191795A0 (en) | 2009-02-11 |
| JP2009519238A (ja) | 2009-05-14 |
| WO2007064741A8 (en) | 2008-01-31 |
| KR20080073771A (ko) | 2008-08-11 |
| KR101470352B1 (ko) | 2014-12-09 |
| AU2006320613A1 (en) | 2007-06-07 |
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