CA2627208C - Polynucleotide contenant un mimetique de phosphate - Google Patents

Polynucleotide contenant un mimetique de phosphate Download PDF

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Publication number
CA2627208C
CA2627208C CA2627208A CA2627208A CA2627208C CA 2627208 C CA2627208 C CA 2627208C CA 2627208 A CA2627208 A CA 2627208A CA 2627208 A CA2627208 A CA 2627208A CA 2627208 C CA2627208 C CA 2627208C
Authority
CA
Canada
Prior art keywords
group
oligonucleotide
nucleotide
substituted
acc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2627208A
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English (en)
Other versions
CA2627208A1 (fr
Inventor
Dieter Heindl
Dirk Kessler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2627208A1 publication Critical patent/CA2627208A1/fr
Application granted granted Critical
Publication of CA2627208C publication Critical patent/CA2627208C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B62/00—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2627208A 2005-11-23 2006-09-12 Polynucleotide contenant un mimetique de phosphate Expired - Fee Related CA2627208C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05025499.4 2005-11-23
EP05025499A EP1801114B8 (fr) 2005-11-23 2005-11-23 Polynucléotides contenant des phosphates mimétiques
PCT/EP2006/008842 WO2007059816A1 (fr) 2005-11-23 2006-09-12 Polynucleotide contenant un mimetique de phosphate

Publications (2)

Publication Number Publication Date
CA2627208A1 CA2627208A1 (fr) 2007-05-31
CA2627208C true CA2627208C (fr) 2011-11-01

Family

ID=36128618

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2627208A Expired - Fee Related CA2627208C (fr) 2005-11-23 2006-09-12 Polynucleotide contenant un mimetique de phosphate
CA2627216A Expired - Fee Related CA2627216C (fr) 2005-11-23 2006-11-21 Reactif de marquage de polynucleotide

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2627216A Expired - Fee Related CA2627216C (fr) 2005-11-23 2006-11-21 Reactif de marquage de polynucleotide

Country Status (13)

Country Link
US (2) US7741472B2 (fr)
EP (3) EP1801114B8 (fr)
JP (2) JP5155177B2 (fr)
KR (2) KR101028980B1 (fr)
CN (2) CN101312985B (fr)
AT (2) ATE443072T1 (fr)
AU (1) AU2006317195B2 (fr)
BR (2) BRPI0618833B1 (fr)
CA (2) CA2627208C (fr)
DE (2) DE502005008153D1 (fr)
ES (2) ES2332139T3 (fr)
HK (2) HK1126224A1 (fr)
WO (1) WO2007059816A1 (fr)

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CA2812500A1 (fr) 2010-10-22 2012-04-26 Simone Budow Conjugue entre une phase solide thiophilique et un oligonuclelotide comprenant un thiooxonucleotide
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JP6162044B2 (ja) 2010-12-23 2017-07-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 結合剤
CA2817928C (fr) 2010-12-23 2019-10-01 Michael Gerg Detection d'un polypeptide a modification post-translationnelle par un agent de liaison bivalent
ES2472965T3 (es) 2011-03-04 2014-07-03 F. Hoffmann-La Roche Ag Nuevo tipo de sondas universales para la detección de variantes gen�micas
KR101411013B1 (ko) 2011-12-01 2014-06-23 제일모직주식회사 (메타)아크릴로일 이미노포스파젠계 화합물, 그 제조방법 및 이를 포함한 공중합체
MX2014009565A (es) 2012-02-10 2014-11-10 Genentech Inc Anticuerpos monocatenarios y otros heteromultimeros.
ES2597228T3 (es) 2012-06-27 2017-01-17 F. Hoffmann-La Roche Ag Procedimiento para la selección y la producción de entidades de objetivación, como dianas, altamente selectivas y multiespecíficas, personalizadas, las cuales contienen por lo menos dos entidades de unión diferentes, y utilización de éstas
WO2014001325A1 (fr) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Méthode de fabrication de conjugués d'anticorps à région fc comprenant au moins une entité de liaison qui se lie spécifiquement à une cible et leurs utilisations
CA2871386A1 (fr) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Procede de selection et de production de molecules therapeutiques multi-specifiques, selectives et personnalisees comprenant au moins deux entites de ciblage differentes et leursutilisations
US9382581B2 (en) 2012-12-13 2016-07-05 Roche Molecular Systems, Inc. Primers with modified phosphate and base in allele-specific PCR
RU2708237C2 (ru) 2014-08-22 2019-12-05 Общество с ограниченной ответственностью "НооГен" Модифицированные олигонуклеотиды и способ их получения
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała
WO2017111137A1 (fr) * 2015-12-22 2017-06-29 味の素株式会社 Procédé de production d'oligonucléotides
RU2740501C2 (ru) * 2017-02-21 2021-01-14 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) МОДИФИЦИРОВАННЫЕ ОЛИГОНУКЛЕОТИДЫ, АКТИВИРУЮЩИЕ РНКазу Н
CA3065523A1 (fr) 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Compositions d'oligonucleotides et leurs procedes d'utilisation
EP3630199A4 (fr) 2017-06-02 2021-11-10 Wave Life Sciences Ltd. Compositions d'oligonucléotides et leurs procédés d'utilisation
JP7353301B2 (ja) 2018-05-07 2023-09-29 アルニラム ファーマスーティカルズ インコーポレイテッド 肝臓外送達
US11384376B2 (en) 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
JP2022544587A (ja) 2019-08-15 2022-10-19 アイオーニス ファーマシューティカルズ， インコーポレーテッド 結合修飾オリゴマー化合物及びその使用
WO2022081046A1 (fr) * 2020-10-12 2022-04-21 Максим Сергеевич КУПРЮШКИН Composé chimique avec un groupe triazine et procédé de production

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Also Published As

Publication number Publication date
BRPI0618855A2 (pt) 2011-09-13
CN101312941A (zh) 2008-11-26
CA2627216A1 (fr) 2007-05-31
CN101312985A (zh) 2008-11-26
ATE478087T1 (de) 2010-09-15
KR101032008B1 (ko) 2011-05-02
ES2349129T3 (es) 2010-12-28
EP1801114B8 (fr) 2009-12-02
KR20080056314A (ko) 2008-06-20
JP5155177B2 (ja) 2013-02-27
EP1954707B1 (fr) 2010-08-18
EP1801114A1 (fr) 2007-06-27
AU2006317195A1 (en) 2007-05-31
DE602006016325D1 (de) 2010-09-30
EP1954707A1 (fr) 2008-08-13
US7795423B2 (en) 2010-09-14
US7741472B2 (en) 2010-06-22
ES2332139T3 (es) 2010-01-27
EP1954671A1 (fr) 2008-08-13
KR20080059323A (ko) 2008-06-26
JP2009516521A (ja) 2009-04-23
CN101312985B (zh) 2015-08-19
ES2349129T8 (es) 2011-02-08
CA2627208A1 (fr) 2007-05-31
KR101028980B1 (ko) 2011-04-12
AU2006317195B2 (en) 2010-04-01
JP5364380B2 (ja) 2013-12-11
BRPI0618833B1 (pt) 2015-06-16
HK1126224A1 (zh) 2009-08-28
CA2627216C (fr) 2011-05-31
US20090012279A1 (en) 2009-01-08
HK1126183A1 (en) 2009-08-28
US20090005550A1 (en) 2009-01-01
BRPI0618833A2 (pt) 2011-09-13
JP2009516715A (ja) 2009-04-23
CN101312941B (zh) 2012-04-18
WO2007059816A1 (fr) 2007-05-31
EP1954671B1 (fr) 2012-10-31
ATE443072T1 (de) 2009-10-15
DE502005008153D1 (de) 2009-10-29
EP1801114B1 (fr) 2009-09-16

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Effective date: 20190912