CA2624973C - Production of hyaluronan from plants transgenic for hyaluronan synthase, gfat and udp-glucose dehydrogenase - Google Patents

Production of hyaluronan from plants transgenic for hyaluronan synthase, gfat and udp-glucose dehydrogenase Download PDF

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Publication number
CA2624973C
CA2624973C CA2624973A CA2624973A CA2624973C CA 2624973 C CA2624973 C CA 2624973C CA 2624973 A CA2624973 A CA 2624973A CA 2624973 A CA2624973 A CA 2624973A CA 2624973 C CA2624973 C CA 2624973C
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Canada
Prior art keywords
hyaluronan
activity
nucleic acid
plants
plant
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Expired - Fee Related
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CA2624973A
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English (en)
French (fr)
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CA2624973A1 (en
Inventor
Claus Frohberg
Bernd Essigmann
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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Priority claimed from EP05090277A external-priority patent/EP1772052A1/de
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Publication of CA2624973A1 publication Critical patent/CA2624973A1/en
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Publication of CA2624973C publication Critical patent/CA2624973C/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C12N15/8246—Non-starch polysaccharides, e.g. cellulose, fructans, levans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
CA2624973A 2005-10-05 2006-10-05 Production of hyaluronan from plants transgenic for hyaluronan synthase, gfat and udp-glucose dehydrogenase Expired - Fee Related CA2624973C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP05090277.4 2005-10-05
EP05090277A EP1772052A1 (de) 2005-10-05 2005-10-05 Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan
US72553005P 2005-10-11 2005-10-11
US60/725,530 2005-10-11
EP06090053 2006-04-07
EP06090053.7 2006-04-07
PCT/EP2006/009775 WO2007039316A1 (en) 2005-10-05 2006-10-05 Improved methods and means for producings hyaluronan

Publications (2)

Publication Number Publication Date
CA2624973A1 CA2624973A1 (en) 2007-04-12
CA2624973C true CA2624973C (en) 2016-01-19

Family

ID=37546686

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2624973A Expired - Fee Related CA2624973C (en) 2005-10-05 2006-10-05 Production of hyaluronan from plants transgenic for hyaluronan synthase, gfat and udp-glucose dehydrogenase

Country Status (7)

Country Link
US (1) US8106256B2 (https=)
EP (1) EP1951030B1 (https=)
JP (1) JP2009509557A (https=)
AU (1) AU2006298963A1 (https=)
CA (1) CA2624973C (https=)
PL (1) PL1951030T3 (https=)
WO (1) WO2007039316A1 (https=)

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