CA2615372A1 - Influenza virus-like particles (vlps) comprising hemagglutinin - Google Patents

Influenza virus-like particles (vlps) comprising hemagglutinin Download PDF

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Publication number
CA2615372A1
CA2615372A1 CA002615372A CA2615372A CA2615372A1 CA 2615372 A1 CA2615372 A1 CA 2615372A1 CA 002615372 A CA002615372 A CA 002615372A CA 2615372 A CA2615372 A CA 2615372A CA 2615372 A1 CA2615372 A1 CA 2615372A1
Authority
CA
Canada
Prior art keywords
plant
influenza
virus
vlps
vlp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002615372A
Other languages
English (en)
French (fr)
Inventor
Marc-Andre D'aoust
Manon Couture
Frederic Ors
Sonia Trepanier
Pierre-Olivier Lavoie
Michele Dargis
Louis-Philippe Vezina
Nathalie Landry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicago Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU2008278222A priority Critical patent/AU2008278222B2/en
Priority to CA2693956A priority patent/CA2693956C/en
Priority to EA201000195A priority patent/EA018206B1/ru
Priority to BRPI0813724-2A priority patent/BRPI0813724B1/pt
Priority to MYPI2010000142A priority patent/MY155236A/en
Priority to KR1020107002538A priority patent/KR101541330B1/ko
Priority to EP08783201.0A priority patent/EP2173886B1/en
Priority to PL08783201T priority patent/PL2173886T3/pl
Priority to PT87832010T priority patent/PT2173886E/pt
Priority to PCT/CA2008/001281 priority patent/WO2009009876A1/en
Priority to US12/669,033 priority patent/US20100239610A1/en
Priority to HK10109048.1A priority patent/HK1142627B/en
Priority to NZ582360A priority patent/NZ582360A/en
Priority to CN2008801070729A priority patent/CN101883856B/zh
Priority to MX2010000525A priority patent/MX2010000525A/es
Priority to ES08783201T priority patent/ES2428384T3/es
Priority to JP2010516334A priority patent/JP5624465B2/ja
Priority to DK08783201.0T priority patent/DK2173886T3/da
Priority to SI200831024T priority patent/SI2173886T1/sl
Priority to BRPI0906960-7A priority patent/BRPI0906960B1/pt
Priority to KR1020167010959A priority patent/KR101956910B1/ko
Priority to DK12183854.4T priority patent/DK2610345T3/en
Priority to EP09700061A priority patent/EP2238253B1/en
Priority to AU2009202819A priority patent/AU2009202819B2/en
Priority to KR1020107018343A priority patent/KR20100120157A/ko
Priority to ES12183854.4T priority patent/ES2554703T3/es
Priority to PCT/CA2009/000032 priority patent/WO2009076778A1/en
Priority to NZ587108A priority patent/NZ587108A/xx
Priority to PT121838544T priority patent/PT2610345E/pt
Priority to CN201310021693.8A priority patent/CN103122354B/zh
Priority to MX2010007962A priority patent/MX2010007962A/es
Priority to EA201001198A priority patent/EA034733B1/ru
Priority to CA2707235A priority patent/CA2707235C/en
Priority to US12/863,772 priority patent/US20100310604A1/en
Priority to SG2013004577A priority patent/SG187500A1/en
Priority to CN2009801097815A priority patent/CN101978066A/zh
Priority to JP2010542486A priority patent/JP2011509661A/ja
Priority to EP12183854.4A priority patent/EP2610345B1/en
Publication of CA2615372A1 publication Critical patent/CA2615372A1/en
Priority to US13/003,570 priority patent/US9492528B2/en
Priority to IL203018A priority patent/IL203018A/en
Priority to CR11209A priority patent/CR11209A/es
Priority to IS8874A priority patent/IS2920B/is
Priority to MA32604A priority patent/MA31681B1/fr
Priority to ZA2010/00972A priority patent/ZA201000972B/en
Priority to IL206967A priority patent/IL206967A/en
Priority to CR11612A priority patent/CR11612A/es
Priority to IS8919A priority patent/IS2982B/is
Priority to MA33088A priority patent/MA32439B1/fr
Priority to ZA2010/05917A priority patent/ZA201005917B/en
Priority to US13/734,886 priority patent/US9452210B2/en
Priority to US13/748,531 priority patent/US9458470B2/en
Priority to HK13113472.5A priority patent/HK1186207B/en
Priority to IL230708A priority patent/IL230708A/en
Priority to JP2014039035A priority patent/JP5990207B2/ja
Priority to JP2015231583A priority patent/JP2016032477A/ja
Priority to US15/256,119 priority patent/US10190132B2/en
Priority to US16/219,306 priority patent/US11434497B2/en
Priority to US17/815,503 priority patent/US20230044454A1/en
Abandoned legal-status Critical Current

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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • G06F9/50—Allocation of resources, e.g. of the central processing unit [CPU]
    • G06F9/5005—Allocation of resources, e.g. of the central processing unit [CPU] to service a request
    • G06F9/5027—Allocation of resources, e.g. of the central processing unit [CPU] to service a request the resource being a machine, e.g. CPUs, Servers, Terminals
    • G06F9/505—Allocation of resources, e.g. of the central processing unit [CPU] to service a request the resource being a machine, e.g. CPUs, Servers, Terminals considering the load
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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CA002615372A 2007-07-13 2008-01-21 Influenza virus-like particles (vlps) comprising hemagglutinin Abandoned CA2615372A1 (en)

Priority Applications (58)

Application Number Priority Date Filing Date Title
AU2008278222A AU2008278222B2 (en) 2007-07-13 2008-07-11 Influenza virus-like particles (VLPs) comprising hemagglutinin produced within a plant
CA2693956A CA2693956C (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
EA201000195A EA018206B1 (ru) 2007-07-13 2008-07-11 Вирусоподобные частицы вируса гриппа, включающие гемагглютинин, продуцированный в растении
BRPI0813724-2A BRPI0813724B1 (pt) 2007-07-13 2008-07-11 Método de produção de partículas similares ao vírus influenza (vlps) em uma planta, partículas similares a vírus (vlps) e composição
MYPI2010000142A MY155236A (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
KR1020107002538A KR101541330B1 (ko) 2007-07-13 2008-07-11 식물에서 생산된 헤마글루티닌을 포함하는 인플루엔자 바이러스-유사 입자(ＶＬＰｓ)
EP08783201.0A EP2173886B1 (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
PL08783201T PL2173886T3 (pl) 2007-07-13 2008-07-11 Cząstki wirusopodobne (VLP) obejmujące hemaglutyninę wytworzoną w roślinie
PT87832010T PT2173886E (pt) 2007-07-13 2008-07-11 Partículas semelhantes ao vírus da gripe (vlps) compreendendo hemaglutinina produzida numa planta
PCT/CA2008/001281 WO2009009876A1 (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
US12/669,033 US20100239610A1 (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
HK10109048.1A HK1142627B (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
NZ582360A NZ582360A (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
CN2008801070729A CN101883856B (zh) 2007-07-13 2008-07-11 包含植物内生产之血凝素的流感病毒样颗粒(vlp)
MX2010000525A MX2010000525A (es) 2007-07-13 2008-07-11 Particulas similares al virus de la influenza (vlps) que comprenden hemaglutinina producida dentro de una planta.
ES08783201T ES2428384T3 (es) 2007-07-13 2008-07-11 Partículas similares al virus de la influenza (VLP) que contienen hemaglutinina producida dentro de una planta
JP2010516334A JP5624465B2 (ja) 2007-07-13 2008-07-11 植物内で生成されるヘマグルチニンを含むインフルエンザウイルス様粒子（ｖｌｐ）
DK08783201.0T DK2173886T3 (da) 2007-07-13 2008-07-11 Influenzaviruslignende partikler (VLPS) omfattende hæmagglutinin produceret i en plante
SI200831024T SI2173886T1 (sl) 2007-07-13 2008-07-11 Delci podobni virusu gripe (VLPs), ki vsebujejo v rastlini proizveden hemagglutin
BRPI0906960-7A BRPI0906960B1 (pt) 2008-01-21 2009-01-12 Ácido nucleico compreendendo uma sequência de nucleotídeos codificando uma hemaglutinina do vírus de influenza (ha), partículas semelhantes a vírus (vlps), seu método de produção, composição e uso dos mesmos
KR1020167010959A KR101956910B1 (ko) 2008-01-21 2009-01-12 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ)
DK12183854.4T DK2610345T3 (en) 2007-11-27 2009-01-12 RECOMBINANT INFLUENZA VIRUS SIMULAR PARTICULARS (VLPS) MADE IN TRANSGENE PLANTS THAT EXPRESS HEMAGGLUTININ
EP09700061A EP2238253B1 (en) 2007-11-27 2009-01-12 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
AU2009202819A AU2009202819B2 (en) 2007-07-13 2009-01-12 Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
KR1020107018343A KR20100120157A (ko) 2007-11-27 2009-01-12 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ)
ES12183854.4T ES2554703T3 (es) 2007-11-27 2009-01-12 Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina
PCT/CA2009/000032 WO2009076778A1 (en) 2007-11-27 2009-01-12 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
NZ587108A NZ587108A (en) 2007-11-27 2009-01-12 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
PT121838544T PT2610345E (pt) 2007-11-27 2009-01-12 Partículas semelhantes ao vírus (vlps) da gripe recombinantes produzidas em plantas transgénicas que expressam hemaglutinina
CN201310021693.8A CN103122354B (zh) 2007-11-27 2009-01-12 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp)
MX2010007962A MX2010007962A (es) 2007-11-27 2009-01-12 Particulas tipo virus de influenza recombinante (vlp) producidas en plantas transgenicas que expresan hemaglutinina.
EA201001198A EA034733B1 (ru) 2008-01-21 2009-01-12 Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение
CA2707235A CA2707235C (en) 2007-11-27 2009-01-12 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
US12/863,772 US20100310604A1 (en) 2007-11-27 2009-01-12 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
SG2013004577A SG187500A1 (en) 2008-01-21 2009-01-12 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
CN2009801097815A CN101978066A (zh) 2007-11-27 2009-01-12 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp)
JP2010542486A JP2011509661A (ja) 2007-11-27 2009-01-12 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）
EP12183854.4A EP2610345B1 (en) 2007-11-27 2009-01-12 Recombinant influenza virus-like particles (VLPS) produced in transgenic plants expressing hemagglutinin
US13/003,570 US9492528B2 (en) 2007-07-13 2009-07-02 Influenza virus-like particles (VLPS) comprising hemagglutinin
IL203018A IL203018A (en) 2007-07-13 2009-12-29 Influenza virus-like particles containing megalotinin produced in a plant
CR11209A CR11209A (es) 2007-07-13 2010-01-11 Particulas similares al virus de la influenza (vlps) que comprenden hemaglutinina producida dentro de una planta
IS8874A IS2920B (is) 2007-07-13 2010-01-27 Inflúensu veirulíkar agnir (VLPs) sem innihalda rauðkornakekki framleiddar í plöntu.
MA32604A MA31681B1 (fr) 2007-07-13 2010-02-08 Pseudo-particules du virus de la grippe (vlp) comprenant de l'hémagglutinine (ha) produit dans une plante.
ZA2010/00972A ZA201000972B (en) 2007-07-13 2010-02-10 Influenza virus-like particles (vlps) comprising hemagglutinin produces produced within a plant
IL206967A IL206967A (en) 2007-11-27 2010-07-13 Nucleic acid comprising a nucleotide sequence encoded for influenza virus hemoglutinin and a method for preparing the influenza virus-like particle comprising it
CR11612A CR11612A (es) 2007-11-27 2010-07-29 Particulas tipo virus de influenza recombinante (vlp) producidas en plantas transgenicas que expresan hemaglutinina
IS8919A IS2982B (is) 2007-11-27 2010-08-04 Raðbrigði inflúensuveitu-líkra agna (VLP) framleidd í erfðabreyttum plöntum sem tjá rauðkornakekk.
MA33088A MA32439B1 (fr) 2007-11-27 2010-08-13 Particules pseudovirales (vlp) de la grippe recombinées produites dans des plantes transgéniques exprimant l'hémagglutinine
ZA2010/05917A ZA201005917B (en) 2007-11-27 2010-08-19 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
US13/734,886 US9452210B2 (en) 2007-07-13 2013-01-04 Influenza virus-like particles (VLPS) comprising hemagglutinin produced within a plant
US13/748,531 US9458470B2 (en) 2007-11-27 2013-01-23 Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
HK13113472.5A HK1186207B (en) 2008-01-21 2013-12-04 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
IL230708A IL230708A (en) 2007-07-13 2014-01-29 Influenza virus-like particles containing megalotinin produced in a plant
JP2014039035A JP5990207B2 (ja) 2007-11-27 2014-02-28 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）
JP2015231583A JP2016032477A (ja) 2007-11-27 2015-11-27 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）
US15/256,119 US10190132B2 (en) 2007-11-27 2016-09-02 Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
US16/219,306 US11434497B2 (en) 2007-11-27 2018-12-13 Recombinant influenza virus-like particles (VLPS) produced in transgenic plants
US17/815,503 US20230044454A1 (en) 2007-07-13 2022-07-27 Recombinant influenza virus-like particles (vlps) produced in transgenic plants

Applications Claiming Priority (6)

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US95941407P 2007-07-13 2007-07-13
US60/959,414 2007-07-13
US99060307P 2007-11-27 2007-11-27
US60/990,603 2007-11-27
US1327207P 2007-12-12 2007-12-12
US61/013,272 2007-12-12

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010151159A2 (en) 2009-06-26 2010-12-29 Instytut Biochemii I Biofizyki Virus-like particle vector as a polyvalent platform for intracellular delivery of high-molecular-weight therapeutic substances, method for generating a virus like particle vector and use of a virus-like particle vector and a pharmaceutical composition containing said virus-like particle vector
US8771703B2 (en) 2008-07-08 2014-07-08 Medicago Inc. Soluble recombinant influenza antigens
US9452210B2 (en) 2007-07-13 2016-09-27 Medicago Inc. Influenza virus-like particles (VLPS) comprising hemagglutinin produced within a plant
US9458470B2 (en) 2007-11-27 2016-10-04 Medicago Inc. Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
US9546375B2 (en) 2008-07-18 2017-01-17 Medicago Inc. Influenza virus immunizing epitope
US9815873B2 (en) 2011-03-23 2017-11-14 Medicago Inc. Method for recovering plant-derived proteins
US10272148B2 (en) 2009-06-24 2019-04-30 Medicago Inc. Chimeric influenza virus-like particles comprising hemagglutinin
US11826419B2 (en) 2009-09-22 2023-11-28 Medicago Inc. Method of preparing plant-derived VLPs

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI377253B (en) 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
WO2005018539A2 (en) 2003-06-16 2005-03-03 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
EP2471552B1 (en) 2005-03-08 2015-05-06 MedImmune, LLC Reassortant influenza viruses
US9439959B2 (en) * 2006-07-27 2016-09-13 Takeda Vaccines, Inc. Chimeric influenza virus-like particles
CN102149405A (zh) * 2008-07-11 2011-08-10 米迪缪尼股份有限公司 流感血凝素和神经氨酸酶变体
AU2015202195B2 (en) * 2008-07-18 2017-10-12 Medicago Inc. New influenza virus immunizing epitope
KR101939014B1 (ko) 2009-03-16 2019-01-15 디에스엠 아이피 어셋츠 비.브이. 라비린툴로바이코타문 미생물에서의 단백질 생산
EP3009145A1 (en) 2009-03-30 2016-04-20 Mount Sinai School of Medicine of New York University Influenza virus vaccines and uses thereof
DK2417153T3 (en) * 2009-04-09 2014-12-01 Alfa Biogene Internat B V Filtration of a liquid comprising a stress protein from a plant
JP5886194B2 (ja) 2009-07-02 2016-03-16 マサチューセッツ インスティテュート オブ テクノロジー インフルエンザ感染の診断および／または処置のための組成物および方法
CN103260643A (zh) * 2009-12-28 2013-08-21 梅里亚有限公司 重组ndv抗原及其用途
EP2519636B8 (en) 2009-12-28 2017-08-09 DSM IP Assets B.V. Production of hemagglutinin-neuraminidase protein in microalgae
AU2010343095B2 (en) * 2009-12-28 2017-01-05 Sanofi Vaccine Technologies, S.A.S. Production of heterologous polypeptides in microalgae, microalgal extracellular bodies, compositions, and methods of making and uses thereof
AU2015202267B2 (en) * 2010-01-26 2017-03-23 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
CA2790380A1 (en) 2010-02-18 2011-08-25 Mount Sinai School Of Medicine Vaccines for use in the prophylaxis and treatment of influenza virus disease
MX2012011300A (es) 2010-03-30 2012-11-29 Sinai School Medicine Vacunas del virus de influenza y usos de las mismas.
JP2013541528A (ja) 2010-09-21 2013-11-14 マサチューセッツ インスティテュート オブ テクノロジー ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置
BR112013007593A2 (pt) 2010-09-30 2016-08-09 Franvax S R L partícula de virossoma produzida sinteticamente, vacina, método para produzir uma partícula de virossoma, uso de uma partícula de virossoma e de uma vacina
SG10201709806VA (en) 2010-10-04 2017-12-28 Massachusetts Inst Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
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US20140059718A1 (en) * 2011-01-17 2014-02-27 Philip Morris Products S.A. Vectors for nucleic acid expression in plants
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EP2827893B1 (en) 2012-03-22 2017-11-29 Fraunhofer USA, Inc. Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof
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US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
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KR101637955B1 (ko) * 2015-05-18 2016-07-08 한국생명공학연구원 범용성 인플루엔자 바이러스 백신 조성물
EP3316677B1 (en) 2015-07-02 2021-02-17 Medicago Inc. Jasmonic acid pathway activator
BR112018075032A2 (pt) 2016-06-15 2019-03-26 Icahn School Of Medicine At Mount Sinai proteínas de hemaglutinina do vírus influenza e seus uso
US11254733B2 (en) 2017-04-07 2022-02-22 Icahn School Of Medicine At Mount Sinai Anti-influenza B virus neuraminidase antibodies and uses thereof
KR101964044B1 (ko) * 2018-03-14 2019-04-02 인제대학교 산학협력단 재조합 아데노바이러스를 이용한 다가형 인플루엔자 생백신 플랫폼
AU2019233860B2 (en) 2018-03-14 2025-02-13 Aramis Biotechnologies Inc. Plant expression enhancer
US12364746B2 (en) 2018-06-21 2025-07-22 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
CA3103840A1 (en) * 2018-06-27 2020-01-02 Medicago Inc. Influenza virus hemagglutinin mutants
CN112384615A (zh) 2018-07-04 2021-02-19 普罗拜奥根股份公司 用于纯化包膜病毒的方法
BR112021017899A2 (pt) 2019-03-14 2021-12-21 Medicago Inc Intensificador de expressão vegetal endógeno
WO2021002355A1 (ja) 2019-07-03 2021-01-07 アイリス株式会社 インフルエンザウイルス感染症を治療するための医薬組成物
CN111122417B (zh) * 2020-02-22 2022-06-21 太原理工大学 一种测定含瓦斯煤开闭孔总体积膨胀率的装置及方法
EP4351320A1 (en) 2021-06-09 2024-04-17 ImmunityBio, Inc. Methods and systems for producing a protein of interest in a plant
CN115992101B (zh) * 2023-03-22 2023-07-28 深圳市卫光生物制品股份有限公司 一种流感病毒裂解疫苗原液的制备方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003224A1 (en) 1984-11-29 1986-06-05 Scripps Clinic And Research Foundation Polypeptides and antibodies related to deglycosylated viral glycoproteins
US5232833A (en) * 1988-09-14 1993-08-03 Stressgen Biotechnologies Corporation Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants
EP0509656B1 (en) * 1991-03-28 1996-09-18 Rooperol (Na) Nv Compositions of phytosterols and phytosterolins as immunmodulators
US6326470B1 (en) 1997-04-15 2001-12-04 The Penn State Research Foundation Enhancement of accessibility of cellulose by expansins
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
GB9414118D0 (en) 1994-07-13 1994-08-31 Axis Genetics Ltd Modified plant viruses as vectors of heterologous peptides
AU6504796A (en) 1995-07-20 1997-02-18 Washington State University Research Foundation Production of secreted foreign polypeptides in plant cell culture
US6042832A (en) 1996-08-28 2000-03-28 Thomas Jefferson University Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins
US20010006950A1 (en) 1998-02-11 2001-07-05 Juha Punnonen Genetic vaccine vector engineering
US6489537B1 (en) 1998-08-07 2002-12-03 The Trustees Of The University Of Pennsylvania Phytochelatin synthases and uses therefor
KR20010072372A (ko) 1998-08-11 2001-07-31 맥기 데이비드 알 식물조직의 간질액으로부터 단백질을 추출하는 방법
WO2000020557A2 (en) 1998-10-07 2000-04-13 Boyce Institute For Plant Research At Cornell University Gemini virus vectors for gene expression in plants
US6287570B1 (en) * 1998-11-23 2001-09-11 Patricia L. Foley Vaccine against swine influenza virus
FR2791358B1 (fr) 1999-03-22 2003-05-16 Meristem Therapeutics Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention
HUP0300187A3 (en) 1999-04-29 2004-11-29 Syngenta Ltd Haslemere Herbicide resistant plants
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
ATE433491T1 (de) 2001-01-18 2009-06-15 Vlaams Interuniv Inst Biotech Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential
CN1333370A (zh) * 2001-08-16 2002-01-30 深圳市三方圆信息技术有限公司 抗家禽病毒病的作物及其生产方法
JP4430942B2 (ja) 2002-02-13 2010-03-10 ウィスコンシン・アルムナイ・リサーチ・ファウンデーション インフルエンザウイルスベクターのパッケージングのためのシグナル
US20040063188A1 (en) 2002-02-14 2004-04-01 Novavax, Inc. Kit for treating gastrointestinal tract
CN1665934B (zh) * 2002-03-19 2010-05-26 国际植物研究所 GNTIII(UDP-N乙酰葡萄糖胺:β-D-甘露糖苷β(1,4)-N-乙酰葡萄糖胺基-转移酶III)在植物中的表达
ES2224792B1 (es) 2002-06-28 2007-02-16 Era Plantech, S.L. Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas.
CU23202A1 (es) * 2003-01-31 2007-05-18 Ct Ingenieria Genetica Biotech ANTIGENOS RECOMBINANTES DEL VIRUS DE LA HEPATITIS A OBTENIDOS EN CéLULAS VEGETALES
CN1460718A (zh) * 2003-04-11 2003-12-10 浙江大学 表达传染性支气管炎病毒纤突蛋白的转基因马铃薯生产方法
CN101123871B (zh) 2003-05-05 2011-05-18 美国陶氏益农公司 来源于转基因植物细胞的稳定免疫预防性和治疗性组合物及其制备方法
AU2004235813B2 (en) * 2003-05-05 2010-07-29 Boyce Thompson Institute For Plant Research Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
WO2005018539A2 (en) * 2003-06-16 2005-03-03 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
EP3388521A1 (en) * 2004-02-27 2018-10-17 Dow AgroSciences LLC High efficiency peptide production in plant cells
US7901691B2 (en) 2004-08-13 2011-03-08 Council Of Scientific And Indistrial Research Chimeric G protein based rabies vaccine
EP1883701B1 (en) 2005-04-29 2012-01-18 University of Cape Town Expression of viral proteins in plants
CN100410378C (zh) 2005-05-09 2008-08-13 中国农业科学院生物技术研究所 编码禽流感血凝素的基因及其植物表达载体和应用
CA2615658A1 (en) 2005-07-19 2007-01-25 Dow Global Technolgies Inc. Recombinant flu vaccines
US7871626B2 (en) 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
EP1945250A4 (en) 2005-08-16 2010-05-19 Hawaii Biotech Inc RECOMBINANT SUBUNIT VACCINE AGAINST INFLUENZA
RU2483751C2 (ru) * 2005-10-18 2013-06-10 Новавакс, Инк. ФУНКЦИОНАЛЬНЫЕ ВИРУСОПОДОБНЫЕ ЧАСТИЦЫ ГРИППА (VLPs)
CA2630220C (en) 2005-11-22 2020-10-13 Doris Coit Norovirus and sapovirus antigens
WO2008060669A2 (en) 2006-04-21 2008-05-22 Dow Agrosciences Llc Vaccine for avian influenza and methods of use
BRPI0707733B1 (pt) 2006-02-13 2019-12-31 Ibio, Inc. antígeno isolado, composição de vacina, uso da referida composição e método para produção de uma proteína de antígeno
WO2007130327A2 (en) 2006-05-01 2007-11-15 Technovax, Inc. Influenza virus-like particle (vlp) compositions
WO2008054540A2 (en) 2006-05-18 2008-05-08 Pharmexa Inc. Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions
US20070286873A1 (en) * 2006-05-23 2007-12-13 Williams John V Recombinant Influenza H5 Hemagluttinin Protein And Nucleic Acid Coding Therefor
US7730950B2 (en) 2007-01-19 2010-06-08 Halliburton Energy Services, Inc. Methods for treating intervals of a subterranean formation having variable permeability
EP2155880B1 (en) 2007-06-15 2016-08-10 Medicago Inc. Modifying glycoprotein production in plants
KR100964462B1 (ko) 2007-07-10 2010-06-16 성균관대학교산학협력단 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
CA2696764A1 (en) 2007-08-20 2009-02-26 Fraunhofer Usa, Inc. Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods
CN103122354B (zh) 2007-11-27 2018-03-23 麦迪卡格公司 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp)
WO2009083420A1 (en) 2007-12-28 2009-07-09 Unilever Plc Process for recovering aroma from tea
GB0800272D0 (en) 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
SG187500A1 (en) 2008-01-21 2013-02-28 Medicago Inc Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
ES2545607T3 (es) 2008-07-08 2015-09-14 Medicago Inc. Antígenos de la gripe recombinantes solubles
ES2593277T3 (es) 2008-07-18 2016-12-07 Medicago Inc. Nuevo epítopo de inmunización contra el virus de la influenza
AU2009285667B2 (en) 2008-08-27 2015-05-28 Arizona Board Of Regents For And On Behalf Of Arizona State University A DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants
US8283368B2 (en) 2008-08-29 2012-10-09 The Regents Of The University Of Michigan Selective ligands for the dopamine 3 (D3) receptor and methods of using the same
WO2010077712A1 (en) 2008-12-09 2010-07-08 Novavax, Inc. Bovine respiratory syncytial virus virus-like particle (vlps)
KR101377725B1 (ko) * 2009-06-24 2014-03-27 메디카고 인코포레이티드 헤마글루티닌을 포함하는 키메라 인플루엔자 바이러스-유사 입자
WO2011011390A1 (en) 2009-07-20 2011-01-27 Novavax, Inc. Purified recombinant influenza virus ha proteins
BR112012006414B1 (pt) 2009-09-22 2020-09-15 Medicago Inc Métodos para preparação de proteínas derivadas de plantas
WO2011102900A1 (en) 2010-02-18 2011-08-25 Technovax, Inc. Universal virus-like particle (vlp) influenza vaccines
CN103282501A (zh) 2010-11-04 2013-09-04 麦迪卡格公司 植物表达系统
EP3246019B1 (en) 2010-11-05 2021-03-03 Novavax, Inc. Rabies glycoprotein virus-like particles (vlps)
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9452210B2 (en) 2007-07-13 2016-09-27 Medicago Inc. Influenza virus-like particles (VLPS) comprising hemagglutinin produced within a plant
US9492528B2 (en) 2007-07-13 2016-11-15 Medicago Inc. Influenza virus-like particles (VLPS) comprising hemagglutinin
US9458470B2 (en) 2007-11-27 2016-10-04 Medicago Inc. Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
US10190132B2 (en) 2007-11-27 2019-01-29 Medicago Inc. Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
US11434497B2 (en) 2007-11-27 2022-09-06 Medicago Inc. Recombinant influenza virus-like particles (VLPS) produced in transgenic plants
US8771703B2 (en) 2008-07-08 2014-07-08 Medicago Inc. Soluble recombinant influenza antigens
US9546375B2 (en) 2008-07-18 2017-01-17 Medicago Inc. Influenza virus immunizing epitope
US10272148B2 (en) 2009-06-24 2019-04-30 Medicago Inc. Chimeric influenza virus-like particles comprising hemagglutinin
WO2010151159A2 (en) 2009-06-26 2010-12-29 Instytut Biochemii I Biofizyki Virus-like particle vector as a polyvalent platform for intracellular delivery of high-molecular-weight therapeutic substances, method for generating a virus like particle vector and use of a virus-like particle vector and a pharmaceutical composition containing said virus-like particle vector
US11826419B2 (en) 2009-09-22 2023-11-28 Medicago Inc. Method of preparing plant-derived VLPs
US11833200B2 (en) 2009-09-22 2023-12-05 Medicago Inc. Method of preparing plant-derived proteins
US9815873B2 (en) 2011-03-23 2017-11-14 Medicago Inc. Method for recovering plant-derived proteins
CN110041397A (zh) * 2011-03-23 2019-07-23 麦迪卡格公司 回收植物来源的蛋白质的方法

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