CA2614145A1 - Nucleic acid capable of binding to immunoglobulin g and use thereof - Google Patents
Nucleic acid capable of binding to immunoglobulin g and use thereof Download PDFInfo
- Publication number
- CA2614145A1 CA2614145A1 CA002614145A CA2614145A CA2614145A1 CA 2614145 A1 CA2614145 A1 CA 2614145A1 CA 002614145 A CA002614145 A CA 002614145A CA 2614145 A CA2614145 A CA 2614145A CA 2614145 A1 CA2614145 A1 CA 2614145A1
- Authority
- CA
- Canada
- Prior art keywords
- aptamer
- nucleotide
- igg
- seq
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 229960004964 temozolomide Drugs 0.000 description 1
- ABZLKHKQJHEPAX-UHFFFAOYSA-N tetramethylrhodamine Chemical compound C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C([O-])=O ABZLKHKQJHEPAX-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 229960003087 tioguanine Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
- 229960000303 topotecan Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 229960000875 trofosfamide Drugs 0.000 description 1
- UMKFEPPTGMDVMI-UHFFFAOYSA-N trofosfamide Chemical compound ClCCN(CCCl)P1(=O)OCCCN1CCCl UMKFEPPTGMDVMI-UHFFFAOYSA-N 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005195717 | 2005-07-05 | ||
| JP2005-195717 | 2005-07-05 | ||
| US74902605P | 2005-12-12 | 2005-12-12 | |
| US60/749,026 | 2005-12-12 | ||
| PCT/JP2006/313811 WO2007004748A1 (ja) | 2005-07-05 | 2006-07-05 | 免疫グロブリンｇに結合する核酸とその利用法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2614145A1 true CA2614145A1 (en) | 2007-01-11 |
Family
ID=37604595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002614145A Abandoned CA2614145A1 (en) | 2005-07-05 | 2006-07-05 | Nucleic acid capable of binding to immunoglobulin g and use thereof |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8637656B2 (de) |
| EP (1) | EP1918372A4 (de) |
| KR (1) | KR20080036595A (de) |
| CA (1) | CA2614145A1 (de) |
| WO (1) | WO2007004748A1 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008290416B2 (en) * | 2007-08-14 | 2013-11-21 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Method for purifying or detecting a target protein |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4698559B2 (ja) | 2006-11-24 | 2011-06-08 | Ｎｅｃソフト株式会社 | ウサギ由来のＩｇＧ抗体に結合性を有する核酸分子 |
| JP5344671B2 (ja) * | 2008-02-14 | 2013-11-20 | 国立大学法人山口大学 | 心不全治療薬 |
| DE102008013622A1 (de) * | 2008-03-10 | 2009-09-17 | Freie Universität Berlin | Pharmazeutische Zusammensetzung zur Diagnose oder Behandlung des Plasmozytoms |
| US8440801B2 (en) * | 2008-07-14 | 2013-05-14 | The University Of Tokyo | Aptamer against IL-17 and use thereof |
| FR2942232B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre |
| WO2011060435A1 (en) | 2009-11-16 | 2011-05-19 | Memorial Sloan Kettering Cancer Center | Compositions and methods for treating cancer and other diseases |
| AU2012295913A1 (en) * | 2011-08-12 | 2014-03-13 | Tagcyx Biotechnologies | Production method for nucleic acid aptamer |
| WO2013111953A2 (ko) * | 2012-01-27 | 2013-08-01 | 경희대학교 산학협력단 | 앱타머 칩을 이용한 표적 단백질 또는 표적 세포의 검출 및 정량 방법 |
| SG11201407505XA (en) * | 2012-06-07 | 2014-12-30 | Somalogic Inc | Aptamer-based multiplexed assays |
| AU2014238740B2 (en) | 2013-03-22 | 2017-04-20 | The University Of Tokyo | Aptamer to IL-17 and use thereof |
| WO2017136849A1 (en) * | 2016-02-05 | 2017-08-10 | Base Pair Biotechnologies, Inc. | Functional ligands to igg |
| EP3491136A1 (de) * | 2016-07-28 | 2019-06-05 | Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme | Aptamere gegen immunoglobulin g und verwendungen davon |
| WO2018019537A1 (en) | 2016-07-28 | 2018-02-01 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Method for obtaining aptamers |
| JP2018126117A (ja) * | 2017-02-10 | 2018-08-16 | 学校法人日本大学 | 核酸アプタマー、固相担体、ヒトＩｇＧ精製用カラム、及びヒトＩｇＧの精製方法 |
| EP3617235A4 (de) | 2017-04-28 | 2020-12-16 | Ajinomoto Co., Inc. | Verbindung mit einer substanz mit affinität zu löslichem protein, spaltbarem teil und reaktiver gruppe oder salz davon |
| SG11202004154SA (en) * | 2017-11-09 | 2020-06-29 | Ribomic Inc | Aptamer for adamts5 and use for aptamer for adamts5 |
| AT521238B1 (de) | 2018-05-09 | 2020-02-15 | Lifetaq Analytics Gmbh | In-situ zellanalyse im zellkultursystem |
| CN112261954A (zh) | 2018-06-14 | 2021-01-22 | 味之素株式会社 | 具有针对抗体的亲和性物质和生物正交性官能团的化合物或其盐 |
| CN110483643B (zh) * | 2018-09-19 | 2021-06-08 | 深圳市雅为泓源生物科技有限公司 | 一种新型的抗体组合物、分离的核酸和制备方法 |
| US20210317456A1 (en) * | 2018-10-15 | 2021-10-14 | Somalogic, Inc. | Nucleic Acid Compounds for Binding Immunoglobulin G |
| WO2020124095A1 (en) * | 2018-12-14 | 2020-06-18 | Board Of Regents, The University Of Texas System Aka | Dna aptamers and use thereof for the treatment of cancer |
| CN114026235A (zh) * | 2019-06-26 | 2022-02-08 | 沃特世科技公司 | 用于选择性富集人免疫球蛋白Fc结构域的基于适体的亲和捕获方法 |
| AU2021301788A1 (en) | 2020-06-30 | 2023-01-19 | Gaia Biomedicine Inc. | Method for stabilizing binding of NK cell and antibody, and use thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2259800T3 (es) | 1990-06-11 | 2006-10-16 | Gilead Sciences, Inc. | Procedimientos de uso de ligandos de acido nucleico. |
| US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US6344321B1 (en) | 1990-06-11 | 2002-02-05 | Gilead Sciences, Inc. | Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met |
| US5686592A (en) | 1990-06-11 | 1997-11-11 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to immunoglobulin E (IgE) |
| KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| IE920562A1 (en) * | 1991-02-21 | 1992-08-26 | Gilead Sciences | Aptamer specific for biomolecules and method of making |
| US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| US6762290B1 (en) | 1999-07-29 | 2004-07-13 | Gilead Sciences, Inc. | High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors |
| US5756291A (en) * | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
| DE69333961T2 (de) | 1992-09-29 | 2006-08-24 | Gilead Sciences, Inc., Foster City | Nukleinsäureliganden und ihre herstellungsmethoden |
| AU692469B2 (en) | 1993-09-08 | 1998-06-11 | Gilead Sciences, Inc. | Nucleic acid ligands and improved methods for producing the same |
| US20030186311A1 (en) | 1999-05-21 | 2003-10-02 | Bioforce Nanosciences, Inc. | Parallel analysis of molecular interactions |
| DE60042021D1 (de) | 1999-07-29 | 2009-05-28 | Gilead Sciences Inc | Nukleinsäureliganden für den hepatozytischen wachstumsfaktor/dispersionsfaktor (hgf/sf) und seines c-met rezeptors |
| JP4167403B2 (ja) | 2001-04-05 | 2008-10-15 | 株式会社リボミック | 翻訳開始因子に特異的に結合する核酸リガンド |
| US20050124565A1 (en) * | 2002-11-21 | 2005-06-09 | Diener John L. | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| WO2004104586A1 (en) | 2003-05-16 | 2004-12-02 | Ciphergen Biosystems, Inc. | Allergen test devices and methods for their use |
| JP3940097B2 (ja) | 2003-05-20 | 2007-07-04 | 株式会社リボミック | 翻訳開始因子ｅＩＦ４Ｅに結合するリガンド |
| KR101159071B1 (ko) * | 2005-01-14 | 2012-06-26 | 삼성전자주식회사 | 신규한 히드로겔 공중합체, 상기 공중합체가 코팅되어있는 기판, 상기 공중합체를 이용하여 마이크로어레이를제조하는 방법 및 그에 의하여 제조된 마이크로어레이 |
| US20090018093A1 (en) * | 2005-03-07 | 2009-01-15 | Sharon Cload | Nucleic Acid Ligands Specific to Immunoglobuline E and Their Use as Atopic Disease Therapeutics |
-
2006
- 2006-07-05 US US11/988,164 patent/US8637656B2/en active Active
- 2006-07-05 KR KR1020087002768A patent/KR20080036595A/ko not_active Application Discontinuation
- 2006-07-05 EP EP06780981A patent/EP1918372A4/de not_active Withdrawn
- 2006-07-05 CA CA002614145A patent/CA2614145A1/en not_active Abandoned
- 2006-07-05 WO PCT/JP2006/313811 patent/WO2007004748A1/ja active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008290416B2 (en) * | 2007-08-14 | 2013-11-21 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Method for purifying or detecting a target protein |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007004748A1 (ja) | 2007-01-11 |
| US8637656B2 (en) | 2014-01-28 |
| EP1918372A1 (de) | 2008-05-07 |
| EP1918372A4 (de) | 2009-08-12 |
| KR20080036595A (ko) | 2008-04-28 |
| US20090170219A1 (en) | 2009-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20160429 |