CA2609733C - 6,7-unsaturated-7-carbamoyl-substituted morphinan derivative - Google Patents

6,7-unsaturated-7-carbamoyl-substituted morphinan derivative Download PDF

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Publication number
CA2609733C
CA2609733C CA2609733A CA2609733A CA2609733C CA 2609733 C CA2609733 C CA 2609733C CA 2609733 A CA2609733 A CA 2609733A CA 2609733 A CA2609733 A CA 2609733A CA 2609733 C CA2609733 C CA 2609733C
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CA
Canada
Prior art keywords
optionally substituted
compound
chiral
lower alkyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2609733A
Other languages
English (en)
French (fr)
Other versions
CA2609733A1 (en
Inventor
Masanao Inagaki
Shin-Ichiro Hara
Nobuhiro Haga
Yoshinori Tamura
Yoshihisa Goto
Tsuyoshi Hasegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of CA2609733A1 publication Critical patent/CA2609733A1/en
Application granted granted Critical
Publication of CA2609733C publication Critical patent/CA2609733C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2609733A 2005-05-25 2006-05-25 6,7-unsaturated-7-carbamoyl-substituted morphinan derivative Active CA2609733C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2005151864 2005-05-25
JP2005-151864 2005-05-25
JP2006-065762 2006-03-10
JP2006065762 2006-03-10
JPPCT/JP2006/310231 2006-05-23
PCT/JP2006/310231 WO2006126529A1 (ja) 2005-05-25 2006-05-23 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
PCT/JP2006/310454 WO2006126637A1 (ja) 2005-05-25 2006-05-25 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体

Publications (2)

Publication Number Publication Date
CA2609733A1 CA2609733A1 (en) 2006-11-30
CA2609733C true CA2609733C (en) 2011-07-19

Family

ID=37451954

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2609733A Active CA2609733C (en) 2005-05-25 2006-05-25 6,7-unsaturated-7-carbamoyl-substituted morphinan derivative

Country Status (20)

Country Link
US (4) USRE46365E1 (OSRAM)
EP (1) EP1889848B8 (OSRAM)
JP (1) JP4323547B2 (OSRAM)
KR (1) KR100912782B1 (OSRAM)
CN (1) CN101228172B (OSRAM)
AU (1) AU2006250390B2 (OSRAM)
BE (1) BE2019C533I2 (OSRAM)
BR (1) BRPI0610343B8 (OSRAM)
CA (1) CA2609733C (OSRAM)
DK (1) DK1889848T3 (OSRAM)
ES (1) ES2525215T3 (OSRAM)
FR (1) FR19C1042I2 (OSRAM)
HU (1) HUS1900034I1 (OSRAM)
MX (1) MX2007014588A (OSRAM)
NL (1) NL300996I2 (OSRAM)
PL (1) PL1889848T3 (OSRAM)
PT (1) PT1889848E (OSRAM)
RU (1) RU2403255C2 (OSRAM)
TW (1) TWI311056B (OSRAM)
WO (2) WO2006126529A1 (OSRAM)

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WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
EP3090743A1 (en) * 2008-01-09 2016-11-09 Charleston Laboratories, Inc. Pharmaceutical compositions for treating headache and eliminating nausea
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
JP5827123B2 (ja) * 2008-09-16 2015-12-02 ウェルズ ファーゴ バンク ナショナル アソシエイション 乱用の可能性が低いｐｅｇ化オピオイド
MX342548B (es) * 2009-09-18 2016-10-04 Merck Sharp & Dohme Corp * Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal.
US20130217672A1 (en) * 2010-05-13 2013-08-22 Green Cross Corporation (+)-3-hydroxymorphinan-based polycycle derivatives
AU2011327113B9 (en) * 2010-11-12 2015-07-30 Shionogi & Co., Ltd. Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
PL2851075T3 (pl) 2012-05-14 2022-02-21 Shionogi & Co., Ltd. Preparat zawierający pochodną 6,7-nienasyconego-7-karbamoilomorfinanu
CA3048360C (en) * 2016-12-26 2021-06-29 Shionogi & Co., Ltd. Production method for formulation having improved content uniformity
JP7365358B2 (ja) 2018-04-12 2023-10-19 モーフィック セラピューティック，インコーポレイテッド ヒトインテグリンα４β７のアンタゴニスト
KR102201609B1 (ko) 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
TWI857592B (zh) 2019-10-16 2024-10-01 美商莫菲克醫療股份有限公司 抑制人類整合素α4β7
EP4062973A4 (en) 2019-11-20 2023-11-29 Shionogi & Co., Ltd 6,7-unsaturated-7-carbamoyl morphinan derivative-containing solid formulation
CN111905111B (zh) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法
IT202300009864A1 (it) 2023-05-16 2024-11-16 Procos Spa Processo per la preparazione di naldemedina

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US4272541A (en) 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4275205A (en) 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
US4347361A (en) 1980-12-10 1982-08-31 Sisa, Incorporated 4,5α-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-oxoalkyl)morphinan-6-one compounds
US4370333A (en) 1981-06-29 1983-01-25 Sisa, Incorporated 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it
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US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
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JP2003528819A (ja) * 1999-11-29 2003-09-30 アドラー コーポレーション オピオイドおよびそのアンタゴニストに関する新規方法および組成物
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Also Published As

Publication number Publication date
FR19C1042I1 (OSRAM) 2019-08-09
PL1889848T3 (pl) 2015-04-30
KR20080014791A (ko) 2008-02-14
HUS1900034I1 (hu) 2019-07-29
NL300996I1 (nl) 2019-07-03
CN101228172B (zh) 2013-04-03
AU2006250390B2 (en) 2010-07-08
WO2006126637A1 (ja) 2006-11-30
BRPI0610343B1 (pt) 2020-03-10
KR100912782B1 (ko) 2009-08-18
US20120135978A1 (en) 2012-05-31
CN101228172A (zh) 2008-07-23
TWI311056B (en) 2009-06-21
AU2006250390A1 (en) 2006-11-30
NL300996I2 (nl) 2019-07-30
BRPI0610343B8 (pt) 2021-05-25
WO2006126529A1 (ja) 2006-11-30
EP1889848B8 (en) 2014-12-17
JP4323547B2 (ja) 2009-09-02
US8536192B2 (en) 2013-09-17
EP1889848A4 (en) 2011-08-10
CA2609733A1 (en) 2006-11-30
DK1889848T3 (en) 2014-12-01
TW200726470A (en) 2007-07-16
FR19C1042I2 (fr) 2020-06-19
MX2007014588A (es) 2008-01-24
PT1889848E (pt) 2014-12-09
JPWO2006126637A1 (ja) 2008-12-25
US20090203723A1 (en) 2009-08-13
ES2525215T3 (es) 2014-12-19
US8084460B2 (en) 2011-12-27
EP1889848A1 (en) 2008-02-20
BRPI0610343A2 (pt) 2010-06-15
RU2007148412A (ru) 2009-06-27
RU2403255C2 (ru) 2010-11-10
USRE46365E1 (en) 2017-04-11
BE2019C533I2 (OSRAM) 2025-12-10
EP1889848B1 (en) 2014-10-15
USRE46375E1 (en) 2017-04-25

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