CA2608750A1 - Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component - Google Patents
Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component Download PDFInfo
- Publication number
- CA2608750A1 CA2608750A1 CA002608750A CA2608750A CA2608750A1 CA 2608750 A1 CA2608750 A1 CA 2608750A1 CA 002608750 A CA002608750 A CA 002608750A CA 2608750 A CA2608750 A CA 2608750A CA 2608750 A1 CA2608750 A1 CA 2608750A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- monoclonal antibody
- sequence shown
- biological sample
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G01N33/5758—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68257505P | 2005-05-18 | 2005-05-18 | |
| US60/682,575 | 2005-05-18 | ||
| US74933605P | 2005-12-09 | 2005-12-09 | |
| US60/749,336 | 2005-12-09 | ||
| PCT/US2006/019325 WO2006125117A2 (en) | 2005-05-18 | 2006-05-18 | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2608750A1 true CA2608750A1 (en) | 2006-11-23 |
Family
ID=36968724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002608750A Abandoned CA2608750A1 (en) | 2005-05-18 | 2006-05-18 | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8333970B2 (enExample) |
| EP (2) | EP1889065B1 (enExample) |
| JP (1) | JP5421590B2 (enExample) |
| AU (1) | AU2006247134B2 (enExample) |
| CA (1) | CA2608750A1 (enExample) |
| DK (1) | DK1889065T3 (enExample) |
| ES (1) | ES2429564T3 (enExample) |
| HR (1) | HRP20130852T1 (enExample) |
| PL (1) | PL1889065T3 (enExample) |
| PT (1) | PT1889065E (enExample) |
| WO (1) | WO2006125117A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003067210A2 (en) | 2001-07-10 | 2003-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting the activation state of the multiple proteins in single cells |
| US7381535B2 (en) | 2002-07-10 | 2008-06-03 | The Board Of Trustees Of The Leland Stanford Junior | Methods and compositions for detecting receptor-ligand interactions in single cells |
| US7393656B2 (en) * | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
| US8277810B2 (en) * | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
| US8945564B2 (en) | 2006-04-21 | 2015-02-03 | Novartis Ag | Antagonist anti-CD40 antibody pharmaceutical compositions |
| WO2009059259A2 (en) * | 2007-10-31 | 2009-05-07 | Children's Hospital Medical Center | Detection of worsening renal disease in subjects with systemic lupus erythematosus |
| US9068230B2 (en) | 2007-11-07 | 2015-06-30 | Genentech, Inc. | Methods and compositions for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
| NZ586834A (en) | 2008-01-18 | 2013-03-28 | Methods of detecting signatures of disease or conditions in bodily fluids | |
| EP2352998A4 (en) | 2008-11-07 | 2011-09-21 | Centocor Ortho Biotech Inc | MARKERS AND METHOD FOR THE STUDY AND TREATMENT OF LIGHT-SENSITIVELY LUPUS PATIENTS |
| KR20110110247A (ko) * | 2008-12-30 | 2011-10-06 | 센토코 오르토 바이오테크 인코포레이티드 | 강직성 척추염 환자에서 항-TNFα 항체에 대한 임상적 반응을 예측하는 혈청 마커 |
| JP5302054B2 (ja) * | 2009-03-06 | 2013-10-02 | オリンパス株式会社 | Dnaが断片化されたアポトーシス細胞の検出方法、細胞画像解析装置、及びプログラム |
| ES2605228T3 (es) | 2009-04-18 | 2017-03-13 | Genentech, Inc. | Métodos para evaluar la capacidad de respuesta de un linfoma de células B al tratamiento con anticuerpos anti-CD40 |
| WO2011006119A2 (en) | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
| JP2013520208A (ja) * | 2010-02-24 | 2013-06-06 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ | 自己免疫疾患の診断、予後判定、及び処置法 |
| EP2796563A1 (en) * | 2010-05-04 | 2014-10-29 | MedImmune, LLC | Optimized degenerative muscle disease diagnostics and treatments |
| US20120040846A1 (en) | 2010-07-23 | 2012-02-16 | President And Fellows Of Harvard College | Methods of Detecting Diseases or Conditions Using Phagocytic Cells |
| KR20130041961A (ko) | 2010-07-23 | 2013-04-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 체액에서 질환 또는 상태의 특징을 검출하는 방법 |
| EP2596116A4 (en) | 2010-07-23 | 2014-03-19 | Harvard College | METHOD FOR DETECTING AUTOIMMUNE OR AUTOIMMUNE DISORDERS OR SUFFERING |
| WO2012012717A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| US20120196762A1 (en) * | 2011-01-27 | 2012-08-02 | Paradis Norman A | Method and apparatus for discovery, development and clinical application of multiplex assays based on patterns of cellular response |
| MX339239B (es) | 2011-04-29 | 2016-05-18 | Apexigen Inc | Anticuerpos anti-cd40 y metodos de uso. |
| US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| WO2014042981A2 (en) * | 2012-09-17 | 2014-03-20 | Digital Therapeutics Llc | Treating digital ulcers, hypertension, vasculitis conditions, or inflammatory myositis conditions |
| AU2013337903B2 (en) | 2012-10-30 | 2018-08-16 | Apexigen, Inc. | Anti-CD40 antibodies and methods of use |
| NZ771629A (en) | 2013-03-09 | 2022-12-23 | Harry Stylli | Methods of detecting cancer |
| EP3385717A3 (en) | 2013-03-09 | 2018-10-24 | Harry Stylli | Methods of detecting prostate cancer |
| TWI502199B (zh) * | 2013-05-23 | 2015-10-01 | Univ Nat Central | 腫瘤壞死因子受體相關因子7作爲紅斑性狼瘡的生物標記物之用途、偵測人體患有紅斑性狼瘡的方法以及偵測人體患有紅斑性狼瘡的套組 |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| AU2015314813B2 (en) | 2014-09-11 | 2022-02-24 | Immunis.Ai, Inc. | Methods of detecting prostate cancer |
| ES2885476T3 (es) * | 2015-10-05 | 2021-12-13 | Ucb Biopharma Sprl | Firmas moleculares para uso en diagnóstico y análisis de respuesta al tratamiento de enfermedades autoinmunes |
| US11946927B2 (en) | 2016-03-14 | 2024-04-02 | Musidora Biotechnology Llc | Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment |
| US10295527B2 (en) | 2016-03-14 | 2019-05-21 | Bruce Yacyshyn | Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis |
| WO2018026442A1 (en) * | 2016-08-01 | 2018-02-08 | The Regents Of The University Of California | Small molecule inhibition for preventing or treating fibrotic diseases |
| JP2021528393A (ja) | 2018-06-15 | 2021-10-21 | フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド | 後細胞シグナル伝達因子の調節による免疫活性の上昇 |
| US20210261678A1 (en) * | 2018-06-29 | 2021-08-26 | Boehringer Ingelheim International Gmbh | Anti-cd40 antibodies for use in treating autoimmune disease |
| WO2020102721A1 (en) * | 2018-11-16 | 2020-05-22 | Rapa Therapeutics, Llc | Immune monitoring of neuro-inflammatory amyotrophic lateral sclerosis (als) |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| JP2021518854A (ja) * | 2019-05-08 | 2021-08-05 | ノバルティス アーゲー | T1dm及び膵島炎の治療に使用するための抗cd40抗体 |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| WO2022006179A1 (en) | 2020-06-29 | 2022-01-06 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| EP4256087A4 (en) * | 2020-12-02 | 2024-12-04 | Albert Einstein College of Medicine | METHOD FOR PREDICTING PATIENT RESPONSE TO CD40-TARGETED THERAPIES |
| CN112860824B (zh) * | 2021-01-15 | 2021-12-10 | 中国科学院沈阳应用生态研究所 | 一种高分辨率dem地形特征提取的尺度适应性评价方法 |
| EP4313109A1 (en) | 2021-03-31 | 2024-02-07 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| CA3224374A1 (en) | 2021-06-29 | 2023-01-05 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| CA3233863A1 (en) | 2021-10-04 | 2023-04-13 | Arasteh AZHIR | Treatment methods for als patients |
| CA3257247A1 (en) * | 2022-05-27 | 2023-11-30 | Eledon Pharmaceuticals, Inc. | METHODS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS |
| EP4598946A1 (en) | 2022-10-05 | 2025-08-13 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
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-
2006
- 2006-05-18 DK DK06770605.1T patent/DK1889065T3/da active
- 2006-05-18 CA CA002608750A patent/CA2608750A1/en not_active Abandoned
- 2006-05-18 ES ES06770605T patent/ES2429564T3/es active Active
- 2006-05-18 EP EP06770605.1A patent/EP1889065B1/en active Active
- 2006-05-18 HR HRP20130852TT patent/HRP20130852T1/hr unknown
- 2006-05-18 AU AU2006247134A patent/AU2006247134B2/en not_active Ceased
- 2006-05-18 PT PT67706051T patent/PT1889065E/pt unknown
- 2006-05-18 EP EP10187778A patent/EP2312315A1/en not_active Withdrawn
- 2006-05-18 US US11/914,710 patent/US8333970B2/en not_active Expired - Fee Related
- 2006-05-18 WO PCT/US2006/019325 patent/WO2006125117A2/en not_active Ceased
- 2006-05-18 JP JP2008512518A patent/JP5421590B2/ja not_active Expired - Fee Related
- 2006-05-18 PL PL06770605T patent/PL1889065T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006125117A2 (en) | 2006-11-23 |
| ES2429564T3 (es) | 2013-11-15 |
| JP5421590B2 (ja) | 2014-02-19 |
| EP1889065A2 (en) | 2008-02-20 |
| HRP20130852T1 (en) | 2013-10-25 |
| DK1889065T3 (da) | 2013-09-02 |
| JP2008539791A (ja) | 2008-11-20 |
| US8333970B2 (en) | 2012-12-18 |
| PT1889065E (pt) | 2013-09-27 |
| WO2006125117A3 (en) | 2007-01-18 |
| EP1889065B1 (en) | 2013-07-10 |
| AU2006247134B2 (en) | 2012-05-10 |
| HK1110942A1 (en) | 2008-07-25 |
| US20080274118A1 (en) | 2008-11-06 |
| EP2312315A1 (en) | 2011-04-20 |
| AU2006247134A1 (en) | 2006-11-23 |
| PL1889065T3 (pl) | 2013-12-31 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20170518 |