CA2594860A1 - Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity - Google Patents

Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity Download PDF

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Publication number
CA2594860A1
CA2594860A1 CA002594860A CA2594860A CA2594860A1 CA 2594860 A1 CA2594860 A1 CA 2594860A1 CA 002594860 A CA002594860 A CA 002594860A CA 2594860 A CA2594860 A CA 2594860A CA 2594860 A1 CA2594860 A1 CA 2594860A1
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Prior art keywords
ring
optionally substituted
alkyl
aliphatic
independently
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CA002594860A
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English (en)
French (fr)
Inventor
Ruth S. Adams
Emily F. Calderwood
Alexandra E. Gould
Paul D. Greenspan
Matthew J. Lamarche
Yuan Tian
Tricia J. Vos
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Millennium Pharmaceuticals Inc
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Individual
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002594860A 2005-01-14 2006-01-12 Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity Abandoned CA2594860A1 (en)

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US64392805P 2005-01-14 2005-01-14
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JP2008527007A (ja) 2008-07-24
WO2006076706A1 (en) 2006-07-20
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US7652041B2 (en) 2010-01-26
US20060160803A1 (en) 2006-07-20

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