CA2586915A1 - Molecules favorisant l'hematopoiese - Google Patents
Molecules favorisant l'hematopoiese Download PDFInfo
- Publication number
- CA2586915A1 CA2586915A1 CA002586915A CA2586915A CA2586915A1 CA 2586915 A1 CA2586915 A1 CA 2586915A1 CA 002586915 A CA002586915 A CA 002586915A CA 2586915 A CA2586915 A CA 2586915A CA 2586915 A1 CA2586915 A1 CA 2586915A1
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- Prior art keywords
- peptide
- amino acid
- groups
- peptides
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000011132 hemopoiesis Effects 0.000 title description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 388
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- 235000001014 amino acid Nutrition 0.000 claims description 141
- 150000001413 amino acids Chemical class 0.000 claims description 133
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- 108090000394 Erythropoietin Proteins 0.000 claims description 117
- 102000003951 Erythropoietin Human genes 0.000 claims description 117
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 107
- 230000027455 binding Effects 0.000 claims description 58
- 238000009739 binding Methods 0.000 claims description 57
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- 238000006243 chemical reaction Methods 0.000 claims description 13
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- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 12
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- 125000003636 chemical group Chemical group 0.000 claims description 7
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- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 6
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 5
- 239000004475 Arginine Substances 0.000 claims description 5
- 150000008574 D-amino acids Chemical class 0.000 claims description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 5
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 5
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 5
- 150000001408 amides Chemical class 0.000 claims description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 5
- 235000009697 arginine Nutrition 0.000 claims description 5
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- 229910052717 sulfur Inorganic materials 0.000 claims description 5
- RWLSBXBFZHDHHX-VIFPVBQESA-N (2s)-2-(naphthalen-2-ylamino)propanoic acid Chemical compound C1=CC=CC2=CC(N[C@@H](C)C(O)=O)=CC=C21 RWLSBXBFZHDHHX-VIFPVBQESA-N 0.000 claims description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 4
- 230000021736 acetylation Effects 0.000 claims description 4
- 238000006640 acetylation reaction Methods 0.000 claims description 4
- 230000009435 amidation Effects 0.000 claims description 4
- 238000007112 amidation reaction Methods 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical compound C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 claims description 3
- KFHRMMHGGBCRIV-BYPYZUCNSA-N (2s)-2-azaniumyl-4-methoxybutanoate Chemical compound COCC[C@H](N)C(O)=O KFHRMMHGGBCRIV-BYPYZUCNSA-N 0.000 claims description 3
- KIUMMUBSPKGMOY-UHFFFAOYSA-N 3,3'-Dithiobis(6-nitrobenzoic acid) Chemical group C1=C([N+]([O-])=O)C(C(=O)O)=CC(SSC=2C=C(C(=CC=2)[N+]([O-])=O)C(O)=O)=C1 KIUMMUBSPKGMOY-UHFFFAOYSA-N 0.000 claims description 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 3
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 3
- 229910052698 phosphorus Inorganic materials 0.000 claims description 3
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical group O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 claims description 3
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- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
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- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- OILAIQUEIWYQPH-UHFFFAOYSA-N cyclohexane-1,2-dione Chemical group O=C1CCCCC1=O OILAIQUEIWYQPH-UHFFFAOYSA-N 0.000 claims description 2
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- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004054422 | 2004-11-10 | ||
| DE102004054422.0 | 2004-11-10 | ||
| EP04029536.2 | 2004-12-14 | ||
| EP04029536 | 2004-12-14 | ||
| US11/041,207 US7589063B2 (en) | 2004-12-14 | 2005-01-25 | Molecules which promote hematopoiesis |
| US11/041,207 | 2005-01-25 | ||
| EP05002113.8 | 2005-02-02 | ||
| EP05002113 | 2005-02-02 | ||
| EP05012637 | 2005-06-13 | ||
| EP05012637.4 | 2005-06-13 | ||
| EP05013594 | 2005-06-23 | ||
| EP05013594.6 | 2005-06-23 | ||
| EP05020035 | 2005-09-14 | ||
| EP05020035.1 | 2005-09-14 | ||
| PCT/EP2005/012075 WO2006050959A2 (fr) | 2004-11-10 | 2005-11-10 | Molecules favorisant l'hematopoiese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2586915A1 true CA2586915A1 (fr) | 2006-05-18 |
Family
ID=36336855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002586915A Abandoned CA2586915A1 (fr) | 2004-11-10 | 2005-11-10 | Molecules favorisant l'hematopoiese |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1812461A2 (fr) |
| JP (1) | JP2008519589A (fr) |
| KR (1) | KR20070092706A (fr) |
| AU (1) | AU2005303887A1 (fr) |
| CA (1) | CA2586915A1 (fr) |
| NO (1) | NO20072856L (fr) |
| WO (1) | WO2006050959A2 (fr) |
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| US7589063B2 (en) | 2004-12-14 | 2009-09-15 | Aplagen Gmbh | Molecules which promote hematopoiesis |
| US7919461B2 (en) * | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| JP2008546732A (ja) * | 2005-06-23 | 2008-12-25 | アプラゲン ゲーエムベーハー | 多価化合物 |
| AU2007222526A1 (en) * | 2006-03-09 | 2007-09-13 | Aplagen Gmbh | Modified molecules which promote hematopoiesis |
| EP2018835B1 (fr) | 2007-07-09 | 2014-03-05 | Augustinus Bader | Pavé sortant d'agent actif |
| WO2009043049A2 (fr) | 2007-09-27 | 2009-04-02 | Amgen Inc. | Formules pharmaceutiques |
| US8440787B2 (en) | 2007-10-23 | 2013-05-14 | Nektar Therapeutics | Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom |
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| JP2009191056A (ja) * | 2008-02-15 | 2009-08-27 | Affymax Inc | 合成ペプチドをベースとするｅｐｏレセプターアゴニストを用いた抗エリスロポエチン抗体に媒介された障害の治療 |
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| MX2021000748A (es) | 2018-07-24 | 2021-03-26 | Amgen Inc | Dispositivos de suministro para administrar farmacos. |
| WO2020023336A1 (fr) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Dispositifs hybrides d'administration de médicament dotés d'une partie de préhension |
| US20210228797A1 (en) | 2018-07-31 | 2021-07-29 | Amgen Inc. | Fluid path assembly for a drug delivery device |
| MA53724A (fr) | 2018-09-24 | 2021-12-29 | Amgen Inc | Systèmes et procédés de dosage interventionnel |
| MA53718A (fr) | 2018-09-28 | 2022-01-05 | Amgen Inc | Ensemble d'activation d'échappement de fil de muscle pour un dispositif d'administration de médicament |
| MA53815A (fr) | 2018-10-02 | 2022-01-05 | Amgen Inc | Systèmes d'injection pour administration de médicament avec transmission de force interne |
| AU2019355979A1 (en) | 2018-10-05 | 2021-03-18 | Amgen Inc. | Drug delivery device having dose indicator |
| US12053617B2 (en) | 2018-10-15 | 2024-08-06 | Amgen Inc. | Drug delivery device having damping mechanism |
| JP2022504805A (ja) | 2018-10-15 | 2022-01-13 | アムジエン・インコーポレーテツド | 薬物送達デバイスのプラットフォーム式組み立てプロセス |
| WO2020091956A1 (fr) | 2018-11-01 | 2020-05-07 | Amgen Inc. | Dispositifs d'administration de médicament avec rétraction partielle de l'organe d'administration de médicament |
| MA54057A (fr) | 2018-11-01 | 2022-02-09 | Amgen Inc | Dispositifs d'administration de médicament à rétraction partielle d'élément d'administration de médicament |
| TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
| MX2021012557A (es) | 2019-04-24 | 2021-11-12 | Amgen Inc | Conjuntos y metodos de verificacion de esterilizacion de jeringuillas. |
| WO2021041067A2 (fr) | 2019-08-23 | 2021-03-04 | Amgen Inc. | Dispositif d'administration de médicament doté de composants configurables de mise en prise de protection d'aiguille et méthodes associées |
| AU2022279223A1 (en) | 2021-05-21 | 2023-10-19 | Amgen Inc. | Method of optimizing a filling recipe for a drug container |
| WO2024094457A1 (fr) | 2022-11-02 | 2024-05-10 | F. Hoffmann-La Roche Ag | Procédé de production de compositions de glycoprotéines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3924746A1 (de) * | 1989-07-26 | 1991-01-31 | Behringwerke Ag | Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper |
| DE69630708T2 (de) * | 1995-06-07 | 2004-08-05 | Ortho Pharmaceutical Corp. | An den erythropoietin-rezeptor bindende zusammensetzungen und peptide |
| EP1575499A2 (fr) * | 2002-06-28 | 2005-09-21 | Centocor, Inc. | Corps mimetiques d'epo de mammifere a deletion ch1, compositions, methodes et utilisations associees |
-
2005
- 2005-11-10 CA CA002586915A patent/CA2586915A1/fr not_active Abandoned
- 2005-11-10 EP EP05819212A patent/EP1812461A2/fr not_active Withdrawn
- 2005-11-10 KR KR1020077012937A patent/KR20070092706A/ko not_active Application Discontinuation
- 2005-11-10 WO PCT/EP2005/012075 patent/WO2006050959A2/fr active Application Filing
- 2005-11-10 AU AU2005303887A patent/AU2005303887A1/en not_active Abandoned
- 2005-11-10 JP JP2007540582A patent/JP2008519589A/ja active Pending
-
2007
- 2007-06-05 NO NO20072856A patent/NO20072856L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1812461A2 (fr) | 2007-08-01 |
| WO2006050959A2 (fr) | 2006-05-18 |
| JP2008519589A (ja) | 2008-06-12 |
| AU2005303887A1 (en) | 2006-05-18 |
| WO2006050959A3 (fr) | 2006-12-21 |
| KR20070092706A (ko) | 2007-09-13 |
| NO20072856L (no) | 2007-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |