CA2580532C - Methods and compositions relating to alzheimer's disease - Google Patents

Methods and compositions relating to alzheimer's disease Download PDF

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Publication number
CA2580532C
CA2580532C CA2580532A CA2580532A CA2580532C CA 2580532 C CA2580532 C CA 2580532C CA 2580532 A CA2580532 A CA 2580532A CA 2580532 A CA2580532 A CA 2580532A CA 2580532 C CA2580532 C CA 2580532C
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CA
Canada
Prior art keywords
precursor
disease
alzheimer
expression
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2580532A
Other languages
English (en)
French (fr)
Other versions
CA2580532A1 (en
Inventor
Jules Westbrook
Helen Byers
Malcolm Ward
Simon Lovestone
Abdul Hye
Stephen Lynham
Richard Joubert
Petra Prefot
Karsten Kuhn
Christian Baumann
Juergen Schaefer
Thorsten Prinz
Stefan Kienle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kings College London
Proteome Sciences PLC
Original Assignee
Kings College London
Proteome Sciences PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kings College London, Proteome Sciences PLC filed Critical Kings College London
Publication of CA2580532A1 publication Critical patent/CA2580532A1/en
Application granted granted Critical
Publication of CA2580532C publication Critical patent/CA2580532C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
CA2580532A 2004-09-29 2005-09-29 Methods and compositions relating to alzheimer's disease Expired - Lifetime CA2580532C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0421639.6 2004-09-29
GBGB0421639.6A GB0421639D0 (en) 2004-09-29 2004-09-29 Methods and compositions relating to alzheimer's disease
PCT/GB2005/003756 WO2006035237A2 (en) 2004-09-29 2005-09-29 Methods and compositions relating to alzheimer's disease

Publications (2)

Publication Number Publication Date
CA2580532A1 CA2580532A1 (en) 2006-04-06
CA2580532C true CA2580532C (en) 2019-06-25

Family

ID=33397455

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2580532A Expired - Lifetime CA2580532C (en) 2004-09-29 2005-09-29 Methods and compositions relating to alzheimer's disease

Country Status (10)

Country Link
US (2) US7897361B2 (cg-RX-API-DMAC7.html)
EP (3) EP1794594B1 (cg-RX-API-DMAC7.html)
JP (3) JP5483816B2 (cg-RX-API-DMAC7.html)
AT (1) ATE495445T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005288689B2 (cg-RX-API-DMAC7.html)
CA (1) CA2580532C (cg-RX-API-DMAC7.html)
DE (1) DE602005025897D1 (cg-RX-API-DMAC7.html)
DK (1) DK2354795T3 (cg-RX-API-DMAC7.html)
GB (1) GB0421639D0 (cg-RX-API-DMAC7.html)
WO (1) WO2006035237A2 (cg-RX-API-DMAC7.html)

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JP6758184B2 (ja) * 2013-08-27 2020-09-23 シーアールシー・フォー・メンタル・ヘルス・リミテッドＣｒｃ Ｆｏｒ Ｍｅｎｔａｌ Ｈｅａｌｔｈ Ｌｔｄ 神経疾患のバイオマーカーを同定するための方法および神経疾患の診断
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JP6947451B2 (ja) * 2016-06-29 2021-10-13 学校法人自治医科大学 バイオマーカー、診断用組成物、及び診断用キット
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Also Published As

Publication number Publication date
WO2006035237A3 (en) 2006-08-03
US20080070995A1 (en) 2008-03-20
JP2008514946A (ja) 2008-05-08
DE602005025897D1 (de) 2011-02-24
JP2014209132A (ja) 2014-11-06
EP2354795A1 (en) 2011-08-10
AU2005288689A1 (en) 2006-04-06
US20110165146A1 (en) 2011-07-07
EP1794594B1 (en) 2011-01-12
US7897361B2 (en) 2011-03-01
GB0421639D0 (en) 2004-10-27
JP5893269B2 (ja) 2016-03-23
JP5483816B2 (ja) 2014-05-07
AU2005288689B2 (en) 2011-10-27
ATE495445T1 (de) 2011-01-15
JP2011209291A (ja) 2011-10-20
DK2354795T3 (en) 2015-02-16
CA2580532A1 (en) 2006-04-06
EP2354795B1 (en) 2014-12-17
EP2562545A1 (en) 2013-02-27
WO2006035237A2 (en) 2006-04-06
EP1794594A2 (en) 2007-06-13

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