CA2579207C - Morpholine compound - Google Patents

Info

Publication number

CA2579207C

CA2579207C CA2579207A CA2579207A CA2579207C CA 2579207 C CA2579207 C CA 2579207C CA 2579207 A CA2579207 A CA 2579207A CA 2579207 A CA2579207 A CA 2579207A CA 2579207 C CA2579207 C CA 2579207C

Authority

CA

Canada

Prior art keywords

substituent

optionally

methyl

morpholin

acetamide

Prior art date

2004-09-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• -1 Morpholine compound Chemical class 0.000 title claims description 224
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Natural products C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 title claims description 11
• 150000001875 compounds Chemical class 0.000 claims abstract description 533
• 125000001424 substituent group Chemical group 0.000 claims abstract description 417
• 150000003839 salts Chemical class 0.000 claims abstract description 78
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 62
• 239000012453 solvate Substances 0.000 claims abstract description 44
• 125000003118 aryl group Chemical group 0.000 claims abstract description 36
• 238000011282 treatment Methods 0.000 claims abstract description 16
• 238000011321 prophylaxis Methods 0.000 claims abstract description 14
• DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 124
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 114
• 125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 claims description 82
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 63
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 53
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 43
• 125000000623 heterocyclic group Chemical group 0.000 claims description 38
• 125000001072 heteroaryl group Chemical group 0.000 claims description 37
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 36
• 229910052717 sulfur Inorganic materials 0.000 claims description 32
• 125000005843 halogen group Chemical group 0.000 claims description 31
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 27
• 125000004434 sulfur atom Chemical group 0.000 claims description 27
• 125000004430 oxygen atom Chemical group O* 0.000 claims description 26
• 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims description 21
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 21
• 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims description 18
• 125000004043 oxo group Chemical group O=* 0.000 claims description 18
• 125000004429 atom Chemical group 0.000 claims description 17
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 16
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 16
• 125000004442 acylamino group Chemical group 0.000 claims description 15
• 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims description 14
• 239000003795 chemical substances by application Substances 0.000 claims description 12
• 125000002993 cycloalkylene group Chemical group 0.000 claims description 12
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
• 229910006074 SO2NH2 Inorganic materials 0.000 claims description 11
• 125000002252 acyl group Chemical group 0.000 claims description 11
• 230000000172 allergic effect Effects 0.000 claims description 11
• 208000010668 atopic eczema Diseases 0.000 claims description 11
• 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims description 11
• 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims description 11
• 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims description 11
• 208000006673 asthma Diseases 0.000 claims description 10
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 10
• 201000009890 sinusitis Diseases 0.000 claims description 10
• 206010009900 Colitis ulcerative Diseases 0.000 claims description 9
• 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 9
• 208000011231 Crohn disease Diseases 0.000 claims description 9
• 206010012438 Dermatitis atopic Diseases 0.000 claims description 9
• 208000003926 Myelitis Diseases 0.000 claims description 9
• 206010039085 Rhinitis allergic Diseases 0.000 claims description 9
• 201000006704 Ulcerative Colitis Diseases 0.000 claims description 9
• 208000002205 allergic conjunctivitis Diseases 0.000 claims description 9
• 201000010105 allergic rhinitis Diseases 0.000 claims description 9
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 9
• 208000024998 atopic conjunctivitis Diseases 0.000 claims description 9
• 201000008937 atopic dermatitis Diseases 0.000 claims description 9
• 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims description 8
• 239000008194 pharmaceutical composition Substances 0.000 claims description 8
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 7
• 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 6
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 5
• QBXNXHODSIQDRT-AWEZNQCLSA-N 2-[2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetic acid Chemical compound OC(=O)CC1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 QBXNXHODSIQDRT-AWEZNQCLSA-N 0.000 claims description 5
• SEEDFUCUSZPZMA-ZDUSSCGKSA-N 2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-5-methyl-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=C(C)SC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 SEEDFUCUSZPZMA-ZDUSSCGKSA-N 0.000 claims description 5
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
• RCEAQZCVLJBUPB-SFHVURJKSA-N 2-(3-acetyl-2-oxochromen-6-yl)sulfanyl-n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]acetamide Chemical compound C([C@@H](OCC1)CNC(=O)CSC=2C=C3C=C(C(OC3=CC=2)=O)C(=O)C)N1CC1=CC=C(Cl)C(Cl)=C1 RCEAQZCVLJBUPB-SFHVURJKSA-N 0.000 claims description 4
• ZBYMZNLMGDOJRZ-ZDUSSCGKSA-N 2-[(5-acetamido-1,3,4-thiadiazol-2-yl)sulfanyl]-n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]acetamide Chemical compound S1C(NC(=O)C)=NN=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 ZBYMZNLMGDOJRZ-ZDUSSCGKSA-N 0.000 claims description 4
• JITPANMJXSCJNC-ZDUSSCGKSA-N 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-n-[[(2s)-4-[(3-chlorophenyl)methyl]morpholin-2-yl]methyl]acetamide Chemical compound S1C(N)=NN=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C=CC=2)C1 JITPANMJXSCJNC-ZDUSSCGKSA-N 0.000 claims description 4
• ZDFHMCAOQDXYCN-KRWDZBQOSA-N 2-[(7-amino-4h-indeno[1,2-d][1,3]thiazol-2-yl)sulfanyl]-n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]acetamide Chemical compound C([C@@H](OCC1)CNC(=O)CSC=2SC=3CC4=CC=C(C=C4C=3N=2)N)N1CC1=CC=C(Cl)C(Cl)=C1 ZDFHMCAOQDXYCN-KRWDZBQOSA-N 0.000 claims description 4
• UNRAASSPCKFPTN-INIZCTEOSA-N 2-[2-[2-[[(2s)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetamide Chemical compound NC(=O)CC1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=CC(F)=CC=3)C2)=N1 UNRAASSPCKFPTN-INIZCTEOSA-N 0.000 claims description 4
• GDQUBYKQAAAMHY-ZDUSSCGKSA-N 2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-5-methyl-1,3-thiazole-4-carboxamide Chemical compound NC(=O)C1=C(C)SC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 GDQUBYKQAAAMHY-ZDUSSCGKSA-N 0.000 claims description 4
• COLYWBWHQIYLIY-LBPRGKRZSA-N 2-[2-[[(2s)-4-[(3-chloro-4-fluorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazole-4-carboxamide Chemical compound NC(=O)C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(F)=CC=3)C2)=N1 COLYWBWHQIYLIY-LBPRGKRZSA-N 0.000 claims description 4
• VHMUOSIHURRIOK-HNNXBMFYSA-N 2-[6-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylpyrazin-2-yl]acetamide Chemical compound NC(=O)CC1=CN=CC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 VHMUOSIHURRIOK-HNNXBMFYSA-N 0.000 claims description 4
• MCSMWUCDTFROPY-INIZCTEOSA-N 4-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylbenzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 MCSMWUCDTFROPY-INIZCTEOSA-N 0.000 claims description 4
• 125000005915 C6-C14 aryl group Chemical group 0.000 claims description 4
• 239000003937 drug carrier Substances 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 4
• OGIBHBVUTSXUNQ-ZDUSSCGKSA-N n-(2-amino-2-oxoethyl)-2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazole-4-carboxamide Chemical compound NC(=O)CNC(=O)C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 OGIBHBVUTSXUNQ-ZDUSSCGKSA-N 0.000 claims description 4
• WCUBBLPSNASPHU-ZDUSSCGKSA-N n-(2-amino-2-oxoethyl)-2-[2-[[(2s)-4-[(3,4-difluorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazole-4-carboxamide Chemical compound NC(=O)CNC(=O)C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(F)C(F)=CC=3)C2)=N1 WCUBBLPSNASPHU-ZDUSSCGKSA-N 0.000 claims description 4
• CKMVPBRTBYFTCH-KRWDZBQOSA-N n-(2-amino-2-oxoethyl)-4-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylbenzamide Chemical compound C1=CC(C(=O)NCC(=O)N)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 CKMVPBRTBYFTCH-KRWDZBQOSA-N 0.000 claims description 4
• GDGICJILJQXWOP-AWEZNQCLSA-N n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]-2-([1,3]thiazolo[5,4-b]pyridin-2-ylsulfanyl)acetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1CN1C[C@H](CNC(=O)CSC=2SC3=NC=CC=C3N=2)OCC1 GDGICJILJQXWOP-AWEZNQCLSA-N 0.000 claims description 4
• LGZARZGSMBBJQD-KRWDZBQOSA-N n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]-2-[(4-pyridin-4-yl-1,3-thiazol-2-yl)sulfanyl]acetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1CN1C[C@H](CNC(=O)CSC=2SC=C(N=2)C=2C=CN=CC=2)OCC1 LGZARZGSMBBJQD-KRWDZBQOSA-N 0.000 claims description 4
• XJSQYVGABDQLJE-LBPRGKRZSA-N n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]-2-[[4-(2h-tetrazol-5-yl)-1,3-thiazol-2-yl]sulfanyl]acetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1CN1C[C@H](CNC(=O)CSC=2SC=C(N=2)C2=NNN=N2)OCC1 XJSQYVGABDQLJE-LBPRGKRZSA-N 0.000 claims description 4
• FDTBFLRNMBNHPV-SFHVURJKSA-N n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]-2-[[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]sulfanyl]acetamide Chemical compound C1=C(OC)C(OC)=CC=C1C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 FDTBFLRNMBNHPV-SFHVURJKSA-N 0.000 claims description 4
• 125000000464 thioxo group Chemical group S=* 0.000 claims description 4
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 3
• 125000006625 (C3-C8) cycloalkyloxy group Chemical group 0.000 claims description 3
• ATPHLTVSIZUOQU-OMDKTOEGSA-N (e)-3-[2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]prop-2-enamide Chemical compound NC(=O)\C=C\C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 ATPHLTVSIZUOQU-OMDKTOEGSA-N 0.000 claims description 3
• NDZYPHLNJZSQJY-QNWVGRARSA-N 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(1r,2s)-2-[[(3s)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea Chemical compound CC1=C(C(=O)C)SC(NC(=O)N[C@H]2[C@@H](CCCC2)CN2C[C@H](CC=3C=CC(F)=CC=3)CCC2)=N1 NDZYPHLNJZSQJY-QNWVGRARSA-N 0.000 claims description 3
• WCGHRJQVIANHKK-NSHDSACASA-N 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-n-[[(2s)-4-[(3,4-difluorophenyl)methyl]morpholin-2-yl]methyl]acetamide Chemical compound S1C(N)=NN=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(F)C(F)=CC=2)C1 WCGHRJQVIANHKK-NSHDSACASA-N 0.000 claims description 3
• QSNXLUIYSBWRIZ-LBPRGKRZSA-N 2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazole-4-carboxamide Chemical compound NC(=O)C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 QSNXLUIYSBWRIZ-LBPRGKRZSA-N 0.000 claims description 3
• QGONGVRPAFCFAI-SFHVURJKSA-N 2-[[4-(3-aminophenyl)-1,3-thiazol-2-yl]sulfanyl]-n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]acetamide Chemical compound NC1=CC=CC(C=2N=C(SCC(=O)NC[C@@H]3OCCN(CC=4C=C(Cl)C(Cl)=CC=4)C3)SC=2)=C1 QGONGVRPAFCFAI-SFHVURJKSA-N 0.000 claims description 3
• PHLJPNFEYLXPLG-INIZCTEOSA-N 5-[2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]-2-hydroxybenzamide Chemical compound C1=C(O)C(C(=O)N)=CC(C=2N=C(SCC(=O)NC[C@@H]3OCCN(CC=4C=C(Cl)C(Cl)=CC=4)C3)SC=2)=C1 PHLJPNFEYLXPLG-INIZCTEOSA-N 0.000 claims description 3
• 125000005914 C6-C14 aryloxy group Chemical group 0.000 claims description 3
• 125000005110 aryl thio group Chemical group 0.000 claims description 3
• WWJIFXKKDKLLKE-AWEZNQCLSA-N n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]-2-pyrimidin-2-ylsulfanylacetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1CN1C[C@H](CNC(=O)CSC=2N=CC=CN=2)OCC1 WWJIFXKKDKLLKE-AWEZNQCLSA-N 0.000 claims description 3
• XTVMOROSHPPZHJ-KRWDZBQOSA-N n-[[(2s)-4-[(3-chloro-4-fluorophenyl)methyl]morpholin-2-yl]methyl]-4-cyclopentylsulfonylbutanamide Chemical compound C1=C(Cl)C(F)=CC=C1CN1C[C@H](CNC(=O)CCCS(=O)(=O)C2CCCC2)OCC1 XTVMOROSHPPZHJ-KRWDZBQOSA-N 0.000 claims description 3
• 229940124530 sulfonamide Drugs 0.000 claims description 3
• 150000003456 sulfonamides Chemical class 0.000 claims description 3
• VZSDKGKNCJATBB-AWEZNQCLSA-N 2-[2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]-2-methylpropanoic acid Chemical compound OC(=O)C(C)(C)C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 VZSDKGKNCJATBB-AWEZNQCLSA-N 0.000 claims description 2
• OLACTMBIIPDKTP-AWEZNQCLSA-N 2-[2-[2-[[(2s)-4-[(3,4-difluorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetamide Chemical compound NC(=O)CC1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(F)C(F)=CC=3)C2)=N1 OLACTMBIIPDKTP-AWEZNQCLSA-N 0.000 claims description 2
• HLCULUJJSQDJBT-AWEZNQCLSA-N 2-[4-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-4-oxobutyl]sulfanyl-1,3-thiazole-4-carboxamide Chemical compound NC(=O)C1=CSC(SCCCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 HLCULUJJSQDJBT-AWEZNQCLSA-N 0.000 claims description 2
• XVXKETOKMHCGMP-AWEZNQCLSA-N 3-[[2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazole-4-carbonyl]amino]propanoic acid Chemical compound OC(=O)CCNC(=O)C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 XVXKETOKMHCGMP-AWEZNQCLSA-N 0.000 claims description 2
• 239000004480 active ingredient Substances 0.000 claims description 2
• YKNIEYROACRQKV-AWEZNQCLSA-N n-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl]-2-[[4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]sulfanyl]acetamide Chemical compound O1C(C)=NC(C=2N=C(SCC(=O)NC[C@@H]3OCCN(CC=4C=C(Cl)C(Cl)=CC=4)C3)SC=2)=N1 YKNIEYROACRQKV-AWEZNQCLSA-N 0.000 claims description 2
• 229910006069 SO3H Inorganic materials 0.000 claims 2
• MPCRFESRJODMTF-ZDUSSCGKSA-N n-[[(2s)-4-[(3,4-difluorophenyl)methyl]morpholin-2-yl]methyl]-2-[(6-oxo-1h-pyridazin-3-yl)sulfanyl]acetamide Chemical compound C1=C(F)C(F)=CC=C1CN1C[C@H](CNC(=O)CSC2=NNC(=O)C=C2)OCC1 MPCRFESRJODMTF-ZDUSSCGKSA-N 0.000 claims 2
• PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 2
• 102100024167 C-C chemokine receptor type 3 Human genes 0.000 abstract description 22
• 101710149862 C-C chemokine receptor type 3 Proteins 0.000 abstract description 22
• 125000000732 arylene group Chemical group 0.000 abstract description 14
• 208000026278 immune system disease Diseases 0.000 abstract description 7
• 239000000825 pharmaceutical preparation Substances 0.000 abstract description 7
• 229940127557 pharmaceutical product Drugs 0.000 abstract description 6
• 208000027866 inflammatory disease Diseases 0.000 abstract description 5
• IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 470
• 238000003786 synthesis reaction Methods 0.000 description 465
• 230000015572 biosynthetic process Effects 0.000 description 463
• 238000000034 method Methods 0.000 description 383
• 239000000047 product Substances 0.000 description 324
• 238000005160 1H NMR spectroscopy Methods 0.000 description 241
• 239000007787 solid Substances 0.000 description 237
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 129
• 239000000203 mixture Substances 0.000 description 96
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 91
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 90
• 239000002904 solvent Substances 0.000 description 87
• 239000012230 colorless oil Substances 0.000 description 63
• 239000003480 eluent Substances 0.000 description 61
• 125000000217 alkyl group Chemical group 0.000 description 59
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 58
• 239000011541 reaction mixture Substances 0.000 description 55
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 54
• 239000002253 acid Substances 0.000 description 49
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 48
• 239000012046 mixed solvent Substances 0.000 description 48
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 43
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 43
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 42
• OJBBVTPPCDAKPT-XRIOVQLTSA-N [(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methanamine;dihydrochloride Chemical compound Cl.Cl.C1CO[C@@H](CN)CN1CC1=CC=C(Cl)C(Cl)=C1 OJBBVTPPCDAKPT-XRIOVQLTSA-N 0.000 description 42
• 239000003921 oil Substances 0.000 description 39
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• ZTDWJKYVAGYQMK-SFHVURJKSA-N ethyl 2-[2-[2-[[(2s)-4-[(4-chlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate Chemical compound CCOC(=O)CC1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=CC(Cl)=CC=3)C2)=N1 ZTDWJKYVAGYQMK-SFHVURJKSA-N 0.000 description 1
• UCAMRRCHHFAETO-SFHVURJKSA-N ethyl 2-[2-[2-[[(2s)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate Chemical compound CCOC(=O)CC1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=CC(F)=CC=3)C2)=N1 UCAMRRCHHFAETO-SFHVURJKSA-N 0.000 description 1
• AOQIYOFHAMNIIP-INIZCTEOSA-N ethyl 2-[2-[2-[[(2s)-4-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate Chemical compound CCOC(=O)CC1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(C(Cl)=CC=3)C(F)(F)F)C2)=N1 AOQIYOFHAMNIIP-INIZCTEOSA-N 0.000 description 1
• WZZCOWPOFVMFIX-INIZCTEOSA-N ethyl 2-[2-[2-[[(2s)-4-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate Chemical compound CCOC(=O)CC1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(C(F)=CC=3)C(F)(F)F)C2)=N1 WZZCOWPOFVMFIX-INIZCTEOSA-N 0.000 description 1
• XUPLCGBWPLRIFM-NSHDSACASA-N ethyl 2-[2-[2-[[(2s)-morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate Chemical compound CCOC(=O)CC1=CSC(SCC(=O)NC[C@H]2OCCNC2)=N1 XUPLCGBWPLRIFM-NSHDSACASA-N 0.000 description 1
• GTQGZCBXTHFBNM-MERQFXBCSA-N ethyl 2-[2-[2-[[(2s)-morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate;hydrochloride Chemical compound Cl.CCOC(=O)CC1=CSC(SCC(=O)NC[C@H]2OCCNC2)=N1 GTQGZCBXTHFBNM-MERQFXBCSA-N 0.000 description 1
• JXNDETNYIPHFFR-SFHVURJKSA-N ethyl 2-[2-[4-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-4-oxobutyl]sulfanyl-1,3-thiazol-4-yl]acetate Chemical compound CCOC(=O)CC1=CSC(SCCCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 JXNDETNYIPHFFR-SFHVURJKSA-N 0.000 description 1
• HLXBHPWLBWSQES-AWEZNQCLSA-N ethyl 2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazole-4-carboxylate Chemical compound CCOC(=O)C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 HLXBHPWLBWSQES-AWEZNQCLSA-N 0.000 description 1
• CRDVHTSNIXPLPM-INIZCTEOSA-N ethyl 2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-4-methylpyrimidine-5-carboxylate Chemical compound N1=C(C)C(C(=O)OCC)=CN=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 CRDVHTSNIXPLPM-INIZCTEOSA-N 0.000 description 1
• KBHPZIICJVFECT-HNNXBMFYSA-N ethyl 2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-5-methyl-1,3-thiazole-4-carboxylate Chemical compound S1C(C)=C(C(=O)OCC)N=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 KBHPZIICJVFECT-HNNXBMFYSA-N 0.000 description 1
• MGNVPXINIICODI-AWEZNQCLSA-N ethyl 2-[2-[[(2s)-4-[(3-chloro-4-fluorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazole-4-carboxylate Chemical compound CCOC(=O)C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(F)=CC=3)C2)=N1 MGNVPXINIICODI-AWEZNQCLSA-N 0.000 description 1
• MFQFGLVRWOLQLF-IBGZPJMESA-N ethyl 2-[4-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylphenyl]acetate Chemical compound C1=CC(CC(=O)OCC)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 MFQFGLVRWOLQLF-IBGZPJMESA-N 0.000 description 1
• OWZFULPEVHKEKS-UHFFFAOYSA-N ethyl 2-chloro-2-oxoacetate Chemical compound CCOC(=O)C(Cl)=O OWZFULPEVHKEKS-UHFFFAOYSA-N 0.000 description 1
• RDULEYWUGKOCMR-UHFFFAOYSA-N ethyl 2-chloro-3-oxobutanoate Chemical compound CCOC(=O)C(Cl)C(C)=O RDULEYWUGKOCMR-UHFFFAOYSA-N 0.000 description 1
• UDDSDBJYAMHCCW-UHFFFAOYSA-N ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Chemical compound CCOC(=O)C1=CN=C(Cl)N=C1C(F)(F)F UDDSDBJYAMHCCW-UHFFFAOYSA-N 0.000 description 1
• CEIPQQODRKXDSB-UHFFFAOYSA-N ethyl 3-(6-hydroxynaphthalen-2-yl)-1H-indazole-5-carboximidate dihydrochloride Chemical compound Cl.Cl.C1=C(O)C=CC2=CC(C3=NNC4=CC=C(C=C43)C(=N)OCC)=CC=C21 CEIPQQODRKXDSB-UHFFFAOYSA-N 0.000 description 1
• CQODDLBWKHYTFX-AWEZNQCLSA-N ethyl 3-[2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]-1,2,4-oxadiazole-5-carboxylate Chemical compound O1C(C(=O)OCC)=NC(C=2N=C(SCC(=O)NC[C@@H]3OCCN(CC=4C=C(Cl)C(Cl)=CC=4)C3)SC=2)=N1 CQODDLBWKHYTFX-AWEZNQCLSA-N 0.000 description 1
• JIPNSLUSEDUITA-AWEZNQCLSA-N ethyl 3-[[5-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]amino]-3-oxopropanoate Chemical compound S1C(NC(=O)CC(=O)OCC)=NN=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 JIPNSLUSEDUITA-AWEZNQCLSA-N 0.000 description 1
• SIOIQIWIQSMQAG-UHFFFAOYSA-N ethyl 3-bromo-2-oxobutanoate Chemical compound CCOC(=O)C(=O)C(C)Br SIOIQIWIQSMQAG-UHFFFAOYSA-N 0.000 description 1
• KVXJMHIZAAREGJ-UHFFFAOYSA-N ethyl 3-bromo-2-oxopropanoate ethyl 2-sulfanylidene-3H-1,3-thiazole-4-carboxylate Chemical compound BrCC(C(=O)OCC)=O.C(C)OC(=O)C=1N=C(SC1)S KVXJMHIZAAREGJ-UHFFFAOYSA-N 0.000 description 1
• OHLRLMWUFVDREV-UHFFFAOYSA-N ethyl 4-chloro-3-oxobutanoate Chemical compound CCOC(=O)CC(=O)CCl OHLRLMWUFVDREV-UHFFFAOYSA-N 0.000 description 1
• OHKNSXMQSNDXAI-UHFFFAOYSA-N ethyl 4-methyl-2-sulfanylidene-3h-1,3-thiazole-5-carboxylate Chemical compound CCOC(=O)C=1SC(=S)NC=1C OHKNSXMQSNDXAI-UHFFFAOYSA-N 0.000 description 1
• FQFSHLBWRUOCPX-UHFFFAOYSA-N ethyl 4-oxo-2-sulfanylidene-1h-pyrimidine-5-carboxylate Chemical compound CCOC(=O)C1=CNC(=S)NC1=O FQFSHLBWRUOCPX-UHFFFAOYSA-N 0.000 description 1
• GUYZRQOTADGHII-UHFFFAOYSA-N ethyl 5-(2-bromoacetyl)-1,2-oxazole-3-carboxylate Chemical compound CCOC(=O)C=1C=C(C(=O)CBr)ON=1 GUYZRQOTADGHII-UHFFFAOYSA-N 0.000 description 1
• NBXLGGSVNYQKPR-UHFFFAOYSA-N ethyl 5-(2-sulfanylidene-3h-1,3-thiazol-4-yl)-1,2-oxazole-3-carboxylate Chemical compound O1N=C(C(=O)OCC)C=C1C1=CSC(S)=N1 NBXLGGSVNYQKPR-UHFFFAOYSA-N 0.000 description 1
• QVYKEPLDKBAKKB-HNNXBMFYSA-N ethyl 5-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylthiophene-2-carboxylate Chemical compound S1C(C(=O)OCC)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 QVYKEPLDKBAKKB-HNNXBMFYSA-N 0.000 description 1
• MVJPVDSRSXLJNQ-UHFFFAOYSA-N ethyl 5-bromopyridine-2-carboxylate Chemical compound CCOC(=O)C1=CC=C(Br)C=N1 MVJPVDSRSXLJNQ-UHFFFAOYSA-N 0.000 description 1
• PCPIANOJERKFJI-UHFFFAOYSA-N ethyl 5-bromopyridine-3-carboxylate Chemical compound CCOC(=O)C1=CN=CC(Br)=C1 PCPIANOJERKFJI-UHFFFAOYSA-N 0.000 description 1
• VQDMWIFJQSRHOI-UHFFFAOYSA-N ethyl 5-methyl-2-sulfanylidene-3h-1,3-thiazole-4-carboxylate Chemical compound CCOC(=O)C=1N=C(S)SC=1C VQDMWIFJQSRHOI-UHFFFAOYSA-N 0.000 description 1
• MVEAAGBEUOMFRX-UHFFFAOYSA-N ethyl acetate;hydrochloride Chemical compound Cl.CCOC(C)=O MVEAAGBEUOMFRX-UHFFFAOYSA-N 0.000 description 1
• 125000006534 ethyl amino methyl group Chemical group [H]N(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 description 1
• PQJJJMRNHATNKG-UHFFFAOYSA-N ethyl bromoacetate Chemical compound CCOC(=O)CBr PQJJJMRNHATNKG-UHFFFAOYSA-N 0.000 description 1
• WUDNUHPRLBTKOJ-UHFFFAOYSA-N ethyl isocyanate Chemical compound CCN=C=O WUDNUHPRLBTKOJ-UHFFFAOYSA-N 0.000 description 1
• 125000006260 ethylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])C([H])([H])[H] 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• 238000003304 gavage Methods 0.000 description 1
• 238000003209 gene knockout Methods 0.000 description 1
• 150000008282 halocarbons Chemical class 0.000 description 1
• 229910052736 halogen Inorganic materials 0.000 description 1
• 150000002367 halogens Chemical class 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 150000004677 hydrates Chemical class 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
• 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
• 230000009610 hypersensitivity Effects 0.000 description 1
• 239000005457 ice water Substances 0.000 description 1
• 125000002636 imidazolinyl group Chemical group 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 238000002649 immunization Methods 0.000 description 1
• 238000001727 in vivo Methods 0.000 description 1
• 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 1
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 1
• 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 1
• 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
• 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 description 1
• 210000004969 inflammatory cell Anatomy 0.000 description 1
• 239000007928 intraperitoneal injection Substances 0.000 description 1
• 239000011630 iodine Substances 0.000 description 1
• 125000005929 isobutyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])OC(*)=O 0.000 description 1
• 125000003384 isochromanyl group Chemical group C1(OCCC2=CC=CC=C12)* 0.000 description 1
• 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
• 125000005969 isothiazolinyl group Chemical group 0.000 description 1
• 125000003971 isoxazolinyl group Chemical group 0.000 description 1
• 210000001821 langerhans cell Anatomy 0.000 description 1
• VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 210000004072 lung Anatomy 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 229910001629 magnesium chloride Inorganic materials 0.000 description 1
• 206010025482 malaise Diseases 0.000 description 1
• 229910052987 metal hydride Inorganic materials 0.000 description 1
• 150000004681 metal hydrides Chemical class 0.000 description 1
• WDWDWGRYHDPSDS-UHFFFAOYSA-N methanimine Chemical compound N=C WDWDWGRYHDPSDS-UHFFFAOYSA-N 0.000 description 1
• PMRYVIKBURPHAH-UHFFFAOYSA-N methimazole Chemical compound CN1C=CNC1=S PMRYVIKBURPHAH-UHFFFAOYSA-N 0.000 description 1
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
• DODCBMODXGJOKD-RGMNGODLSA-N methyl (2s)-2-amino-4-methylpentanoate;hydrochloride Chemical compound Cl.COC(=O)[C@@H](N)CC(C)C DODCBMODXGJOKD-RGMNGODLSA-N 0.000 description 1
• ULSSGHADTSRELG-UHFFFAOYSA-N methyl 2-(3-bromophenyl)acetate Chemical compound COC(=O)CC1=CC=CC(Br)=C1 ULSSGHADTSRELG-UHFFFAOYSA-N 0.000 description 1
• FCNYOGAKDMMTDC-UHFFFAOYSA-N methyl 2-(6-sulfanylidene-1h-pyridazin-3-yl)acetate Chemical compound COC(=O)CC1=CC=C(S)N=N1 FCNYOGAKDMMTDC-UHFFFAOYSA-N 0.000 description 1
• OOAUMMBSRQCJDW-HNNXBMFYSA-N methyl 2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylpyrimidine-5-carboxylate Chemical compound N1=CC(C(=O)OC)=CN=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 OOAUMMBSRQCJDW-HNNXBMFYSA-N 0.000 description 1
• DCRXKXKRJCYNGH-SFHVURJKSA-N methyl 2-[3-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylphenyl]acetate Chemical compound COC(=O)CC1=CC=CC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=C1 DCRXKXKRJCYNGH-SFHVURJKSA-N 0.000 description 1
• RMLKOTZUPZVGCQ-IBGZPJMESA-N methyl 2-[4-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylphenoxy]-2-methylpropanoate Chemical compound C1=CC(OC(C)(C)C(=O)OC)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 RMLKOTZUPZVGCQ-IBGZPJMESA-N 0.000 description 1
• KRENYPUWUGHJED-INIZCTEOSA-N methyl 2-[6-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylpyridazin-3-yl]acetate Chemical compound N1=NC(CC(=O)OC)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 KRENYPUWUGHJED-INIZCTEOSA-N 0.000 description 1
• JVIGIBRXMCACMR-UHFFFAOYSA-N methyl 2-benzylsulfanyl-4-methylpyrimidine-5-carboxylate Chemical compound N1=C(C)C(C(=O)OC)=CN=C1SCC1=CC=CC=C1 JVIGIBRXMCACMR-UHFFFAOYSA-N 0.000 description 1
• YDCHPLOFQATIDS-UHFFFAOYSA-N methyl 2-bromoacetate Chemical compound COC(=O)CBr YDCHPLOFQATIDS-UHFFFAOYSA-N 0.000 description 1
• LFGRGJFMWACNLR-UHFFFAOYSA-N methyl 4-(2-chloroacetyl)benzoate Chemical compound COC(=O)C1=CC=C(C(=O)CCl)C=C1 LFGRGJFMWACNLR-UHFFFAOYSA-N 0.000 description 1
• RMJZZEQHSQFCIC-UHFFFAOYSA-N methyl 4-(2-sulfanylidene-3h-1,3-thiazol-4-yl)benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=CSC(S)=N1 RMJZZEQHSQFCIC-UHFFFAOYSA-N 0.000 description 1
• PAVMVWRHWQJLKG-IBGZPJMESA-N methyl 4-[2-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(Cl)C(Cl)=CC=3)C2)=N1 PAVMVWRHWQJLKG-IBGZPJMESA-N 0.000 description 1
• ZGDKMTNMUYPJKL-IBGZPJMESA-N methyl 4-[2-[2-[[(2s)-4-[(3,4-difluorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=CSC(SCC(=O)NC[C@@H]2OCCN(CC=3C=C(F)C(F)=CC=3)C2)=N1 ZGDKMTNMUYPJKL-IBGZPJMESA-N 0.000 description 1
• GFJFASJCGAUMTF-KRWDZBQOSA-N methyl 4-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylbenzoate Chemical compound C1=CC(C(=O)OC)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 GFJFASJCGAUMTF-KRWDZBQOSA-N 0.000 description 1
• ACTPEEVUTDWHBM-BKVVKPGQSA-N methyl 4-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfinylbenzoate Chemical compound C1=CC(C(=O)OC)=CC=C1S(=O)CC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 ACTPEEVUTDWHBM-BKVVKPGQSA-N 0.000 description 1
• DSQZXIAQTJCDLA-KRWDZBQOSA-N methyl 4-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfonylbenzoate Chemical compound C1=CC(C(=O)OC)=CC=C1S(=O)(=O)CC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 DSQZXIAQTJCDLA-KRWDZBQOSA-N 0.000 description 1
• NYMHVOHGRHAFCK-KRWDZBQOSA-N methyl 4-[2-[[(2s)-4-[(3-chloro-4-fluorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylbenzoate Chemical compound C1=CC(C(=O)OC)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(F)=CC=2)C1 NYMHVOHGRHAFCK-KRWDZBQOSA-N 0.000 description 1
• CZNGTXVOZOWWKM-UHFFFAOYSA-N methyl 4-bromobenzoate Chemical compound COC(=O)C1=CC=C(Br)C=C1 CZNGTXVOZOWWKM-UHFFFAOYSA-N 0.000 description 1
• ZZUYIRISBMWFMV-UHFFFAOYSA-N methyl 4-chlorobutanoate Chemical compound COC(=O)CCCCl ZZUYIRISBMWFMV-UHFFFAOYSA-N 0.000 description 1
• HWRNVCCRWALOJO-AWEZNQCLSA-N methyl 5-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylfuran-2-carboxylate Chemical compound O1C(C(=O)OC)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 HWRNVCCRWALOJO-AWEZNQCLSA-N 0.000 description 1
• FBPIDMAELBIRLE-UHFFFAOYSA-N methyl 5-bromofuran-2-carboxylate Chemical compound COC(=O)C1=CC=C(Br)O1 FBPIDMAELBIRLE-UHFFFAOYSA-N 0.000 description 1
• VOENIWQQKIRGNP-NRFANRHFSA-N methyl 6-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylnaphthalene-2-carboxylate Chemical compound C([C@@H](OCC1)CNC(=O)CSC2=CC3=CC=C(C=C3C=C2)C(=O)OC)N1CC1=CC=C(Cl)C(Cl)=C1 VOENIWQQKIRGNP-NRFANRHFSA-N 0.000 description 1
• WTJHJRDWWVOQLX-AWEZNQCLSA-N methyl 6-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanylpyridazine-3-carboxylate Chemical compound N1=NC(C(=O)OC)=CC=C1SCC(=O)NC[C@@H]1OCCN(CC=2C=C(Cl)C(Cl)=CC=2)C1 WTJHJRDWWVOQLX-AWEZNQCLSA-N 0.000 description 1
• CSJHGVIKEOYMML-UHFFFAOYSA-N methyl 6-bromo-2-oxochromene-3-carboxylate Chemical compound BrC1=CC=C2OC(=O)C(C(=O)OC)=CC2=C1 CSJHGVIKEOYMML-UHFFFAOYSA-N 0.000 description 1
• JEUBRLPXJZOGPX-UHFFFAOYSA-N methyl 6-bromonaphthalene-2-carboxylate Chemical compound C1=C(Br)C=CC2=CC(C(=O)OC)=CC=C21 JEUBRLPXJZOGPX-UHFFFAOYSA-N 0.000 description 1
• NJZJABRBOKNMFO-NRFANRHFSA-N methyl 7-[2-[[(2s)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1-methyl-2,3-dihydro-1-benzazepine-4-carboxylate Chemical compound C([C@@H](OCC1)CNC(=O)CSC=2C=C3C=C(CCN(C)C3=CC=2)C(=O)OC)N1CC1=CC=C(Cl)C(Cl)=C1 NJZJABRBOKNMFO-NRFANRHFSA-N 0.000 description 1
• BXGDVRAQHTXSEV-UHFFFAOYSA-N methyl 7-bromo-1-methyl-2,3-dihydro-1-benzazepine-4-carboxylate Chemical compound CN1CCC(C(=O)OC)=CC2=CC(Br)=CC=C21 BXGDVRAQHTXSEV-UHFFFAOYSA-N 0.000 description 1
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