CA2557307A1 - 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease - Google Patents

3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease Download PDF

Info

Publication number
CA2557307A1
CA2557307A1 CA002557307A CA2557307A CA2557307A1 CA 2557307 A1 CA2557307 A1 CA 2557307A1 CA 002557307 A CA002557307 A CA 002557307A CA 2557307 A CA2557307 A CA 2557307A CA 2557307 A1 CA2557307 A1 CA 2557307A1
Authority
CA
Canada
Prior art keywords
compound
alkyl
group
hcv
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002557307A
Other languages
English (en)
French (fr)
Inventor
F. George Njoroge
Srikanth Venkatraman
Ashok Arasappan
Francisco Velazquez
Viyyoor M. Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2557307A1 publication Critical patent/CA2557307A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CA002557307A 2004-02-27 2005-02-24 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease Abandoned CA2557307A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54865504P 2004-02-27 2004-02-27
US60/548,655 2004-02-27
PCT/US2005/005778 WO2005087730A1 (en) 2004-02-27 2005-02-24 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease

Publications (1)

Publication Number Publication Date
CA2557307A1 true CA2557307A1 (en) 2005-09-22

Family

ID=34961939

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002557307A Abandoned CA2557307A1 (en) 2004-02-27 2005-02-24 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease

Country Status (11)

Country Link
US (1) US7342041B2 (enExample)
EP (1) EP1737821B1 (enExample)
JP (1) JP2007525512A (enExample)
CN (1) CN1946692A (enExample)
AR (1) AR048413A1 (enExample)
AT (1) ATE438622T1 (enExample)
CA (1) CA2557307A1 (enExample)
DE (1) DE602005015834D1 (enExample)
ES (1) ES2328589T3 (enExample)
TW (1) TWI302835B (enExample)
WO (1) WO2005087730A1 (enExample)

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Also Published As

Publication number Publication date
US7342041B2 (en) 2008-03-11
AR048413A1 (es) 2006-04-26
EP1737821A1 (en) 2007-01-03
ES2328589T3 (es) 2009-11-16
DE602005015834D1 (de) 2009-09-17
CN1946692A (zh) 2007-04-11
EP1737821B1 (en) 2009-08-05
TWI302835B (en) 2008-11-11
JP2007525512A (ja) 2007-09-06
WO2005087730A1 (en) 2005-09-22
HK1095820A1 (en) 2007-05-18
US20050197301A1 (en) 2005-09-08
TW200536530A (en) 2005-11-16
ATE438622T1 (de) 2009-08-15

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EEER Examination request
FZDE Discontinued

Effective date: 20130225