ES2328589T3 - Compuestos de la prolina 3,4(ciclopentil) fusionados como inhibidores de la proteasa serina ns3 del virus de la hepatitis c. - Google Patents

Compuestos de la prolina 3,4(ciclopentil) fusionados como inhibidores de la proteasa serina ns3 del virus de la hepatitis c. Download PDF

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Publication number
ES2328589T3
ES2328589T3 ES05723594T ES05723594T ES2328589T3 ES 2328589 T3 ES2328589 T3 ES 2328589T3 ES 05723594 T ES05723594 T ES 05723594T ES 05723594 T ES05723594 T ES 05723594T ES 2328589 T3 ES2328589 T3 ES 2328589T3
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ES
Spain
Prior art keywords
baselineskip
compound
heterocyclyl
alkyl
independently
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05723594T
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English (en)
Spanish (es)
Inventor
F. George Njoroge
Srikanth Venkatraman
Ashok Arasappan
Francisco Velazquez
Viyyoor M. Girijavallabhan
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of ES2328589T3 publication Critical patent/ES2328589T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
ES05723594T 2004-02-27 2005-02-24 Compuestos de la prolina 3,4(ciclopentil) fusionados como inhibidores de la proteasa serina ns3 del virus de la hepatitis c. Expired - Lifetime ES2328589T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54865504P 2004-02-27 2004-02-27
US548655P 2004-02-27

Publications (1)

Publication Number Publication Date
ES2328589T3 true ES2328589T3 (es) 2009-11-16

Family

ID=34961939

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05723594T Expired - Lifetime ES2328589T3 (es) 2004-02-27 2005-02-24 Compuestos de la prolina 3,4(ciclopentil) fusionados como inhibidores de la proteasa serina ns3 del virus de la hepatitis c.

Country Status (11)

Country Link
US (1) US7342041B2 (enExample)
EP (1) EP1737821B1 (enExample)
JP (1) JP2007525512A (enExample)
CN (1) CN1946692A (enExample)
AR (1) AR048413A1 (enExample)
AT (1) ATE438622T1 (enExample)
CA (1) CA2557307A1 (enExample)
DE (1) DE602005015834D1 (enExample)
ES (1) ES2328589T3 (enExample)
TW (1) TWI302835B (enExample)
WO (1) WO2005087730A1 (enExample)

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WO2009018657A1 (en) 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
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ES2438576T3 (es) * 2008-06-24 2014-01-17 Codexis, Inc. Procesos biocatalíticos para la preparación de compuestos de prolina bicíclica fusionada considerablemente pura estereoméricamente
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Also Published As

Publication number Publication date
EP1737821B1 (en) 2009-08-05
US20050197301A1 (en) 2005-09-08
CN1946692A (zh) 2007-04-11
HK1095820A1 (en) 2007-05-18
ATE438622T1 (de) 2009-08-15
EP1737821A1 (en) 2007-01-03
TW200536530A (en) 2005-11-16
TWI302835B (en) 2008-11-11
WO2005087730A1 (en) 2005-09-22
US7342041B2 (en) 2008-03-11
DE602005015834D1 (de) 2009-09-17
CA2557307A1 (en) 2005-09-22
AR048413A1 (es) 2006-04-26
JP2007525512A (ja) 2007-09-06

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