CA2535199C - Derives d'amide - Google Patents

Derives d'amide Download PDF

Info

Publication number
CA2535199C
CA2535199C CA2535199A CA2535199A CA2535199C CA 2535199 C CA2535199 C CA 2535199C CA 2535199 A CA2535199 A CA 2535199A CA 2535199 A CA2535199 A CA 2535199A CA 2535199 C CA2535199 C CA 2535199C
Authority
CA
Canada
Prior art keywords
group
alkyl
alkylene
phenyl
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2535199A
Other languages
English (en)
Other versions
CA2535199A1 (fr
Inventor
Toru Kontani
Junji Miyata
Wataru Hamaguchi
Tomoaki Kawano
Akio Kamikawa
Hiroshi Suzuki
Kenji Sudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of CA2535199A1 publication Critical patent/CA2535199A1/fr
Application granted granted Critical
Publication of CA2535199C publication Critical patent/CA2535199C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

L'invention concerne un composé utile dans des médicaments, notamment dans des médicaments destinés à diverses maladies engendrées par une infection aux virus appartenant à la famille Herpesviridae, notamment dans la prévention ou le traitement d'infections aux divers virus de l'herpès, et plus précisément, de la varicelle engendrée par l'infection au virus varicelle zona, de l'herpès zoster engendré par une infection récurrente au virus varicelle zoster persistant, de l'herpès labial et de l'encéphalite herpétique engendrés par une infection au HSV-1, de l'herpès génital engendré par une infection au HSV-2, etc. L'invention concerne enfin un dérivé de N-{2-[(4-phényle substitué)amino]-2-oxoéthyl}tétrahydro-2H-thiopyran-4-carboxamide comprenant un substituant hétéroaryle à 5 ou 6 chaînons spécifique au niveau de la position 4 et possédant une activité antivirale favorable permettant de traiter les maladies susmentionnées par administration orale d'une petite dose.
CA2535199A 2003-08-08 2004-08-05 Derives d'amide Active CA2535199C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003290850 2003-08-08
JP2003-290850 2003-08-08
PCT/JP2004/011573 WO2005014559A1 (fr) 2003-08-08 2004-08-05 Derives d'amide

Publications (2)

Publication Number Publication Date
CA2535199A1 CA2535199A1 (fr) 2005-02-17
CA2535199C true CA2535199C (fr) 2010-12-14

Family

ID=34114142

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2535199A Active CA2535199C (fr) 2003-08-08 2004-08-05 Derives d'amide

Country Status (19)

Country Link
US (2) US7465748B2 (fr)
EP (1) EP1652843B1 (fr)
JP (1) JP4549974B2 (fr)
KR (1) KR101157074B1 (fr)
CN (1) CN100445271C (fr)
AU (1) AU2004263448B2 (fr)
BR (1) BRPI0413430B8 (fr)
CA (1) CA2535199C (fr)
CY (1) CY1115461T1 (fr)
DK (1) DK1652843T3 (fr)
ES (1) ES2462292T3 (fr)
MX (1) MXPA06001526A (fr)
NO (1) NO335467B1 (fr)
PL (1) PL1652843T3 (fr)
PT (1) PT1652843E (fr)
RU (1) RU2336273C2 (fr)
SI (1) SI1652843T1 (fr)
TW (1) TW200505894A (fr)
WO (1) WO2005014559A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005518391A (ja) * 2001-12-21 2005-06-23 ノボ　ノルディスク　アクティーゼルスカブ Ｇｋ活性化剤としてのアミド誘導体
JP4881559B2 (ja) * 2002-06-27 2012-02-22 ノボ・ノルデイスク・エー／エス 治療薬としてのアリールカルボニル誘導体
TW200505894A (en) * 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative
EP2444397A1 (fr) * 2004-01-06 2012-04-25 Novo Nordisk A/S Hétéroaryl-urées et leur utilisation en tant qu'activateurs de glucokinase
DE602006016069D1 (de) * 2005-02-02 2010-09-23 Astellas Pharma Inc Therapeutischer wirkstoff zur behandlung von herpes progenitalis nach der entwicklung von läsionen
EP1857108B1 (fr) * 2005-02-02 2010-12-08 Astellas Pharma Inc. Agent preventif ou therapeutique contre une maladie liee au virus de l'herpes
US20090048310A1 (en) * 2005-02-02 2009-02-19 Astellas Pharma Inc. Agent for prevention/treatment of disease caused by acyclovir-resistant herpesvirus
JP5011739B2 (ja) * 2005-02-03 2012-08-29 アステラス製薬株式会社 テトラヒドロ−２ｈ−チオピラン−４−カルボキサミド誘導体を含有する医薬組成物
AU2006268708A1 (en) * 2005-07-08 2007-01-18 Transtech Pharma Inc. Dicycloalkyl urea glucokinase activators
EP1904438B1 (fr) * 2005-07-08 2012-02-29 Novo Nordisk A/S Dicycloalkylcarbamoylurées en tant qu' activateurs de glucokinase
ES2422383T3 (es) 2005-07-14 2013-09-11 Novo Nordisk As Activadores de urea glucoquinasa
WO2008084043A1 (fr) * 2007-01-09 2008-07-17 Novo Nordisk A/S Activateurs de la glucokinase à base d'urée
JP5226008B2 (ja) * 2007-01-11 2013-07-03 ノボ・ノルデイスク・エー／エス ウレアグルコキナーゼアクチベーター
DE102008014523A1 (de) * 2008-03-15 2009-09-17 Robert Bosch Gmbh Heizgerät
EP2263671B1 (fr) * 2008-04-02 2016-07-20 Astellas Pharma Inc. Composition pharmaceutique contenant un dérivé d'amide
EP2565191B1 (fr) 2008-05-14 2014-10-08 Astellas Pharma Inc. Dérivés d'acide 4-(indol-7-ylcarbonylaminométhyl)cyclohexanecarboxylique comme antagonistes du récepteur EP4 utilisables pour le traitement de l'insuffisance rénale chronique ou de la néphropathie diabétique
EP2351565A1 (fr) 2008-10-20 2011-08-03 Astellas Pharma Inc. Médicament destiné à la prévention ou au traitement de la douleur associée à un zona
CN108623577B (zh) * 2018-05-08 2020-09-25 山东百诺医药股份有限公司 阿莫奈韦及其中间体的制备方法
CN112040945A (zh) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途
WO2020038812A1 (fr) * 2018-08-20 2020-02-27 Rijksuniversiteit Groningen Nouveau procédé de préparation d'aménamévir
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE227279T1 (de) * 1995-12-29 2002-11-15 Boehringer Ingelheim Pharma Phenyl thiazol derivate mit antiherpesvirus eigenschaften
US6288091B1 (en) * 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
AU3289299A (en) * 1998-02-19 1999-09-06 Tularik Inc. Antiviral agents
WO2000029399A1 (fr) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Composes antiherpes
DE50008597D1 (de) * 1999-03-08 2004-12-16 Bayer Healthcare Ag Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel
JP2003500383A (ja) * 1999-05-24 2003-01-07 コア・セラピューティクス，インコーポレイテッド 第Ｘａ因子阻害剤
US6545055B1 (en) * 1999-05-24 2003-04-08 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6949543B2 (en) * 2000-11-10 2005-09-27 Yamanouchi Pharmaceutical Co., Ltd. Amide derivative
DE10139060A1 (de) 2001-08-08 2003-02-20 Merck Patent Gmbh Phenylderivate
WO2003095435A1 (fr) 2002-05-09 2003-11-20 Yamanouchi Pharmaceutical Co., Ltd. Derives d'amides
TW200505894A (en) * 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative

Also Published As

Publication number Publication date
AU2004263448B2 (en) 2009-02-05
CN100445271C (zh) 2008-12-24
KR20060073928A (ko) 2006-06-29
ES2462292T3 (es) 2014-05-22
BRPI0413430B8 (pt) 2021-05-25
KR101157074B1 (ko) 2012-06-22
PT1652843E (pt) 2014-06-02
NO335467B1 (no) 2014-12-15
CY1115461T1 (el) 2017-01-04
US6903125B2 (en) 2005-06-07
NO20061100L (no) 2006-03-07
JP4549974B2 (ja) 2010-09-22
AU2004263448A1 (en) 2005-02-17
EP1652843A1 (fr) 2006-05-03
EP1652843A4 (fr) 2010-07-28
US7465748B2 (en) 2008-12-16
RU2006106922A (ru) 2006-08-27
CN1832930A (zh) 2006-09-13
DK1652843T3 (da) 2014-05-05
TW200505894A (en) 2005-02-16
PL1652843T3 (pl) 2014-09-30
US20050032855A1 (en) 2005-02-10
JPWO2005014559A1 (ja) 2006-10-05
CA2535199A1 (fr) 2005-02-17
EP1652843B1 (fr) 2014-04-02
MXPA06001526A (es) 2006-05-25
TWI341311B (fr) 2011-05-01
RU2336273C2 (ru) 2008-10-20
SI1652843T1 (sl) 2014-06-30
WO2005014559A1 (fr) 2005-02-17
BRPI0413430B1 (pt) 2019-04-30
US20060229295A1 (en) 2006-10-12
BRPI0413430A (pt) 2006-10-17

Similar Documents

Publication Publication Date Title
CA2535199C (fr) Derives d'amide
CN108779096B (zh) 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途
EP1644320B1 (fr) Derives d'indane utilises comme agonistes du recepteur muscarinique
EP1340750B1 (fr) Derives amides
EP1857108B1 (fr) Agent preventif ou therapeutique contre une maladie liee au virus de l'herpes
CA3008485C (fr) Composes sulfonamides de dihydroquinoline d'alcynyle
JP5011739B2 (ja) テトラヒドロ−２ｈ−チオピラン−４−カルボキサミド誘導体を含有する医薬組成物
CN111978312B (zh) 5-芳基-1,3,4-噻二唑/1,3,4-噁二唑-2-胺类化合物及制备方法和应用
EP1844775B1 (fr) Agent thérapeutique pour le traitement de l'herpès génital après le développement de lésions
JP3623228B1 (ja) テトラヒドロ−２ｈ−チオピラン−４−カルボキサミド誘導体
EP1844776B1 (fr) Agent destine a la prevention/au traitement d'une maladie causee par un virus de l'herpes acyclovir-resistant
JP2005089451A (ja) アミド誘導体又はその塩
JP2004026819A (ja) 医薬組成物
JP2004026818A (ja) アミド誘導体又はその塩
JP2006241145A (ja) テトラヒドロ−２ｈ−チオピラン−４−カルボキサミド誘導体の製造方法

Legal Events

Date Code Title Description
EEER Examination request