CA2529949C - Antiviral compounds and methods - Google Patents

Info

Publication number

CA2529949C

CA2529949C CA2529949A CA2529949A CA2529949C CA 2529949 C CA2529949 C CA 2529949C CA 2529949 A CA2529949 A CA 2529949A CA 2529949 A CA2529949 A CA 2529949A CA 2529949 C CA2529949 C CA 2529949C

Authority

CA

Canada

Prior art keywords

guanidine

strain

coronavirus

cinnamoylguanidine

virus

Prior art date

2003-06-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 247
• 230000000840 anti-viral effect Effects 0.000 title claims abstract description 51
• 238000000034 method Methods 0.000 title abstract description 43
• ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 304
• 102000004310 Ion Channels Human genes 0.000 claims description 159
• CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 151
• SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 151
• 239000001257 hydrogen Substances 0.000 claims description 130
• 229910052739 hydrogen Inorganic materials 0.000 claims description 130
• 241000700605 Viruses Species 0.000 claims description 117
• DMRPQMZUZKCGFD-VOTSOKGWSA-N (e)-n-(diaminomethylidene)-3-phenylprop-2-enamide Chemical compound NC(N)=NC(=O)\C=C\C1=CC=CC=C1 DMRPQMZUZKCGFD-VOTSOKGWSA-N 0.000 claims description 104
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 102
• 229960002576 amiloride Drugs 0.000 claims description 99
• UWICDWBEVIDNNJ-UHFFFAOYSA-N n-(diaminomethylidene)prop-2-enamide Chemical compound NC(=N)NC(=O)C=C UWICDWBEVIDNNJ-UHFFFAOYSA-N 0.000 claims description 85
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 83
• 101710204837 Envelope small membrane protein Proteins 0.000 claims description 82
• 101710145006 Lysis protein Proteins 0.000 claims description 82
• 239000012528 membrane Substances 0.000 claims description 74
• -1 C1-6alkyloxy Chemical group 0.000 claims description 66
• 241000315672 SARS coronavirus Species 0.000 claims description 62
• 241000711549 Hepacivirus C Species 0.000 claims description 59
• 241000725303 Human immunodeficiency virus Species 0.000 claims description 59
• XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 claims description 57
• 125000001475 halogen functional group Chemical group 0.000 claims description 55
• RQQJJXVETXFINY-UHFFFAOYSA-N 5-(N,N-hexamethylene)amiloride Chemical compound N1=C(N)C(C(=O)N=C(N)N)=NC(Cl)=C1N1CCCCCC1 RQQJJXVETXFINY-UHFFFAOYSA-N 0.000 claims description 51
• 241000711573 Coronaviridae Species 0.000 claims description 50
• FAJIOICCLPXHDD-UHFFFAOYSA-N n-(diaminomethylidene)-6-methoxynaphthalene-2-carboxamide Chemical compound C1=C(C(=O)NC(N)=N)C=CC2=CC(OC)=CC=C21 FAJIOICCLPXHDD-UHFFFAOYSA-N 0.000 claims description 49
• ORHXTMBRQJROCY-UHFFFAOYSA-N 3-(3-bromophenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC(Br)=C1 ORHXTMBRQJROCY-UHFFFAOYSA-N 0.000 claims description 48
• FYOXCRMHHBYILR-UHFFFAOYSA-N n-(diaminomethylidene)-5-phenylpenta-2,4-dienamide Chemical compound NC(=N)NC(=O)C=CC=CC1=CC=CC=C1 FYOXCRMHHBYILR-UHFFFAOYSA-N 0.000 claims description 46
• DHUGRAINHFHLBE-UHFFFAOYSA-N n-(diaminomethylidene)-4-phenylbenzamide Chemical compound C1=CC(C(=O)NC(=N)N)=CC=C1C1=CC=CC=C1 DHUGRAINHFHLBE-UHFFFAOYSA-N 0.000 claims description 44
• 239000003814 drug Substances 0.000 claims description 43
• PISVGNWQIULYBS-UHFFFAOYSA-N n-(diaminomethylidene)-3-(4-propan-2-ylphenyl)prop-2-enamide Chemical compound CC(C)C1=CC=C(C=CC(=O)N=C(N)N)C=C1 PISVGNWQIULYBS-UHFFFAOYSA-N 0.000 claims description 43
• YJJRJCGALAGVMY-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3,4-dichlorophenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=C(Cl)C(Cl)=C1 YJJRJCGALAGVMY-UHFFFAOYSA-N 0.000 claims description 42
• ZAYDWNACZRBICF-UHFFFAOYSA-N n-(diaminomethylidene)-3-[3-(trifluoromethoxy)phenyl]prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC(OC(F)(F)F)=C1 ZAYDWNACZRBICF-UHFFFAOYSA-N 0.000 claims description 42
• DKJONGCRYHKAGI-UHFFFAOYSA-N n-(diaminomethylidene)-3-[3-(trifluoromethyl)phenyl]prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC(C(F)(F)F)=C1 DKJONGCRYHKAGI-UHFFFAOYSA-N 0.000 claims description 42
• OKOXJPLBLDXQNV-DTWKUNHWSA-N (1r,2r)-n-(diaminomethylidene)-2-phenylcyclopropane-1-carboxamide Chemical compound NC(=N)NC(=O)[C@@H]1C[C@H]1C1=CC=CC=C1 OKOXJPLBLDXQNV-DTWKUNHWSA-N 0.000 claims description 41
• ZLHBIWZXHDEOFT-UHFFFAOYSA-N 3-(2-tert-butylphenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound CC(C)(C)C1=CC=CC=C1C=CC(=O)N=C(N)N ZLHBIWZXHDEOFT-UHFFFAOYSA-N 0.000 claims description 39
• 208000015181 infectious disease Diseases 0.000 claims description 39
• PZNOJKMDUBWCBQ-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3-methylphenyl)prop-2-enamide Chemical compound CC1=CC=CC(C=CC(=O)N=C(N)N)=C1 PZNOJKMDUBWCBQ-UHFFFAOYSA-N 0.000 claims description 39
• HVVFWRLIARMUOV-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC=C1Cl HVVFWRLIARMUOV-UHFFFAOYSA-N 0.000 claims description 38
• IIORGOGWQSVXAU-UHFFFAOYSA-N 3-(4-bromophenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=C(Br)C=C1 IIORGOGWQSVXAU-UHFFFAOYSA-N 0.000 claims description 37
• 241000711493 Porcine respiratory coronavirus Species 0.000 claims description 37
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 37
• LNOGCEAJDCCGSB-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2,6-dichlorophenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=C(Cl)C=CC=C1Cl LNOGCEAJDCCGSB-UHFFFAOYSA-N 0.000 claims description 36
• VCBGPXCHKPPINZ-UHFFFAOYSA-N n-(diaminomethylidene)-3-(4-fluorophenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=C(F)C=C1 VCBGPXCHKPPINZ-UHFFFAOYSA-N 0.000 claims description 36
• FIZKBCWWZMXZHL-UHFFFAOYSA-N 3-(3-chlorophenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC(Cl)=C1 FIZKBCWWZMXZHL-UHFFFAOYSA-N 0.000 claims description 35
• JBLYNJINPOWRFG-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2,5-dimethylphenyl)prop-2-enamide Chemical compound CC1=CC=C(C)C(C=CC(=O)N=C(N)N)=C1 JBLYNJINPOWRFG-UHFFFAOYSA-N 0.000 claims description 35
• MMVUASXGHTWYSF-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2-methylphenyl)prop-2-enamide Chemical compound CC1=CC=CC=C1C=CC(=O)N=C(N)N MMVUASXGHTWYSF-UHFFFAOYSA-N 0.000 claims description 35
• MHTGKDXWKXQUAQ-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3-nitrophenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC([N+]([O-])=O)=C1 MHTGKDXWKXQUAQ-UHFFFAOYSA-N 0.000 claims description 35
• SAXKBLLZHUBONF-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3-propan-2-ylphenyl)prop-2-enamide;hydrochloride Chemical compound Cl.CC(C)C1=CC=CC(C=CC(=O)N=C(N)N)=C1 SAXKBLLZHUBONF-UHFFFAOYSA-N 0.000 claims description 35
• DXFJUUOQFIHODP-UHFFFAOYSA-N n-(diaminomethylidene)-3-(4-hydroxyphenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=C(O)C=C1 DXFJUUOQFIHODP-UHFFFAOYSA-N 0.000 claims description 35
• VDYFICUZUMSCMU-UHFFFAOYSA-N n-(diaminomethylidene)-4-phenoxybenzamide Chemical compound C1=CC(C(=O)NC(=N)N)=CC=C1OC1=CC=CC=C1 VDYFICUZUMSCMU-UHFFFAOYSA-N 0.000 claims description 35
• 230000010076 replication Effects 0.000 claims description 35
• ZJRXLZFDGGZHTC-UHFFFAOYSA-N 3-(4-chlorophenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=C(Cl)C=C1 ZJRXLZFDGGZHTC-UHFFFAOYSA-N 0.000 claims description 34
• 230000012010 growth Effects 0.000 claims description 34
• QKUJGONOHHSOQJ-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2-ethoxyphenyl)prop-2-enamide Chemical compound CCOC1=CC=CC=C1C=CC(=O)N=C(N)N QKUJGONOHHSOQJ-UHFFFAOYSA-N 0.000 claims description 34
• FGLKXTSTMPDAMW-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2-fluorophenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC=C1F FGLKXTSTMPDAMW-UHFFFAOYSA-N 0.000 claims description 34
• IIQICEWHWURYDB-UHFFFAOYSA-N n-(diaminomethylidene)-3-(4-methoxyphenyl)prop-2-enamide Chemical compound COC1=CC=C(C=CC(=O)N=C(N)N)C=C1 IIQICEWHWURYDB-UHFFFAOYSA-N 0.000 claims description 34
• PFKYZWUGTMREHT-UHFFFAOYSA-N 3-(2-bromophenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC=C1Br PFKYZWUGTMREHT-UHFFFAOYSA-N 0.000 claims description 33
• LTGYAZVREDUARQ-UHFFFAOYSA-N 3-(2-cyclohexylphenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC=C1C1CCCCC1 LTGYAZVREDUARQ-UHFFFAOYSA-N 0.000 claims description 33
• HRKGSHPEYGOZHJ-UHFFFAOYSA-N 3-(3-tert-butylphenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound CC(C)(C)C1=CC=CC(C=CC(=O)N=C(N)N)=C1 HRKGSHPEYGOZHJ-UHFFFAOYSA-N 0.000 claims description 33
• IIUPTHVVXMBJMQ-UHFFFAOYSA-N 3-amino-6-chloro-n-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide;hydrochloride Chemical compound Cl.CN(C)C1=NC(N)=C(C(=O)N=C(N)N)N=C1Cl IIUPTHVVXMBJMQ-UHFFFAOYSA-N 0.000 claims description 33
• NGFWDHLKIUYSIP-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2,3-difluorophenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC(F)=C1F NGFWDHLKIUYSIP-UHFFFAOYSA-N 0.000 claims description 33
• YSPHLCIYDPAMTC-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2-methoxyphenyl)prop-2-enamide Chemical compound COC1=CC=CC=C1C=CC(=O)N=C(N)N YSPHLCIYDPAMTC-UHFFFAOYSA-N 0.000 claims description 33
• OLALSUPQCJAGAU-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3-fluorophenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC(F)=C1 OLALSUPQCJAGAU-UHFFFAOYSA-N 0.000 claims description 33
• FVBMZBLBBKLKTN-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3-methoxyphenyl)prop-2-enamide Chemical compound COC1=CC=CC(C=CC(=O)N=C(N)N)=C1 FVBMZBLBBKLKTN-UHFFFAOYSA-N 0.000 claims description 33
• RXEFMYMSKWTKRU-UHFFFAOYSA-N n-(diaminomethylidene)-3-(4-methylphenyl)prop-2-enamide Chemical compound CC1=CC=C(C=CC(=O)N=C(N)N)C=C1 RXEFMYMSKWTKRU-UHFFFAOYSA-N 0.000 claims description 33
• IBFSKNNSMJANAC-UHFFFAOYSA-N 3-[3-(cyclohexen-1-yl)phenyl]-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC(C=2CCCCC=2)=C1 IBFSKNNSMJANAC-UHFFFAOYSA-N 0.000 claims description 32
• 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims description 32
• DRIQBBXJVJVPGI-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3-phenylphenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC(C=2C=CC=CC=2)=C1 DRIQBBXJVJVPGI-UHFFFAOYSA-N 0.000 claims description 32
• ZAPVDFDIPMJGRX-UHFFFAOYSA-N n-(diaminomethylidene)-3-[2-(trifluoromethyl)phenyl]prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC=C1C(F)(F)F ZAPVDFDIPMJGRX-UHFFFAOYSA-N 0.000 claims description 32
• KZMIUYQOZTVXRV-UHFFFAOYSA-N n-(diaminomethylidene)-3-[4-(trifluoromethyl)phenyl]prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=C(C(F)(F)F)C=C1 KZMIUYQOZTVXRV-UHFFFAOYSA-N 0.000 claims description 32
• BAANTXNFSRCMCP-UHFFFAOYSA-N 5-(3-bromophenyl)-n-(diaminomethylidene)penta-2,4-dienamide Chemical compound NC(=N)NC(=O)C=CC=CC1=CC=CC(Br)=C1 BAANTXNFSRCMCP-UHFFFAOYSA-N 0.000 claims description 31
• AORSRQOKSFUBQU-UHFFFAOYSA-N 3-(5-bromo-2-fluorophenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC(Br)=CC=C1F AORSRQOKSFUBQU-UHFFFAOYSA-N 0.000 claims description 30
• IZTOMICYUSXUFV-UHFFFAOYSA-N 3-(5-bromo-2-methoxyphenyl)-n-(diaminomethylidene)prop-2-enamide Chemical compound COC1=CC=C(Br)C=C1C=CC(=O)N=C(N)N IZTOMICYUSXUFV-UHFFFAOYSA-N 0.000 claims description 30
• 229910052757 nitrogen Inorganic materials 0.000 claims description 30
• 241000710803 Equine arteritis virus Species 0.000 claims description 29
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 29
• VDBNVLGNOVEOPB-UHFFFAOYSA-N n-(diaminomethylidene)-3-phenylpropanamide Chemical compound NC(=N)NC(=O)CCC1=CC=CC=C1 VDBNVLGNOVEOPB-UHFFFAOYSA-N 0.000 claims description 27
• 241000713666 Lentivirus Species 0.000 claims description 26
• CHKULGQCBATXKS-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2,4,6-trimethylphenyl)prop-2-enamide Chemical compound CC1=CC(C)=C(C=CC(=O)N=C(N)N)C(C)=C1 CHKULGQCBATXKS-UHFFFAOYSA-N 0.000 claims description 26
• JRSLBEIEBBOHCW-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3-ethoxyphenyl)prop-2-enamide Chemical compound CCOC1=CC=CC(C=CC(=O)N=C(N)N)=C1 JRSLBEIEBBOHCW-UHFFFAOYSA-N 0.000 claims description 26
• FMKRDNDKDWJOFK-UHFFFAOYSA-N n-(diaminomethylidene)-3-(furan-2-yl)prop-2-enamide Chemical compound NC(=N)NC(=O)C=CC1=CC=CO1 FMKRDNDKDWJOFK-UHFFFAOYSA-N 0.000 claims description 26
• WYZGHFCGQGCOPZ-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2,3-dimethylphenyl)prop-2-enamide Chemical compound CC1=CC=CC(C=CC(=O)N=C(N)N)=C1C WYZGHFCGQGCOPZ-UHFFFAOYSA-N 0.000 claims description 25
• MASFCCGAEYGKRN-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2-phenylphenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC=C1C1=CC=CC=C1 MASFCCGAEYGKRN-UHFFFAOYSA-N 0.000 claims description 25
• WGRUSZZJGBKVDU-UHFFFAOYSA-N n-(diaminomethylidene)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide Chemical compound COC1=CC(C=CC(=O)N=C(N)N)=CC(OC)=C1OC WGRUSZZJGBKVDU-UHFFFAOYSA-N 0.000 claims description 25
• KXDROGADUISDGY-UHFFFAOYSA-N Benzamil hydrochloride Chemical compound C=1C=CC=CC=1CN=C(N)NC(=O)C1=NC(Cl)=C(N)N=C1N KXDROGADUISDGY-UHFFFAOYSA-N 0.000 claims description 24
• MHPIZTURFVSLTJ-UHFFFAOYSA-N 3,5-diamino-n-[amino(anilino)methylidene]-6-chloropyrazine-2-carboxamide;methanesulfonic acid Chemical compound CS(O)(=O)=O.N=1C(Cl)=C(N)N=C(N)C=1C(=O)N=C(N)NC1=CC=CC=C1 MHPIZTURFVSLTJ-UHFFFAOYSA-N 0.000 claims description 23
• 241000282414 Homo sapiens Species 0.000 claims description 23
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 23
• 241000711467 Human coronavirus 229E Species 0.000 claims description 22
• RNJYBXUVPPUWLN-DLPFSFTESA-N n-(diaminomethylidene)-3-[3-[(e)-hept-1-enyl]phenyl]prop-2-enamide Chemical compound CCCCC\C=C\C1=CC=CC(C=CC(=O)N=C(N)N)=C1 RNJYBXUVPPUWLN-DLPFSFTESA-N 0.000 claims description 22
• RVIUMPLAOXSSGN-UHFFFAOYSA-N 3-amino-6-chloro-n-(diaminomethylidene)-5-[methyl(2-methylpropyl)amino]pyrazine-2-carboxamide Chemical compound CC(C)CN(C)C1=NC(N)=C(C(=O)N=C(N)N)N=C1Cl RVIUMPLAOXSSGN-UHFFFAOYSA-N 0.000 claims description 21
• QDERNBXNXJCIQK-UHFFFAOYSA-N ethylisopropylamiloride Chemical compound CCN(C(C)C)C1=NC(N)=C(C(=O)N=C(N)N)N=C1Cl QDERNBXNXJCIQK-UHFFFAOYSA-N 0.000 claims description 21
• 125000003118 aryl group Chemical group 0.000 claims description 20
• 230000005714 functional activity Effects 0.000 claims description 20
• PCEORBLTWJVJHN-UHFFFAOYSA-N n-[amino-(3-phenylprop-2-enoylamino)methylidene]benzamide Chemical compound C=1C=CC=CC=1C(=O)N=C(N)NC(=O)C=CC1=CC=CC=C1 PCEORBLTWJVJHN-UHFFFAOYSA-N 0.000 claims description 19
• 125000003107 substituted aryl group Chemical group 0.000 claims description 19
• LCRHPQDZNWNTDJ-UHFFFAOYSA-N n-(diaminomethylidene)-3-(2-nitrophenyl)prop-2-enamide Chemical compound NC(N)=NC(=O)C=CC1=CC=CC=C1[N+]([O-])=O LCRHPQDZNWNTDJ-UHFFFAOYSA-N 0.000 claims description 18
• BCDKGQNGEDRCKI-UHFFFAOYSA-N n-(diaminomethylidene)quinoline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC(=N)N)=CC=C21 BCDKGQNGEDRCKI-UHFFFAOYSA-N 0.000 claims description 17
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• 230000002401 inhibitory effect Effects 0.000 claims description 16
• FKXYVYMLZGVJIM-UHFFFAOYSA-N 3,5-diamino-n-(diaminomethylidene)-6-iodopyrazine-2-carboxamide Chemical compound NC(N)=NC(=O)C1=NC(I)=C(N)N=C1N FKXYVYMLZGVJIM-UHFFFAOYSA-N 0.000 claims description 14
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• ORAVVJNVOXLQIT-UHFFFAOYSA-N n-(diaminomethylidene)-2-phenylacetamide Chemical compound NC(=N)NC(=O)CC1=CC=CC=C1 ORAVVJNVOXLQIT-UHFFFAOYSA-N 0.000 claims description 13
• 230000000979 retarding effect Effects 0.000 claims description 12
• 150000003839 salts Chemical class 0.000 claims description 12
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 11
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• 239000008194 pharmaceutical composition Substances 0.000 claims description 10
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• DLNOQRGQJYTFNZ-UHFFFAOYSA-N 3-amino-5-(azepan-1-yl)-n-(diaminomethylidene)-6-phenylpyrazine-2-carboxamide Chemical compound C1CCCCCN1C=1N=C(N)C(C(=O)N=C(N)N)=NC=1C1=CC=CC=C1 DLNOQRGQJYTFNZ-UHFFFAOYSA-N 0.000 claims description 9
• 125000000217 alkyl group Chemical group 0.000 claims description 9
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• 241000600138 Bovine coronavirus strain Ontario Species 0.000 claims description 8
• 241000633897 Bovine enteric coronavirus (strain 98TXSF-110-ENT) Species 0.000 claims description 8
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• 241000711465 Murine hepatitis virus strain 1 Species 0.000 claims description 8
• 241001290278 Murine hepatitis virus strain 2 Species 0.000 claims description 8
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• 241000711489 Murine hepatitis virus strain A59 Species 0.000 claims description 8
• 241000711495 Murine hepatitis virus strain S Species 0.000 claims description 8
• 241000334226 Porcine epidemic diarrhea virus CV777 Species 0.000 claims description 8
• 241000585763 Porcine hemagglutinating encephalomyelitis virus (strain 67N) Species 0.000 claims description 8
• 241001467076 Porcine transmissible gastroenteritis coronavirus strain Miller Species 0.000 claims description 8
• 241000711510 Porcine transmissible gastroenteritis coronavirus strain Purdue Species 0.000 claims description 8
• 241000320410 Rat sialodacryoadenitis coronavirus Species 0.000 claims description 8
• 241000319442 SARS coronavirus BJ03 Species 0.000 claims description 8
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• 241000316209 SARS coronavirus Hong Kong/03/2003 Species 0.000 claims description 8
• 241000651110 SARS coronavirus Shanhgai LY Species 0.000 claims description 8
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