CA2527081C - All-mass ms/ms method and apparatus - Google Patents
All-mass ms/ms method and apparatus Download PDFInfo
- Publication number
- CA2527081C CA2527081C CA002527081A CA2527081A CA2527081C CA 2527081 C CA2527081 C CA 2527081C CA 002527081 A CA002527081 A CA 002527081A CA 2527081 A CA2527081 A CA 2527081A CA 2527081 C CA2527081 C CA 2527081C
- Authority
- CA
- Canada
- Prior art keywords
- ions
- mass
- trap
- charge ratio
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 54
- 150000002500 ions Chemical class 0.000 claims abstract description 419
- 239000012634 fragment Substances 0.000 claims abstract description 123
- 239000002243 precursor Substances 0.000 claims abstract description 111
- 238000005040 ion trap Methods 0.000 claims abstract description 37
- 230000005684 electric field Effects 0.000 claims abstract description 33
- 238000010494 dissociation reaction Methods 0.000 claims abstract description 24
- 230000005593 dissociations Effects 0.000 claims abstract description 24
- 230000001419 dependent effect Effects 0.000 claims abstract description 12
- 238000001819 mass spectrum Methods 0.000 claims abstract description 12
- 230000005672 electromagnetic field Effects 0.000 claims description 22
- 238000001514 detection method Methods 0.000 claims description 20
- 238000004949 mass spectrometry Methods 0.000 claims description 12
- 238000001360 collision-induced dissociation Methods 0.000 claims description 9
- 238000013459 approach Methods 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 230000000979 retarding effect Effects 0.000 claims description 2
- 230000010355 oscillation Effects 0.000 description 30
- 238000001228 spectrum Methods 0.000 description 26
- 238000004885 tandem mass spectrometry Methods 0.000 description 17
- 238000004458 analytical method Methods 0.000 description 11
- 238000000926 separation method Methods 0.000 description 11
- 238000010586 diagram Methods 0.000 description 9
- 238000006062 fragmentation reaction Methods 0.000 description 9
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 8
- 238000013467 fragmentation Methods 0.000 description 8
- 230000005284 excitation Effects 0.000 description 7
- 230000003595 spectral effect Effects 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000005686 electrostatic field Effects 0.000 description 4
- 230000005405 multipole Effects 0.000 description 4
- 238000002366 time-of-flight method Methods 0.000 description 4
- 230000001427 coherent effect Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000012491 analyte Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 230000004304 visual acuity Effects 0.000 description 2
- 101100314162 Candida albicans (strain SC5314 / ATCC MYA-2876) YBL053 gene Proteins 0.000 description 1
- 241000819038 Chichester Species 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 101000912440 Homo sapiens Fez family zinc finger protein 2 Proteins 0.000 description 1
- 101100154785 Mus musculus Tulp2 gene Proteins 0.000 description 1
- 101100370021 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TOF2 gene Proteins 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 229910001423 beryllium ion Inorganic materials 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000010265 fast atom bombardment Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000000976 ink Substances 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 238000010849 ion bombardment Methods 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000004812 paul trap Methods 0.000 description 1
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- 238000004611 spectroscopical analysis Methods 0.000 description 1
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- 101150044955 tof1 gene Proteins 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/4245—Electrostatic ion traps
- H01J49/425—Electrostatic ion traps with a logarithmic radial electric potential, e.g. orbitraps
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0312447.6 | 2003-05-30 | ||
| GB0312447A GB2402260B (en) | 2003-05-30 | 2003-05-30 | All mass MS/MS method and apparatus |
| PCT/GB2004/002289 WO2004107388A2 (en) | 2003-05-30 | 2004-05-28 | All-mass ms/ms method and apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2527081A1 CA2527081A1 (en) | 2004-12-09 |
| CA2527081C true CA2527081C (en) | 2009-12-22 |
Family
ID=9959050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002527081A Expired - Fee Related CA2527081C (en) | 2003-05-30 | 2004-05-28 | All-mass ms/ms method and apparatus |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7399962B2 (enExample) |
| EP (1) | EP1629519B1 (enExample) |
| JP (1) | JP4824545B2 (enExample) |
| CN (1) | CN100555554C (enExample) |
| AT (1) | ATE366992T1 (enExample) |
| CA (1) | CA2527081C (enExample) |
| DE (1) | DE602004007514T2 (enExample) |
| GB (1) | GB2402260B (enExample) |
| WO (1) | WO2004107388A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| GB2402260B (en) * | 2003-05-30 | 2006-05-24 | Thermo Finnigan Llc | All mass MS/MS method and apparatus |
| GB0312940D0 (en) * | 2003-06-05 | 2003-07-09 | Shimadzu Res Lab Europe Ltd | A method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis |
| WO2006103448A2 (en) * | 2005-03-29 | 2006-10-05 | Thermo Finnigan Llc | Improvements relating to a mass spectrometer |
| GB2427067B (en) * | 2005-03-29 | 2010-02-24 | Thermo Finnigan Llc | Improvements relating to ion trapping |
| GB0511083D0 (en) * | 2005-05-31 | 2005-07-06 | Thermo Finnigan Llc | Multiple ion injection in mass spectrometry |
| GB2434484B (en) | 2005-06-03 | 2010-11-03 | Thermo Finnigan Llc | Improvements in an electrostatic trap |
| GB0513047D0 (en) * | 2005-06-27 | 2005-08-03 | Thermo Finnigan Llc | Electronic ion trap |
| JP4830450B2 (ja) * | 2005-11-02 | 2011-12-07 | 株式会社島津製作所 | 質量分析装置 |
| GB2432712B (en) * | 2005-11-23 | 2007-12-27 | Micromass Ltd | Mass spectrometer |
| GB0523806D0 (en) * | 2005-11-23 | 2006-01-04 | Micromass Ltd | Mass spectrometer |
| GB0523811D0 (en) * | 2005-11-23 | 2006-01-04 | Micromass Ltd | Mass stectrometer |
| US20080173807A1 (en) * | 2006-04-11 | 2008-07-24 | Oh-Kyu Yoon | Fragmentation modulation mass spectrometry |
| JP4802032B2 (ja) * | 2006-04-14 | 2011-10-26 | 日本電子株式会社 | タンデム型質量分析装置 |
| DE102007024858B4 (de) * | 2007-04-12 | 2011-02-10 | Bruker Daltonik Gmbh | Massenspektrometer mit einer elektrostatischen Ionenfalle |
| DE102008024297B4 (de) * | 2008-05-20 | 2011-03-31 | Bruker Daltonik Gmbh | Fragmentierung von Ionen in Kingdon-Ionenfallen |
| GB0809950D0 (en) | 2008-05-30 | 2008-07-09 | Thermo Fisher Scient Bremen | Mass spectrometer |
| CN102077086B (zh) * | 2008-07-03 | 2013-06-05 | 株式会社岛津制作所 | 质量分析装置 |
| CN102413907B (zh) * | 2009-04-13 | 2015-06-17 | 萨莫芬尼根有限责任公司 | 质谱仪中混合的离子布居的获取与分析 |
| DE102009020886B4 (de) * | 2009-05-12 | 2012-08-30 | Bruker Daltonik Gmbh | Einspeichern von Ionen in Kíngdon-Ionenfallen |
| GB2480660B (en) * | 2010-05-27 | 2012-07-11 | Thermo Fisher Scient Bremen | Mass spectrometry detector system and method of detection |
| US9922812B2 (en) * | 2010-11-26 | 2018-03-20 | Thermo Fisher Scientific (Bremen) Gmbh | Method of mass separating ions and mass separator |
| GB2496994B (en) * | 2010-11-26 | 2015-05-20 | Thermo Fisher Scient Bremen | Method of mass separating ions and mass separator |
| GB2544920B (en) | 2011-05-12 | 2018-02-07 | Thermo Fisher Scient (Bremen) Gmbh | Electrostatic ion trapping with shielding conductor |
| GB2495068B (en) | 2011-05-12 | 2017-05-10 | Thermo Fisher Scient (Bremen) Gmbh | Mass analyser |
| GB201118279D0 (en) * | 2011-10-21 | 2011-12-07 | Shimadzu Corp | Mass analyser, mass spectrometer and associated methods |
| DE102012200211A1 (de) * | 2012-01-09 | 2013-07-11 | Carl Zeiss Nts Gmbh | Vorrichtung und Verfahren zur Oberflächenbearbeitung eines Substrates |
| CN103367094B (zh) * | 2012-03-31 | 2016-12-14 | 株式会社岛津制作所 | 离子阱分析器以及离子阱质谱分析方法 |
| US8796619B1 (en) * | 2013-06-11 | 2014-08-05 | Science And Engineering Services, Llc | Electrostatic orbital trap mass spectrometer |
| CN104538278B (zh) * | 2014-12-16 | 2017-01-04 | 中国科学院长春光学精密机械与物理研究所 | 一种离子迁移发生装置及其控制方法 |
| CN110718442B (zh) | 2015-01-23 | 2022-08-16 | 加州理工学院 | 整合的混合nems质谱测定法 |
| DE102015208188B4 (de) * | 2015-05-04 | 2025-05-22 | Leybold Gmbh | Verfahren zur massenspektrometrischen Untersuchung eines Gases |
| GB2549248B (en) | 2016-01-12 | 2020-07-22 | Thermo Fisher Scient Bremen Gmbh | IRMS sample introduction system and method |
| EP3193352A1 (en) * | 2016-01-14 | 2017-07-19 | Thermo Finnigan LLC | Methods for mass spectrometric based characterization of biological molecules |
| CN107026068A (zh) * | 2016-01-29 | 2017-08-08 | 北京普析通用仪器有限责任公司 | 电感耦合等离子体质谱仪及碰撞反应池 |
| US10192730B2 (en) | 2016-08-30 | 2019-01-29 | Thermo Finnigan Llc | Methods for operating electrostatic trap mass analyzers |
| GB2559395B (en) | 2017-02-03 | 2020-07-01 | Thermo Fisher Scient Bremen Gmbh | High resolution MS1 based quantification |
| EP3958290B1 (en) | 2017-06-02 | 2024-09-25 | Thermo Fisher Scientific (Bremen) GmbH | Hybrid mass spectrometer |
| KR102742962B1 (ko) * | 2018-11-20 | 2024-12-16 | 더 트러스티즈 오브 인디애나 유니버시티 | 단일 입자 질량 분석을 위한 오비트랩 |
| CN113748487B (zh) * | 2019-04-25 | 2024-09-03 | 萨默费尼根有限公司 | 利用谐波振荡和共振离子选择性时间概览（stori）图的电荷检测质谱法 |
| GB2584125B (en) * | 2019-05-22 | 2021-11-03 | Thermo Fisher Scient Bremen Gmbh | Dynamic control of accumulation time for chromatography mass spectrometry |
| CN110376272B (zh) * | 2019-06-12 | 2022-02-08 | 中国科学院微电子研究所 | 气体分压的在线测量装置及其在线测量方法 |
| CN114388339B (zh) * | 2021-11-30 | 2023-08-29 | 宁波大学 | 一种静电离子阱 |
| GB2618673B (en) | 2022-05-09 | 2024-11-06 | Thermo Fisher Scient Bremen Gmbh | Charge detection for ion accumulation control |
| CN116206944A (zh) * | 2023-04-21 | 2023-06-02 | 暨南大学 | 一种静电场轨道阱、畸变场调节装置以及调节方法 |
| WO2024245675A1 (en) | 2023-05-26 | 2024-12-05 | Thermo Fisher Scientific (Bremen) Gmbh | Method of operating a mass spectrometer including an ion trap |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2363364A1 (fr) * | 1976-09-07 | 1978-03-31 | Thomson Csf | Procede de separation isotopique et installation pour sa mise en oeuvre |
| FR2376511A1 (fr) * | 1976-12-31 | 1978-07-28 | Cameca | Spectrometre de masse a balayage ultra-rapide |
| JPH01213950A (ja) * | 1988-02-23 | 1989-08-28 | Jeol Ltd | 質量分析装置及びそれを用いたｍｓ／ｍｓ装置 |
| JP2523781B2 (ja) * | 1988-04-28 | 1996-08-14 | 日本電子株式会社 | 飛行時間型／偏向二重収束型切換質量分析装置 |
| US4978852A (en) * | 1988-09-08 | 1990-12-18 | Cornell Research Foundation, Inc. | Hadamard transform measurement of MSN Fourier-transform mass spectra |
| DE19501835C2 (de) * | 1995-01-21 | 1998-07-02 | Bruker Franzen Analytik Gmbh | Verfahren zur Anregung der Schwingungen von Ionen in Ionenfallen mit Frequenzgemischen |
| GB9506695D0 (en) * | 1995-03-31 | 1995-05-24 | Hd Technologies Limited | Improvements in or relating to a mass spectrometer |
| US5734162A (en) * | 1996-04-30 | 1998-03-31 | Hewlett Packard Company | Method and apparatus for selectively trapping ions into a quadrupole trap |
| US5905258A (en) * | 1997-06-02 | 1999-05-18 | Advanced Research & Techology Institute | Hybrid ion mobility and mass spectrometer |
| GB0107380D0 (en) | 2001-03-23 | 2001-05-16 | Thermo Masslab Ltd | Mass spectrometry method and apparatus |
| GB2404784B (en) * | 2001-03-23 | 2005-06-22 | Thermo Finnigan Llc | Mass spectrometry method and apparatus |
| JP3653504B2 (ja) * | 2002-02-12 | 2005-05-25 | 株式会社日立ハイテクノロジーズ | イオントラップ型質量分析装置 |
| US7049580B2 (en) * | 2002-04-05 | 2006-05-23 | Mds Inc. | Fragmentation of ions by resonant excitation in a high order multipole field, low pressure ion trap |
| US6888130B1 (en) * | 2002-05-30 | 2005-05-03 | Marc Gonin | Electrostatic ion trap mass spectrometers |
| GB2402260B (en) * | 2003-05-30 | 2006-05-24 | Thermo Finnigan Llc | All mass MS/MS method and apparatus |
| JP4223937B2 (ja) * | 2003-12-16 | 2009-02-12 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| US6956217B2 (en) * | 2004-02-10 | 2005-10-18 | Archimedes Operating, Llc | Mass separator with controlled input |
| JP4275545B2 (ja) * | 2004-02-17 | 2009-06-10 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| EP1749307A4 (en) * | 2004-05-24 | 2010-09-22 | Mds Inc Dba Mds Sciex | SYSTEM AND METHOD FOR MOUNTING IONS |
| US7439520B2 (en) * | 2005-01-24 | 2008-10-21 | Applied Biosystems Inc. | Ion optics systems |
| US7351960B2 (en) * | 2005-05-16 | 2008-04-01 | Thermo Finnigan Llc | Enhanced ion desolvation for an ion mobility spectrometry device |
| GB2434484B (en) * | 2005-06-03 | 2010-11-03 | Thermo Finnigan Llc | Improvements in an electrostatic trap |
-
2003
- 2003-05-30 GB GB0312447A patent/GB2402260B/en not_active Expired - Fee Related
-
2004
- 2004-05-28 US US10/558,184 patent/US7399962B2/en not_active Expired - Lifetime
- 2004-05-28 DE DE602004007514T patent/DE602004007514T2/de not_active Expired - Lifetime
- 2004-05-28 CA CA002527081A patent/CA2527081C/en not_active Expired - Fee Related
- 2004-05-28 CN CNB2004800148183A patent/CN100555554C/zh not_active Expired - Fee Related
- 2004-05-28 JP JP2006508377A patent/JP4824545B2/ja not_active Expired - Fee Related
- 2004-05-28 AT AT04735258T patent/ATE366992T1/de not_active IP Right Cessation
- 2004-05-28 EP EP04735258A patent/EP1629519B1/en not_active Expired - Lifetime
- 2004-05-28 WO PCT/GB2004/002289 patent/WO2004107388A2/en not_active Ceased
-
2008
- 2008-07-01 US US12/166,296 patent/US7728290B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004107388A2 (en) | 2004-12-09 |
| GB2402260A (en) | 2004-12-01 |
| DE602004007514D1 (de) | 2007-08-23 |
| CN100555554C (zh) | 2009-10-28 |
| EP1629519B1 (en) | 2007-07-11 |
| EP1629519A2 (en) | 2006-03-01 |
| DE602004007514T2 (de) | 2008-03-06 |
| JP2006526265A (ja) | 2006-11-16 |
| US20080258053A1 (en) | 2008-10-23 |
| JP4824545B2 (ja) | 2011-11-30 |
| GB0312447D0 (en) | 2003-07-09 |
| US7728290B2 (en) | 2010-06-01 |
| US7399962B2 (en) | 2008-07-15 |
| US20070023629A1 (en) | 2007-02-01 |
| ATE366992T1 (de) | 2007-08-15 |
| CN1799119A (zh) | 2006-07-05 |
| WO2004107388A3 (en) | 2005-04-07 |
| CA2527081A1 (en) | 2004-12-09 |
| GB2402260B (en) | 2006-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200831 |