CA2515298C - Modified free-living microbes, vaccine compositions and methods of use thereof - Google Patents

Modified free-living microbes, vaccine compositions and methods of use thereof Download PDF

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Publication number
CA2515298C
CA2515298C CA2515298A CA2515298A CA2515298C CA 2515298 C CA2515298 C CA 2515298C CA 2515298 A CA2515298 A CA 2515298A CA 2515298 A CA2515298 A CA 2515298A CA 2515298 C CA2515298 C CA 2515298C
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Canada
Prior art keywords
antigen
nucleic acid
microbe
listeria
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2515298A
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English (en)
French (fr)
Other versions
CA2515298A1 (en
Inventor
Thomas W. Dubensky, Jr.
Dirk G. Brockstedt
Keith Bahjat
John E. Hearst
David Cook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinook Therapeutics Inc
Original Assignee
Aduro Biotech Inc
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Publication of CA2515298A1 publication Critical patent/CA2515298A1/en
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Publication of CA2515298C publication Critical patent/CA2515298C/en
Anticipated expiration legal-status Critical
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0011Cancer antigens
    • A61K39/001148Regulators of development
    • A61K39/00115Apoptosis related proteins, e.g. survivin or livin
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    • A61K39/001166Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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    • A61K40/42Cancer antigens
    • A61K40/4264Cancer antigens from embryonic or fetal origin
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    • A61K40/46Viral antigens
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • A61P37/08Antiallergic agents
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
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    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • AHUMAN NECESSITIES
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Oncology (AREA)
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  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2515298A 2003-02-06 2004-02-06 Modified free-living microbes, vaccine compositions and methods of use thereof Expired - Fee Related CA2515298C (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US44605103P 2003-02-06 2003-02-06
US60/446,051 2003-02-06
US44915303P 2003-02-21 2003-02-21
US60/449,153 2003-02-21
US49008903P 2003-07-24 2003-07-24
US60/490,089 2003-07-24
US51186903P 2003-10-15 2003-10-15
US60/511,869 2003-10-15
US54151504P 2004-02-02 2004-02-02
US60/541,515 2004-02-02
PCT/US2004/003671 WO2004084936A2 (en) 2003-02-06 2004-02-06 Modified free-living microbes, vaccine compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
CA2515298A1 CA2515298A1 (en) 2004-10-07
CA2515298C true CA2515298C (en) 2014-04-08

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CA2515298A Expired - Fee Related CA2515298C (en) 2003-02-06 2004-02-06 Modified free-living microbes, vaccine compositions and methods of use thereof

Country Status (8)

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US (1) US7833775B2 (enExample)
EP (1) EP1592442A2 (enExample)
JP (2) JP4839209B2 (enExample)
KR (1) KR101173871B1 (enExample)
AU (2) AU2004224425B2 (enExample)
CA (1) CA2515298C (enExample)
MX (1) MXPA05008340A (enExample)
WO (1) WO2004084936A2 (enExample)

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CA2515298A1 (en) 2004-10-07
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US20040197343A1 (en) 2004-10-07
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AU2004224425B2 (en) 2010-06-24
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AU2004224425A1 (en) 2004-10-07
WO2004084936A8 (en) 2004-12-16
JP2007131639A (ja) 2007-05-31
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WO2004084936A3 (en) 2005-06-16
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