CA2501984C - Anticorps se liant au recepteur de l'erythropoietine - Google Patents

Anticorps se liant au recepteur de l'erythropoietine Download PDF

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Publication number
CA2501984C
CA2501984C CA2501984A CA2501984A CA2501984C CA 2501984 C CA2501984 C CA 2501984C CA 2501984 A CA2501984 A CA 2501984A CA 2501984 A CA2501984 A CA 2501984A CA 2501984 C CA2501984 C CA 2501984C
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CA
Canada
Prior art keywords
ser
leu
gly
val
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2501984A
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English (en)
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CA2501984A1 (fr
Inventor
Peter J. Devries
Larry L. Green
David H. Ostrow
Edward B. Reilly
James Wieler
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Abbott Laboratories
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Abbott Laboratories
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Filing date
Publication date
Priority claimed from US10/269,711 external-priority patent/US20040071694A1/en
Priority claimed from US10/684,109 external-priority patent/US7396913B2/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2501984A1 publication Critical patent/CA2501984A1/fr
Application granted granted Critical
Publication of CA2501984C publication Critical patent/CA2501984C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des anticorps et leurs fragments, qui se lient à et activent un récepteur de l'erythropoïétine. Elle concerne également des procédés mettant en oeuvre ces anticorps pour moduler l'activité endogène d'un récepteur de l'erythropoïétine chez un mammifère; et des compositions pharmaceutiques contenant lesdits anticorps.
CA2501984A 2002-10-14 2003-10-14 Anticorps se liant au recepteur de l'erythropoietine Expired - Fee Related CA2501984C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/269,711 US20040071694A1 (en) 2002-10-14 2002-10-14 Erythropoietin receptor binding antibodies
US10/269,711 2002-10-14
US10/684,109 2003-10-10
US10/684,109 US7396913B2 (en) 2002-10-14 2003-10-10 Erythropoietin receptor binding antibodies
PCT/US2003/032243 WO2004035603A2 (fr) 2002-10-14 2003-10-14 Anticorps se liant au recepteur de l'erythropoietine

Publications (2)

Publication Number Publication Date
CA2501984A1 CA2501984A1 (fr) 2004-04-29
CA2501984C true CA2501984C (fr) 2011-04-26

Family

ID=32109805

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2501984A Expired - Fee Related CA2501984C (fr) 2002-10-14 2003-10-14 Anticorps se liant au recepteur de l'erythropoietine

Country Status (13)

Country Link
EP (1) EP1578779A4 (fr)
JP (2) JP4411472B2 (fr)
KR (1) KR20050059263A (fr)
CN (1) CN103524618A (fr)
AU (2) AU2003282588B2 (fr)
BR (1) BR0315275A (fr)
CA (1) CA2501984C (fr)
MX (1) MXPA05003997A (fr)
NZ (1) NZ539263A (fr)
PL (1) PL379985A1 (fr)
TW (1) TWI320716B (fr)
WO (1) WO2004035603A2 (fr)
ZA (1) ZA201004902B (fr)

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Also Published As

Publication number Publication date
PL379985A1 (pl) 2006-11-27
WO2004035603A3 (fr) 2006-04-27
CN103524618A (zh) 2014-01-22
TW200418505A (en) 2004-10-01
CA2501984A1 (fr) 2004-04-29
MXPA05003997A (es) 2005-06-22
NZ539263A (en) 2009-07-31
AU2003282588B2 (en) 2010-06-03
KR20050059263A (ko) 2005-06-17
TWI320716B (en) 2010-02-21
WO2004035603A2 (fr) 2004-04-29
EP1578779A4 (fr) 2011-11-16
EP1578779A2 (fr) 2005-09-28
JP4411472B2 (ja) 2010-02-10
AU2003282588A1 (en) 2004-05-04
ZA201004902B (en) 2012-06-27
JP2009149665A (ja) 2009-07-09
JP2006523083A (ja) 2006-10-12
BR0315275A (pt) 2005-08-30
AU2010214778A1 (en) 2010-09-23

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