CA2491994C - Modulateurs du recepteur glucocorticoide - Google Patents

Modulateurs du recepteur glucocorticoide Download PDF

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CA2491994C
CA2491994C CA2491994A CA2491994A CA2491994C CA 2491994 C CA2491994 C CA 2491994C CA 2491994 A CA2491994 A CA 2491994A CA 2491994 A CA2491994 A CA 2491994A CA 2491994 C CA2491994 C CA 2491994C
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alkyl
heteroaryl
aryl
compounds
heterocyclic
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CA2491994A1 (fr
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Yves Andre Chantigny
Edward Fox Kleinman
Ralph Pelton Robinson, Jr.
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Pfizer Products Inc
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Pfizer Products Inc
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
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  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention porte sur composés de formule (I) dans laquelle: A est la formule (II), (III) où (IV) et X, Y, n, R?1¿-R?25¿ sont tels que définis dans la spécification. Lesdits composés sont des modulateurs du récepteur glucocorticoïde, et s'avèrent de ce fait utiles pour le traitement d'animaux requérant une thérapie par un agoniste du récepteur glucocorticoïde, et pour le traitement de certains troubles inflammatoires.
CA2491994A 2002-07-08 2003-06-25 Modulateurs du recepteur glucocorticoide Expired - Fee Related CA2491994C (fr)

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US39442502P 2002-07-08 2002-07-08
US60/394,425 2002-07-08
PCT/IB2003/002941 WO2004005229A1 (fr) 2002-07-08 2003-06-25 Modulateurs du recepteur glucocorticoide

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CA2491994A1 CA2491994A1 (fr) 2004-01-15
CA2491994C true CA2491994C (fr) 2013-11-05

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HN (1) HN2003000207A (fr)
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SI (1) SI1521733T1 (fr)
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US7138406B2 (en) 2006-11-21
JP2005532389A (ja) 2005-10-27
MXPA05000345A (es) 2005-03-31
PE20040650A1 (es) 2004-09-18
DK1521733T3 (da) 2014-10-13
TW200628440A (en) 2006-08-16
EP1521733B1 (fr) 2014-08-20
US7553877B2 (en) 2009-06-30
AU2003281355A1 (en) 2004-01-23
PT1521733E (pt) 2014-10-29
JP4503436B2 (ja) 2010-07-14
US20040138262A1 (en) 2004-07-15
US20060247264A1 (en) 2006-11-02
BR0312575A (pt) 2005-05-03
UY27884A1 (es) 2004-02-27
TW200409749A (en) 2004-06-16
MY135333A (en) 2008-03-31
PA8576901A1 (es) 2004-03-10
WO2004005229A1 (fr) 2004-01-15
GT200300138A (es) 2004-03-24
EP1521733A1 (fr) 2005-04-13
CA2491994A1 (fr) 2004-01-15
TWI336323B (en) 2011-01-21
HN2003000207A (es) 2004-07-27
AR041186A1 (es) 2005-05-04

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