CA2491994C - Modulateurs du recepteur glucocorticoide - Google Patents
Modulateurs du recepteur glucocorticoide Download PDFInfo
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- CA2491994C CA2491994C CA2491994A CA2491994A CA2491994C CA 2491994 C CA2491994 C CA 2491994C CA 2491994 A CA2491994 A CA 2491994A CA 2491994 A CA2491994 A CA 2491994A CA 2491994 C CA2491994 C CA 2491994C
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- Prior art keywords
- alkyl
- heteroaryl
- aryl
- compounds
- heterocyclic
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
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- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
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- C07C271/52—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C35/42—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings derived from the phenanthrene skeleton
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- C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
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- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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- Steroid Compounds (AREA)
Abstract
L'invention porte sur composés de formule (I) dans laquelle: A est la formule (II), (III) où (IV) et X, Y, n, R?1¿-R?25¿ sont tels que définis dans la spécification. Lesdits composés sont des modulateurs du récepteur glucocorticoïde, et s'avèrent de ce fait utiles pour le traitement d'animaux requérant une thérapie par un agoniste du récepteur glucocorticoïde, et pour le traitement de certains troubles inflammatoires.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39442502P | 2002-07-08 | 2002-07-08 | |
US60/394,425 | 2002-07-08 | ||
PCT/IB2003/002941 WO2004005229A1 (fr) | 2002-07-08 | 2003-06-25 | Modulateurs du recepteur glucocorticoide |
Publications (2)
Publication Number | Publication Date |
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CA2491994A1 CA2491994A1 (fr) | 2004-01-15 |
CA2491994C true CA2491994C (fr) | 2013-11-05 |
Family
ID=30115721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2491994A Expired - Fee Related CA2491994C (fr) | 2002-07-08 | 2003-06-25 | Modulateurs du recepteur glucocorticoide |
Country Status (20)
Country | Link |
---|---|
US (2) | US7138406B2 (fr) |
EP (1) | EP1521733B1 (fr) |
JP (1) | JP4503436B2 (fr) |
AR (1) | AR041186A1 (fr) |
AU (1) | AU2003281355A1 (fr) |
BR (1) | BR0312575A (fr) |
CA (1) | CA2491994C (fr) |
DK (1) | DK1521733T3 (fr) |
ES (1) | ES2518940T3 (fr) |
GT (1) | GT200300138A (fr) |
HN (1) | HN2003000207A (fr) |
MX (1) | MXPA05000345A (fr) |
MY (1) | MY135333A (fr) |
PA (1) | PA8576901A1 (fr) |
PE (1) | PE20040650A1 (fr) |
PT (1) | PT1521733E (fr) |
SI (1) | SI1521733T1 (fr) |
TW (2) | TWI336323B (fr) |
UY (1) | UY27884A1 (fr) |
WO (1) | WO2004005229A1 (fr) |
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EP3710006A4 (fr) | 2017-11-19 | 2021-09-01 | Sunshine Lake Pharma Co., Ltd. | Composés hétéroaryle substitués et leurs méthodes d'utilisation |
US10751339B2 (en) | 2018-01-20 | 2020-08-25 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine compounds and methods of use |
US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
US20200383960A1 (en) | 2019-06-10 | 2020-12-10 | Novartis Ag | Pyridine and Pyrazine derivative for the Treatment of CF, COPD, and Bronchiectasis |
JP2022547427A (ja) | 2019-08-28 | 2022-11-14 | ノバルティス アーゲー | 置換1,3-フェニルヘテロアリール誘導体及び疾患の治療におけるその使用 |
US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
EP4125919A1 (fr) | 2020-03-26 | 2023-02-08 | GlaxoSmithKline Intellectual Property Development Limited | Inhibiteurs de cathepsine pour la prévention ou le traitement d'infections virales |
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MXPA01011018A (es) * | 1999-04-30 | 2002-05-06 | Pfizer Prod Inc | Moduladores del receptor glucocorticoide. |
CO5271670A1 (es) * | 1999-10-29 | 2003-04-30 | Pfizer Prod Inc | Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas |
IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
JP2002193911A (ja) * | 2000-10-28 | 2002-07-10 | Pfizer Prod Inc | グルココルチコイドレセプターモジュレーター |
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2003
- 2003-06-25 EP EP03740911.7A patent/EP1521733B1/fr not_active Expired - Lifetime
- 2003-06-25 JP JP2004519100A patent/JP4503436B2/ja not_active Expired - Fee Related
- 2003-06-25 SI SI200332380T patent/SI1521733T1/sl unknown
- 2003-06-25 AU AU2003281355A patent/AU2003281355A1/en not_active Abandoned
- 2003-06-25 ES ES03740911.7T patent/ES2518940T3/es not_active Expired - Lifetime
- 2003-06-25 DK DK03740911.7T patent/DK1521733T3/da active
- 2003-06-25 PT PT37409117T patent/PT1521733E/pt unknown
- 2003-06-25 MX MXPA05000345A patent/MXPA05000345A/es active IP Right Grant
- 2003-06-25 CA CA2491994A patent/CA2491994C/fr not_active Expired - Fee Related
- 2003-06-25 BR BR0312575-0A patent/BR0312575A/pt not_active IP Right Cessation
- 2003-06-25 WO PCT/IB2003/002941 patent/WO2004005229A1/fr active Application Filing
- 2003-07-04 PE PE2003000681A patent/PE20040650A1/es not_active Application Discontinuation
- 2003-07-04 PA PA20038576901A patent/PA8576901A1/es unknown
- 2003-07-07 AR ARP030102442A patent/AR041186A1/es unknown
- 2003-07-07 HN HN2003000207A patent/HN2003000207A/es unknown
- 2003-07-07 UY UY27884A patent/UY27884A1/es not_active Application Discontinuation
- 2003-07-07 TW TW092118479A patent/TWI336323B/zh not_active IP Right Cessation
- 2003-07-07 GT GT200300138A patent/GT200300138A/es unknown
- 2003-07-07 TW TW095116787A patent/TWI340738B/zh not_active IP Right Cessation
- 2003-07-08 US US10/615,126 patent/US7138406B2/en not_active Expired - Lifetime
- 2003-07-08 MY MYPI20032555A patent/MY135333A/en unknown
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2006
- 2006-07-13 US US11/457,323 patent/US7553877B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
SI1521733T1 (sl) | 2014-10-30 |
ES2518940T3 (es) | 2014-11-06 |
TWI340738B (en) | 2011-04-21 |
US7138406B2 (en) | 2006-11-21 |
JP2005532389A (ja) | 2005-10-27 |
MXPA05000345A (es) | 2005-03-31 |
PE20040650A1 (es) | 2004-09-18 |
DK1521733T3 (da) | 2014-10-13 |
TW200628440A (en) | 2006-08-16 |
EP1521733B1 (fr) | 2014-08-20 |
US7553877B2 (en) | 2009-06-30 |
AU2003281355A1 (en) | 2004-01-23 |
PT1521733E (pt) | 2014-10-29 |
JP4503436B2 (ja) | 2010-07-14 |
US20040138262A1 (en) | 2004-07-15 |
US20060247264A1 (en) | 2006-11-02 |
BR0312575A (pt) | 2005-05-03 |
UY27884A1 (es) | 2004-02-27 |
TW200409749A (en) | 2004-06-16 |
MY135333A (en) | 2008-03-31 |
PA8576901A1 (es) | 2004-03-10 |
WO2004005229A1 (fr) | 2004-01-15 |
GT200300138A (es) | 2004-03-24 |
EP1521733A1 (fr) | 2005-04-13 |
CA2491994A1 (fr) | 2004-01-15 |
TWI336323B (en) | 2011-01-21 |
HN2003000207A (es) | 2004-07-27 |
AR041186A1 (es) | 2005-05-04 |
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