CA2481322A1 - Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine - Google Patents

Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine Download PDF

Info

Publication number
CA2481322A1
CA2481322A1 CA002481322A CA2481322A CA2481322A1 CA 2481322 A1 CA2481322 A1 CA 2481322A1 CA 002481322 A CA002481322 A CA 002481322A CA 2481322 A CA2481322 A CA 2481322A CA 2481322 A1 CA2481322 A1 CA 2481322A1
Authority
CA
Canada
Prior art keywords
isopropylcyclohexylcarbonyl
trans
phenylalanine
methyl ester
phenylalanine methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002481322A
Other languages
English (en)
French (fr)
Inventor
Shanmughasamy Rajamahendra
Chandrashekar Aswathanarayanappa
Tom Thomas Puthiaparampil
Madhavan Sridharan
Sambasivam Ganesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocon Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2481322A1 publication Critical patent/CA2481322A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002481322A 2002-04-29 2002-04-29 Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine Abandoned CA2481322A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2002/000114 WO2003093222A1 (en) 2002-04-29 2002-04-29 Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine

Publications (1)

Publication Number Publication Date
CA2481322A1 true CA2481322A1 (en) 2003-11-13

Family

ID=29287383

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002481322A Abandoned CA2481322A1 (en) 2002-04-29 2002-04-29 Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine

Country Status (13)

Country Link
US (1) US7314955B2 (https=)
EP (1) EP1499586A4 (https=)
JP (1) JP4137053B2 (https=)
KR (1) KR20040111490A (https=)
AU (1) AU2002304281A1 (https=)
CA (1) CA2481322A1 (https=)
CZ (1) CZ2004997A3 (https=)
HR (1) HRP20040920A2 (https=)
HU (1) HUP0500259A2 (https=)
IL (1) IL164327A0 (https=)
MX (1) MXNL04000084A (https=)
SK (1) SK287644B6 (https=)
WO (1) WO2003093222A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040111490A (ko) 2002-04-29 2004-12-31 바이오콘 리미티드 새로운 형태의 ｎ－（트랜스－4－이소프로필사이클로헥실카보닐）－ｄ－페닐알라닌
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7420084B2 (en) 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US20040077725A1 (en) * 2002-08-28 2004-04-22 Dr. Reddy's Laboratories Limited Crystalline form of N-(trans-4-isopropylcyclohexane carbonyl)-D-phenylalanine and process for preparation thereof
EP1616886A4 (en) * 2003-02-18 2006-06-14 Konishi Co Ltd CURABLE RESIN, PROCESS FOR PRODUCING THE SAME, AND CURABLE RESIN COMPOSITION
HU227073B1 (hu) * 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
US20070231393A1 (en) * 2004-05-19 2007-10-04 University Of South Carolina System and Device for Magnetic Drug Targeting with Magnetic Drug Carrier Particles
GB0413084D0 (en) * 2004-06-11 2004-07-14 Cipla Ltd Process
US20100004334A1 (en) * 2008-07-01 2010-01-07 Mead Johnson Nutrition Company Nutritional Compositions Containing Punicalagins
US11390830B2 (en) 2018-10-05 2022-07-19 The Chemours Company Fc, Llc Compositions comprising 1,2-dichloro-1,2-difluoroethylene for use in cleaning and solvent applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤
US4814684A (en) * 1987-09-30 1989-03-21 Trw Inc. Apparatus for extending the Vout/Vin ratio of a DC-to-DC converter
DE10199058I2 (de) * 1991-07-30 2006-04-27 Alcm Co Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
US5463116A (en) * 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
KR20040111490A (ko) 2002-04-29 2004-12-31 바이오콘 리미티드 새로운 형태의 ｎ－（트랜스－4－이소프로필사이클로헥실카보닐）－ｄ－페닐알라닌

Also Published As

Publication number Publication date
KR20040111490A (ko) 2004-12-31
CZ2004997A3 (cs) 2005-01-12
HRP20040920A2 (en) 2005-02-28
EP1499586A4 (en) 2006-01-18
WO2003093222A1 (en) 2003-11-13
US7314955B2 (en) 2008-01-01
MXNL04000084A (es) 2006-02-28
IL164327A0 (en) 2005-12-18
SK287644B6 (sk) 2011-05-06
AU2002304281A1 (en) 2003-11-17
US20050165108A1 (en) 2005-07-28
HUP0500259A2 (hu) 2005-06-28
SK50052004A3 (sk) 2005-03-04
JP4137053B2 (ja) 2008-08-20
EP1499586A1 (en) 2005-01-26
JP2005523933A (ja) 2005-08-11

Similar Documents

Publication Publication Date Title
US7314955B2 (en) Form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine
DE602004013405T2 (de) Polymorphe formen von valsartan
CA2191647C (en) Process improvement in the synthesis of n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide
WO2009132593A1 (zh) 喹啉类化合物及其药物组合物、制备方法和应用
CN1041933C (zh) 克拉维酸的二胺盐及其制备方法和用途
WO2023143158A1 (zh) 苯酚衍生物、及其晶型与制备方法
JPH02306947A (ja) キラルβ―アミノ酸の製造方法
JPS6253966A (ja) 新規ピリジン誘導体
JPH03193799A (ja) ３―（ｌ―ピログルタミル）―ｌ―チアゾリジン―４―カルボン酸およびその誘導体の製造方法
KR100224330B1 (ko) 골관절 질환의 치료에 유용한 n-((4,5-디히드록시-및 4,5,8-트리히드록시-9,10-디히드로-9,10-디옥소-2-안트라센-일)카르보닐)아미노산
TWI777079B (zh) 稠合三環γ-胺基酸衍生物的製備方法及其中間體
CN100383121C (zh) 阿韦苄酯化合物及其制备方法和以该化合物制备阿韦莫哌的工艺
KR100990046B1 (ko) 신규한 몬테루카스트 4-할로 벤질아민염 및 이를 이용한 몬테루카스트 나트륨염의 제조방법
CN103044356A (zh) 合成左西替利嗪的新方法及其关键中间体
AU615026B2 (en) Crystalline beta-lactam solvate
HU185941B (en) Process for optical separating mixture of d- and l-bracket-6-methoxy-2-naphtyl-bracket closed-propionic acids
RU2324676C2 (ru) Кристаллический n-(транс-4-изопропилциклогексилкарбонил)-d-фенилаланин формы с для лечения сахарного диабета типа 2 и способ его получения
WO2005068425A1 (en) New crystalline form of perindopril
JP2002540108A (ja) ［Ｓ−（Ｒ＊，Ｓ＊）］−β−［［［１−［１−オキソ−３−（４−ピペリジニル）プロピル］−３−ピペリジニル］カルボニル］アミノ］−３−ピリジンプロパン酸及び誘導体を製造する方法
KR20150066777A (ko) 광학활성 인돌린 유도체 및 이의 제조방법
KR101469015B1 (ko) 몬테루카스트의 제조방법 및 이에 사용되는 중간체
WO2021109883A1 (zh) 用于制备奥贝胆酸的方法
JP2002540101A (ja) プロピオン酸３−アミノ−３−アリールの合成
EP1709001A2 (en) Solid forms of montelukast acid
KR100829894B1 (ko) 디메크로트산 및 그의 마그네슘염의 제조방법

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued