CA2469364C - Methods and systems for preparing blood products - Google Patents
Methods and systems for preparing blood products Download PDFInfo
- Publication number
- CA2469364C CA2469364C CA2469364A CA2469364A CA2469364C CA 2469364 C CA2469364 C CA 2469364C CA 2469364 A CA2469364 A CA 2469364A CA 2469364 A CA2469364 A CA 2469364A CA 2469364 C CA2469364 C CA 2469364C
- Authority
- CA
- Canada
- Prior art keywords
- container
- blood component
- blood
- plasma
- platelets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 57
- 239000010836 blood and blood product Substances 0.000 title claims abstract description 22
- 229940125691 blood product Drugs 0.000 title claims abstract description 22
- 244000052769 pathogen Species 0.000 claims abstract description 54
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 49
- 230000002779 inactivation Effects 0.000 claims abstract description 45
- 239000012503 blood component Substances 0.000 claims abstract description 44
- 238000011282 treatment Methods 0.000 claims abstract description 19
- 210000001772 blood platelet Anatomy 0.000 claims description 119
- 238000002617 apheresis Methods 0.000 claims description 27
- 210000003743 erythrocyte Anatomy 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 17
- 239000012530 fluid Substances 0.000 claims description 17
- 239000000306 component Substances 0.000 claims description 13
- 238000000926 separation method Methods 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 8
- 238000012546 transfer Methods 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 description 77
- 238000003860 storage Methods 0.000 description 54
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- 238000012545 processing Methods 0.000 description 11
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N furocoumarin Natural products C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 10
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 10
- 238000011287 therapeutic dose Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- -1 photoactivated psoralen compound Chemical class 0.000 description 9
- 239000001509 sodium citrate Substances 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 7
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 7
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 235000017281 sodium acetate Nutrition 0.000 description 6
- 239000001632 sodium acetate Substances 0.000 description 6
- 229910000162 sodium phosphate Inorganic materials 0.000 description 6
- 239000001488 sodium phosphate Substances 0.000 description 6
- 235000011008 sodium phosphates Nutrition 0.000 description 6
- 239000003634 thrombocyte concentrate Substances 0.000 description 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 5
- 230000000415 inactivating effect Effects 0.000 description 5
- 239000012815 thermoplastic material Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 3
- 229930024421 Adenine Natural products 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 229920012485 Plasticized Polyvinyl chloride Polymers 0.000 description 3
- 229960000643 adenine Drugs 0.000 description 3
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical group ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 3
- 239000008121 dextrose Substances 0.000 description 3
- 229910000397 disodium phosphate Inorganic materials 0.000 description 3
- 235000019800 disodium phosphate Nutrition 0.000 description 3
- 238000005304 joining Methods 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 230000002186 photoactivation Effects 0.000 description 3
- 239000004800 polyvinyl chloride Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 235000011083 sodium citrates Nutrition 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000010894 electron beam technology Methods 0.000 description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000012533 medium component Substances 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- 229940021317 other blood product in atc Drugs 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000008279 sol Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229920001862 ultra low molecular weight polyethylene Polymers 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 1
- 229920002633 Kraton (polymer) Polymers 0.000 description 1
- VAYOSLLFUXYJDT-RDTXWAMCSA-N Lysergic acid diethylamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N(CC)CC)C2)=C3C2=CNC3=C1 VAYOSLLFUXYJDT-RDTXWAMCSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000012611 container material Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- IPZJQDSFZGZEOY-UHFFFAOYSA-N dimethylmethylene Chemical group C[C]C IPZJQDSFZGZEOY-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000012953 feeding on blood of other organism Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 150000002790 naphthalenes Chemical class 0.000 description 1
- 150000004780 naphthols Chemical class 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical class N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- AYRVGWHSXIMRAB-UHFFFAOYSA-M sodium acetate trihydrate Chemical compound O.O.O.[Na+].CC([O-])=O AYRVGWHSXIMRAB-UHFFFAOYSA-M 0.000 description 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- DCTZJRUXIXPDJP-UHFFFAOYSA-N trihexyl 2-hydroxy-4-oxoheptane-1,2,3-tricarboxylate Chemical compound CCCCCCOC(=O)CC(O)(C(=O)OCCCCCC)C(C(=O)CCC)C(=O)OCCCCCC DCTZJRUXIXPDJP-UHFFFAOYSA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/004,696 US6936413B1 (en) | 2001-12-05 | 2001-12-05 | Methods and systems for preparing blood products |
| US10/004,696 | 2001-12-05 | ||
| PCT/US2002/037554 WO2003049634A1 (en) | 2001-12-05 | 2002-11-22 | Methods and systems for preparing blood products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2469364A1 CA2469364A1 (en) | 2003-06-19 |
| CA2469364C true CA2469364C (en) | 2013-04-09 |
Family
ID=21712067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2469364A Expired - Lifetime CA2469364C (en) | 2001-12-05 | 2002-11-22 | Methods and systems for preparing blood products |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6936413B1 (enExample) |
| EP (1) | EP1450716B1 (enExample) |
| JP (1) | JP2005511197A (enExample) |
| KR (1) | KR20050044689A (enExample) |
| CN (1) | CN100500231C (enExample) |
| AU (2) | AU2002352877B2 (enExample) |
| CA (1) | CA2469364C (enExample) |
| MX (1) | MXPA04005457A (enExample) |
| WO (1) | WO2003049634A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6936413B1 (en) * | 2001-12-05 | 2005-08-30 | Baxter International Inc. | Methods and systems for preparing blood products |
| EP2208502B1 (en) * | 2001-12-10 | 2019-05-08 | Terumo BCT, Inc. | Disposable assembly for an apheresis system |
| JP2005523337A (ja) * | 2002-04-24 | 2005-08-04 | ガンブロ インコーポレーテッド | 病原体が減少する血液および血液構成成分のプロセスの間でのアデニンの除去 |
| KR100765249B1 (ko) * | 2006-03-23 | 2007-10-09 | 송영완 | 농축혈소판 겔 형성 트레이 |
| US20070243608A1 (en) * | 2006-04-14 | 2007-10-18 | Board Of Regents, The University Of Texas System | Platelet bioreactor |
| US8835104B2 (en) * | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
| US8968992B2 (en) * | 2008-03-21 | 2015-03-03 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US8871434B2 (en) * | 2008-03-21 | 2014-10-28 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| WO2011049709A1 (en) | 2009-10-23 | 2011-04-28 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
| US9164079B2 (en) * | 2011-03-17 | 2015-10-20 | Greyledge Technologies Llc | Systems for autologous biological therapeutics |
| WO2012139017A1 (en) | 2011-04-07 | 2012-10-11 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
| EP2704760B1 (en) * | 2011-05-03 | 2017-09-20 | Fenwal, Inc. | Platelet resuspension method and apparatus |
| US20140086892A1 (en) * | 2011-09-19 | 2014-03-27 | FENWAL, INC. a Delaware Corporation | Red blood cell products and the storage of red blood cells in non-pvc containers |
| CN103028154B (zh) * | 2011-12-14 | 2015-10-07 | 南京双威生物医学科技有限公司 | 一种血小板分离袋及手工分离血小板的方法 |
| WO2014051537A1 (en) * | 2012-09-25 | 2014-04-03 | Biovec Transfusion, Llc | Device and method for removing additives in the blood products |
| US10098813B2 (en) * | 2014-09-03 | 2018-10-16 | Sun Pharmaceutical Industries Limited | Perfusion dosage form |
| AU2016283389B2 (en) | 2015-06-26 | 2022-09-15 | Cerus Corporation | Cryoprecipitate compositions and methods of preparation thereof |
| CA3003097A1 (en) | 2015-10-23 | 2017-04-27 | Cerus Corporation | Plasma compositions and methods of use thereof |
| EP3399986B1 (en) * | 2016-01-07 | 2023-02-22 | Cerus Corporation | Systems and methods for preparation of platelets |
| CN109069342A (zh) | 2016-02-09 | 2018-12-21 | 太阳医药工业有限公司 | 灌注系统 |
| EP3300748B1 (en) * | 2016-09-21 | 2021-11-03 | Fenwal, Inc. | Disposable fluid circuits for extracorporeal photopheresis with integrated source of photoactive agent |
| US11235090B2 (en) | 2017-03-03 | 2022-02-01 | Cerus Corporation | Kits and methods for preparing pathogen-inactivated platelet compositions |
| JP7495360B2 (ja) * | 2019-02-15 | 2024-06-04 | テルモ株式会社 | バッグセット |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322298A (en) * | 1981-06-01 | 1982-03-30 | Advanced Blood Component Technology, Inc. | Centrifugal cell separator, and method of use thereof |
| US4670013A (en) | 1982-12-27 | 1987-06-02 | Miles Laboratories, Inc. | Container for blood and blood components |
| IT1217938B (it) * | 1988-06-28 | 1990-03-30 | Girolamo Sirchia | Procedimento per la preparazione e la conservazione di concentrati eritrocitari e piastrinici |
| US5089146A (en) | 1990-02-12 | 1992-02-18 | Miles Inc. | Pre-storage filtration of platelets |
| SE9001271D0 (sv) | 1990-04-06 | 1990-04-06 | Eric Westberg | Blodpaase foer anvaendning vid separation av blod i komponenter |
| JP3182145B2 (ja) * | 1990-04-16 | 2001-07-03 | 日本赤十字社 | 血小板保存液 |
| JP2838725B2 (ja) | 1990-05-02 | 1998-12-16 | テルモ株式会社 | 血液採取器具 |
| JP2980663B2 (ja) | 1990-10-05 | 1999-11-22 | テルモ株式会社 | バッグ連結体 |
| DE9102709U1 (de) | 1991-03-07 | 1991-05-23 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Oldenburg und Bremen Gemeinnützige GmbH, 3257 Springe | Blutbeutelanordnung |
| JPH06500042A (ja) | 1991-05-08 | 1994-01-06 | バクスター、インターナショナル、インコーポレイテッド | 微生物不含長期間貯蔵のため赤血球製品を処理する方法 |
| US5269946A (en) * | 1991-05-22 | 1993-12-14 | Baxter Healthcare Corporation | Systems and methods for removing undesired matter from blood cells |
| US5459030A (en) * | 1992-03-02 | 1995-10-17 | Steritech, Inc. | Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen |
| US5618662A (en) | 1992-03-02 | 1997-04-08 | Cerus Corporation | Intravenous administration of psoralen |
| WO1996014740A1 (en) | 1992-03-02 | 1996-05-23 | Cerus Corporation | Synthetic media for blood components |
| JPH07509153A (ja) * | 1992-07-13 | 1995-10-12 | ポール・コーポレーション | 生物学的流体を処理するための自動化されたシステムおよび方法 |
| US5399719A (en) | 1993-06-28 | 1995-03-21 | Steritech, Inc. | Compounds for the photodecontamination of pathogens in blood |
| US5445629A (en) * | 1993-12-21 | 1995-08-29 | Baxter International Inc. | Blood storage container and methods of using same |
| AU4286996A (en) * | 1994-11-14 | 1996-06-06 | Pall Corporation | Long-term blood component storage system and method |
| US6544727B1 (en) | 1995-06-07 | 2003-04-08 | Cerus Corporation | Methods and devices for the removal of psoralens from blood products |
| US5836934A (en) | 1995-06-07 | 1998-11-17 | Baxter International Inc. | Closed system and methods for mixing additive solutions while removing undesired matter from blood cells |
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| CN100478038C (zh) * | 1999-10-16 | 2009-04-15 | 汾沃有限公司 | 血液处理系统 |
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-
2001
- 2001-12-05 US US10/004,696 patent/US6936413B1/en not_active Expired - Lifetime
-
2002
- 2002-11-22 CN CNB028242882A patent/CN100500231C/zh not_active Expired - Lifetime
- 2002-11-22 MX MXPA04005457A patent/MXPA04005457A/es active IP Right Grant
- 2002-11-22 KR KR1020047008577A patent/KR20050044689A/ko not_active Ceased
- 2002-11-22 CA CA2469364A patent/CA2469364C/en not_active Expired - Lifetime
- 2002-11-22 AU AU2002352877A patent/AU2002352877B2/en not_active Expired
- 2002-11-22 JP JP2003550685A patent/JP2005511197A/ja active Pending
- 2002-11-22 WO PCT/US2002/037554 patent/WO2003049634A1/en not_active Ceased
- 2002-11-22 EP EP02789836.0A patent/EP1450716B1/en not_active Expired - Lifetime
-
2005
- 2005-07-01 US US11/173,214 patent/US20050256443A1/en not_active Abandoned
-
2008
- 2008-06-19 AU AU2008202709A patent/AU2008202709B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005511197A (ja) | 2005-04-28 |
| MXPA04005457A (es) | 2004-10-11 |
| CN1599581A (zh) | 2005-03-23 |
| AU2002352877A1 (en) | 2003-06-23 |
| AU2008202709B2 (en) | 2010-06-17 |
| US20050256443A1 (en) | 2005-11-17 |
| EP1450716B1 (en) | 2016-04-06 |
| EP1450716A4 (en) | 2010-11-10 |
| CN100500231C (zh) | 2009-06-17 |
| KR20050044689A (ko) | 2005-05-12 |
| US6936413B1 (en) | 2005-08-30 |
| AU2008202709A1 (en) | 2008-07-17 |
| WO2003049634A1 (en) | 2003-06-19 |
| AU2002352877B2 (en) | 2008-03-20 |
| EP1450716A1 (en) | 2004-09-01 |
| CA2469364A1 (en) | 2003-06-19 |
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