CA2455296C - 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors - Google Patents
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors Download PDFInfo
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- CA2455296C CA2455296C CA2455296A CA2455296A CA2455296C CA 2455296 C CA2455296 C CA 2455296C CA 2455296 A CA2455296 A CA 2455296A CA 2455296 A CA2455296 A CA 2455296A CA 2455296 C CA2455296 C CA 2455296C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
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- Pain & Pain Management (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000356A ITRM20010356A1 (it) | 2001-06-21 | 2001-06-21 | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
| ITRM01A000356 | 2001-06-21 | ||
| PCT/IT2002/000398 WO2003000252A1 (en) | 2001-06-21 | 2002-06-17 | 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2455296A1 CA2455296A1 (en) | 2003-01-03 |
| CA2455296C true CA2455296C (en) | 2010-08-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2455296A Expired - Fee Related CA2455296C (en) | 2001-06-21 | 2002-06-17 | 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7098233B2 (OSRAM) |
| EP (1) | EP1404317B1 (OSRAM) |
| JP (2) | JP4683839B2 (OSRAM) |
| KR (1) | KR100885308B1 (OSRAM) |
| CN (1) | CN100482223C (OSRAM) |
| AT (1) | ATE416767T1 (OSRAM) |
| AU (1) | AU2002317482B2 (OSRAM) |
| BR (1) | BR0210538A (OSRAM) |
| CA (1) | CA2455296C (OSRAM) |
| CY (1) | CY1108879T1 (OSRAM) |
| CZ (1) | CZ20033314A3 (OSRAM) |
| DE (1) | DE60230270D1 (OSRAM) |
| DK (1) | DK1404317T3 (OSRAM) |
| ES (1) | ES2319107T3 (OSRAM) |
| HU (1) | HUP0400250A3 (OSRAM) |
| IT (1) | ITRM20010356A1 (OSRAM) |
| MX (1) | MXPA03011510A (OSRAM) |
| PL (1) | PL367618A1 (OSRAM) |
| PT (1) | PT1404317E (OSRAM) |
| SK (1) | SK287828B6 (OSRAM) |
| WO (1) | WO2003000252A1 (OSRAM) |
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| BRPI0308696B8 (pt) * | 2002-03-27 | 2021-05-25 | Axovant Sciences Gmbh | composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos |
| BRPI0412263B1 (pt) | 2003-07-22 | 2019-10-15 | Arena Pharmaceuticals, Inc. | Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição |
| US8086315B2 (en) | 2004-02-12 | 2011-12-27 | Asap Medical, Inc. | Cardiac stimulation apparatus and method for the control of hypertension |
| WO2005079845A1 (ja) | 2004-02-20 | 2005-09-01 | Astellas Pharma Inc. | 片頭痛予防薬 |
| TW200638926A (en) * | 2005-02-08 | 2006-11-16 | Astellas Pharma Inc | A therapeutic agent for irritable bowel disease |
| WO2007018168A1 (ja) * | 2005-08-08 | 2007-02-15 | Astellas Pharma Inc. | アシルグアニジン誘導体またはその塩 |
| WO2007046112A1 (en) * | 2005-10-19 | 2007-04-26 | Suven Life Sciences Inc. | Arylthioether tryptamine derivatives as functional 5-ht6 ligands |
| CN101384549B (zh) * | 2006-02-20 | 2011-04-13 | 安斯泰来制药株式会社 | 吡咯衍生物或其盐 |
| EP2120950B1 (en) * | 2007-03-21 | 2012-07-04 | Glaxo Group Limited | Use of quinoline derivatives in the treatment of pain |
| WO2009049030A1 (en) * | 2007-10-09 | 2009-04-16 | Triton Biopharma, Llc | Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter |
| WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| BR112014002712A8 (pt) * | 2011-08-05 | 2017-06-20 | Sucampo Ag | método para tratamento da esquizofrenia |
| CN102816103B (zh) * | 2012-08-20 | 2014-05-07 | 冉瑞琼 | 硫化天冬氨酸修饰的退黑素衍生物及其应用 |
| US9008769B2 (en) | 2012-12-21 | 2015-04-14 | Backbeat Medical, Inc. | Methods and systems for lowering blood pressure through reduction of ventricle filling |
| US9370662B2 (en) | 2013-12-19 | 2016-06-21 | Backbeat Medical, Inc. | Methods and systems for controlling blood pressure by controlling atrial pressure |
| CN104529865B (zh) * | 2014-12-12 | 2017-02-01 | 广东东阳光药业有限公司 | 苄胺类衍生物及其在药物上的应用 |
| EP4119141A1 (en) | 2015-06-12 | 2023-01-18 | Axovant Sciences GmbH | Nelotanserin for the prophylaxis and treatment of rem sleep behavior disorder |
| EP3322415A4 (en) | 2015-07-15 | 2019-03-13 | Axovant Sciences GmbH | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR FOR PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS RELATED TO A NEUROGENERATIVE DISEASE |
| US10342982B2 (en) | 2015-09-11 | 2019-07-09 | Backbeat Medical, Inc. | Methods and systems for treating cardiac malfunction |
| US10485658B2 (en) | 2016-04-22 | 2019-11-26 | Backbeat Medical, Inc. | Methods and systems for controlling blood pressure |
| CN108926565A (zh) * | 2017-05-26 | 2018-12-04 | 中国科学院上海生命科学研究院 | 五羟色胺受体亚型6小分子激活剂及拮抗剂在防治阿尔茨海默症中的应用 |
| WO2019246532A1 (en) * | 2018-06-21 | 2019-12-26 | Robert John Petcavich | Method of inducing dendritic and synaptic genesis in neurodegenerative chronic diseases |
| GB201907871D0 (en) * | 2019-06-03 | 2019-07-17 | Small Pharma Ltd | Therapeutic compositions |
| JP7242969B2 (ja) * | 2020-02-18 | 2023-03-20 | ギルガメッシュ・ファーマシューティカルズ・インコーポレイテッド | 気分障害の処置での使用に特異的なトリプタミン |
| AU2021268204A1 (en) | 2020-05-08 | 2022-12-08 | Psilera Inc. | Novel compositions of matter and pharmaceutical compositions |
| AU2021276656A1 (en) | 2020-05-19 | 2022-11-24 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| EP3902541B1 (en) * | 2020-06-02 | 2022-09-14 | Small Pharma Ltd | Therapeutic compositions comprising deuterated or partially deuterated n,n-dimethyltryptamine compounds |
| US20230346811A1 (en) * | 2020-09-18 | 2023-11-02 | Mydecine Innovations Group Inc. | Novel Formulations of Psilocybin And Psilocin Compounds as Serotonin Agonists in Combination With 3,4 Methylenedioxymethamphetamine (MDMA) |
| AU2022281358A1 (en) | 2021-05-25 | 2023-11-23 | Atai Therapeutics, Inc. | New n,n-dimethyltryptamine salts and crystalline salt forms |
| MX2023014620A (es) | 2021-06-09 | 2024-01-30 | Atai Therapeutics Inc | Nuevos profarmacos y conjugados de dimetiltriptamina. |
| US20240343692A1 (en) * | 2021-08-09 | 2024-10-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Selective psychedelic compounds |
| US12012381B2 (en) | 2021-12-30 | 2024-06-18 | Atai Therapeutics, Inc. | Dimethyltryptamine analogues as nitric oxide delivery drugs |
| CN114573578B (zh) * | 2022-02-16 | 2023-11-17 | 烟台宁远药业有限公司 | 一种烷基取代氮杂吲哚的制备方法 |
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| US2825734A (en) * | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
| GB966562A (en) * | 1961-04-06 | 1964-08-12 | Parke Davis & Co | Amine compounds and means of producing the same |
| FR2315277A1 (fr) * | 1975-06-25 | 1977-01-21 | Anvar | Nouveaux derives pentacycliques, leur preparation et les compositions qui les contiennent |
| US4428877A (en) * | 1978-07-12 | 1984-01-31 | Richter Gedeon Vegyeszeti Gyar Rt. | Cis-10-bromo-E-homoeburnanes |
| GB8531612D0 (en) * | 1985-12-23 | 1986-02-05 | Beecham Wuelfing Gmbh & Co Kg | Compounds |
| US5300645A (en) * | 1993-04-14 | 1994-04-05 | Eli Lilly And Company | Tetrahydro-pyrido-indole |
| FR2712591B1 (fr) * | 1993-11-19 | 1996-02-09 | Pf Medicament | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. |
| US5688807A (en) * | 1994-03-11 | 1997-11-18 | Eli Lilly And Company | Method for treating 5HT2B receptor related conditions |
| US5504101A (en) * | 1994-05-06 | 1996-04-02 | Allelix Biopharmaceuticals, Inc. | 5-HT-1D receptor ligands |
| DE69733427T2 (de) | 1996-06-28 | 2006-04-27 | Meiji Seika Kaisha Ltd. | Tetrahydrobezindol derivate |
| US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
| US6251893B1 (en) * | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
| DK1149078T3 (da) * | 1998-12-11 | 2006-07-10 | Univ Virginia Commonwealth | Selektive 5-HT6-receptorligander |
| US6403808B1 (en) * | 1999-12-10 | 2002-06-11 | Virginia Commonwealth University | Selective 5-HT6 receptor ligands |
| CA2370147C (en) | 1999-04-21 | 2009-07-28 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-ht6 affinity |
| AU779832B2 (en) * | 1999-08-12 | 2005-02-10 | Nps Pharmaceuticals, Inc. | Azaindoles having serotonin receptor affinity |
| WO2004041781A1 (en) * | 2002-11-07 | 2004-05-21 | Suven Life Sciences Limited | Preparation of 3-aminoalkyl-substituted indole derivatives from phenylhydrazines and aminoketones |
-
2001
- 2001-06-21 IT IT2001RM000356A patent/ITRM20010356A1/it unknown
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2002
- 2002-06-17 US US10/481,433 patent/US7098233B2/en not_active Expired - Fee Related
- 2002-06-17 CA CA2455296A patent/CA2455296C/en not_active Expired - Fee Related
- 2002-06-17 EP EP02745793A patent/EP1404317B1/en not_active Expired - Lifetime
- 2002-06-17 DE DE60230270T patent/DE60230270D1/de not_active Expired - Lifetime
- 2002-06-17 SK SK38-2004A patent/SK287828B6/sk not_active IP Right Cessation
- 2002-06-17 CZ CZ20033314A patent/CZ20033314A3/cs unknown
- 2002-06-17 WO PCT/IT2002/000398 patent/WO2003000252A1/en not_active Ceased
- 2002-06-17 DK DK02745793T patent/DK1404317T3/da active
- 2002-06-17 PL PL02367618A patent/PL367618A1/xx not_active IP Right Cessation
- 2002-06-17 CN CNB02814337XA patent/CN100482223C/zh not_active Expired - Fee Related
- 2002-06-17 AT AT02745793T patent/ATE416767T1/de active
- 2002-06-17 JP JP2003506898A patent/JP4683839B2/ja not_active Expired - Fee Related
- 2002-06-17 BR BR0210538-1A patent/BR0210538A/pt not_active Application Discontinuation
- 2002-06-17 AU AU2002317482A patent/AU2002317482B2/en not_active Ceased
- 2002-06-17 MX MXPA03011510A patent/MXPA03011510A/es active IP Right Grant
- 2002-06-17 PT PT02745793T patent/PT1404317E/pt unknown
- 2002-06-17 KR KR1020037016564A patent/KR100885308B1/ko not_active Expired - Fee Related
- 2002-06-17 HU HU0400250A patent/HUP0400250A3/hu unknown
- 2002-06-17 ES ES02745793T patent/ES2319107T3/es not_active Expired - Lifetime
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2009
- 2009-03-06 CY CY20091100260T patent/CY1108879T1/el unknown
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- 2010-09-13 JP JP2010204733A patent/JP2011016835A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1404317A1 (en) | 2004-04-07 |
| AU2002317482B2 (en) | 2007-08-16 |
| ITRM20010356A1 (it) | 2002-12-23 |
| SK382004A3 (en) | 2004-05-04 |
| KR20040032113A (ko) | 2004-04-14 |
| ES2319107T3 (es) | 2009-05-04 |
| HUP0400250A2 (hu) | 2004-08-30 |
| PL367618A1 (en) | 2005-03-07 |
| JP2011016835A (ja) | 2011-01-27 |
| CA2455296A1 (en) | 2003-01-03 |
| CN100482223C (zh) | 2009-04-29 |
| EP1404317B1 (en) | 2008-12-10 |
| CZ20033314A3 (cs) | 2004-08-18 |
| HUP0400250A3 (en) | 2008-03-28 |
| HK1068792A1 (zh) | 2005-05-06 |
| DK1404317T3 (da) | 2009-02-23 |
| WO2003000252A1 (en) | 2003-01-03 |
| KR100885308B1 (ko) | 2009-02-24 |
| CY1108879T1 (el) | 2014-07-02 |
| BR0210538A (pt) | 2004-06-22 |
| JP4683839B2 (ja) | 2011-05-18 |
| CN1535146A (zh) | 2004-10-06 |
| MXPA03011510A (es) | 2004-03-18 |
| JP2004534816A (ja) | 2004-11-18 |
| US20040235899A1 (en) | 2004-11-25 |
| PT1404317E (pt) | 2009-02-23 |
| DE60230270D1 (de) | 2009-01-22 |
| SK287828B6 (sk) | 2011-11-04 |
| US7098233B2 (en) | 2006-08-29 |
| ITRM20010356A0 (it) | 2001-06-21 |
| ATE416767T1 (de) | 2008-12-15 |
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