CA2454358A1 - Multimeric proteins and methods of making and using same - Google Patents
Multimeric proteins and methods of making and using same Download PDFInfo
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- CA2454358A1 CA2454358A1 CA002454358A CA2454358A CA2454358A1 CA 2454358 A1 CA2454358 A1 CA 2454358A1 CA 002454358 A CA002454358 A CA 002454358A CA 2454358 A CA2454358 A CA 2454358A CA 2454358 A1 CA2454358 A1 CA 2454358A1
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- polypeptide
- multimerization
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- sequence
- chimeric
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30674601P | 2001-07-19 | 2001-07-19 | |
| US60/306,746 | 2001-07-19 | ||
| US33542501P | 2001-11-30 | 2001-11-30 | |
| US60/335,425 | 2001-11-30 | ||
| PCT/US2002/023003 WO2003062370A2 (en) | 2001-07-19 | 2002-07-19 | Multimeric proteins and methods of making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2898314A Division CA2898314A1 (en) | 2001-07-19 | 2002-07-19 | Multimeric proteins and methods of making and using same |
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| Publication Number | Publication Date |
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| CA2454358A1 true CA2454358A1 (en) | 2003-07-31 |
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Family Applications (2)
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| CA002454358A Abandoned CA2454358A1 (en) | 2001-07-19 | 2002-07-19 | Multimeric proteins and methods of making and using same |
| CA2898314A Abandoned CA2898314A1 (en) | 2001-07-19 | 2002-07-19 | Multimeric proteins and methods of making and using same |
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| CA2898314A Abandoned CA2898314A1 (en) | 2001-07-19 | 2002-07-19 | Multimeric proteins and methods of making and using same |
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| AU (2) | AU2002365196C1 (enExample) |
| CA (2) | CA2454358A1 (enExample) |
| WO (1) | WO2003062370A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE293994T1 (de) * | 1997-12-01 | 2005-05-15 | Fang Fang | Multivalente rekombinante antikörper zur behandlung von hrv infektionen |
| US20030035798A1 (en) * | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
| WO2003062370A2 (en) | 2001-07-19 | 2003-07-31 | Perlan Therapeutics, Inc. | Multimeric proteins and methods of making and using same |
| WO2009092383A2 (en) * | 2008-01-22 | 2009-07-30 | Multimerics Aps | Products and methods to prevent infection |
| WO2009111304A2 (en) | 2008-02-29 | 2009-09-11 | President And Fellows Of Harvard College | A fusion-intermediate state of hiv-1 gp41 targeted by broadly neutralizing antibodies |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SMT201900372T1 (it) | 2010-02-08 | 2019-09-09 | Regeneron Pharma | Topo con catena leggera comune |
| HUE068728T2 (hu) | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| WO2013078425A1 (en) * | 2011-11-22 | 2013-05-30 | University Of Maryland, Baltimore | Lambodies with high affinity and selectivity for glycans and uses therefor |
| US10329350B2 (en) | 2012-12-26 | 2019-06-25 | Industrial Technology Research Institute | Method for producing a multivalent fab fragment with collagen-like peptide |
| US20150038682A1 (en) * | 2013-08-02 | 2015-02-05 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via homomultimerizing peptide |
| RU2016141307A (ru) | 2014-03-21 | 2018-04-24 | Регенерон Фармасьютикалз, Инк. | Отличные от человека животные, которые вырабатывают однодоменные связывающие белки |
| RU2017115670A (ru) * | 2014-10-10 | 2018-11-15 | Аблинкс Н.В. | Лечение инфекции рсв |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| KR102682118B1 (ko) * | 2016-04-29 | 2024-07-08 | 주식회사유한양행 | Ccl3 변이체를 포함하는 융합 단백질 및 이의 용도 |
| EP3935080A4 (en) | 2019-03-06 | 2023-04-05 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3935079A4 (en) | 2019-03-06 | 2023-03-22 | Cue Biopharma, Inc. | T LYMPHOCYTE MODULATOR ANTIGEN PRESENTING POLYPEPTIDES AND METHODS OF USE THEREOF |
| CN114728072A (zh) | 2019-10-23 | 2022-07-08 | 库尔生物制药有限公司 | TGF-β多肽 |
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2002
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- 2002-07-19 EP EP02804525A patent/EP1578917A4/en not_active Withdrawn
- 2002-07-19 US US10/199,957 patent/US20030138440A1/en not_active Abandoned
- 2002-07-19 JP JP2003562238A patent/JP2005522192A/ja active Pending
- 2002-07-19 CA CA002454358A patent/CA2454358A1/en not_active Abandoned
- 2002-07-19 AU AU2002365196A patent/AU2002365196C1/en not_active Ceased
- 2002-07-19 CA CA2898314A patent/CA2898314A1/en not_active Abandoned
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2007
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-
2009
- 2009-01-09 JP JP2009004029A patent/JP5264518B2/ja not_active Expired - Fee Related
- 2009-04-15 AU AU2009201466A patent/AU2009201466B2/en not_active Ceased
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2012
- 2012-09-26 JP JP2012212111A patent/JP2013013417A/ja active Pending
-
2013
- 2013-03-11 US US13/794,457 patent/US20130243768A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003062370A3 (en) | 2005-12-15 |
| EP1578917A4 (en) | 2008-01-23 |
| CA2898314A1 (en) | 2003-07-31 |
| JP5264518B2 (ja) | 2013-08-14 |
| EP1578917A2 (en) | 2005-09-28 |
| AU2009201466B2 (en) | 2012-05-03 |
| AU2009201466A1 (en) | 2009-05-07 |
| AU2002365196B8 (en) | 2009-01-29 |
| WO2003062370A2 (en) | 2003-07-31 |
| AU2002365196C1 (en) | 2009-08-13 |
| AU2002365196B2 (en) | 2009-01-15 |
| US20030138440A1 (en) | 2003-07-24 |
| JP2009136292A (ja) | 2009-06-25 |
| US20130243768A1 (en) | 2013-09-19 |
| US8394771B1 (en) | 2013-03-12 |
| JP2005522192A (ja) | 2005-07-28 |
| JP2013013417A (ja) | 2013-01-24 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150728 |