CA2449160A1 - Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method - Google Patents
Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method Download PDFInfo
- Publication number
- CA2449160A1 CA2449160A1 CA002449160A CA2449160A CA2449160A1 CA 2449160 A1 CA2449160 A1 CA 2449160A1 CA 002449160 A CA002449160 A CA 002449160A CA 2449160 A CA2449160 A CA 2449160A CA 2449160 A1 CA2449160 A1 CA 2449160A1
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- CA
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- Prior art keywords
- compound
- mmol
- inhibitor
- alkyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000003472 antidiabetic agent Substances 0.000 title claims abstract description 33
- 239000000883 anti-obesity agent Substances 0.000 title claims abstract description 12
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- 239000002253 acid Substances 0.000 title description 65
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title description 8
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- 230000000694 effects Effects 0.000 claims description 65
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- 239000003112 inhibitor Substances 0.000 claims description 54
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Classifications
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Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29438001P | 2001-05-30 | 2001-05-30 | |
| US60/294,380 | 2001-05-30 | ||
| PCT/US2002/016633 WO2002096358A2 (en) | 2001-05-30 | 2002-05-23 | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2449160A1 true CA2449160A1 (en) | 2002-12-05 |
Family
ID=23133159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002449160A Abandoned CA2449160A1 (en) | 2001-05-30 | 2002-05-23 | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20030092736A1 (enExample) |
| EP (1) | EP1390363A4 (enExample) |
| JP (1) | JP2004536070A (enExample) |
| AU (1) | AU2002259306B2 (enExample) |
| CA (1) | CA2449160A1 (enExample) |
| CZ (1) | CZ20033230A3 (enExample) |
| DE (1) | DE02729306T1 (enExample) |
| ES (1) | ES2214168T1 (enExample) |
| HU (1) | HUP0401504A3 (enExample) |
| MX (1) | MXPA03010997A (enExample) |
| NO (1) | NO327089B1 (enExample) |
| PE (1) | PE20030043A1 (enExample) |
| PL (1) | PL367066A1 (enExample) |
| TR (1) | TR200400650T3 (enExample) |
| TW (1) | TWI235061B (enExample) |
| UY (1) | UY27316A1 (enExample) |
| WO (1) | WO2002096358A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2495799A1 (en) * | 2002-08-21 | 2004-03-04 | Merck & Co., Inc. | Combination therapy using a dual ppar alpha/gamma agonist and an angiotensin ii type i receptor antagonist |
| EP1424070A1 (en) * | 2002-11-28 | 2004-06-02 | Fournier Laboratories Ireland Limited | Combination of a PPAR alpha agonist and metformin for decreasing the serum triglycerides |
| SE0300988D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | New use |
| WO2004108126A1 (en) * | 2003-06-06 | 2004-12-16 | Snowden Pharmaceuticals, Llc | Fibric acid derivatives for the treatment of irritable bowel syndrome |
| MXPA06000118A (es) | 2003-07-08 | 2006-04-27 | Novartis Ag | Compuestos de bencensulfonamino y composiciones farmaceuticas que contienen estos compuestos. |
| RU2349587C2 (ru) * | 2003-09-22 | 2009-03-20 | Оно Фармасьютикал Ко., Лтд. | Производное фенилуксусной кислоты и его применение |
| US20070098778A1 (en) * | 2004-03-02 | 2007-05-03 | Abeille Pharmaceuticals, Inc. | Co-formulations or kits of bioactive agents |
| ATE493973T1 (de) | 2004-06-04 | 2011-01-15 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
| CN1304393C (zh) * | 2004-07-01 | 2007-03-14 | 中国药科大学 | 取代的吡唑啉酮衍生物及其制备方法与药用组合物 |
| KR100706600B1 (ko) * | 2004-11-25 | 2007-04-12 | 주식회사 엘지생명과학 | ＰＰＡＲ ｇａｍｍａ와 ＰＰＡＲ ａｌｐｈａ의 활성을항진시키는 신규 화합물, 그것의 제조방법, 및 그것을함유한 약제 조성물 |
| KR20060058632A (ko) * | 2004-11-25 | 2006-05-30 | 주식회사 엘지생명과학 | ＰＰＡＲ ｇａｍｍａ와 ＰＰＡＲ ａｌｐｈａ의 활성을항진시키는 신규 화합물, 그것의 제조방법, 및 그것을함유한 약제 조성물 |
| WO2007058504A1 (en) * | 2005-11-21 | 2007-05-24 | Lg Life Sciences, Ltd. | Novel compounds as agonist for ppar gamma and ppar alpha, method for preparation of the same, and pharmaceutical composition containing the same |
| US20090048199A1 (en) * | 2007-03-09 | 2009-02-19 | Hiberna Corporation | Hibernation-Related Genes and Proteins, Activators and Inhibitors Thereof and Methods of Use |
| BRPI0822349A2 (pt) * | 2007-11-29 | 2019-09-24 | Neuraltus Pharmaceuticals Inc | composições e métodos para tratar doenças lisossômicas |
| KR20110099687A (ko) * | 2008-10-29 | 2011-09-08 | 데시페라 파마슈티칼스, 엘엘씨. | 항-암과 항-증식성 활성을 나타내는 시클로프로판 아미드와 유사체 |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN109498622A (zh) * | 2018-12-28 | 2019-03-22 | 成都恒瑞制药有限公司 | 一种氯沙坦钾与罗格列酮组合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| US5591862A (en) * | 1993-06-11 | 1997-01-07 | Takeda Chemical Industries, Ltd. | Tetrazole derivatives, their production and use |
| AU782404B2 (en) * | 1999-04-28 | 2005-07-28 | Sanofi-Aventis Deutschland Gmbh | Tri-aryl acid derivatives as PPAR receptor ligands |
| AU7115300A (en) * | 1999-09-08 | 2001-04-10 | Glaxo Group Limited | Oxazole ppar antagonists |
| PL356487A1 (en) * | 1999-11-10 | 2004-06-28 | Takeda Chemical Industries, Ltd. | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity |
| WO2002076959A1 (en) * | 2001-03-23 | 2002-10-03 | Takeda Chemical Industries, Ltd. | Five-membered heterocyclic alkanoic acid derivative |
-
2002
- 2002-05-22 US US10/153,454 patent/US20030092736A1/en not_active Abandoned
- 2002-05-23 MX MXPA03010997A patent/MXPA03010997A/es active IP Right Grant
- 2002-05-23 DE DE0001390363T patent/DE02729306T1/de active Pending
- 2002-05-23 WO PCT/US2002/016633 patent/WO2002096358A2/en not_active Ceased
- 2002-05-23 HU HU0401504A patent/HUP0401504A3/hu unknown
- 2002-05-23 CA CA002449160A patent/CA2449160A1/en not_active Abandoned
- 2002-05-23 PL PL02367066A patent/PL367066A1/xx not_active Application Discontinuation
- 2002-05-23 TR TR2004/00650T patent/TR200400650T3/xx unknown
- 2002-05-23 ES ES02729306T patent/ES2214168T1/es active Pending
- 2002-05-23 CZ CZ20033230A patent/CZ20033230A3/cs unknown
- 2002-05-23 AU AU2002259306A patent/AU2002259306B2/en not_active Ceased
- 2002-05-23 JP JP2002592871A patent/JP2004536070A/ja active Pending
- 2002-05-23 EP EP02729306A patent/EP1390363A4/en not_active Withdrawn
- 2002-05-24 TW TW091111100A patent/TWI235061B/zh not_active IP Right Cessation
- 2002-05-30 PE PE2002000455A patent/PE20030043A1/es not_active Application Discontinuation
- 2002-05-30 UY UY27316A patent/UY27316A1/es not_active Application Discontinuation
-
2003
- 2003-11-28 NO NO20035312A patent/NO327089B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20035312D0 (no) | 2003-11-28 |
| CZ20033230A3 (cs) | 2004-02-18 |
| HUP0401504A2 (hu) | 2004-11-29 |
| AU2002259306B2 (en) | 2007-02-08 |
| HUP0401504A3 (en) | 2008-05-28 |
| US20030092736A1 (en) | 2003-05-15 |
| NO327089B1 (no) | 2009-04-20 |
| UY27316A1 (es) | 2002-12-31 |
| TWI235061B (en) | 2005-07-01 |
| EP1390363A4 (en) | 2011-01-05 |
| WO2002096358A3 (en) | 2003-03-27 |
| PL367066A1 (en) | 2005-02-21 |
| WO2002096358A2 (en) | 2002-12-05 |
| MXPA03010997A (es) | 2004-02-27 |
| PE20030043A1 (es) | 2003-02-05 |
| DE02729306T1 (de) | 2004-08-26 |
| ES2214168T1 (es) | 2004-09-16 |
| JP2004536070A (ja) | 2004-12-02 |
| TR200400650T3 (tr) | 2004-06-21 |
| EP1390363A2 (en) | 2004-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |