CA2441562C - Short bioactive peptides and methods for their use - Google Patents

Short bioactive peptides and methods for their use Download PDF

Info

Publication number
CA2441562C
CA2441562C CA2441562A CA2441562A CA2441562C CA 2441562 C CA2441562 C CA 2441562C CA 2441562 A CA2441562 A CA 2441562A CA 2441562 A CA2441562 A CA 2441562A CA 2441562 C CA2441562 C CA 2441562C
Authority
CA
Canada
Prior art keywords
seq
peptide
lys
leu
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2441562A
Other languages
English (en)
French (fr)
Other versions
CA2441562A1 (en
Inventor
Donald R. Owen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helix Biomedix Inc
Original Assignee
Helix Biomedix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/820,053 external-priority patent/US6875744B2/en
Application filed by Helix Biomedix Inc filed Critical Helix Biomedix Inc
Publication of CA2441562A1 publication Critical patent/CA2441562A1/en
Application granted granted Critical
Publication of CA2441562C publication Critical patent/CA2441562C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723Cationic antimicrobial peptides, e.g. defensins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Insects & Arthropods (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2441562A 2001-03-28 2002-03-28 Short bioactive peptides and methods for their use Expired - Lifetime CA2441562C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27950501P 2001-03-28 2001-03-28
US09/820,053 US6875744B2 (en) 2001-03-28 2001-03-28 Short bioactive peptides
US09/820,053 2001-03-28
US60/279,505 2001-03-28
PCT/US2002/009534 WO2002079408A2 (en) 2001-03-28 2002-03-28 Short bioactive peptides and methods for their use

Publications (2)

Publication Number Publication Date
CA2441562A1 CA2441562A1 (en) 2002-10-10
CA2441562C true CA2441562C (en) 2013-05-14

Family

ID=26959709

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2441562A Expired - Lifetime CA2441562C (en) 2001-03-28 2002-03-28 Short bioactive peptides and methods for their use

Country Status (8)

Country Link
US (1) US7381704B2 (enExample)
EP (2) EP2105141B1 (enExample)
JP (2) JP4310107B2 (enExample)
KR (1) KR100891157B1 (enExample)
AU (1) AU2002255952A1 (enExample)
CA (1) CA2441562C (enExample)
ES (1) ES2389285T3 (enExample)
WO (1) WO2002079408A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004091495A2 (en) * 2003-04-09 2004-10-28 University Of Utah Research Foundation Compositions and methods related to production of erythropoietin
JP2005281225A (ja) * 2004-03-30 2005-10-13 Japan Science & Technology Agency 新規塩基性抗菌ペプチド及びその利用
KR20080042843A (ko) * 2005-07-27 2008-05-15 나스텍 파마수티컬 컴퍼니 인코포레이티드 치료제의 점막 전달 향상을 위한 밀착 연접 조절 펩티드성분
US7601361B2 (en) * 2005-10-03 2009-10-13 E. I. Du Pont De Nemours And Company Process for providing antimicrobial surfaces
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
CA2822302A1 (en) 2006-02-13 2007-08-23 Alethia Biotherapeutics Inc. Methods of impairing osteoclast differentiation
KR101552453B1 (ko) * 2006-06-01 2015-09-11 데라퓨틱 펩타이즈, 인코포레이션 중합성 생계면활성제
RU2441877C2 (ru) 2006-06-13 2012-02-10 Хеликс Байомедикс Инк. Тетрапептид, композиция (варианты) и способ стимуляции продукции коллагена фибробластом
KR100742982B1 (ko) * 2006-06-22 2007-07-26 케이맥(주) 초점 타원계측기
US7696174B2 (en) * 2007-01-05 2010-04-13 Helix Biomedix, Inc. Short bio-active peptides for cellular and immunological modulation
EP2152726B8 (en) * 2007-05-01 2015-02-18 Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP Analgesic compounds
CN101855235B (zh) 2007-10-29 2013-04-24 赫里克斯生物医疗公司 保护性皮肤护理四肽
GB0803352D0 (en) * 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
EP2168591A1 (en) * 2008-09-24 2010-03-31 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Antimicrobial peptides
US20120270770A1 (en) * 2010-08-03 2012-10-25 Jesse Michael Jaynes Anti-angiogenic peptides and their uses
WO2014012165A1 (en) 2012-07-19 2014-01-23 Alethia Biotherapeutics Inc. Anti-siglec-15 antibodies
ITBS20120126A1 (it) * 2012-08-01 2014-02-02 Paoli Ambrosi Gianfranco De Composizione antibatterica per uso topico
JP2016518352A (ja) * 2013-04-09 2016-06-23 モヘイ エルディン エラウダン,カーレド 悪性腫瘍のコントロールにおける単剤治療としての新規ペプチド
GB201319620D0 (en) 2013-11-06 2013-12-18 Norwegian University Of Science And Technology Immunosuppressive agents and their use in therapy
KR102478073B1 (ko) 2014-10-14 2022-12-16 립타이드 바이오사이언스, 인코포레이티드 항-염증 특성을 갖는 펩타이드
CN105061562B (zh) * 2015-09-16 2018-01-12 山东电力中心医院 一种具有抗肺癌作用的寡肽及其应用
US9439917B1 (en) * 2015-12-28 2016-09-13 Shetal Amit Shah Anti-blepharitis compositions and their use
JP7105696B2 (ja) 2016-02-29 2022-07-25 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド
JP7305614B2 (ja) 2017-07-19 2023-07-10 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド
WO2019210377A1 (en) * 2018-04-30 2019-11-07 L'oreal Bioactive peptides having high binding affinity to human muscular nicotinic acetylcholine receptor
FR3099060B1 (fr) * 2019-07-26 2022-01-14 Bionuclei Complexe hybride mineral et organique et son utilisation pour le maintien de l’equilibre microbiologique de la peau et/ou d’une composition cosmetique et/ou dermopharmaceutique
WO2025122089A1 (en) * 2023-12-06 2025-06-12 Karadeni̇z Tekni̇k Uni̇versi̇tesi̇ Teknoloji̇ Transferi̇ Uygulama Ve Arasti̇rma Merkezi̇ Development of a novel chitosan conjugated antimicrobial peptide as an alternative to antibiotics
WO2025157595A2 (en) * 2024-01-25 2025-07-31 Lipotrue, S.L. Peptides and cosmetic compositions for use in the treatment of acne and its related skin conditions

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355104A (en) 1980-06-17 1982-10-19 Kabigen Ab Bacteriolytic proteins
US4520016A (en) 1980-06-17 1985-05-28 Kabigen Ab Bacteriolytic proteins
US5861478A (en) 1987-07-06 1999-01-19 Helix Biomedix, Inc. Lytic peptides
CA1327311C (en) * 1987-07-06 1994-03-01 Jesse M. Jaynes Therapeutic antimicrobial polypeptides, their use and methods for preparation
KR970006154B1 (ko) * 1987-07-06 1997-04-24 루이지아나 스테이트 유니버시티 아그리컬춰럴 앤드 메카니칼 컬리지 용해성 펩티드에 의한 진핵 병원체와 신생물의 억제 및 섬유아세포와 임파구의 자극
WO1990012866A1 (en) * 1989-04-10 1990-11-01 Louisiana State University And Agricultural And Mechanical College Lytic peptides, use for growth, infection and cancer
WO1992017195A1 (en) * 1991-04-08 1992-10-15 Magainin Pharmaceuticals, Inc. Novel peptide compositions and uses therefor
US5561107A (en) 1993-06-04 1996-10-01 Demeter Biotechnologies, Ltd. Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides
US5955573A (en) * 1993-06-04 1999-09-21 Demegen, Inc. Ubiquitin-lytic peptide fusion gene constructs, protein products deriving therefrom, and methods of making and using same
AU7050294A (en) * 1993-06-04 1995-01-03 Demeter Biotechnologies, Ltd. Method of treating pulmonary disease states with non-naturally occurring amphipathic peptides
AU1086595A (en) * 1993-11-08 1995-05-29 Demeter Biotechnologies, Ltd. Methylated lysine-rich lytic peptides and method of making same by reductive alkylation
US5789542A (en) * 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
IL114697A0 (en) * 1994-07-22 1995-11-27 Demeter Biotech Ltd Polypeptides comprising ubiquitin-lytic peptide fusion protein products deriving therefrom their preparation and use
EP0866805A1 (en) * 1995-12-12 1998-09-30 Karolinska Innovations AB PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b)
US6566334B1 (en) * 1997-02-06 2003-05-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Short amphipathic peptides with activity against bacteria and intracellular pathogens
US6635740B1 (en) * 1997-03-27 2003-10-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ligand/lytic peptide compositions and methods of use
US6958212B1 (en) * 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
WO2001049834A2 (en) 2000-01-06 2001-07-12 Monsanto Technology Llc Preparation of deallergenized patatin proteins and patatin permutein proteins

Also Published As

Publication number Publication date
JP4484941B2 (ja) 2010-06-16
CA2441562A1 (en) 2002-10-10
JP2005506300A (ja) 2005-03-03
WO2002079408A3 (en) 2002-11-28
AU2002255952A1 (en) 2002-10-15
ES2389285T3 (es) 2012-10-24
EP1379265A4 (en) 2005-09-14
US20030109452A1 (en) 2003-06-12
HK1135330A1 (en) 2010-06-04
JP2009137992A (ja) 2009-06-25
WO2002079408A2 (en) 2002-10-10
JP4310107B2 (ja) 2009-08-05
KR100891157B1 (ko) 2009-04-07
EP1379265A2 (en) 2004-01-14
KR20040002880A (ko) 2004-01-07
US7381704B2 (en) 2008-06-03
EP2105141A1 (en) 2009-09-30
EP2105141B1 (en) 2012-08-08

Similar Documents

Publication Publication Date Title
CA2441562C (en) Short bioactive peptides and methods for their use
EP1853620B1 (en) Antimicrobial hexapeptides
Patocka et al. Antimicrobial peptides: amphibian host defense peptides
US6875744B2 (en) Short bioactive peptides
ES2784484T3 (es) Péptido antimicrobiano
EP1412380B1 (en) Broad spectrum antibiotic peptides of the phylloseptin family
CA2338885A1 (en) Antimicrobial peptides isolated from the skin of american frogs
EP0998489B1 (en) A NOVEL ANTIMICROBIAL PEPTIDE ISOLATED FROM $i(PARASILURUS ASOTUS) AND ITS USES
US5235038A (en) Deletion and substitution analogues of melittin peptide
US5994308A (en) Broad spectrum antimicrobial peptides containing a tryptophan triplet and methods of use
US5654274A (en) Biologically active peptides having N-terminal substitutions
Pathan et al. Recent patents on antimicrobial peptides
US20050209157A1 (en) Short bioactive peptides and methods for their use
KR20180078853A (ko) 홍합에서 유래한 항균 펩타이드 및 이의 용도
WO1991017760A1 (en) Composition of and treatment with biologically active peptides having d-amino acid residues
HK1135330B (en) Short bioactive peptides and methods for their use
US20060241026A1 (en) Novel cyclic peptides and use thereof as anti-microbial agents
Rangel et al. Peptides with Therapeutic Potential against Acinetobacter
EP3049432A1 (en) ANALOGUES OF TEMPORIN-SHa AND USES THEREOF

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20220328