MXPA02006752A - Preparacion de proteinas y permutenias desalergenizadas. - Google Patents

Preparacion de proteinas y permutenias desalergenizadas.

Info

Publication number
MXPA02006752A
MXPA02006752A MXPA02006752A MXPA02006752A MXPA02006752A MX PA02006752 A MXPA02006752 A MX PA02006752A MX PA02006752 A MXPA02006752 A MX PA02006752A MX PA02006752 A MXPA02006752 A MX PA02006752A MX PA02006752 A MXPA02006752 A MX PA02006752A
Authority
MX
Mexico
Prior art keywords
proteins
permuteins
observed
disclosed
deallergenized
Prior art date
Application number
MXPA02006752A
Other languages
English (en)
Inventor
Charles A Mcwherter
Original Assignee
Monsanto Technology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Technology Llc filed Critical Monsanto Technology Llc
Publication of MXPA02006752A publication Critical patent/MXPA02006752A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Abstract

Se describen proteinas modificadas que mantienen la actividad enzimatica e insecticida mientras se exhiben una alergenicidad reducida o eliminada; se identificaron epitopos que se unen a los anticuerpos anti-patatina, y se removieron a traves de mutagenesis dirigida al sitio; se observo que las tirosinas generalmente contribuyen a las propiedades alergenicas de proteinas de patatina. Se observo la remocion de sitios de glicosilacion para reducir o eliminar la union de anticuerpo. Tambien se describen permuteinas que tienen una secuencia de aminoacido redispuesta, mientras retiene la actividad enzimaitica; se pueden utilizar proteinas y permuteinas desalergenizadas como materiales insecticidas, suplementos nutricionales, y como agentes inmunoterapeuticos.
MXPA02006752A 2000-01-06 2001-01-05 Preparacion de proteinas y permutenias desalergenizadas. MXPA02006752A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17466900P 2000-01-06 2000-01-06
PCT/US2001/000342 WO2001049834A2 (en) 2000-01-06 2001-01-05 Preparation of deallergenized patatin proteins and patatin permutein proteins

Publications (1)

Publication Number Publication Date
MXPA02006752A true MXPA02006752A (es) 2004-09-10

Family

ID=22637052

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02006752A MXPA02006752A (es) 2000-01-06 2001-01-05 Preparacion de proteinas y permutenias desalergenizadas.

Country Status (9)

Country Link
US (5) US6639054B1 (es)
EP (1) EP1254167A2 (es)
CN (1) CN1411469A (es)
AU (1) AU2631501A (es)
BR (1) BR0107474A (es)
CA (1) CA2396422A1 (es)
MX (1) MXPA02006752A (es)
WO (1) WO2001049834A2 (es)
ZA (1) ZA200205242B (es)

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DE60234475D1 (de) * 2001-03-02 2009-12-31 Univ Rockefeller Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens
EP1379265A4 (en) 2001-03-28 2005-09-14 Helix Biomedix Inc SHORT BIOACTIVE PEPTIDES AND METHODS OF USE
US6875744B2 (en) * 2001-03-28 2005-04-05 Helix Biomedix, Inc. Short bioactive peptides
DK1414471T3 (da) * 2001-07-17 2012-07-16 Res Dev Foundation Terapeutiske midler omfattende pro-apoptotiske proteiner
EP1572170A4 (en) * 2002-06-12 2007-02-28 Res Dev Foundation IMMUNOTOXIN AS THERAPEUTIC AGENT AND USES THEREOF
WO2005069986A2 (en) 2004-01-20 2005-08-04 Monsanto Technology Llc Chimeric promoters for use in plants
DK1853620T3 (da) 2005-02-09 2012-03-26 Helix Biomedix Inc Antimikrobielle hexapeptider
US7688207B2 (en) * 2006-07-28 2010-03-30 Abbott Laboratories Inc. System for tracking vessels in automated laboratory analyzers by radio frequency identification
US7838729B2 (en) 2007-02-26 2010-11-23 Monsanto Technology Llc Chloroplast transit peptides for efficient targeting of DMO and uses thereof
US20110079544A1 (en) 2009-10-01 2011-04-07 Pioneer Hi-Bred International, Inc. Method for sorting resistant seed from a mixture with susceptible seed
SI2262896T1 (sl) 2008-04-07 2014-05-30 Monsanto Technology Llc Rastlinski regulatorni elementi in njihove uporabe
BRPI1008674A2 (pt) 2009-02-19 2015-08-25 Pioneer Hi Bred Int Métodos de redução do desenvolvimento de pragas resistentes.
US20120277117A1 (en) 2009-02-27 2012-11-01 Adel Zayed Hydroponic apparatus and methods of use
BRPI1013946B1 (pt) 2009-05-03 2021-05-18 Monsanto Technology Llc Sistemas e processos para combinar tipos diferentes de sementes
WO2011050271A1 (en) 2009-10-23 2011-04-28 Monsanto Technology Llc Methods and compositions for expression of transgenes in plants
CA3121068C (en) 2010-01-14 2023-11-28 Monsanto Technology Llc Plant regulatory elements and uses thereof
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TWI680139B (zh) * 2018-07-21 2019-12-21 東海大學 短胜肽、及其組合物用於治療/預防糖尿病及與之相關疾病之用途
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Also Published As

Publication number Publication date
US20060206962A1 (en) 2006-09-14
CN1411469A (zh) 2003-04-16
EP1254167A2 (en) 2002-11-06
US20040216187A1 (en) 2004-10-28
US7381556B2 (en) 2008-06-03
US20080254484A1 (en) 2008-10-16
US7238511B2 (en) 2007-07-03
US6943002B2 (en) 2005-09-13
WO2001049834A2 (en) 2001-07-12
ZA200205242B (en) 2003-09-29
US20080010700A1 (en) 2008-01-10
BR0107474A (pt) 2002-10-08
AU2631501A (en) 2001-07-16
US6639054B1 (en) 2003-10-28
WO2001049834A3 (en) 2002-09-06
US20030194399A1 (en) 2003-10-16
CA2396422A1 (en) 2001-07-12

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