BR0107474A - Preparação de proteìnas e permuteìnas desalergenizadas - Google Patents

Preparação de proteìnas e permuteìnas desalergenizadas

Info

Publication number
BR0107474A
BR0107474A BR0107474-1A BR0107474A BR0107474A BR 0107474 A BR0107474 A BR 0107474A BR 0107474 A BR0107474 A BR 0107474A BR 0107474 A BR0107474 A BR 0107474A
Authority
BR
Brazil
Prior art keywords
proteins
allergenized
preparation
permuteins
observed
Prior art date
Application number
BR0107474-1A
Other languages
English (en)
Inventor
Murtaza F Alibhai
James D Astwood
Charles A Mcwherter
Hugh A Sampson
Original Assignee
Monsanto Technology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Technology Llc filed Critical Monsanto Technology Llc
Publication of BR0107474A publication Critical patent/BR0107474A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Insects & Arthropods (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"PREPARAçãO DE PROTEìNAS E PERMUTEìNAS DESALERGENIZADAS". Proteínas modificadas são descritas as quais mantém atividade enzimática e inseticida enquanto exibindo alergenicidade reduzida ou eliminada. Epitopos os quais aglutinam a anticorpos de anti-patatina foram identificadas, e removidas via mutagênese direcionada a sítio. Tirosina foram observadas a geralmente contribuírem às propriedades alérgicas de proteínas de patatina. Remoção de sítios de glicosilação foi observada a reduzir ou eliminar aglutinação a anticorpo. Permuteínas são também descritas as quais têm uma seq³ência de aminoácido redisposta enquanto retendo atividade enzimática. Proteínas e permuteínas alergenizadas podem ser usadas como materiais inseticidas, como suplementos nutricionais, e como agentes imunoterapêuticos.
BR0107474-1A 2000-01-06 2001-01-05 Preparação de proteìnas e permuteìnas desalergenizadas BR0107474A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17466900P 2000-01-06 2000-01-06
PCT/US2001/000342 WO2001049834A2 (en) 2000-01-06 2001-01-05 Preparation of deallergenized patatin proteins and patatin permutein proteins

Publications (1)

Publication Number Publication Date
BR0107474A true BR0107474A (pt) 2002-10-08

Family

ID=22637052

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0107474-1A BR0107474A (pt) 2000-01-06 2001-01-05 Preparação de proteìnas e permuteìnas desalergenizadas

Country Status (9)

Country Link
US (5) US6639054B1 (pt)
EP (1) EP1254167A2 (pt)
CN (1) CN1411469A (pt)
AU (1) AU2631501A (pt)
BR (1) BR0107474A (pt)
CA (1) CA2396422A1 (pt)
MX (1) MXPA02006752A (pt)
WO (1) WO2001049834A2 (pt)
ZA (1) ZA200205242B (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750329B1 (en) * 1989-05-05 2004-06-15 Research Development Foundation Antibody delivery system for biological response modifiers
WO2001036468A2 (en) * 1999-11-15 2001-05-25 Pioneer Hi-Bred International, Inc. Novel proteins having insecticidal activities and method of use
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
JP2005508134A (ja) * 2001-03-02 2005-03-31 ザ ロックフェラー ユニヴァーシティ 天然アレルゲンの免疫原性を保持する、アレルゲン性が低下した組み換えハイブリッドアレルゲン構築体
US6875744B2 (en) 2001-03-28 2005-04-05 Helix Biomedix, Inc. Short bioactive peptides
EP1379265A4 (en) 2001-03-28 2005-09-14 Helix Biomedix Inc SHORT BIOACTIVE PEPTIDES AND METHODS OF USE
CN1555268B (zh) * 2001-07-17 2013-04-03 研究发展基金会 含促调亡蛋白质的治疗剂
CA2488858A1 (en) * 2002-06-12 2003-12-24 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
US7371848B2 (en) 2004-01-20 2008-05-13 Monsanto Technology Llc Chimeric promoters comprising a caulimovirus promoter enhancer for use in plants
CN101155825B (zh) 2005-02-09 2014-11-26 赫里克斯生物医疗公司 抗微生物六肽
US7688207B2 (en) * 2006-07-28 2010-03-30 Abbott Laboratories Inc. System for tracking vessels in automated laboratory analyzers by radio frequency identification
US7838729B2 (en) 2007-02-26 2010-11-23 Monsanto Technology Llc Chloroplast transit peptides for efficient targeting of DMO and uses thereof
US20110079544A1 (en) 2009-10-01 2011-04-07 Pioneer Hi-Bred International, Inc. Method for sorting resistant seed from a mixture with susceptible seed
ES2562908T3 (es) 2008-04-07 2016-03-09 Monsanto Technology Llc Elementos reguladores de plantas y sus usos
WO2010096613A1 (en) 2009-02-19 2010-08-26 Pioneer Hi-Bred International, Inc. Blended refuge deployment via manipulation during hybrid seed production
US20120277117A1 (en) 2009-02-27 2012-11-01 Adel Zayed Hydroponic apparatus and methods of use
MX336396B (es) 2009-05-03 2016-01-15 Monsanto Technology Llc Sistemas y procesos para combinar diferentes tipos de semillas.
US8937214B2 (en) 2009-10-23 2015-01-20 Monsanto Technology Llc Methods and compositions for expression of transgenes in plants
BR122021001281B1 (pt) 2010-01-14 2022-03-03 Monsanto Technology Llc Molécula de dna compreendendo elementos reguladores de plantas
MX345696B (es) 2010-08-30 2017-02-10 Dow Agrosciences Llc Intensificador viral baciliforme de caña de azucar (vbca) y uso en la genomica funcional de la planta.
KR102003175B1 (ko) 2011-03-25 2019-07-24 몬산토 테크놀로지 엘엘씨 식물 조절 요소 및 그의 용도
EA031667B1 (ru) 2011-05-13 2019-02-28 Монсанто Текнолоджи Ллс Регуляторные элементы растений и их применение
JP2015508668A (ja) 2012-02-29 2015-03-23 ダウ アグロサイエンシィズ エルエルシー サトウキビ桿状ウイルス（ｓｃｂｖ）エンハンサーおよび植物機能ゲノミクスにおけるその使用
US9663793B2 (en) 2012-04-20 2017-05-30 Monsanto Technology, Llc Plant regulatory elements and uses thereof
CA2881787A1 (en) 2012-08-13 2014-02-20 University Of Georgia Research Foundation, Inc. Compositions and methods for increasing pest resistance in plants
CN108866076B (zh) 2012-12-19 2022-09-27 孟山都技术公司 植物调控元件及其用途
WO2014159434A1 (en) 2013-03-14 2014-10-02 Monsanto Technology Llc Plant regulatory elements and uses thereof
CR20200121A (es) 2013-03-14 2020-07-03 Monsanto Technology Llc Elementos regulatorios de planta y sus usos (divisional 2015-0554)
US11519011B2 (en) 2015-03-26 2022-12-06 The Texas A&M University System Conversion of lignin into bioplastics and lipid fuels
US20170177802A1 (en) * 2015-12-17 2017-06-22 Allergy Solutions, Inc. Allergy Service Management Portal
AU2017229608B2 (en) 2016-03-11 2022-12-01 Monsanto Technology Llc Plant regulatory elements and uses thereof
NZ748198A (en) 2016-05-24 2023-05-26 Monsanto Technology Llc Plant regulatory elements and uses thereof
US20190359992A1 (en) 2016-06-28 2019-11-28 Cellectis Altering expression of gene products in plants through targeted insertion of nucleic acid sequences
US20200332311A1 (en) 2018-01-12 2020-10-22 The Texas A&M University System Increasing plant bioproduct yield
TWI680139B (zh) * 2018-07-21 2019-12-21 東海大學 短胜肽、及其組合物用於治療/預防糖尿病及與之相關疾病之用途
TWI694835B (zh) * 2018-12-14 2020-06-01 東海大學 短胜肽用於治療/預防高血壓及其相關疾病之用途
AU2020307369A1 (en) 2019-06-26 2022-01-20 Eg Crop Science, Inc. Identification of resistance genes from wild relatives of banana and their uses in controlling Panama disease
US20220293228A1 (en) * 2021-03-09 2022-09-15 Glenn Loomis Identification of Allergens in Food Products
EP4314289A1 (en) 2021-03-26 2024-02-07 Flagship Pioneering Innovations VII, LLC Production of circular polyribonucleotides in a prokaryotic system
TW202300650A (zh) 2021-03-26 2023-01-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 真核系統中環狀多核糖核苷酸的產生
AR125216A1 (es) 2021-03-26 2023-06-28 Flagship Pioneering Innovations Vii Llc Producción de polirribonucleótidos circulares en un sistema eucariota
US20220372078A1 (en) * 2021-05-20 2022-11-24 Samsung Electronics Co., Ltd. Polypetide, photoresist composition including the same, and method of forming pattern using the same
AU2022375817A1 (en) 2021-11-01 2024-05-09 Flagship Pioneering Innovations Vii, Llc Polynucleotides for modifying organisms
WO2023141540A2 (en) 2022-01-20 2023-07-27 Flagship Pioneering Innovations Vii, Llc Polynucleotides for modifying organisms
WO2024052856A1 (en) 2022-09-09 2024-03-14 Friedrich Alexander Universität Erlangen-Nürnberg Plant regulatory elements and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0587798A4 (en) 1991-06-07 1995-04-19 Dowelanco INSECTICIDE PROTEINS AND METHOD FOR PROTECTING PLANTS.
US5743477A (en) * 1992-08-27 1998-04-28 Dowelanco Insecticidal proteins and method for plant protection
CA2155430A1 (en) 1993-03-12 1994-09-29 Sherri Marie Brown Method of controlling insects in plants using patatin gene expression
US5824864A (en) * 1995-05-25 1998-10-20 Pioneer Hi-Bred International, Inc. Maize gene and protein for insect control
US6057491A (en) * 1997-05-29 2000-05-02 Borad Of Regents For University Of Oklahoma Protein having insecticidal activities and method of use
DE69940805D1 (de) * 1998-01-31 2009-06-10 Sinai School Medicine Verfahren und reagenzien zur verminderung der klinischen reaktion zur allergie
AU3085299A (en) * 1998-03-12 1999-09-27 Board Of Trustees Of The University Of Arkansas, The Tertiary structure of peanut allergen ara h 1

Also Published As

Publication number Publication date
US20040216187A1 (en) 2004-10-28
CA2396422A1 (en) 2001-07-12
US6639054B1 (en) 2003-10-28
ZA200205242B (en) 2003-09-29
MXPA02006752A (es) 2004-09-10
US7381556B2 (en) 2008-06-03
US20080010700A1 (en) 2008-01-10
CN1411469A (zh) 2003-04-16
US7238511B2 (en) 2007-07-03
US20080254484A1 (en) 2008-10-16
US20030194399A1 (en) 2003-10-16
US6943002B2 (en) 2005-09-13
WO2001049834A2 (en) 2001-07-12
EP1254167A2 (en) 2002-11-06
WO2001049834A3 (en) 2002-09-06
AU2631501A (en) 2001-07-16
US20060206962A1 (en) 2006-09-14

Similar Documents

Publication Publication Date Title
BR0107474A (pt) Preparação de proteìnas e permuteìnas desalergenizadas
Tsuji et al. Purification and characterization of soybean allergen Gly m Bd 28K
DK0561907T3 (da) Proteiner med ændrede epitoper og fremgangsmåder til fremstilling deraf
WO2000034317A3 (en) Method for reducing immunogenicity of proteins
BRPI0410342A (pt) composições imunoprofiláticas e terapêuticas estáveis derivadas de células vegetais transgênicas e processos para produção
DK1423419T3 (da) Hybrid- og tandemekspression af Neisseria-proteiner
WO2003035847A3 (en) Il-13 mutein proteins, antibodies, compositions, methods and uses
NL300106I2 (nl) N-terminaal chemisch gemodificeerde eiwitpreparaten en werkwijzen.
BR9500747A (pt) Composição enteral,processo para sua preparação e uso de caseína micelar nativa
RU2007139808A (ru) Способ улучшения обучаемости и памяти у млекопитающих
CY1106111T1 (el) Ανασυνδυασμενος σταθepος κυτταρικος κλωνος, η παρασκευη και χρησιμοποιηση του
DE69230135D1 (de) Dna-sequenz, die für rinder-g(a)-lactalbumin kodiert, und nutzungsmethoden
BR9911549A (pt) Processo de produção de fitase em levedura
de Almeida et al. Development of process to produce polyvalent IgY antibodies anti-African snake venom
NO965621L (no) Nye hIL-4-mutantproteiner som antagonister eller partielle agonister for det humane interleukin 4
ATE176993T1 (de) Molkenprotein-dominante säuglingsmilchnahrung
DK1209985T3 (da) Modification af proteiners skumningsegenskaber
WO2003074004A3 (en) Method of producing antigens
PT1276763E (pt) Proteinas anti-congelantes sua producao e utilizacao
AU7556487A (en) Immunotoxins, process for their preparation and pharmaceutical compositions in which they are present
WO2003057821A3 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
IL106407A (en) Antigens, vaccines containing them and their preparation
ES2074983T3 (es) Procedimieto para el aislamiento de proteinas de membranas basales a partir de tejidos humanos y animales.
DE3877136D1 (de) Rekombinantes histidinreiches protein von plasmodium falciparum, seine herstellung und verwendung.
Malhotra et al. Antigenic characterization of excretory-secretory products of Setaria cervi

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]