BR0107474A - Preparação de proteìnas e permuteìnas desalergenizadas - Google Patents
Preparação de proteìnas e permuteìnas desalergenizadasInfo
- Publication number
- BR0107474A BR0107474A BR0107474-1A BR0107474A BR0107474A BR 0107474 A BR0107474 A BR 0107474A BR 0107474 A BR0107474 A BR 0107474A BR 0107474 A BR0107474 A BR 0107474A
- Authority
- BR
- Brazil
- Prior art keywords
- proteins
- allergenized
- preparation
- permuteins
- observed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Abstract
"PREPARAçãO DE PROTEìNAS E PERMUTEìNAS DESALERGENIZADAS". Proteínas modificadas são descritas as quais mantém atividade enzimática e inseticida enquanto exibindo alergenicidade reduzida ou eliminada. Epitopos os quais aglutinam a anticorpos de anti-patatina foram identificadas, e removidas via mutagênese direcionada a sítio. Tirosina foram observadas a geralmente contribuírem às propriedades alérgicas de proteínas de patatina. Remoção de sítios de glicosilação foi observada a reduzir ou eliminar aglutinação a anticorpo. Permuteínas são também descritas as quais têm uma seq³ência de aminoácido redisposta enquanto retendo atividade enzimática. Proteínas e permuteínas alergenizadas podem ser usadas como materiais inseticidas, como suplementos nutricionais, e como agentes imunoterapêuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17466900P | 2000-01-06 | 2000-01-06 | |
PCT/US2001/000342 WO2001049834A2 (en) | 2000-01-06 | 2001-01-05 | Preparation of deallergenized patatin proteins and patatin permutein proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0107474A true BR0107474A (pt) | 2002-10-08 |
Family
ID=22637052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0107474-1A BR0107474A (pt) | 2000-01-06 | 2001-01-05 | Preparação de proteìnas e permuteìnas desalergenizadas |
Country Status (9)
Country | Link |
---|---|
US (5) | US6639054B1 (pt) |
EP (1) | EP1254167A2 (pt) |
CN (1) | CN1411469A (pt) |
AU (1) | AU2631501A (pt) |
BR (1) | BR0107474A (pt) |
CA (1) | CA2396422A1 (pt) |
MX (1) | MXPA02006752A (pt) |
WO (1) | WO2001049834A2 (pt) |
ZA (1) | ZA200205242B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6750329B1 (en) * | 1989-05-05 | 2004-06-15 | Research Development Foundation | Antibody delivery system for biological response modifiers |
AU1612901A (en) * | 1999-11-15 | 2001-05-30 | Pioneer Hi-Bred International, Inc. | Novel proteins having insecticidal activities and method of use |
ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
ATE448793T1 (de) * | 2001-03-02 | 2009-12-15 | Univ Rockefeller | Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens |
KR100891157B1 (ko) | 2001-03-28 | 2009-04-07 | 헬릭스 바이오메딕스, 인코포레이티드 | 짧은 생물활성 펩티드 및 그것들의 사용 방법 |
US6875744B2 (en) * | 2001-03-28 | 2005-04-05 | Helix Biomedix, Inc. | Short bioactive peptides |
JP2004535202A (ja) * | 2001-07-17 | 2004-11-25 | リサーチ ディベロップメント ファンデーション | アポトーシス促進性蛋白質を含む治療剤 |
WO2003105761A2 (en) * | 2002-06-12 | 2003-12-24 | Research Development Foundation | Immunotoxin as a therapeutic agent and uses thereof |
WO2005069986A2 (en) | 2004-01-20 | 2005-08-04 | Monsanto Technology Llc | Chimeric promoters for use in plants |
KR101306643B1 (ko) | 2005-02-09 | 2013-09-12 | 헬릭스 바이오메딕스, 인코포레이티드 | 항미생물성 헥사펩티드 |
US7688207B2 (en) * | 2006-07-28 | 2010-03-30 | Abbott Laboratories Inc. | System for tracking vessels in automated laboratory analyzers by radio frequency identification |
US7838729B2 (en) | 2007-02-26 | 2010-11-23 | Monsanto Technology Llc | Chloroplast transit peptides for efficient targeting of DMO and uses thereof |
US20110079544A1 (en) | 2009-10-01 | 2011-04-07 | Pioneer Hi-Bred International, Inc. | Method for sorting resistant seed from a mixture with susceptible seed |
SI2262896T1 (sl) | 2008-04-07 | 2014-05-30 | Monsanto Technology Llc | Rastlinski regulatorni elementi in njihove uporabe |
CA2751724A1 (en) | 2009-02-19 | 2010-08-26 | Pioneer Hi-Bred International, Inc. | Blended refuge deployment via manipulation during hybrid seed production |
WO2010099431A2 (en) | 2009-02-27 | 2010-09-02 | Monsanto Technology Llc | Hydroponic apparatus and methods of use |
MX336396B (es) | 2009-05-03 | 2016-01-15 | Monsanto Technology Llc | Sistemas y procesos para combinar diferentes tipos de semillas. |
US8937214B2 (en) | 2009-10-23 | 2015-01-20 | Monsanto Technology Llc | Methods and compositions for expression of transgenes in plants |
BR122021001281B1 (pt) | 2010-01-14 | 2022-03-03 | Monsanto Technology Llc | Molécula de dna compreendendo elementos reguladores de plantas |
CA2809643C (en) | 2010-08-30 | 2019-09-24 | John P. Davies | Sugarcane bacilliform viral (scbv) enhancer and its use in plant functional genomics |
ES2666149T3 (es) | 2011-03-25 | 2018-05-03 | Monsanto Technology Llc | Elementos reguladores de plantas y usos de los mismos |
KR102080055B1 (ko) | 2011-05-13 | 2020-02-24 | 몬산토 테크놀로지 엘엘씨 | 식물 조절 요소 및 그의 용도 |
US10077450B2 (en) | 2012-02-29 | 2018-09-18 | Dow Agrosciences Llc | Sugarcane bacilliform viral (SCBV) enhancer and its use in plant functional genomics |
US9663793B2 (en) | 2012-04-20 | 2017-05-30 | Monsanto Technology, Llc | Plant regulatory elements and uses thereof |
WO2014028426A1 (en) | 2012-08-13 | 2014-02-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for increasing pest resistance in plants |
UA118661C2 (uk) | 2012-12-19 | 2019-02-25 | Монсанто Текнолоджи Ллс | Рекомбінантна молекула днк, яка має промоторну активність |
KR102270068B1 (ko) | 2013-03-14 | 2021-06-28 | 몬산토 테크놀로지 엘엘씨 | 식물 조절 성분 및 이의 용도 |
EP3613280A1 (en) | 2013-03-14 | 2020-02-26 | Monsanto Technology LLC | Plant regulatory elements and uses thereof |
EP3274462A4 (en) | 2015-03-26 | 2018-12-26 | The Texas A&M University System | Conversion of lignin into bioplastics and lipid fuels |
US20170177802A1 (en) * | 2015-12-17 | 2017-06-22 | Allergy Solutions, Inc. | Allergy Service Management Portal |
CN114807170A (zh) | 2016-03-11 | 2022-07-29 | 孟山都技术公司 | 植物调控元件及其用途 |
KR102374017B1 (ko) | 2016-05-24 | 2022-03-14 | 몬산토 테크놀로지 엘엘씨 | 식물 조절 요소 및 이들의 용도 |
US20190359992A1 (en) | 2016-06-28 | 2019-11-28 | Cellectis | Altering expression of gene products in plants through targeted insertion of nucleic acid sequences |
WO2019139616A1 (en) | 2018-01-12 | 2019-07-18 | The Texas A&M University System | Increasing plant bioproduct yield |
TWI680139B (zh) * | 2018-07-21 | 2019-12-21 | 東海大學 | 短胜肽、及其組合物用於治療/預防糖尿病及與之相關疾病之用途 |
TWI694835B (zh) * | 2018-12-14 | 2020-06-01 | 東海大學 | 短胜肽用於治療/預防高血壓及其相關疾病之用途 |
CA3143157A1 (en) | 2019-06-26 | 2020-12-30 | Eg Crop Science, Inc. | Identification of resistance genes from wild relatives of banana and their uses in controlling panama disease |
US20220293228A1 (en) * | 2021-03-09 | 2022-09-15 | Glenn Loomis | Identification of Allergens in Food Products |
AR125217A1 (es) | 2021-03-26 | 2023-06-28 | Flagship Pioneering Innovations Vii Llc | Producción de polirribonucleótidos circulares en un sistema procariota |
TW202305130A (zh) | 2021-03-26 | 2023-02-01 | 美商旗艦先鋒創新有限責任(Vii)公司 | 原核系統中環狀多核糖核苷酸之產生 |
WO2022204464A1 (en) | 2021-03-26 | 2022-09-29 | Flagship Pioneering Innovations Vii, Llc | Production of circular polyribonucleotides in a eukaryotic system |
US20220372078A1 (en) * | 2021-05-20 | 2022-11-24 | Samsung Electronics Co., Ltd. | Polypetide, photoresist composition including the same, and method of forming pattern using the same |
WO2023077118A1 (en) | 2021-11-01 | 2023-05-04 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
WO2023141540A2 (en) | 2022-01-20 | 2023-07-27 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
WO2024052856A1 (en) | 2022-09-09 | 2024-03-14 | Friedrich Alexander Universität Erlangen-Nürnberg | Plant regulatory elements and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0587798A4 (en) | 1991-06-07 | 1995-04-19 | Dowelanco | INSECTICIDE PROTEINS AND METHOD FOR PROTECTING PLANTS. |
US5743477A (en) * | 1992-08-27 | 1998-04-28 | Dowelanco | Insecticidal proteins and method for plant protection |
HUT72479A (en) | 1993-03-12 | 1996-04-29 | Monsanto Co | Method of controlling insects inplants |
US5824864A (en) * | 1995-05-25 | 1998-10-20 | Pioneer Hi-Bred International, Inc. | Maize gene and protein for insect control |
US6057491A (en) * | 1997-05-29 | 2000-05-02 | Borad Of Regents For University Of Oklahoma | Protein having insecticidal activities and method of use |
DE69940805D1 (de) * | 1998-01-31 | 2009-06-10 | Sinai School Medicine | Verfahren und reagenzien zur verminderung der klinischen reaktion zur allergie |
AU3085299A (en) * | 1998-03-12 | 1999-09-27 | Board Of Trustees Of The University Of Arkansas, The | Tertiary structure of peanut allergen ara h 1 |
-
2001
- 2001-01-05 EP EP01900904A patent/EP1254167A2/en not_active Withdrawn
- 2001-01-05 BR BR0107474-1A patent/BR0107474A/pt not_active Application Discontinuation
- 2001-01-05 AU AU26315/01A patent/AU2631501A/en not_active Abandoned
- 2001-01-05 CN CN01806028A patent/CN1411469A/zh active Pending
- 2001-01-05 MX MXPA02006752A patent/MXPA02006752A/es unknown
- 2001-01-05 US US09/755,630 patent/US6639054B1/en not_active Expired - Lifetime
- 2001-01-05 WO PCT/US2001/000342 patent/WO2001049834A2/en not_active Application Discontinuation
- 2001-01-05 CA CA002396422A patent/CA2396422A1/en not_active Abandoned
-
2002
- 2002-06-28 ZA ZA200205242A patent/ZA200205242B/en unknown
-
2003
- 2003-09-09 US US10/658,180 patent/US6943002B2/en not_active Expired - Lifetime
-
2005
- 2005-09-07 US US11/220,856 patent/US7238511B2/en not_active Expired - Lifetime
-
2007
- 2007-06-28 US US11/823,825 patent/US7381556B2/en not_active Expired - Lifetime
-
2008
- 2008-05-30 US US12/130,401 patent/US20080254484A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080254484A1 (en) | 2008-10-16 |
US7238511B2 (en) | 2007-07-03 |
MXPA02006752A (es) | 2004-09-10 |
CN1411469A (zh) | 2003-04-16 |
US6639054B1 (en) | 2003-10-28 |
WO2001049834A3 (en) | 2002-09-06 |
US6943002B2 (en) | 2005-09-13 |
US20030194399A1 (en) | 2003-10-16 |
US7381556B2 (en) | 2008-06-03 |
US20040216187A1 (en) | 2004-10-28 |
EP1254167A2 (en) | 2002-11-06 |
US20060206962A1 (en) | 2006-09-14 |
AU2631501A (en) | 2001-07-16 |
CA2396422A1 (en) | 2001-07-12 |
ZA200205242B (en) | 2003-09-29 |
WO2001049834A2 (en) | 2001-07-12 |
US20080010700A1 (en) | 2008-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |