CA2421974C - Pulmonary delivery in treating disorders of the central nervous system - Google Patents
Pulmonary delivery in treating disorders of the central nervous system Download PDFInfo
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- CA2421974C CA2421974C CA2421974A CA2421974A CA2421974C CA 2421974 C CA2421974 C CA 2421974C CA 2421974 A CA2421974 A CA 2421974A CA 2421974 A CA2421974 A CA 2421974A CA 2421974 C CA2421974 C CA 2421974C
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- pulmonary
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Classifications
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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Landscapes
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/665,252 | 2000-09-19 | ||
| US09/665,252 US6514482B1 (en) | 2000-09-19 | 2000-09-19 | Pulmonary delivery in treating disorders of the central nervous system |
| US09/877,734 US6613308B2 (en) | 2000-09-19 | 2001-06-08 | Pulmonary delivery in treating disorders of the central nervous system |
| US09/877,734 | 2001-06-08 | ||
| PCT/US2001/029311 WO2002024158A2 (en) | 2000-09-19 | 2001-09-19 | Pulmonary delivery in treating disorders of the central nervous system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2421974A1 CA2421974A1 (en) | 2002-03-28 |
| CA2421974C true CA2421974C (en) | 2011-03-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2421974A Expired - Lifetime CA2421974C (en) | 2000-09-19 | 2001-09-19 | Pulmonary delivery in treating disorders of the central nervous system |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US6613308B2 (enExample) |
| EP (2) | EP3061453A1 (enExample) |
| JP (2) | JP5421510B2 (enExample) |
| AU (2) | AU9112201A (enExample) |
| CA (1) | CA2421974C (enExample) |
| CY (1) | CY1118851T1 (enExample) |
| DK (1) | DK1318785T3 (enExample) |
| ES (1) | ES2621549T3 (enExample) |
| PT (1) | PT1318785T (enExample) |
| WO (1) | WO2002024158A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10589039B2 (en) | 2012-02-29 | 2020-03-17 | Pulmatric Operating Company, Inc. | Methods for producing respirable dry powders |
Families Citing this family (179)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020052310A1 (en) * | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| US7779020B2 (en) * | 2002-03-01 | 2010-08-17 | International Business Machines Corporation | Small-footprint applicative query interpreter method, system and program product |
| ES2211151T3 (es) | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| CA2307278A1 (en) * | 2000-04-28 | 2001-10-28 | University Of British Columbia | Use of n-heterocyclic substituted salicylic acids for inhibition of cellular uptake of cystine |
| FR2812545B1 (fr) * | 2000-08-03 | 2003-03-28 | Air Liquide Sante Int | Aerosol medicamenteux inhalable dans le traitement ou la prevention de la douceur |
| US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| WO2002094246A2 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of nonsteroidal antiinflammatory drugs through an inhalation route |
| AU2002310074B2 (en) * | 2001-05-24 | 2008-09-04 | Alexza Pharmaceuticals, Inc. | Delivery of compounds for the treatment of migraine through an inhalation route |
| WO2002094237A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of beta-blockers through an inhalation route |
| EP1392260A2 (en) * | 2001-05-24 | 2004-03-03 | Alexza Molecular Delivery Corporation | Delivery of benzodiazepines through an inhalation route |
| DE60227660D1 (de) * | 2001-05-24 | 2008-08-28 | Alexza Pharmaceuticals Inc | Freisetzung von antiemetika auf dem inhalationsweg |
| WO2002094238A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of anti-migraine compounds through an inhalation route |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US6759029B2 (en) * | 2001-05-24 | 2004-07-06 | Alexza Molecular Delivery Corporation | Delivery of rizatriptan and zolmitriptan through an inhalation route |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| AU2002259241B2 (en) * | 2001-05-24 | 2008-09-04 | Alexza Pharmaceuticals, Inc. | Delivery of sedative-hypnotics through an inhalation route |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US6737042B2 (en) | 2001-05-24 | 2004-05-18 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| WO2002094234A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of opioids through an inhalation route |
| WO2002094232A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of antidepressants through an inhalation route |
| US20080038363A1 (en) * | 2001-05-24 | 2008-02-14 | Zaffaroni Alejandro C | Aerosol delivery system and uses thereof |
| CA2447519C (en) * | 2001-05-24 | 2008-09-16 | Alexza Molecular Delivery Corporation | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
| US7498019B2 (en) | 2001-05-24 | 2009-03-03 | Alexza Pharmaceuticals, Inc. | Delivery of compounds for the treatment of headache through an inhalation route |
| DE10137633A1 (de) * | 2001-08-03 | 2003-02-20 | Boehringer Ingelheim Pharma | Pramipexol zur Behandlung von ADHD |
| WO2003041693A1 (en) * | 2001-11-09 | 2003-05-22 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
| WO2003057188A1 (en) | 2001-11-21 | 2003-07-17 | Alexza Molecular Delivery Corporation | Delivery of caffeine through an inhalation route |
| ES2364636T3 (es) | 2001-12-19 | 2011-09-08 | Novartis Ag | Administración pulmonar de aminoglucósidos. |
| US20040009231A1 (en) * | 2002-03-20 | 2004-01-15 | Advanced Inhalation Research, Inc. | hGH (human growth hormone) formulations for pulmonary administration |
| US6923175B2 (en) | 2002-03-20 | 2005-08-02 | Mannkind Corporation | Inhalation apparatus |
| US7872048B2 (en) | 2004-09-18 | 2011-01-18 | University Of Maryland, Baltimore | Methods for treating spinal cord injury with a compound that inhibits a NCCa-ATP channel |
| LT2630954T (lt) * | 2002-03-20 | 2017-01-25 | Civitas Therapeutics, Inc. | Levodopos įvedimas į plaučius |
| US7105576B2 (en) * | 2002-04-24 | 2006-09-12 | Research Development Foundation | Synergistic effects of nuclear transcription factor NF-κB inhibitors and anti-neoplastic agents |
| EP1503744A1 (en) | 2002-05-13 | 2005-02-09 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
| US20060193788A1 (en) * | 2002-11-26 | 2006-08-31 | Hale Ron L | Acute treatment of headache with phenothiazine antipsychotics |
| EP1523318A4 (en) * | 2002-06-24 | 2007-07-04 | Res Dev Foundation | TREATMENT OF HUMAN MULTIPLE MYELOMA BY CURCUMIN |
| CA2488976C (en) * | 2002-06-28 | 2009-08-25 | Advanced Inhalation Research, Inc. | Inhalable epinephrine |
| WO2004006841A2 (en) * | 2002-07-12 | 2004-01-22 | University Of Rochester | Use of amino acids for treatment of various conditions |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| US8288372B2 (en) * | 2002-11-26 | 2012-10-16 | Alexza Pharmaceuticals, Inc. | Method for treating headache with loxapine |
| US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
| WO2004047841A1 (en) * | 2002-11-26 | 2004-06-10 | Alexza Molecular Delivery Corporation | Treatment of headache with antipsychotics delivered by inhalation |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| EP1596824A4 (en) * | 2003-02-04 | 2011-11-23 | Chrysalis Tech Inc | AEROSOL FORMULATIONS AND AEROSOL DISTRIBUTION OF BUSPIRONE, BUPRENORPHINE, TRIAZOLAM, CYCLOBENZAPRINE AND ZOLPIDEM |
| EP1617820B1 (en) | 2003-04-14 | 2018-03-21 | Vectura Limited | Dry power inhaler devices and dry power formulations for enhancing dosing efficiency |
| US20050079166A1 (en) | 2003-05-21 | 2005-04-14 | Alexza Molecular Delivery Corporation | Self-contained heating unit and drug-supply unit employing same |
| AU2004249166B2 (en) * | 2003-06-13 | 2008-10-09 | Alkermes, Inc. | Low dose pharmaceutical powders for inhalation |
| US7462646B2 (en) | 2003-08-26 | 2008-12-09 | Research Development Foundation | Osteoclastogenesis inhibitors and uses thereof |
| US20050181036A1 (en) * | 2003-08-26 | 2005-08-18 | Research Development Foundation | Aerosol delivery of curcumin |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| KR20120131245A (ko) | 2004-06-18 | 2012-12-04 | 노파르티스 아게 | 기관지 감염의 치료 방법 |
| CA2576961A1 (en) | 2004-08-12 | 2006-03-02 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| CN101010305B (zh) | 2004-08-20 | 2010-08-11 | 曼金德公司 | 二酮哌嗪合成的催化反应 |
| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
| US10583094B2 (en) | 2004-09-18 | 2020-03-10 | University Of Maryland | Therapeutic methods that target the NCCA-ATP channel |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| US20060134009A1 (en) * | 2004-12-16 | 2006-06-22 | Daniel Deaver | Low dose corticosteroid powders for inhalation |
| US8466133B2 (en) | 2005-04-22 | 2013-06-18 | University Of Geneva | Polylactides compositions and uses thereof |
| KR101384456B1 (ko) | 2005-09-14 | 2014-04-10 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
| ES2647080T3 (es) | 2006-02-22 | 2017-12-19 | Mannkind Corporation | Un método para mejorar las propiedades farmacéuticas de micropartículas que comprenden dicetopiperazina y un agente activo |
| CA2674949A1 (en) | 2007-01-12 | 2008-07-24 | J. Marc Simard | Targeting ncca-atp channel for organ protection following ischemic episode |
| US20080275030A1 (en) * | 2007-01-19 | 2008-11-06 | Sveinbjorn Gizurarson | Methods and Compositions for the Delivery of a Therapeutic Agent |
| CN101674730B (zh) | 2007-02-02 | 2014-09-10 | 贝勒医学院 | 用于治疗代谢疾病的组合物和方法 |
| EP2114160B1 (en) | 2007-02-09 | 2016-11-16 | University of Maryland, Baltimore | Antagonists of a non-selective cation channel in neural cells |
| ES2691033T3 (es) | 2007-02-11 | 2018-11-23 | Map Pharmaceuticals Inc. | Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios |
| WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| CA2691199C (en) | 2007-06-22 | 2017-09-12 | Marc J. Simard | Inhibitors of ncca-atp channels for therapy |
| EP2173380A4 (en) * | 2007-07-13 | 2011-08-31 | Abbott Biotech Ltd | METHOD AND COMPOSITIONS FOR PULMONARY ADMINISTRATION OF A TNFa HEMMER |
| WO2011163272A1 (en) | 2010-06-21 | 2011-12-29 | Mannkind Corporation | Dry powder drug delivery system and methods |
| GB0721394D0 (en) * | 2007-10-31 | 2007-12-12 | Vectura Group Plc | Compositions for trating parkinson's disease |
| GB2454480A (en) * | 2007-11-07 | 2009-05-13 | Vectura Group Plc | Pulmonary inhalation of levodopa containing compositions in the treatment of Parkinsons disease and other central nervous system disorders |
| US20090247537A1 (en) * | 2008-03-25 | 2009-10-01 | William Dale Overfield | Methods for preventing or treating bruxism using dopaminergic agents |
| DK2293833T3 (en) | 2008-06-13 | 2016-05-23 | Mannkind Corp | DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CA2728523C (en) | 2008-06-20 | 2020-03-10 | Mannkind Corporation | An interactive apparatus and method for real-time profiling of inhalation efforts |
| TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| CN117530912A (zh) * | 2008-08-15 | 2024-02-09 | 硬木药品公司 | 适合口服给药的鸟苷酸环化酶-c受体激动剂多肽的稳定的固体制剂 |
| EP2340254B8 (en) * | 2008-09-15 | 2014-05-21 | Biovista, Inc. | Compositions and methods for treating epilepsy |
| EP2719380A3 (en) | 2008-09-16 | 2014-07-30 | University of Maryland, Baltimore | SUR1 inhibitors for therapy |
| US8349899B1 (en) | 2008-12-03 | 2013-01-08 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| US8765817B1 (en) | 2008-12-03 | 2014-07-01 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| EP2228054A1 (en) * | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Riluzole aqueous suspensions |
| EP2410981B2 (en) | 2009-03-26 | 2020-02-26 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US20120294868A1 (en) | 2009-04-24 | 2012-11-22 | Edwards James R | Anti-tgf-beta induction of bone cell function and bone growth |
| US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| EP2456304B1 (en) | 2009-07-24 | 2015-08-19 | Baylor College Of Medicine | Methods of modulation of branched chain acids and uses thereof |
| MX2012001660A (es) * | 2009-08-06 | 2012-03-26 | Ironwood Pharmaceuticals Inc | Formulaciones que contienen linaclotida para adminstracion oral. |
| JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
| EA201290799A1 (ru) | 2010-02-17 | 2013-03-29 | Айронвуд Фармасьютикалз, Инк. | Лечение желудочно-кишечных расстройств |
| LT2603232T (lt) | 2010-08-11 | 2020-01-27 | Ironwood Pharmaceuticals, Inc. | Stabilios linaklotido vaisto formos |
| EP4050109A1 (en) | 2010-08-18 | 2022-08-31 | Fred Hutchinson Cancer Center | Agents for use in treating facioscapulohumeral dystrophy (fshd) |
| WO2012030647A1 (en) | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| CN107096014B (zh) | 2010-09-29 | 2022-07-15 | 普马特里克斯营业公司 | 吸入用单价金属阳离子干粉剂 |
| ES2625858T3 (es) | 2011-04-01 | 2017-07-20 | Mannkind Corporation | Paquete de tipo blíster para cartuchos farmacéuticos |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| WO2013016223A2 (en) | 2011-07-22 | 2013-01-31 | The University Of Chicago | Treatments for migraine and related disorders |
| MX347354B (es) | 2011-08-17 | 2017-04-24 | Ironwood Pharmaceuticals Inc | Tratamientos para trastornos gastrointestinales. |
| WO2013057592A2 (en) | 2011-09-14 | 2013-04-25 | King Abdullah University Of Science And Technology | Treatment of sickle cell disease |
| US9644005B2 (en) | 2011-09-21 | 2017-05-09 | King Abdullah University Of Science And Technology | Didemnin biosynthetic gene cluster in Tistrella mobilis |
| WO2013043985A1 (en) | 2011-09-23 | 2013-03-28 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| HK1201475A1 (en) | 2011-10-24 | 2015-09-04 | Mannkind Corporation | Methods and compositions for treating pain |
| DK2806877T3 (da) | 2012-01-23 | 2019-11-04 | Sage Therapeutics Inc | Neuroaktive steroidformuleringer omfattende et kompleks af allopregnanolon og sulfobutylether beta-cyclodekstrin |
| AU2013221448B2 (en) | 2012-02-16 | 2017-02-23 | The University Of Toledo | Xenoantigen-displaying anti-cancer vaccines and method of making |
| WO2013130422A1 (en) | 2012-02-27 | 2013-09-06 | Biovista, Inc. | Compositions and methods for treating mitochondrial diseases |
| AR092821A1 (es) | 2012-04-20 | 2015-05-06 | Sucampo Ag | Conjugado de derivado de acido graso-polimero |
| US10307490B2 (en) | 2012-05-23 | 2019-06-04 | The Ohio State University | Lipid nanoparticle compositions for antisense oligonucleotides delivery |
| CA3098386C (en) | 2012-07-12 | 2022-11-29 | Mannkind Corporation | Dry powder drug delivery systems and methods |
| US20140050789A1 (en) | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids |
| CA2882708A1 (en) | 2012-08-21 | 2014-02-27 | Sage Therapeutics, Inc. | Methods of treating epilepsy or status epilepticus |
| KR102237007B1 (ko) * | 2012-10-22 | 2021-04-06 | 키비타스 테라퓨틱스, 인코포레이티드. | 레보도파 혈장 농도의 환자간 변산도의 감소 |
| CN104884046A (zh) | 2012-10-22 | 2015-09-02 | 丝维塔斯治疗公司 | 用于快速缓解帕金森病的左旋多巴制剂 |
| EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
| WO2014074797A1 (en) * | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
| US8545878B1 (en) * | 2012-11-09 | 2013-10-01 | Civitas Therapeutics, Inc. | Capsules containing high doses of levodopa for pulmonary use |
| JP2016501876A (ja) | 2012-11-30 | 2016-01-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ステロイドの抗痙攣活性 |
| US9757395B2 (en) * | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| FR3000392B1 (fr) * | 2012-12-27 | 2015-03-27 | Virbac | Nouvelles compositions pharmaceutiques veterinaires et leur procede de preparation |
| WO2014160339A1 (en) | 2013-03-13 | 2014-10-02 | Board Of Regents, The University Of Texas System | Compounds for treating inflammatory and hyperproliferative diseases |
| MX369136B (es) | 2013-03-15 | 2019-10-30 | Mannkind Corp | Composiciones de dicetopiperazina microcristalina y metodos. |
| MX2015013774A (es) * | 2013-03-26 | 2016-02-29 | Optinose As | Administracion nasal. |
| US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
| WO2014165303A1 (en) | 2013-04-01 | 2014-10-09 | Pulmatrix, Inc. | Tiotropium dry powders |
| US10149823B2 (en) * | 2013-04-30 | 2018-12-11 | Otitopic Inc. | Dry powder formulations and methods of use |
| BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| NZ759287A (en) | 2013-12-02 | 2022-10-28 | Baylor College Medicine | Identification of a new polypeptide hormone for maintenance of optimal body weight and blood glucose |
| CN112656780A (zh) | 2014-02-20 | 2021-04-16 | 奥迪托皮克股份有限公司 | 用于吸入的干粉制剂 |
| WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
| WO2015157500A1 (en) | 2014-04-09 | 2015-10-15 | Research Development Foundation | Class iia hdac inhibitors for the treatment of infection |
| MX2016013741A (es) * | 2014-04-21 | 2017-04-06 | Civitas Therapeutics Inc | Rápido alivio de las fluctuaciones motoras en la enfermedad de parkinson. |
| WO2016025202A1 (en) | 2014-08-14 | 2016-02-18 | The Regents Of The University Of Colorado | Antibody-sirna conjugates and uses therefor |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| CN107106641B (zh) | 2014-10-31 | 2021-12-21 | 葛兰素史密斯克莱知识产权发展有限公司 | 粉末制剂 |
| WO2016073184A1 (en) | 2014-11-04 | 2016-05-12 | Dana Farber Cancer Institute, Inc. | Compositions and methods for treating multiple myeloma |
| EP3285792B1 (en) | 2015-04-20 | 2020-11-04 | The Board of Regents of The University of Texas System | Clec11a is a bone growth agent |
| MX2017013950A (es) * | 2015-05-01 | 2018-08-28 | Civitas Therapeutics Inc | Polvos de zolmitriptán para suministro pulmonar. |
| US10962551B2 (en) | 2015-06-17 | 2021-03-30 | The Johns Hopkins University | TDP-43 in degenerative disease |
| WO2017004501A1 (en) | 2015-07-02 | 2017-01-05 | Civitas Therapeutics, Inc. | Triptan powders for pulmonary delivery |
| WO2017132321A1 (en) | 2016-01-29 | 2017-08-03 | The Johns Hopkins University | Novel inhibitors of bacterial growth |
| WO2017143112A2 (en) | 2016-02-17 | 2017-08-24 | The Johns Hopkins University | An oxazolidinone for treatment of infections with mycobacterium tuberculosis |
| WO2017147370A1 (en) | 2016-02-24 | 2017-08-31 | The Johns Hopkins University | Novel antiviral proteins and their uses in therapeutic methods |
| US10888549B2 (en) | 2016-03-07 | 2021-01-12 | The Johns Hopkins University | Pharmaceutical agents targeting cancer stem cells |
| WO2017156103A1 (en) | 2016-03-08 | 2017-09-14 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| CA3017143A1 (en) | 2016-03-10 | 2017-09-14 | The Johns Hopkins University | Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses |
| US11203626B2 (en) | 2016-03-10 | 2021-12-21 | The Johns Hopkins University | Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses |
| KR102889062B1 (ko) | 2016-03-17 | 2025-11-21 | 더 존스 홉킨스 유니버시티 | Paris의 파네실화에 의해 파킨슨병을 예방 또는 치료하기 위한 방법 |
| WO2017173055A1 (en) | 2016-03-30 | 2017-10-05 | The Johns Hopkins University | Olfr90 specificity and methods of detection |
| US11016085B2 (en) | 2016-04-25 | 2021-05-25 | The Johns Hopkins University | ZNT8 assays for drug development and pharmaceutical compositions |
| EP3463378A4 (en) | 2016-06-03 | 2020-01-08 | Otitopic Inc. | DRY POWDER FORMULAS FOR INHALATION |
| US11149275B2 (en) | 2016-10-10 | 2021-10-19 | The Johns Hopkins University | Device and method to treat esophageal disorders |
| HUE064864T2 (hu) | 2016-12-09 | 2024-04-28 | Alexza Pharmaceuticals Inc | Az alprazolam alkalmazása epilepszia kezelésében |
| US10434089B2 (en) | 2017-01-25 | 2019-10-08 | The Johns Hopkins University | Avibactam and carbapenems antibacterial agents |
| MX2019010986A (es) | 2017-03-14 | 2020-02-05 | Baylor College Medicine | Yap activo dominante, un efector de hippo, induce la accesibilidad a la cromatina y la renovación de cardiomiocitos. |
| US11892457B2 (en) | 2017-07-12 | 2024-02-06 | The Johns Hopkins University | Proteoliposome-based ZnT8 self-antigen for type 1 diabetes diagnosis |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| AU2017432640B2 (en) | 2017-09-22 | 2023-11-30 | Aspeya US Inc. | Dry powder compositions with magnesium stearate |
| WO2019099613A1 (en) | 2017-11-16 | 2019-05-23 | University Of Maine System Board Of Trustees | Compositions and methods for modulating endothelial cell migration and angiogenesis |
| US11246857B2 (en) | 2017-12-14 | 2022-02-15 | The Johns Hopkins University | Anti-fungal inhibitors |
| KR102852740B1 (ko) | 2018-02-02 | 2025-08-29 | 알렉스자 파마스티칼즈, 인크. | 전기적 응축 에어로졸 디바이스 |
| CN112105631A (zh) | 2018-03-06 | 2020-12-18 | 约翰霍普金斯大学 | Treg耗尽和检查点抑制剂的组合 |
| CN112770735A (zh) | 2018-07-29 | 2021-05-07 | Musc研究发展基金会 | 用于治疗神经或线粒体疾病的化合物 |
| US12226433B2 (en) | 2018-08-06 | 2025-02-18 | The Johns Hopkins University | Treatment of irritable bowel syndrome with molybdenum |
| CN113166241B (zh) | 2018-08-16 | 2025-02-25 | 约翰霍普金斯大学 | 人类znt8抗体 |
| EP3921029B1 (en) | 2019-02-07 | 2025-07-30 | Baylor College of Medicine | Composition comprising ccl5 for use in treating bone break, bone fracture, bone degeneration and osteoporosis |
| US11717506B2 (en) | 2019-05-07 | 2023-08-08 | The Johns Hopkins University | Neuroprotective compounds for amyotrophic lateral sclerosis |
| US12366570B2 (en) | 2019-10-01 | 2025-07-22 | The Johns Hopkins University | Cell-based ZNT8 assay |
| WO2021133793A1 (en) | 2019-12-26 | 2021-07-01 | Figene, Llc | Suppression of interleukin-17 production and inhibition of th17 cell generation by fibroblasts and products thereof |
| WO2021133790A1 (en) | 2019-12-26 | 2021-07-01 | Figene, Llc | Prevention and treatment of kidney failure by administration of fibroblasts and products thereof |
| MX2022010960A (es) | 2020-03-04 | 2022-11-16 | Pleopharma L L C | Métodos y composiciones para tratar el trastorno por uso de cannabis y mitigar la abstinencia de cannabinoides. |
| WO2022087270A1 (en) | 2020-10-23 | 2022-04-28 | Mirati Therapeutics, Inc. | Methods for treatment of lung cancers |
| US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| JPS6122019A (ja) | 1984-07-06 | 1986-01-30 | Tomio Konno | 吸入細胞活性薬品とその使用方法 |
| GB8501015D0 (en) | 1985-01-16 | 1985-02-20 | Riker Laboratories Inc | Drug |
| AU587472B2 (en) | 1985-05-22 | 1989-08-17 | Liposome Technology, Inc. | Liposome inhalation method and system |
| WO1987005210A1 (fr) * | 1986-03-10 | 1987-09-11 | Kurt Burghart | Produit pharmaceutique et son procede de preparation |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US6048857A (en) | 1989-10-17 | 2000-04-11 | Ellinwood, Jr.; Everett H. | Dosing method of administering medicaments via inhalation administration |
| US5118494A (en) | 1990-03-23 | 1992-06-02 | Minnesota Mining And Manufacturing Company | Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations |
| EP0527940A1 (en) | 1990-05-08 | 1993-02-24 | Liposome Technology, Inc. | Direct spray-dried drug/lipid powder composition |
| US5166202A (en) | 1990-09-19 | 1992-11-24 | Trustees Of The University Of Pennsylvania | Method for the treatment of panic disorder |
| GB9101592D0 (en) | 1991-01-24 | 1991-03-06 | Glaxo Group Ltd | Compositions |
| DE69229070T2 (de) * | 1991-02-09 | 1999-11-18 | B.S.D. Bio Science Development Snc Di Omini C. & Zuccari G., Bussero | Antireaktive antiasthmatische Wirkung von Acetylsalicylsäure durch Inhalation |
| ATE204262T1 (de) | 1991-09-18 | 2001-09-15 | Glaxo Group Ltd | Benzanilidderivate als 5-ht1d-antagonisten |
| US5457100A (en) | 1991-12-02 | 1995-10-10 | Daniel; David G. | Method for treatment of recurrent paroxysmal neuropsychiatric |
| US5756071A (en) | 1992-06-03 | 1998-05-26 | Arrowdean Limited | Method for nasally administering aerosols of therapeutic agents to enhance penetration of the blood brain barrier |
| US5284133A (en) | 1992-07-23 | 1994-02-08 | Armstrong Pharmaceuticals, Inc. | Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means |
| AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| US5354885A (en) * | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
| JPH10501519A (ja) | 1994-03-07 | 1998-02-10 | インヘイル・セラピューティック・システムズ | インシュリンを肺に送給できる方法および組成物 |
| CA2190502A1 (en) * | 1994-05-18 | 1995-11-23 | Robert M. Platz | Methods and compositions for the dry powder formulation of interferons |
| CA2152684A1 (en) | 1994-07-01 | 1996-01-02 | Richard Anthony Henry | Aerosol delivery of midazolam |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US5654007A (en) | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| GB9606188D0 (en) * | 1996-03-23 | 1996-05-29 | Danbiosyst Uk | Pollysaccharide microspheres for the pulmonary delivery of drugs |
| US5875776A (en) | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6503480B1 (en) * | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6103270A (en) | 1996-06-07 | 2000-08-15 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| ZA9711732B (en) * | 1996-12-31 | 1998-12-28 | Quadrant Holdings Cambridge | Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery |
| ES2236832T3 (es) | 1997-01-16 | 2005-07-16 | Massachusetts Institute Of Technology | Preparacion de particulas para inhalacion. |
| US5958902A (en) | 1997-04-16 | 1999-09-28 | Wisconsin Alumni Research Foundation | Method and composition for treating sleep apnea |
| US6284282B1 (en) * | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
| US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| DK1180020T4 (da) | 1999-05-27 | 2009-10-05 | Acusphere Inc | Poröse lægemiddelmatrixer og fremgangsmåder til fremstilling deraf |
| US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| WO2002094243A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route |
| US7090830B2 (en) * | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
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2001
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- 2001-09-19 CA CA2421974A patent/CA2421974C/en not_active Expired - Lifetime
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- 2001-09-19 AU AU9112201A patent/AU9112201A/xx active Pending
- 2001-09-19 EP EP15201016.1A patent/EP3061453A1/en not_active Ceased
- 2001-09-19 EP EP01971210.8A patent/EP1318785B1/en not_active Expired - Lifetime
- 2001-09-19 AU AU2001291122A patent/AU2001291122B2/en not_active Expired
- 2001-09-19 PT PT1971210T patent/PT1318785T/pt unknown
- 2001-09-19 DK DK01971210.8T patent/DK1318785T3/en active
- 2001-09-19 JP JP2002528195A patent/JP5421510B2/ja not_active Expired - Lifetime
- 2001-09-19 ES ES01971210.8T patent/ES2621549T3/es not_active Expired - Lifetime
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2003
- 2003-05-20 US US10/441,968 patent/US6979437B2/en not_active Expired - Lifetime
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2004
- 2004-01-21 US US10/762,200 patent/US20040228923A1/en not_active Abandoned
- 2004-07-21 US US10/895,577 patent/US20040265242A1/en not_active Abandoned
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2008
- 2008-07-02 US US12/166,704 patent/US20090162441A1/en not_active Abandoned
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2011
- 2011-09-13 US US13/231,405 patent/US20120087952A1/en not_active Abandoned
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2012
- 2012-06-27 JP JP2012144071A patent/JP2012180378A/ja not_active Withdrawn
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2014
- 2014-01-10 US US14/152,492 patent/US20140193501A1/en not_active Abandoned
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2017
- 2017-03-21 CY CY20171100358T patent/CY1118851T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10589039B2 (en) | 2012-02-29 | 2020-03-17 | Pulmatric Operating Company, Inc. | Methods for producing respirable dry powders |
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| US20140193501A1 (en) | 2014-07-10 |
| US20040265242A1 (en) | 2004-12-30 |
| WO2002024158A3 (en) | 2002-09-19 |
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| US6613308B2 (en) | 2003-09-02 |
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| CY1118851T1 (el) | 2018-01-10 |
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| EP1318785A2 (en) | 2003-06-18 |
| JP5421510B2 (ja) | 2014-02-19 |
| EP3061453A1 (en) | 2016-08-31 |
| US20020058009A1 (en) | 2002-05-16 |
| WO2002024158A2 (en) | 2002-03-28 |
| CA2421974A1 (en) | 2002-03-28 |
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