CA2419223A1 - Utilisation de complexes metalliques contenant du perfluoroalkyle en tant qu'agents de contraste dans le cadre de l'imagerie rm servant a la visualisation des plaques, tumeurs et necroses - Google Patents

Utilisation de complexes metalliques contenant du perfluoroalkyle en tant qu'agents de contraste dans le cadre de l'imagerie rm servant a la visualisation des plaques, tumeurs et necroses Download PDF

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Publication number
CA2419223A1
CA2419223A1 CA002419223A CA2419223A CA2419223A1 CA 2419223 A1 CA2419223 A1 CA 2419223A1 CA 002419223 A CA002419223 A CA 002419223A CA 2419223 A CA2419223 A CA 2419223A CA 2419223 A1 CA2419223 A1 CA 2419223A1
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CA
Canada
Prior art keywords
beta
alpha
groups
general formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002419223A
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English (en)
Inventor
Johannes Platzek
Peter Mareski
Ulrich Niedballa
Bernd Raduchel
Hanns-Joachim Weinmann
Bernd Misselwitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10040380A external-priority patent/DE10040380B4/de
Application filed by Individual filed Critical Individual
Publication of CA2419223A1 publication Critical patent/CA2419223A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La présente invention concerne l'utilisation de complexes métalliques contenant du perfluoroalkyle, présentant une concentration critique de formation de micelle < 10<-3> mol/l, un diamètre de micelle hydrodynamique (2 Rh) > 1 nm et une relaxivité de proton dans le plasma (R<1>) > 10 l/mmol.s, en tant qu'agents de contraste dans le cadre de l'imagerie RM à la fois pour la représentation de plaques, de ganglions lymphatiques, de tissus sujets à l'infarctus ou à la nécrose, et pour la représentation indépendante de tissus nécrosés et de tissus tumoraux.
CA002419223A 2000-08-11 2001-07-23 Utilisation de complexes metalliques contenant du perfluoroalkyle en tant qu'agents de contraste dans le cadre de l'imagerie rm servant a la visualisation des plaques, tumeurs et necroses Abandoned CA2419223A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10040380.8 2000-08-11
DE10040380A DE10040380B4 (de) 2000-08-11 2000-08-11 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
PCT/EP2001/008498 WO2002013874A2 (fr) 2000-08-11 2001-07-23 Utilisation de complexes metalliques contenant du perfluoroalkyle, en tant qu'agents de contraste dans le cadre de l'imagerie rm servant a representer des plaques, tumeurs et necroses

Publications (1)

Publication Number Publication Date
CA2419223A1 true CA2419223A1 (fr) 2003-02-11

Family

ID=7652860

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002419223A Abandoned CA2419223A1 (fr) 2000-08-11 2001-07-23 Utilisation de complexes metalliques contenant du perfluoroalkyle en tant qu'agents de contraste dans le cadre de l'imagerie rm servant a la visualisation des plaques, tumeurs et necroses

Country Status (26)

Country Link
EP (1) EP1307236A2 (fr)
JP (1) JP2004506025A (fr)
KR (1) KR20030022387A (fr)
CN (1) CN1469757A (fr)
AR (1) AR034139A1 (fr)
AU (2) AU7754901A (fr)
BG (1) BG107542A (fr)
BR (1) BR0113188A (fr)
CA (1) CA2419223A1 (fr)
CZ (1) CZ2003392A3 (fr)
DE (1) DE10066210B4 (fr)
EE (1) EE200300061A (fr)
HR (1) HRP20030173A2 (fr)
HU (1) HUP0300736A3 (fr)
IL (1) IL154385A0 (fr)
MX (1) MXPA03001287A (fr)
NO (1) NO20030604L (fr)
NZ (1) NZ523932A (fr)
PL (1) PL365596A1 (fr)
RU (1) RU2290206C2 (fr)
SK (1) SK1572003A3 (fr)
TW (1) TWI296931B (fr)
UA (1) UA82642C2 (fr)
WO (1) WO2002013874A2 (fr)
YU (1) YU10603A (fr)
ZA (1) ZA200301949B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263040B2 (en) 2006-10-18 2012-09-11 Bayer Schering Pharma Ag Metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use
US11104639B2 (en) 2016-09-14 2021-08-31 Daikin Industries, Ltd. Branched fluorine-containing compound

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US7887835B2 (en) * 2006-09-19 2011-02-15 Fujifilm Corporation Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
US9976072B2 (en) 2014-03-26 2018-05-22 Chevron U.S.A. Inc. Multicarboxylate compositions and method of making the same
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
KR20210095168A (ko) 2018-11-23 2021-07-30 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
JPH10112939A (ja) * 1996-10-07 1998-04-28 Nec Corp 電源切替回路
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263040B2 (en) 2006-10-18 2012-09-11 Bayer Schering Pharma Ag Metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use
US11104639B2 (en) 2016-09-14 2021-08-31 Daikin Industries, Ltd. Branched fluorine-containing compound
US11680037B2 (en) 2016-09-14 2023-06-20 Daikin Industries, Ltd. Branched fluorine-containing compound

Also Published As

Publication number Publication date
ZA200301949B (en) 2004-12-14
PL365596A1 (en) 2005-01-10
EE200300061A (et) 2004-12-15
AU2001277549B2 (en) 2007-02-08
MXPA03001287A (es) 2003-10-06
HUP0300736A2 (hu) 2003-09-29
KR20030022387A (ko) 2003-03-15
CN1469757A (zh) 2004-01-21
EP1307236A2 (fr) 2003-05-07
BG107542A (bg) 2003-09-30
NZ523932A (en) 2007-07-27
HRP20030173A2 (en) 2005-04-30
DE10066210B4 (de) 2008-02-28
CZ2003392A3 (cs) 2003-09-17
RU2290206C2 (ru) 2006-12-27
SK1572003A3 (en) 2003-10-07
AU7754901A (en) 2002-02-25
WO2002013874A2 (fr) 2002-02-21
BR0113188A (pt) 2003-06-24
AR034139A1 (es) 2004-02-04
NO20030604D0 (no) 2003-02-07
WO2002013874A8 (fr) 2002-06-13
HUP0300736A3 (en) 2010-01-28
UA82642C2 (uk) 2008-05-12
YU10603A (sh) 2006-05-25
IL154385A0 (en) 2003-09-17
TWI296931B (en) 2008-05-21
JP2004506025A (ja) 2004-02-26
NO20030604L (no) 2003-04-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued