HRP20030173A2 - Use of metal complexes containing perfluoroalkyl as contrast agents in mr-imaging for the representation of plaques, tumors and necroses - Google Patents
Use of metal complexes containing perfluoroalkyl as contrast agents in mr-imaging for the representation of plaques, tumors and necrosesInfo
- Publication number
- HRP20030173A2 HRP20030173A2 HR20030173A HRP20030173A HRP20030173A2 HR P20030173 A2 HRP20030173 A2 HR P20030173A2 HR 20030173 A HR20030173 A HR 20030173A HR P20030173 A HRP20030173 A HR P20030173A HR P20030173 A2 HRP20030173 A2 HR P20030173A2
- Authority
- HR
- Croatia
- Prior art keywords
- image
- general formula
- complex
- mmol
- groups
- Prior art date
Links
- 229910052751 metal Inorganic materials 0.000 title claims description 50
- 239000002184 metal Substances 0.000 title claims description 50
- 125000005010 perfluoroalkyl group Chemical group 0.000 title claims description 50
- 206010028980 Neoplasm Diseases 0.000 title claims description 18
- 239000002872 contrast media Substances 0.000 title claims description 18
- 238000003384 imaging method Methods 0.000 title claims description 18
- 239000000126 substance Substances 0.000 claims description 401
- 239000000203 mixture Substances 0.000 claims description 215
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- -1 phenylenoxy Chemical group 0.000 claims description 81
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 80
- 239000001257 hydrogen Substances 0.000 claims description 58
- 229910052739 hydrogen Inorganic materials 0.000 claims description 58
- 150000003839 salts Chemical class 0.000 claims description 58
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 49
- 238000009739 binding Methods 0.000 claims description 46
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 43
- 150000004696 coordination complex Chemical class 0.000 claims description 38
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 30
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- 229910021645 metal ion Inorganic materials 0.000 claims description 27
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 17
- 229910052731 fluorine Inorganic materials 0.000 claims description 16
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- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 claims description 4
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- 125000003118 aryl group Chemical group 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10040380A DE10040380B4 (de) | 2000-08-11 | 2000-08-11 | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques |
PCT/EP2001/008498 WO2002013874A2 (fr) | 2000-08-11 | 2001-07-23 | Utilisation de complexes metalliques contenant du perfluoroalkyle, en tant qu'agents de contraste dans le cadre de l'imagerie rm servant a representer des plaques, tumeurs et necroses |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20030173A2 true HRP20030173A2 (en) | 2005-04-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HR20030173A HRP20030173A2 (en) | 2000-08-11 | 2003-03-10 | Use of metal complexes containing perfluoroalkyl as contrast agents in mr-imaging for the representation of plaques, tumors and necroses |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1307236A2 (fr) |
JP (1) | JP2004506025A (fr) |
KR (1) | KR20030022387A (fr) |
CN (1) | CN1469757A (fr) |
AR (1) | AR034139A1 (fr) |
AU (2) | AU2001277549B2 (fr) |
BG (1) | BG107542A (fr) |
BR (1) | BR0113188A (fr) |
CA (1) | CA2419223A1 (fr) |
CZ (1) | CZ2003392A3 (fr) |
DE (1) | DE10066210B4 (fr) |
EE (1) | EE200300061A (fr) |
HR (1) | HRP20030173A2 (fr) |
HU (1) | HUP0300736A3 (fr) |
IL (1) | IL154385A0 (fr) |
MX (1) | MXPA03001287A (fr) |
NO (1) | NO20030604L (fr) |
NZ (1) | NZ523932A (fr) |
PL (1) | PL365596A1 (fr) |
RU (1) | RU2290206C2 (fr) |
SK (1) | SK1572003A3 (fr) |
TW (1) | TWI296931B (fr) |
UA (1) | UA82642C2 (fr) |
WO (1) | WO2002013874A2 (fr) |
YU (1) | YU10603A (fr) |
ZA (1) | ZA200301949B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7344704B2 (en) | 2002-07-10 | 2008-03-18 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi |
DE10231799B4 (de) * | 2002-07-10 | 2006-10-05 | Schering Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben |
DE102005008309A1 (de) * | 2005-02-17 | 2006-08-24 | Schering Ag | Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone |
DE102006021495A1 (de) * | 2006-05-09 | 2007-11-15 | Bayer Schering Pharma Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit |
US7887835B2 (en) * | 2006-09-19 | 2011-02-15 | Fujifilm Corporation | Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound |
DE102006049821A1 (de) * | 2006-10-18 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung |
DE102007015598A1 (de) * | 2007-03-29 | 2008-10-02 | Heinrich-Heine-Universität Düsseldorf | Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren |
JP2011190183A (ja) * | 2010-03-11 | 2011-09-29 | Noguchi Institute | フルオラス化糖結合型クラウンエーテル誘導体 |
US9976072B2 (en) | 2014-03-26 | 2018-05-22 | Chevron U.S.A. Inc. | Multicarboxylate compositions and method of making the same |
EP3101012A1 (fr) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique |
CN109715597A (zh) | 2016-09-14 | 2019-05-03 | 大金工业株式会社 | 含支链含氟化合物 |
WO2018096082A1 (fr) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | Composés de chélate de gadolinium à relaxivité élevée pour utilisation dans l'imagerie par résonance magnétique |
CA3120665A1 (fr) | 2018-11-23 | 2020-05-28 | Bayer Aktiengesellschaft | Formulation de milieux de contraste et procede de preparation associe |
CN109867635A (zh) * | 2019-02-14 | 2019-06-11 | 华东师范大学 | 一种t1型胶束磁共振成像造影剂及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
JPH10112939A (ja) * | 1996-10-07 | 1998-04-28 | Nec Corp | 電源切替回路 |
DE19729013A1 (de) * | 1997-07-03 | 1999-02-04 | Schering Ag | Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
US6019959A (en) * | 1997-07-31 | 2000-02-01 | Schering Aktiengesellschaft | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis |
-
2000
- 2000-08-11 DE DE10066210A patent/DE10066210B4/de not_active Expired - Fee Related
-
2001
- 2001-07-23 CA CA002419223A patent/CA2419223A1/fr not_active Abandoned
- 2001-07-23 YU YU10603A patent/YU10603A/sh unknown
- 2001-07-23 CN CNA018172717A patent/CN1469757A/zh active Pending
- 2001-07-23 AU AU2001277549A patent/AU2001277549B2/en not_active Ceased
- 2001-07-23 KR KR10-2003-7002023A patent/KR20030022387A/ko not_active IP Right Cessation
- 2001-07-23 UA UA2003032067A patent/UA82642C2/uk unknown
- 2001-07-23 JP JP2002519012A patent/JP2004506025A/ja active Pending
- 2001-07-23 HU HU0300736A patent/HUP0300736A3/hu unknown
- 2001-07-23 EE EEP200300061A patent/EE200300061A/xx unknown
- 2001-07-23 SK SK157-2003A patent/SK1572003A3/sk not_active Application Discontinuation
- 2001-07-23 PL PL01365596A patent/PL365596A1/xx not_active Application Discontinuation
- 2001-07-23 IL IL15438501A patent/IL154385A0/xx unknown
- 2001-07-23 NZ NZ523932A patent/NZ523932A/en unknown
- 2001-07-23 AU AU7754901A patent/AU7754901A/xx active Pending
- 2001-07-23 RU RU2003105810/15A patent/RU2290206C2/ru not_active IP Right Cessation
- 2001-07-23 WO PCT/EP2001/008498 patent/WO2002013874A2/fr not_active Application Discontinuation
- 2001-07-23 MX MXPA03001287A patent/MXPA03001287A/es active IP Right Grant
- 2001-07-23 CZ CZ2003392A patent/CZ2003392A3/cs unknown
- 2001-07-23 EP EP01955366A patent/EP1307236A2/fr not_active Withdrawn
- 2001-07-23 BR BR0113188-5A patent/BR0113188A/pt not_active IP Right Cessation
- 2001-08-10 AR ARP010103833A patent/AR034139A1/es unknown
- 2001-08-10 TW TW090119643A patent/TWI296931B/zh active
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2003
- 2003-02-07 NO NO20030604A patent/NO20030604L/no not_active Application Discontinuation
- 2003-02-07 BG BG107542A patent/BG107542A/bg unknown
- 2003-03-10 ZA ZA200301949A patent/ZA200301949B/en unknown
- 2003-03-10 HR HR20030173A patent/HRP20030173A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU7754901A (en) | 2002-02-25 |
ZA200301949B (en) | 2004-12-14 |
BR0113188A (pt) | 2003-06-24 |
EE200300061A (et) | 2004-12-15 |
WO2002013874A8 (fr) | 2002-06-13 |
SK1572003A3 (en) | 2003-10-07 |
YU10603A (sh) | 2006-05-25 |
HUP0300736A3 (en) | 2010-01-28 |
EP1307236A2 (fr) | 2003-05-07 |
IL154385A0 (en) | 2003-09-17 |
WO2002013874A2 (fr) | 2002-02-21 |
JP2004506025A (ja) | 2004-02-26 |
NZ523932A (en) | 2007-07-27 |
MXPA03001287A (es) | 2003-10-06 |
BG107542A (bg) | 2003-09-30 |
NO20030604D0 (no) | 2003-02-07 |
CN1469757A (zh) | 2004-01-21 |
CA2419223A1 (fr) | 2003-02-11 |
UA82642C2 (uk) | 2008-05-12 |
RU2290206C2 (ru) | 2006-12-27 |
DE10066210B4 (de) | 2008-02-28 |
AU2001277549B2 (en) | 2007-02-08 |
TWI296931B (en) | 2008-05-21 |
KR20030022387A (ko) | 2003-03-15 |
AR034139A1 (es) | 2004-02-04 |
NO20030604L (no) | 2003-04-11 |
CZ2003392A3 (cs) | 2003-09-17 |
HUP0300736A2 (hu) | 2003-09-29 |
PL365596A1 (en) | 2005-01-10 |
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