CA2403871A1 - Inhibition de l'angiogenese et de la croissance tumorale - Google Patents

Inhibition de l'angiogenese et de la croissance tumorale Download PDF

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Publication number
CA2403871A1
CA2403871A1 CA002403871A CA2403871A CA2403871A1 CA 2403871 A1 CA2403871 A1 CA 2403871A1 CA 002403871 A CA002403871 A CA 002403871A CA 2403871 A CA2403871 A CA 2403871A CA 2403871 A1 CA2403871 A1 CA 2403871A1
Authority
CA
Canada
Prior art keywords
cis
covalent bond
cyclohexyl
alkyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002403871A
Other languages
English (en)
Other versions
CA2403871C (fr
Inventor
Dale L. Boger
David A. Cheresh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2403871A1 publication Critical patent/CA2403871A1/fr
Application granted granted Critical
Publication of CA2403871C publication Critical patent/CA2403871C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention concerne des composés qui inhibent la croissance tumorale et l'angiogénèse, représentés par la formule générale (II). Ces composés comprennent des dérivés de lysine de glycyle fixés sur un noyau de fixation aromatique principal.
CA2403871A 2000-03-27 2001-03-27 Inhibition de l'angiogenese et de la croissance tumorale Expired - Fee Related CA2403871C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19226000P 2000-03-27 2000-03-27
US60/192,260 2000-03-27
PCT/US2001/009756 WO2001072699A1 (fr) 2000-03-27 2001-03-27 Inhibition de l'angiogenese et de la croissance tumorale

Publications (2)

Publication Number Publication Date
CA2403871A1 true CA2403871A1 (fr) 2001-10-04
CA2403871C CA2403871C (fr) 2010-05-11

Family

ID=22708924

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002659030A Abandoned CA2659030A1 (fr) 2000-03-27 2001-03-27 Methodes d'inhibition de l'angiogenese et de la croissance de tumeurs
CA002403630A Expired - Fee Related CA2403630C (fr) 2000-03-27 2001-03-27 Methodes d'inhibition de l'angiogenese et de la croissance de tumeurs
CA2403871A Expired - Fee Related CA2403871C (fr) 2000-03-27 2001-03-27 Inhibition de l'angiogenese et de la croissance tumorale

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA002659030A Abandoned CA2659030A1 (fr) 2000-03-27 2001-03-27 Methodes d'inhibition de l'angiogenese et de la croissance de tumeurs
CA002403630A Expired - Fee Related CA2403630C (fr) 2000-03-27 2001-03-27 Methodes d'inhibition de l'angiogenese et de la croissance de tumeurs

Country Status (15)

Country Link
EP (2) EP1272173A4 (fr)
JP (2) JP2003528850A (fr)
KR (2) KR100767616B1 (fr)
CN (2) CN1229339C (fr)
AU (4) AU5101801A (fr)
CA (3) CA2659030A1 (fr)
CZ (2) CZ20023510A3 (fr)
HU (2) HUP0301621A3 (fr)
MX (2) MXPA02009510A (fr)
NO (2) NO328969B1 (fr)
PL (2) PL358272A1 (fr)
RU (2) RU2276133C2 (fr)
SK (2) SK14852002A3 (fr)
WO (2) WO2001072699A1 (fr)
ZA (2) ZA200208628B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2315721T5 (es) 2003-10-23 2012-08-24 Otsuka Pharmaceutical Co., Ltd. Formulación de aripiprazol inyectable estéril de liberación controlada y procedimiento
UA97286C2 (ru) 2007-07-31 2012-01-25 Оцука Фармасьютикал Ко., Лтд. Способ изготовления суспензии арипипразола и лиофилизированного состава

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
JPH05125029A (ja) 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
GB9308695D0 (en) * 1993-04-27 1993-06-09 Celltech Ltd Peptidyl derivatives
GB9405076D0 (en) * 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
AUPO104496A0 (en) * 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Angiogenic inhibitory compounds
KR20000068415A (ko) * 1996-09-04 2000-11-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 매트릭스 메탈로프로테이나제 억제용 화합물 및 방법
EP0968423A4 (fr) * 1997-02-07 2002-10-30 Scripps Research Inst Synthese convergente de banque combinatoire
KR100596109B1 (ko) * 1998-03-27 2006-07-05 제넨테크, 인크. Ｃｄ11/ｃｄ18 부착 수용체 매개 질환 치료용 길항제

Also Published As

Publication number Publication date
CA2403630C (fr) 2009-05-26
JP2003528850A (ja) 2003-09-30
RU2276133C2 (ru) 2006-05-10
CA2659030A1 (fr) 2001-10-04
EP1272173A4 (fr) 2006-05-03
CN1245967C (zh) 2006-03-22
EP1272173A1 (fr) 2003-01-08
AU2001251018B2 (en) 2005-12-01
WO2001072699A1 (fr) 2001-10-04
MXPA02009504A (es) 2003-05-21
AU4949901A (en) 2001-10-08
CZ20023510A3 (cs) 2003-03-12
KR20020091156A (ko) 2002-12-05
KR20020084258A (ko) 2002-11-04
AU2001249499B2 (en) 2005-04-21
CA2403630A1 (fr) 2001-10-04
AU5101801A (en) 2001-10-08
NO20024578L (no) 2002-11-20
CZ20023509A3 (cs) 2003-06-18
SK14852002A3 (sk) 2003-06-03
CA2403871C (fr) 2010-05-11
HUP0301797A3 (en) 2010-09-28
ZA200208626B (en) 2004-02-16
NO20024576L (no) 2002-11-20
CN1229339C (zh) 2005-11-30
PL358272A1 (en) 2004-08-09
RU2269339C2 (ru) 2006-02-10
CN1429106A (zh) 2003-07-09
CN1441777A (zh) 2003-09-10
PL366316A1 (en) 2005-01-24
KR100767616B1 (ko) 2007-10-18
NO328969B1 (no) 2010-06-28
SK14842002A3 (sk) 2003-04-01
KR100776185B1 (ko) 2007-11-16
JP2003528140A (ja) 2003-09-24
HUP0301621A2 (hu) 2003-09-29
NO20024576D0 (no) 2002-09-24
NO20024578D0 (no) 2002-09-24
WO2001072297A1 (fr) 2001-10-04
EP1276713A1 (fr) 2003-01-22
HUP0301621A3 (en) 2009-06-29
RU2002128751A (ru) 2004-03-10
HUP0301797A2 (hu) 2003-09-29
EP1276713A4 (fr) 2006-05-03
PL205134B1 (pl) 2010-03-31
ZA200208628B (en) 2004-02-12
MXPA02009510A (es) 2003-05-21

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