CA2403817C - Methods of modulating hair growth - Google Patents

Methods of modulating hair growth Download PDF

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Publication number
CA2403817C
CA2403817C CA2403817A CA2403817A CA2403817C CA 2403817 C CA2403817 C CA 2403817C CA 2403817 A CA2403817 A CA 2403817A CA 2403817 A CA2403817 A CA 2403817A CA 2403817 C CA2403817 C CA 2403817C
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CA
Canada
Prior art keywords
wnt
cell
agent
cells
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2403817A
Other languages
English (en)
French (fr)
Other versions
CA2403817A1 (en
Inventor
Jiro Kishimoto
Robert Burgeson
Bruce A. Morgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of CA2403817A1 publication Critical patent/CA2403817A1/en
Application granted granted Critical
Publication of CA2403817C publication Critical patent/CA2403817C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2403817A 2000-03-31 2001-03-30 Methods of modulating hair growth Expired - Lifetime CA2403817C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19377100P 2000-03-31 2000-03-31
US60/193,771 2000-03-31
US26169001P 2001-01-12 2001-01-12
US60/261,690 2001-01-12
PCT/US2001/010164 WO2001074164A1 (en) 2000-03-31 2001-03-30 Methods of modulating hair growth

Publications (2)

Publication Number Publication Date
CA2403817A1 CA2403817A1 (en) 2001-10-11
CA2403817C true CA2403817C (en) 2012-05-29

Family

ID=26889330

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2403817A Expired - Lifetime CA2403817C (en) 2000-03-31 2001-03-30 Methods of modulating hair growth

Country Status (9)

Country Link
US (4) US6924141B2 (de)
EP (1) EP1267616B1 (de)
JP (3) JP4813734B2 (de)
AT (1) ATE369144T1 (de)
AU (2) AU5301201A (de)
CA (1) CA2403817C (de)
DE (1) DE60129799T2 (de)
ES (1) ES2290125T3 (de)
WO (1) WO2001074164A1 (de)

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US20050130181A1 (en) * 2001-05-18 2005-06-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of wingless gene expression using short interfering nucleic acid (siNA)
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EP1546392A4 (de) * 2002-08-02 2006-05-24 Stratatech Corp Spezies-spezifischer dna-nachweis
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WO2004076642A2 (en) * 2003-02-27 2004-09-10 The Rockefeller University Method for modulating epithelial stem cell lineage
DE602004026898D1 (de) 2003-10-10 2010-06-10 Deutsches Krebsforsch Zusammensetzungen für die diagnose und therapie von erkrankungen, die im zusammenhang mit einer anomalen expression von futrinen (r-spondinen) stehen
CN101061217A (zh) 2004-02-27 2007-10-24 通用医疗公司 用于毛发生长的方法和组合物
WO2006026617A2 (en) * 2004-08-30 2006-03-09 Iken Tissue Therapeutics, Inc. Compositions and methods of promoting hair growth
AU2005279934A1 (en) * 2004-08-30 2006-03-09 Theregen, Inc. Compositions and methods of promoting hair growth
CA2580780A1 (en) * 2004-09-21 2006-04-06 Rhode Island Hospital, A Lifespan-Partner Frizzled proteins and detection and treatment of cancer
WO2006036175A2 (en) * 2004-09-21 2006-04-06 Rhode Island Hospital, A Lifespan-Partner Wnt proteins and detection and treatment of cancer
US7850960B2 (en) * 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
JP2008179540A (ja) * 2005-01-07 2008-08-07 Noevir Co Ltd 細胞分化、発生、増殖を制御する物質および該物質を含む細胞分化・発生・増殖調節剤
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WO2006105109A2 (en) * 2005-03-29 2006-10-05 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness, and hair removal
AU2012204059B2 (en) * 2005-03-29 2015-01-15 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness and hair removal
WO2010056759A1 (en) * 2008-11-12 2010-05-20 The Trustees Of The University Of Pennsylvania Fibroblast growth factor-9 promotes hair follicle regeneration after wounding
EP3409296A1 (de) * 2005-04-07 2018-12-05 The Trustees of the University of Pennsylvania Verfahren zur erhöhung der funktion eines aav-vektors
WO2006124356A2 (en) * 2005-05-16 2006-11-23 The Rockefeller University Method for isolating dermal papilla cells and uses thereof
US20070148138A1 (en) 2005-11-22 2007-06-28 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
EP2007877B1 (de) 2006-02-28 2013-04-17 The Trustees of Columbia University in the City of New York Verfahren für kompakte aggregation von hautzellen
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EP2077819A4 (de) * 2006-09-28 2011-05-25 Follica Inc Verfahren, kits und zusammensetzungen zur erzeugung von neuen haarfollikeln und wachsendem haar
US7922688B2 (en) 2007-01-08 2011-04-12 Restoration Robotics, Inc. Automated delivery of a therapeutic or cosmetic substance to cutaneous, subcutaneous and intramuscular tissue regions
US8580236B2 (en) * 2007-03-19 2013-11-12 Richard P. De Maria Hair sustaining formulation
US8158757B2 (en) 2007-07-02 2012-04-17 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
JP5300273B2 (ja) * 2008-01-21 2013-09-25 株式会社 資生堂 ヒトＷｎｔ３ａ遺伝子形質転換細胞
US20100166824A1 (en) * 2008-01-30 2010-07-01 Histogen, Inc. Extracellular matrix compositions
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Also Published As

Publication number Publication date
US6924141B2 (en) 2005-08-02
EP1267616A4 (de) 2003-07-16
JP4813734B2 (ja) 2011-11-09
US7175842B2 (en) 2007-02-13
EP1267616B1 (de) 2007-08-08
DE60129799T2 (de) 2008-04-30
JP2004500407A (ja) 2004-01-08
US20050271632A1 (en) 2005-12-08
DE60129799D1 (de) 2007-09-20
CA2403817A1 (en) 2001-10-11
JP5580252B2 (ja) 2014-08-27
US20080286261A1 (en) 2008-11-20
ATE369144T1 (de) 2007-08-15
JP2014159471A (ja) 2014-09-04
US20020114772A1 (en) 2002-08-22
WO2001074164A9 (en) 2002-01-10
WO2001074164A1 (en) 2001-10-11
ES2290125T3 (es) 2008-02-16
US20040170611A1 (en) 2004-09-02
JP2011207908A (ja) 2011-10-20
EP1267616A1 (de) 2003-01-02
AU2001253012B2 (en) 2006-02-23
AU5301201A (en) 2001-10-15
US7985587B2 (en) 2011-07-26
JP5960749B2 (ja) 2016-08-02

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