CA2394539C - Agent de contraste fluorescent proche infrarouge et imagerie par fluorescence - Google Patents
Agent de contraste fluorescent proche infrarouge et imagerie par fluorescence Download PDFInfo
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- CA2394539C CA2394539C CA002394539A CA2394539A CA2394539C CA 2394539 C CA2394539 C CA 2394539C CA 002394539 A CA002394539 A CA 002394539A CA 2394539 A CA2394539 A CA 2394539A CA 2394539 C CA2394539 C CA 2394539C
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- Prior art keywords
- compound
- so3na
- nao3s
- salt
- 4so3na
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 description 1
- 229960002078 sevoflurane Drugs 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 125000004436 sodium atom Chemical group 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
Abstract
L'invention concerne un agent de contraste fluorescent proche infrarouge renfermant un composé doté d'au moins trois groupes d'acide sulfonique dans une molécule et un procédé d'imagerie par fluorescence consistant à introduire ledit agent de contraste de cette invention dans un corps en vie, exposer le corps à une lumière d'excitation, et détecter la fluorescence proche infrarouge émanant de l'agent de contraste. Cet agent de contraste fluorescent proche infrarouge de ladite invention est excité par une lumière d'excitation et émet une fluorescence proche infrarouge. Cette fluorescence infrarouge possède une meilleure transmission à travers des tissus biologiques. Ainsi on rend possible la détection de lésions dans la région peu apparente d'un corps en vie. De plus, ledit agent de contraste présente une solubilité plus grande dans l'eau et une toxicité plus faible et peut, de ce fait, être utilisé sans danger.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1999/009959 WO2001043781A1 (fr) | 1999-12-15 | 1999-12-15 | Agent de contraste fluorescent proche infrarouge et imagerie par fluorescence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2394539A1 CA2394539A1 (fr) | 2001-06-21 |
| CA2394539C true CA2394539C (fr) | 2009-10-27 |
Family
ID=8167530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002394539A Expired - Fee Related CA2394539C (fr) | 1999-12-15 | 1999-12-15 | Agent de contraste fluorescent proche infrarouge et imagerie par fluorescence |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1237583A1 (fr) |
| JP (1) | JP2003517025A (fr) |
| KR (1) | KR20020082207A (fr) |
| CN (1) | CN1217701C (fr) |
| AU (1) | AU2097500A (fr) |
| BG (1) | BG106822A (fr) |
| BR (1) | BR9917587A (fr) |
| CA (1) | CA2394539C (fr) |
| EA (1) | EA200200635A1 (fr) |
| EE (1) | EE200200321A (fr) |
| HU (1) | HUP0204024A2 (fr) |
| IL (1) | IL149798A0 (fr) |
| MX (1) | MXPA02005806A (fr) |
| NO (1) | NO328630B1 (fr) |
| PL (1) | PL355891A1 (fr) |
| SK (1) | SK8142002A3 (fr) |
| TR (1) | TR200201567T2 (fr) |
| WO (1) | WO2001043781A1 (fr) |
| YU (1) | YU44402A (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682602B2 (en) * | 2003-12-19 | 2010-03-23 | Konica Minolta Medical & Graphic, Inc. | Near-infrared fluorescent contrast medium |
| JP2005220045A (ja) * | 2004-02-04 | 2005-08-18 | Konica Minolta Medical & Graphic Inc | 蛍光造影剤 |
| JP5074044B2 (ja) * | 2007-01-18 | 2012-11-14 | オリンパス株式会社 | 蛍光観察装置および蛍光観察装置の作動方法 |
| WO2009023813A1 (fr) * | 2007-08-15 | 2009-02-19 | Applied Soil Water Technologies Llc | Récupération de métaux à partir d'un minerai de lixiviation en tas d'exploitation minière |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| AU2010286592B2 (en) | 2009-08-28 | 2015-08-13 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
| JP2011046663A (ja) | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| AU2010298388B2 (en) | 2009-09-22 | 2015-05-28 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
| CN102711595A (zh) * | 2010-01-14 | 2012-10-03 | 加利福尼亚大学董事会 | 检测以及降低或阻止炎性介质进入乳管的装置、系统和方法 |
| GB201010878D0 (en) | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| EP2806781B1 (fr) | 2012-01-23 | 2018-03-21 | Washington University | Systèmes et procédés d'imagerie |
| WO2014062716A1 (fr) | 2012-10-15 | 2014-04-24 | Visen Medical, Inc. | Systèmes, procédés et appareil d'imagerie de milieu de diffusion comportant une pondération entre modalités de sources fluorescentes et bioluminescentes |
| CA2903994C (fr) | 2013-03-15 | 2017-08-22 | Philip S. Low | Synthese et composition de groupes de liaison d'acides amines conjugues a des composes utilises pour l'imagerie ciblee de tumeurs |
| EP3089653A1 (fr) | 2013-12-31 | 2016-11-09 | Memorial Sloan Kettering Cancer Center | Systèmes, procédés, et appareil pour l'imagerie multicanal de sources fluorescentes en temps réel |
| CN107249647A (zh) | 2014-12-15 | 2017-10-13 | 纪念斯隆-凯特琳癌症中心 | 具有增强的神经结合选择性的环状肽、与所述环状肽结合的纳米颗粒和此二者用于实时体内神经组织成像的用途 |
| WO2016179350A1 (fr) | 2015-05-06 | 2016-11-10 | Washington University | Composés à motifs de ciblage rd et leurs procédés d'utilisation |
| KR20180014027A (ko) | 2015-06-03 | 2018-02-07 | 서지마브 에스.에이.에스. | 형광 접합체 |
| CN105222828B (zh) * | 2015-09-30 | 2017-05-24 | 东南大学 | 一种贴壁射流速度场和浓度场的同步测量装置与方法 |
| JP2019509252A (ja) | 2015-12-15 | 2019-04-04 | メモリアル スローン ケタリング キャンサー センター | 組織の区別、例えば、手術中の可視化のための、イメージングシステムおよび方法 |
| BR112019010947A2 (pt) | 2016-11-30 | 2019-10-01 | Univ Cornell | nanopartículas ultrapequenas funcionalizadas por inibidores e métodos das mesmas |
| EP4072598A4 (fr) | 2019-12-13 | 2024-02-21 | Washington University St Louis | Colorants fluorescents dans l'infrarouge proche, formulations et procédés associés |
| EP4015004A1 (fr) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Peptides ramifiés spécifiques de protéoglycane |
| CN114459862A (zh) * | 2022-01-13 | 2022-05-10 | 华腾实业（深圳）股份有限公司 | 一种高识别的真菌荧光染色液 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69132750T2 (de) * | 1990-05-15 | 2002-06-20 | Hyperion Inc | Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden |
| CA2211470A1 (fr) * | 1995-01-30 | 1996-08-08 | Daiichi Pure Chemicals Co., Ltd. | Marqueur de diagnostic |
| JP2000095758A (ja) * | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
-
1999
- 1999-12-15 BR BR9917587-8A patent/BR9917587A/pt not_active Application Discontinuation
- 1999-12-15 JP JP2001544917A patent/JP2003517025A/ja active Pending
- 1999-12-15 EA EA200200635A patent/EA200200635A1/ru unknown
- 1999-12-15 CA CA002394539A patent/CA2394539C/fr not_active Expired - Fee Related
- 1999-12-15 KR KR1020027007635A patent/KR20020082207A/ko not_active Application Discontinuation
- 1999-12-15 CN CN998170437A patent/CN1217701C/zh not_active Expired - Fee Related
- 1999-12-15 EE EEP200200321A patent/EE200200321A/xx unknown
- 1999-12-15 SK SK814-2002A patent/SK8142002A3/sk unknown
- 1999-12-15 IL IL14979899A patent/IL149798A0/xx not_active IP Right Cessation
- 1999-12-15 PL PL99355891A patent/PL355891A1/xx not_active Application Discontinuation
- 1999-12-15 WO PCT/EP1999/009959 patent/WO2001043781A1/fr not_active Application Discontinuation
- 1999-12-15 YU YU44402A patent/YU44402A/sh unknown
- 1999-12-15 MX MXPA02005806A patent/MXPA02005806A/es unknown
- 1999-12-15 EP EP99965468A patent/EP1237583A1/fr not_active Withdrawn
- 1999-12-15 TR TR2002/01567T patent/TR200201567T2/xx unknown
- 1999-12-15 HU HU0204024A patent/HUP0204024A2/hu unknown
- 1999-12-15 AU AU20975/00A patent/AU2097500A/en not_active Abandoned
-
2002
- 2002-06-13 BG BG106822A patent/BG106822A/bg unknown
- 2002-06-14 NO NO20022837A patent/NO328630B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2394539A1 (fr) | 2001-06-21 |
| EE200200321A (et) | 2003-10-15 |
| WO2001043781A1 (fr) | 2001-06-21 |
| JP2003517025A (ja) | 2003-05-20 |
| BR9917587A (pt) | 2002-08-06 |
| AU2097500A (en) | 2001-06-25 |
| BG106822A (bg) | 2003-01-31 |
| IL149798A0 (en) | 2002-11-10 |
| SK8142002A3 (en) | 2002-12-03 |
| CN1217701C (zh) | 2005-09-07 |
| MXPA02005806A (es) | 2010-10-26 |
| KR20020082207A (ko) | 2002-10-30 |
| HUP0204024A2 (en) | 2003-04-28 |
| EP1237583A1 (fr) | 2002-09-11 |
| YU44402A (sh) | 2005-03-15 |
| CN1384760A (zh) | 2002-12-11 |
| EA200200635A1 (ru) | 2002-12-26 |
| TR200201567T2 (tr) | 2002-11-21 |
| NO20022837L (no) | 2002-06-14 |
| NO328630B1 (no) | 2010-04-12 |
| NO20022837D0 (no) | 2002-06-14 |
| PL355891A1 (en) | 2004-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |