CA2377585A1 - Methods for making apo-2 ligand using divalent metal ions - Google Patents
Methods for making apo-2 ligand using divalent metal ions Download PDFInfo
- Publication number
- CA2377585A1 CA2377585A1 CA002377585A CA2377585A CA2377585A1 CA 2377585 A1 CA2377585 A1 CA 2377585A1 CA 002377585 A CA002377585 A CA 002377585A CA 2377585 A CA2377585 A CA 2377585A CA 2377585 A1 CA2377585 A1 CA 2377585A1
- Authority
- CA
- Canada
- Prior art keywords
- apo
- ligand
- formulation
- metal ions
- divalent metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US14134299P | 1999-06-28 | 1999-06-28 | |
| US60/141,342 | 1999-06-28 | ||
| PCT/US2000/017579 WO2001000832A1 (en) | 1999-06-28 | 2000-06-26 | Methods for making apo-2 ligand using divalent metal ions |
Publications (1)
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|---|---|
| CA2377585A1 true CA2377585A1 (en) | 2001-01-04 |
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| CA002377585A Abandoned CA2377585A1 (en) | 1999-06-28 | 2000-06-26 | Methods for making apo-2 ligand using divalent metal ions |
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| EP (3) | EP2311956A1 (enExample) |
| JP (2) | JP5118796B2 (enExample) |
| KR (1) | KR100674528B1 (enExample) |
| CN (2) | CN100526463C (enExample) |
| AU (3) | AU6338200A (enExample) |
| CA (1) | CA2377585A1 (enExample) |
| ES (1) | ES2392392T3 (enExample) |
| IL (2) | IL147029A0 (enExample) |
| MX (1) | MXPA01013236A (enExample) |
| NZ (2) | NZ537920A (enExample) |
| WO (1) | WO2001000832A1 (enExample) |
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| US20020106728A1 (en) * | 2000-06-20 | 2002-08-08 | Genentech, Inc. | NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders |
| EP1873244A3 (en) * | 1999-06-02 | 2008-04-02 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| IL147029A0 (en) * | 1999-06-28 | 2002-08-14 | Genentech Inc | Method for making apo-2 ligand using divalent metal ions |
| JP2005508162A (ja) * | 2001-10-02 | 2005-03-31 | ジェネンテック・インコーポレーテッド | Ａｐｏ−２リガンド変異体とその使用法 |
| AU2007200478A1 (en) * | 2001-11-13 | 2007-02-22 | Genentech, Inc. | APO2 ligand/trail formulations |
| IL161812A0 (en) * | 2001-11-13 | 2005-11-20 | Genentech Inc | Apo2 ligand/trail formulations |
| US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
| US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
| EP1556076A4 (en) * | 2002-06-24 | 2009-07-08 | Genentech Inc | APO-2 LIGAND / TRAIL VARIANTS AND ITS USES |
| GB0328261D0 (en) | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
| SI1733037T1 (sl) | 2004-03-11 | 2015-02-27 | Genentech, Inc. | Postopek za izdelavo polipeptidov |
| AU2005271601A1 (en) | 2004-08-06 | 2006-02-16 | Genentech, Inc. | Assays and methods using biomarkers |
| MX2007001468A (es) | 2004-08-06 | 2007-03-26 | Genentech Inc | Ensayos y metodos que utilizan biomarcadores. |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| PT1915626E (pt) | 2005-08-16 | 2012-02-03 | Genentech Inc | Sensibilidade da apoptose a apo2l/trail por ensaio de expressão de galnac-t14 em células/tecidos |
| GB0524316D0 (en) * | 2005-11-29 | 2006-01-04 | Medical Res Council | Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) |
| WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
| CA2834776A1 (en) | 2011-05-03 | 2012-11-08 | Genentech, Inc. | Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies |
| CN102775491A (zh) * | 2011-05-09 | 2012-11-14 | 中国人民解放军第二军医大学 | 单链化的人凋亡素2配体三聚体蛋白质的制法和用途 |
| CN102443055B (zh) * | 2011-10-26 | 2017-07-28 | 浙江海正药业股份有限公司 | 一种重组人肿瘤坏死因子相关凋亡诱导配体的纯化工艺 |
| JP6355425B2 (ja) * | 2014-05-20 | 2018-07-11 | キヤノン株式会社 | システムおよびその制御方法 |
| US11279768B1 (en) | 2015-04-03 | 2022-03-22 | Precision Biologics, Inc. | Anti-cancer antibodies, combination therapies, and uses thereof |
| US10906951B2 (en) * | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| EP3430034A1 (en) * | 2016-03-16 | 2019-01-23 | Merrimack Pharmaceuticals, Inc. | Engineered trail for cancer therapy |
| CN119461783A (zh) * | 2019-04-04 | 2025-02-18 | 株式会社小原 | 光学玻璃的制造方法 |
| JP7429622B2 (ja) * | 2020-08-26 | 2024-02-08 | 株式会社オハラ | 光学ガラスの製造方法 |
| CN115980241B (zh) * | 2023-02-11 | 2025-01-07 | 烟台新特路新材料科技有限公司 | 一种硫代酯类抗氧化剂含量的检测方法 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
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| DE19547933A1 (de) * | 1995-12-22 | 1997-06-26 | Boehringer Mannheim Gmbh | Multimere Formen von IL-16, Verfahren zu ihrer Herstellung und Verwendung |
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| ATE516354T1 (de) | 1997-05-15 | 2011-07-15 | Genentech Inc | Apo-2-rezeptor |
| ES2331900T3 (es) | 1997-08-26 | 2010-01-19 | Genentech, Inc. | Receptor rtd. |
| ES2316182T3 (es) * | 1998-01-15 | 2009-04-01 | Genentech, Inc. | Ligando apo-2. |
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| IL147029A0 (en) * | 1999-06-28 | 2002-08-14 | Genentech Inc | Method for making apo-2 ligand using divalent metal ions |
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| IL161812A0 (en) * | 2001-11-13 | 2005-11-20 | Genentech Inc | Apo2 ligand/trail formulations |
| CN100500841C (zh) * | 2005-10-10 | 2009-06-17 | 华东理工大学 | 一种表达可溶性trail蛋白的方法 |
-
2000
- 2000-06-26 IL IL14702900A patent/IL147029A0/xx unknown
- 2000-06-26 NZ NZ537920A patent/NZ537920A/en not_active IP Right Cessation
- 2000-06-26 MX MXPA01013236A patent/MXPA01013236A/es active IP Right Grant
- 2000-06-26 EP EP10010654A patent/EP2311956A1/en not_active Withdrawn
- 2000-06-26 EP EP10010653A patent/EP2339003A3/en not_active Withdrawn
- 2000-06-26 CA CA002377585A patent/CA2377585A1/en not_active Abandoned
- 2000-06-26 AU AU63382/00A patent/AU6338200A/en not_active Abandoned
- 2000-06-26 CN CNB008119589A patent/CN100526463C/zh not_active Expired - Lifetime
- 2000-06-26 CN CN200910145880A patent/CN101633692A/zh active Pending
- 2000-06-26 WO PCT/US2000/017579 patent/WO2001000832A1/en not_active Ceased
- 2000-06-26 ES ES00950255T patent/ES2392392T3/es not_active Expired - Lifetime
- 2000-06-26 NZ NZ515990A patent/NZ515990A/en not_active IP Right Cessation
- 2000-06-26 JP JP2001506824A patent/JP5118796B2/ja not_active Expired - Lifetime
- 2000-06-26 EP EP00950255A patent/EP1194555B1/en not_active Expired - Lifetime
- 2000-06-26 KR KR1020017016748A patent/KR100674528B1/ko not_active Expired - Lifetime
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2001
- 2001-12-11 IL IL147029A patent/IL147029A/en active IP Right Grant
-
2005
- 2005-09-16 AU AU2005211561A patent/AU2005211561B2/en not_active Expired
-
2006
- 2006-09-28 US US11/528,948 patent/US7855066B1/en not_active Expired - Fee Related
- 2006-11-22 US US11/603,584 patent/US20070161564A1/en not_active Abandoned
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2008
- 2008-11-21 AU AU2008249162A patent/AU2008249162A1/en not_active Abandoned
-
2010
- 2010-11-11 JP JP2010253233A patent/JP2011088897A/ja active Pending
- 2010-12-10 US US12/928,422 patent/US20120077740A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1370232A (zh) | 2002-09-18 |
| KR20020016856A (ko) | 2002-03-06 |
| JP2003503057A (ja) | 2003-01-28 |
| US20070161564A1 (en) | 2007-07-12 |
| MXPA01013236A (es) | 2002-06-21 |
| JP2011088897A (ja) | 2011-05-06 |
| WO2001000832A1 (en) | 2001-01-04 |
| EP2339003A3 (en) | 2011-10-19 |
| IL147029A0 (en) | 2002-08-14 |
| AU6338200A (en) | 2001-01-31 |
| IL147029A (en) | 2012-02-29 |
| NZ537920A (en) | 2006-10-27 |
| ES2392392T3 (es) | 2012-12-10 |
| NZ515990A (en) | 2003-10-31 |
| KR100674528B1 (ko) | 2007-01-29 |
| EP1194555A1 (en) | 2002-04-10 |
| AU2005211561A1 (en) | 2005-10-13 |
| EP2339003A2 (en) | 2011-06-29 |
| WO2001000832A9 (en) | 2012-03-08 |
| CN100526463C (zh) | 2009-08-12 |
| EP1194555B1 (en) | 2012-09-26 |
| AU2005211561B2 (en) | 2008-08-21 |
| US7855066B1 (en) | 2010-12-21 |
| US20120077740A1 (en) | 2012-03-29 |
| CN101633692A (zh) | 2010-01-27 |
| JP5118796B2 (ja) | 2013-01-16 |
| EP2311956A1 (en) | 2011-04-20 |
| AU2008249162A1 (en) | 2008-12-11 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20160408 |