CA2375283A1 - Process for preparing a 10,11-methanodibenzosuberane derivative - Google Patents

Process for preparing a 10,11-methanodibenzosuberane derivative Download PDF

Info

Publication number
CA2375283A1
CA2375283A1 CA002375283A CA2375283A CA2375283A1 CA 2375283 A1 CA2375283 A1 CA 2375283A1 CA 002375283 A CA002375283 A CA 002375283A CA 2375283 A CA2375283 A CA 2375283A CA 2375283 A1 CA2375283 A1 CA 2375283A1
Authority
CA
Canada
Prior art keywords
compound
formula
acid
iii
syn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002375283A
Other languages
English (en)
French (fr)
Inventor
Bret Anthony Astleford
Charles Jackson Barnett
Michael Edward Kobierski
Thomas Michael Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2375283A1 publication Critical patent/CA2375283A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA002375283A 1999-06-03 2000-05-30 Process for preparing a 10,11-methanodibenzosuberane derivative Abandoned CA2375283A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13728499P 1999-06-03 1999-06-03
US60/137,284 1999-06-03
PCT/US2000/011863 WO2000075132A1 (en) 1999-06-03 2000-05-30 Process for preparing a 10,11-methanodibenzosuberane derivative

Publications (1)

Publication Number Publication Date
CA2375283A1 true CA2375283A1 (en) 2000-12-14

Family

ID=22476646

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002375283A Abandoned CA2375283A1 (en) 1999-06-03 2000-05-30 Process for preparing a 10,11-methanodibenzosuberane derivative

Country Status (10)

Country Link
US (2) US6570016B1 (enExample)
EP (1) EP1198462B1 (enExample)
JP (1) JP2003501425A (enExample)
AT (1) ATE277922T1 (enExample)
AU (1) AU5125200A (enExample)
CA (1) CA2375283A1 (enExample)
DE (1) DE60014386T2 (enExample)
ES (1) ES2228534T3 (enExample)
PE (1) PE20010291A1 (enExample)
WO (1) WO2000075132A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
CA2375283A1 (en) * 1999-06-03 2000-12-14 Eli Lilly And Company Process for preparing a 10,11-methanodibenzosuberane derivative
PT1387683E (pt) 2001-04-25 2005-06-30 Lilly Co Eli Novos sais e formas cristalinas de (2r) -anti-5{3-[4-(10,11-difluorometanodibenzosuber-5-il]-2-hidroxipropoxi}quinolina
ATE489482T1 (de) * 2005-08-19 2010-12-15 Nanosphere Inc Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69322707T2 (de) * 1992-07-31 1999-08-19 Bristol-Myers Squibb Company Diphenyl Oxazole-, Thiazole- und Imidazole-Derivate als Inhibitoren der Wiederaufnahme des Adenosins
US5643909A (en) * 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
AU6167696A (en) * 1995-06-07 1996-12-30 Dade Chemistry Systems Inc. Preparation of immunogens and other conjugates of drugs
CA2258556A1 (en) * 1996-06-17 1997-12-24 Julian Stanley Kroin Drug resistance and multidrug resistance modulators
AU3485797A (en) * 1996-11-22 1998-06-10 Eli Lilly And Company Drug resistance and multidrug resistance modulators
CA2375283A1 (en) * 1999-06-03 2000-12-14 Eli Lilly And Company Process for preparing a 10,11-methanodibenzosuberane derivative
TWI267511B (en) * 1999-06-03 2006-12-01 Lilly Co Eli Process for preparing 10,11-methanobenzosuberane derivatives

Also Published As

Publication number Publication date
WO2000075132A1 (en) 2000-12-14
EP1198462B1 (en) 2004-09-29
JP2003501425A (ja) 2003-01-14
DE60014386T2 (de) 2005-10-13
DE60014386D1 (de) 2004-11-04
AU5125200A (en) 2000-12-28
PE20010291A1 (es) 2001-03-07
EP1198462A1 (en) 2002-04-24
ATE277922T1 (de) 2004-10-15
US6624304B1 (en) 2003-09-23
ES2228534T3 (es) 2005-04-16
US6570016B1 (en) 2003-05-27

Similar Documents

Publication Publication Date Title
US7977337B2 (en) Quinoline derivatives and their use as 5-HT6 ligands
JP5819284B2 (ja) オロパタジンの製造方法
US6624304B1 (en) Process for preparing a 10,11-methanodibenzosuberane derivative
US4634768A (en) Halo-containing 3-methylflavone-8-carboxylic acid derivatives
CA2584789C (en) Method for the preparation of aripiprazole, and corresponding intermediates and their preparation
WO2008026220A1 (en) A process for purification of 7-(4-bromobutoxy)-3,4 dihydrocarbostyril, an intermediate for manufacture of aripirazole
JPS6368568A (ja) ｐ−アミノフエノ−ル誘導体
WO2009011654A1 (en) Process for the preparation of cyclic spiropiperidines
WO1997013753A1 (en) Process for the preparation of anti-malarial drugs
US6521755B1 (en) Process for preparing 10,11-methanobenzosuberane derivatives
CN101360727A (zh) 药物中间体的制备方法
US4017490A (en) Pyrido (3,4-d)pyridazines
EP0105484B1 (en) 3-propionylsalicyclic acid derivatives and process for the preparation of the same
JP2022514782A (ja) 化合物の製造、その新しい塩形態および治療的使用
EP1501802B1 (en) Process for the preparation of quinoline derivatives
WO2025021674A2 (en) Process for the preparation of tapinarof
JP2001199985A (ja) 高純度フェノチアジン化合物とその製造方法、およびその中間体の製造方法、並びにその中間体の原料の水和物と新規結晶
CA2301074A1 (en) Crystalline 10,10-bis((2-fluoro-4-pyridinyl)methyl)-9(10h)-anthracenone and an improved process for preparing the same
JPH09278773A (ja) オキセピノール誘導体の製造方法
JPS628114B2 (enExample)
JPH09227562A (ja) インドール誘導体の製造法

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued