ATE277922T1 - Verfahren zur herstellung von 10, 11methanodibenzosuberanderivaten - Google Patents

Verfahren zur herstellung von 10, 11methanodibenzosuberanderivaten

Info

Publication number
ATE277922T1
ATE277922T1 AT00935852T AT00935852T ATE277922T1 AT E277922 T1 ATE277922 T1 AT E277922T1 AT 00935852 T AT00935852 T AT 00935852T AT 00935852 T AT00935852 T AT 00935852T AT E277922 T1 ATE277922 T1 AT E277922T1
Authority
AT
Austria
Prior art keywords
producing
difluoromethanodibenzosuber
hydroxypropoxy
piperazin
quinoline
Prior art date
Application number
AT00935852T
Other languages
English (en)
Inventor
Bret Anthony Astleford
Charles Jackson Barnett
Michael Edward Kobierski
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE277922T1 publication Critical patent/ATE277922T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)
AT00935852T 1999-06-03 2000-05-30 Verfahren zur herstellung von 10, 11methanodibenzosuberanderivaten ATE277922T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13728499P 1999-06-03 1999-06-03
PCT/US2000/011863 WO2000075132A1 (en) 1999-06-03 2000-05-30 Process for preparing a 10,11-methanodibenzosuberane derivative

Publications (1)

Publication Number Publication Date
ATE277922T1 true ATE277922T1 (de) 2004-10-15

Family

ID=22476646

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00935852T ATE277922T1 (de) 1999-06-03 2000-05-30 Verfahren zur herstellung von 10, 11methanodibenzosuberanderivaten

Country Status (10)

Country Link
US (2) US6570016B1 (de)
EP (1) EP1198462B1 (de)
JP (1) JP2003501425A (de)
AT (1) ATE277922T1 (de)
AU (1) AU5125200A (de)
CA (1) CA2375283A1 (de)
DE (1) DE60014386T2 (de)
ES (1) ES2228534T3 (de)
PE (1) PE20010291A1 (de)
WO (1) WO2000075132A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
ES2228534T3 (es) * 1999-06-03 2005-04-16 Eli Lilly And Company Procedimiento de preparacion de un derivado de 10,11-metanodibenzosuberano.
US7282585B2 (en) 2001-04-25 2007-10-16 Eli Lilly And Company Salt and crystalline forms of (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline
WO2007024676A2 (en) * 2005-08-19 2007-03-01 Nanosphere, Inc. Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101311A1 (en) * 1992-07-31 1994-02-01 Neelakantan Balasubramanian Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
US5643909A (en) 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
JPH10504324A (ja) * 1995-06-07 1998-04-28 デイド、ケミストリー、システムズ、インコーポレイテッド 薬物の免疫原その他の接合体の製造
US6025359A (en) * 1996-06-17 2000-02-15 Eli Lilly And Company Drug resistance and multidrug resistance modulators
KR20000057157A (ko) * 1996-11-22 2000-09-15 피터 지. 스트링거 약물 내성 및 복합 약물 내성 조절제
TWI267511B (en) * 1999-06-03 2006-12-01 Lilly Co Eli Process for preparing 10,11-methanobenzosuberane derivatives
ES2228534T3 (es) * 1999-06-03 2005-04-16 Eli Lilly And Company Procedimiento de preparacion de un derivado de 10,11-metanodibenzosuberano.

Also Published As

Publication number Publication date
US6570016B1 (en) 2003-05-27
DE60014386D1 (de) 2004-11-04
WO2000075132A1 (en) 2000-12-14
EP1198462A1 (de) 2002-04-24
JP2003501425A (ja) 2003-01-14
PE20010291A1 (es) 2001-03-07
ES2228534T3 (es) 2005-04-16
AU5125200A (en) 2000-12-28
CA2375283A1 (en) 2000-12-14
EP1198462B1 (de) 2004-09-29
US6624304B1 (en) 2003-09-23
DE60014386T2 (de) 2005-10-13

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Legal Events

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