CA2374616A1 - Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits - Google Patents
Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits Download PDFInfo
- Publication number
- CA2374616A1 CA2374616A1 CA002374616A CA2374616A CA2374616A1 CA 2374616 A1 CA2374616 A1 CA 2374616A1 CA 002374616 A CA002374616 A CA 002374616A CA 2374616 A CA2374616 A CA 2374616A CA 2374616 A1 CA2374616 A1 CA 2374616A1
- Authority
- CA
- Canada
- Prior art keywords
- oxo
- thioxo
- thiazolidin
- benzylidene
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13854499P | 1999-06-10 | 1999-06-10 | |
US60/138,544 | 1999-06-10 | ||
PCT/US2000/015069 WO2000076987A1 (en) | 1999-06-10 | 2000-05-31 | Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2374616A1 true CA2374616A1 (en) | 2000-12-21 |
Family
ID=22482512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002374616A Abandoned CA2374616A1 (en) | 1999-06-10 | 2000-05-31 | Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1192143A1 (pt) |
JP (1) | JP2003502320A (pt) |
AU (1) | AU5311800A (pt) |
BR (1) | BR0011441A (pt) |
CA (1) | CA2374616A1 (pt) |
MX (1) | MXPA01010490A (pt) |
TR (1) | TR200103562T2 (pt) |
WO (1) | WO2000076987A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020394A1 (es) | 2000-08-18 | 2002-06-21 | Agouron Pharma | Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 |
AU2003280188A1 (en) | 2002-12-06 | 2004-06-30 | Warner-Lambert Company Llc | Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k |
US20060106077A1 (en) * | 2003-07-18 | 2006-05-18 | Pintex Pharmaceuticals, Inc. | Pin1-Modulating compounds and methods of use thereof |
JP2010518064A (ja) | 2007-02-12 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | Adおよび関連状態の治療のためのピペラジン誘導体 |
US8933075B2 (en) | 2010-06-17 | 2015-01-13 | Fuzians Biomedicals, Inc. | Compounds useful as antiviral agents, compositions, and methods of use |
CN106045986B (zh) * | 2016-05-31 | 2019-12-06 | 广东工业大学 | 一种新型吩噻嗪衍生物及其制备方法与应用 |
CN106045987B (zh) * | 2016-06-21 | 2019-04-23 | 广东工业大学 | 一种具有多功能近红外荧光磁性纳米微粒及其制备和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5740478A (en) * | 1980-08-22 | 1982-03-06 | Ono Pharmaceut Co Ltd | Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative |
JPH01147476A (ja) * | 1987-12-03 | 1989-06-09 | Mita Ind Co Ltd | 光導電性トナー |
JPH01147462A (ja) * | 1987-12-03 | 1989-06-09 | Mita Ind Co Ltd | 電荷発生材料およびその製法 |
US5143929A (en) * | 1991-05-09 | 1992-09-01 | Warner-Lambert Company | 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents |
EP0915090A1 (en) * | 1992-09-10 | 1999-05-12 | Eli Lilly And Company | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease |
DE4318550A1 (de) * | 1993-06-04 | 1994-12-08 | Boehringer Mannheim Gmbh | Aryliden-4-oxo-2-thioxo-3- thiazolidincarbonsäuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
AU1529297A (en) * | 1996-01-24 | 1997-08-20 | Warner-Lambert Company | Method of imaging amyloid deposits |
EP1128832A4 (en) * | 1998-08-21 | 2003-03-05 | Viropharma Inc | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS AND RELATED DISEASES |
EP1117655A1 (en) * | 1998-09-30 | 2001-07-25 | Angelika Esswein | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders |
-
2000
- 2000-05-31 TR TR2001/03562T patent/TR200103562T2/xx unknown
- 2000-05-31 CA CA002374616A patent/CA2374616A1/en not_active Abandoned
- 2000-05-31 BR BR0011441-3A patent/BR0011441A/pt not_active IP Right Cessation
- 2000-05-31 EP EP00938021A patent/EP1192143A1/en not_active Withdrawn
- 2000-05-31 AU AU53118/00A patent/AU5311800A/en not_active Abandoned
- 2000-05-31 WO PCT/US2000/015069 patent/WO2000076987A1/en not_active Application Discontinuation
- 2000-05-31 MX MXPA01010490A patent/MXPA01010490A/es unknown
- 2000-05-31 JP JP2001503845A patent/JP2003502320A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1192143A1 (en) | 2002-04-03 |
TR200103562T2 (tr) | 2002-04-22 |
AU5311800A (en) | 2001-01-02 |
MXPA01010490A (es) | 2005-05-27 |
JP2003502320A (ja) | 2003-01-21 |
WO2000076987A1 (en) | 2000-12-21 |
BR0011441A (pt) | 2002-07-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |