CA2356174A1 - Kidney disease detection and treatment - Google Patents
Kidney disease detection and treatment Download PDFInfo
- Publication number
- CA2356174A1 CA2356174A1 CA002356174A CA2356174A CA2356174A1 CA 2356174 A1 CA2356174 A1 CA 2356174A1 CA 002356174 A CA002356174 A CA 002356174A CA 2356174 A CA2356174 A CA 2356174A CA 2356174 A1 CA2356174 A1 CA 2356174A1
- Authority
- CA
- Canada
- Prior art keywords
- disease
- protein
- albumin
- renal
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000017169 kidney disease Diseases 0.000 title claims description 69
- 238000001514 detection method Methods 0.000 title claims description 14
- 238000000034 method Methods 0.000 claims abstract description 96
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 83
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 83
- 210000002700 urine Anatomy 0.000 claims abstract description 81
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 63
- 201000010099 disease Diseases 0.000 claims abstract description 59
- 102000035118 modified proteins Human genes 0.000 claims abstract description 30
- 108091005573 modified proteins Proteins 0.000 claims abstract description 30
- 102000009027 Albumins Human genes 0.000 claims description 164
- 108010088751 Albumins Proteins 0.000 claims description 164
- 210000003712 lysosome Anatomy 0.000 claims description 45
- 230000001868 lysosomic effect Effects 0.000 claims description 45
- 238000003127 radioimmunoassay Methods 0.000 claims description 41
- 239000000523 sample Substances 0.000 claims description 41
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 40
- 206010012601 diabetes mellitus Diseases 0.000 claims description 33
- 150000001875 compounds Chemical class 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 102000003886 Glycoproteins Human genes 0.000 claims description 9
- 108090000288 Glycoproteins Proteins 0.000 claims description 9
- 238000003018 immunoassay Methods 0.000 claims description 9
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 8
- 230000003213 activating effect Effects 0.000 claims description 8
- 238000003556 assay Methods 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims description 8
- 230000001154 acute effect Effects 0.000 claims description 7
- 238000001962 electrophoresis Methods 0.000 claims description 7
- 208000027866 inflammatory disease Diseases 0.000 claims description 7
- 206010003210 Arteriosclerosis Diseases 0.000 claims description 6
- 201000001320 Atherosclerosis Diseases 0.000 claims description 6
- 102000004895 Lipoproteins Human genes 0.000 claims description 6
- 108090001030 Lipoproteins Proteins 0.000 claims description 6
- 208000034578 Multiple myelomas Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 102000005686 Serum Globulins Human genes 0.000 claims description 6
- 108010045362 Serum Globulins Proteins 0.000 claims description 6
- 208000014674 injury Diseases 0.000 claims description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims description 5
- 238000004587 chromatography analysis Methods 0.000 claims description 5
- 201000010064 diabetes insipidus Diseases 0.000 claims description 5
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 4
- 208000024985 Alport syndrome Diseases 0.000 claims description 4
- 208000010061 Autosomal Dominant Polycystic Kidney Diseases 0.000 claims description 4
- 208000002814 Autosomal Recessive Polycystic Kidney Diseases 0.000 claims description 4
- 208000017354 Autosomal recessive polycystic kidney disease Diseases 0.000 claims description 4
- 208000025760 Benign familial haematuria Diseases 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 4
- 108010035532 Collagen Proteins 0.000 claims description 4
- 206010010356 Congenital anomaly Diseases 0.000 claims description 4
- 208000024720 Fabry Disease Diseases 0.000 claims description 4
- 208000022461 Glomerular disease Diseases 0.000 claims description 4
- 206010018370 Glomerulonephritis membranoproliferative Diseases 0.000 claims description 4
- 206010018372 Glomerulonephritis membranous Diseases 0.000 claims description 4
- 206010018374 Glomerulonephritis minimal lesion Diseases 0.000 claims description 4
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims description 4
- 206010021263 IgA nephropathy Diseases 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 206010024229 Leprosy Diseases 0.000 claims description 4
- 208000004883 Lipoid Nephrosis Diseases 0.000 claims description 4
- 208000004451 Membranoproliferative Glomerulonephritis Diseases 0.000 claims description 4
- 208000000175 Nail-Patella Syndrome Diseases 0.000 claims description 4
- 206010029148 Nephrolithiasis Diseases 0.000 claims description 4
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 4
- 206010037596 Pyelonephritis Diseases 0.000 claims description 4
- 206010065427 Reflux nephropathy Diseases 0.000 claims description 4
- 208000033626 Renal failure acute Diseases 0.000 claims description 4
- 208000034189 Sclerosis Diseases 0.000 claims description 4
- 206010052779 Transplant rejections Diseases 0.000 claims description 4
- 206010048302 Tubulointerstitial nephritis Diseases 0.000 claims description 4
- 201000011040 acute kidney failure Diseases 0.000 claims description 4
- 208000012998 acute renal failure Diseases 0.000 claims description 4
- 208000022185 autosomal dominant polycystic kidney disease Diseases 0.000 claims description 4
- 230000001580 bacterial effect Effects 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 230000002255 enzymatic effect Effects 0.000 claims description 4
- 208000030376 fibronectin glomerulopathy Diseases 0.000 claims description 4
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 4
- 238000005227 gel permeation chromatography Methods 0.000 claims description 4
- 230000002068 genetic effect Effects 0.000 claims description 4
- 208000003215 hereditary nephritis Diseases 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 201000006334 interstitial nephritis Diseases 0.000 claims description 4
- 201000008350 membranous glomerulonephritis Diseases 0.000 claims description 4
- 231100000855 membranous nephropathy Toxicity 0.000 claims description 4
- 208000030761 polycystic kidney disease Diseases 0.000 claims description 4
- 230000003612 virological effect Effects 0.000 claims description 4
- 208000006542 von Hippel-Lindau disease Diseases 0.000 claims description 4
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 claims description 3
- 208000030507 AIDS Diseases 0.000 claims description 3
- 206010000599 Acromegaly Diseases 0.000 claims description 3
- 206010002091 Anaesthesia Diseases 0.000 claims description 3
- 208000019838 Blood disease Diseases 0.000 claims description 3
- 206010013654 Drug abuse Diseases 0.000 claims description 3
- 238000002965 ELISA Methods 0.000 claims description 3
- 208000005189 Embolism Diseases 0.000 claims description 3
- 208000017701 Endocrine disease Diseases 0.000 claims description 3
- 108010049003 Fibrinogen Proteins 0.000 claims description 3
- 102000008946 Fibrinogen Human genes 0.000 claims description 3
- 102000006395 Globulins Human genes 0.000 claims description 3
- 108010044091 Globulins Proteins 0.000 claims description 3
- 206010018378 Glomerulonephritis rapidly progressive Diseases 0.000 claims description 3
- 108010015776 Glucose oxidase Proteins 0.000 claims description 3
- 239000004366 Glucose oxidase Substances 0.000 claims description 3
- 201000005569 Gout Diseases 0.000 claims description 3
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims description 3
- 108010051696 Growth Hormone Proteins 0.000 claims description 3
- 208000031886 HIV Infections Diseases 0.000 claims description 3
- 208000037357 HIV infectious disease Diseases 0.000 claims description 3
- 206010019280 Heart failures Diseases 0.000 claims description 3
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 claims description 3
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 102000004877 Insulin Human genes 0.000 claims description 3
- 108090001061 Insulin Proteins 0.000 claims description 3
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 3
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 3
- 102000016943 Muramidase Human genes 0.000 claims description 3
- 108010014251 Muramidase Proteins 0.000 claims description 3
- 101001026869 Mus musculus F-box/LRR-repeat protein 3 Proteins 0.000 claims description 3
- 108010062374 Myoglobin Proteins 0.000 claims description 3
- 102100030856 Myoglobin Human genes 0.000 claims description 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 3
- 206010028851 Necrosis Diseases 0.000 claims description 3
- 108010061952 Orosomucoid Proteins 0.000 claims description 3
- 102000012404 Orosomucoid Human genes 0.000 claims description 3
- 206010033645 Pancreatitis Diseases 0.000 claims description 3
- 208000002774 Paraproteinemias Diseases 0.000 claims description 3
- 102000003982 Parathyroid hormone Human genes 0.000 claims description 3
- 108090000445 Parathyroid hormone Proteins 0.000 claims description 3
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 206010037549 Purpura Diseases 0.000 claims description 3
- 241001672981 Purpura Species 0.000 claims description 3
- 206010037660 Pyrexia Diseases 0.000 claims description 3
- 102100038803 Somatotropin Human genes 0.000 claims description 3
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 3
- 208000004732 Systemic Vasculitis Diseases 0.000 claims description 3
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 3
- 206010043561 Thrombocytopenic purpura Diseases 0.000 claims description 3
- 208000001435 Thromboembolism Diseases 0.000 claims description 3
- 102000004338 Transferrin Human genes 0.000 claims description 3
- 108090000901 Transferrin Proteins 0.000 claims description 3
- 208000027418 Wounds and injury Diseases 0.000 claims description 3
- 230000003187 abdominal effect Effects 0.000 claims description 3
- 238000012084 abdominal surgery Methods 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 208000009956 adenocarcinoma Diseases 0.000 claims description 3
- 238000005377 adsorption chromatography Methods 0.000 claims description 3
- 238000001042 affinity chromatography Methods 0.000 claims description 3
- 238000001949 anaesthesia Methods 0.000 claims description 3
- 230000037005 anaesthesia Effects 0.000 claims description 3
- 210000000481 breast Anatomy 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 208000029078 coronary artery disease Diseases 0.000 claims description 3
- 201000005637 crescentic glomerulonephritis Diseases 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 201000001981 dermatomyositis Diseases 0.000 claims description 3
- 208000030172 endocrine system disease Diseases 0.000 claims description 3
- 229940012952 fibrinogen Drugs 0.000 claims description 3
- 238000001030 gas--liquid chromatography Methods 0.000 claims description 3
- 229940116332 glucose oxidase Drugs 0.000 claims description 3
- 235000019420 glucose oxidase Nutrition 0.000 claims description 3
- 239000000122 growth hormone Substances 0.000 claims description 3
- 208000014951 hematologic disease Diseases 0.000 claims description 3
- 208000018706 hematopoietic system disease Diseases 0.000 claims description 3
- 229940088597 hormone Drugs 0.000 claims description 3
- 239000005556 hormone Substances 0.000 claims description 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 3
- 229940072221 immunoglobulins Drugs 0.000 claims description 3
- 230000006698 induction Effects 0.000 claims description 3
- 229940125396 insulin Drugs 0.000 claims description 3
- 238000004255 ion exchange chromatography Methods 0.000 claims description 3
- 238000001155 isoelectric focusing Methods 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 3
- 229960000274 lysozyme Drugs 0.000 claims description 3
- 239000004325 lysozyme Substances 0.000 claims description 3
- 235000010335 lysozyme Nutrition 0.000 claims description 3
- 230000003211 malignant effect Effects 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 208000010125 myocardial infarction Diseases 0.000 claims description 3
- 230000017074 necrotic cell death Effects 0.000 claims description 3
- 230000002956 necrotizing effect Effects 0.000 claims description 3
- 230000000414 obstructive effect Effects 0.000 claims description 3
- 238000004816 paper chromatography Methods 0.000 claims description 3
- 239000000199 parathyroid hormone Substances 0.000 claims description 3
- 229960001319 parathyroid hormone Drugs 0.000 claims description 3
- 238000004810 partition chromatography Methods 0.000 claims description 3
- 229960001639 penicillamine Drugs 0.000 claims description 3
- 201000006292 polyarteritis nodosa Diseases 0.000 claims description 3
- 230000002285 radioactive effect Effects 0.000 claims description 3
- 208000023504 respiratory system disease Diseases 0.000 claims description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 3
- 238000004062 sedimentation Methods 0.000 claims description 3
- 208000007056 sickle cell anemia Diseases 0.000 claims description 3
- 208000017520 skin disease Diseases 0.000 claims description 3
- 201000002859 sleep apnea Diseases 0.000 claims description 3
- 150000003431 steroids Chemical class 0.000 claims description 3
- 208000011117 substance-related disease Diseases 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 3
- 238000004809 thin layer chromatography Methods 0.000 claims description 3
- 230000001732 thrombotic effect Effects 0.000 claims description 3
- 239000012581 transferrin Substances 0.000 claims description 3
- 230000008733 trauma Effects 0.000 claims description 3
- 238000007631 vascular surgery Methods 0.000 claims description 3
- 238000007693 zone electrophoresis Methods 0.000 claims description 3
- 108010075016 Ceruloplasmin Proteins 0.000 claims description 2
- 102100023321 Ceruloplasmin Human genes 0.000 claims description 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 2
- 206010002022 amyloidosis Diseases 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 230000001900 immune effect Effects 0.000 abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 15
- 230000000694 effects Effects 0.000 description 15
- 210000003734 kidney Anatomy 0.000 description 14
- 230000015556 catabolic process Effects 0.000 description 13
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 12
- 230000029142 excretion Effects 0.000 description 12
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 11
- 241000282414 Homo sapiens Species 0.000 description 11
- 230000008859 change Effects 0.000 description 11
- 208000033679 diabetic kidney disease Diseases 0.000 description 11
- 239000012634 fragment Substances 0.000 description 10
- 238000013467 fragmentation Methods 0.000 description 10
- 238000006062 fragmentation reaction Methods 0.000 description 10
- 230000014759 maintenance of location Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 9
- 230000002132 lysosomal effect Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 102000008100 Human Serum Albumin Human genes 0.000 description 7
- 108091006905 Human Serum Albumin Proteins 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 238000001542 size-exclusion chromatography Methods 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 210000005084 renal tissue Anatomy 0.000 description 6
- 206010027525 Microalbuminuria Diseases 0.000 description 5
- 230000033077 cellular process Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 201000001474 proteinuria Diseases 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000008427 tissue turnover Effects 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 102000003923 Protein Kinase C Human genes 0.000 description 3
- 108090000315 Protein Kinase C Proteins 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 229960005188 collagen Drugs 0.000 description 3
- 238000013399 early diagnosis Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 206010001580 Albuminuria Diseases 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 208000032170 Congenital Abnormalities Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical group 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000012156 elution solvent Substances 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 230000000984 immunochemical effect Effects 0.000 description 2
- -1 immunosuppressives Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007420 reactivation Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 239000005541 ACE inhibitor Substances 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 102100031673 Corneodesmosin Human genes 0.000 description 1
- 101710139375 Corneodesmosin Proteins 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 108010059378 Endopeptidases Proteins 0.000 description 1
- 102000005593 Endopeptidases Human genes 0.000 description 1
- 102000018389 Exopeptidases Human genes 0.000 description 1
- 108010091443 Exopeptidases Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 229940034982 antineoplastic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000036252 glycation Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000006525 intracellular process Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Virology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP7843 | 1998-12-21 | ||
| AUPP7843A AUPP784398A0 (en) | 1998-12-21 | 1998-12-21 | Kidney disease detection and treatment |
| US09/415,217 | 1999-10-12 | ||
| US09/415,217 US6447989B1 (en) | 1998-12-21 | 1999-10-12 | Kidney disease detection and treatment |
| PCT/IB1999/002029 WO2000037944A1 (en) | 1998-12-21 | 1999-12-20 | Kidney disease detection and treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2356174A1 true CA2356174A1 (en) | 2000-06-29 |
Family
ID=25645955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002356174A Abandoned CA2356174A1 (en) | 1998-12-21 | 1999-12-20 | Kidney disease detection and treatment |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20020012906A1 (enExample) |
| EP (1) | EP1141728B1 (enExample) |
| JP (2) | JP4160263B2 (enExample) |
| CN (1) | CN1331801A (enExample) |
| AT (1) | ATE376187T1 (enExample) |
| AU (1) | AU1674400A (enExample) |
| BR (1) | BR9916407A (enExample) |
| CA (1) | CA2356174A1 (enExample) |
| DE (1) | DE69937368T2 (enExample) |
| DK (1) | DK1141728T3 (enExample) |
| IL (1) | IL143892A0 (enExample) |
| MX (1) | MXPA01006404A (enExample) |
| WO (1) | WO2000037944A1 (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP784398A0 (en) | 1998-12-21 | 1999-01-21 | Monash University | Kidney disease detection and treatment |
| AU1674400A (en) | 1998-12-21 | 2000-07-12 | Monash University | Kidney disease detection and treatment |
| US7250294B2 (en) * | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| AU2002305159B2 (en) * | 2001-03-28 | 2007-12-13 | Heska Corporation | Methods of detecting early renal disease in animals |
| US20030003588A1 (en) * | 2001-06-28 | 2003-01-02 | Comper Wayne D. | Method for kidney disease detection by protein profiling |
| CN100556546C (zh) * | 2003-02-13 | 2009-11-04 | 贝克顿·迪金森公司 | 在血液收集过程中去除成分的装置及其使用 |
| US7482128B2 (en) | 2003-03-27 | 2009-01-27 | Heska Corporation | Anti-feline albumin antibodies |
| JP2007521232A (ja) | 2003-08-08 | 2007-08-02 | アブジェニックス・インコーポレーテッド | 副甲状腺ホルモン（ｐｔｈ）に対する抗体およびその使用 |
| US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| US20050112123A1 (en) * | 2003-10-06 | 2005-05-26 | Vaughan Michael R. | Methods of treating proteinuria |
| US20060286602A1 (en) * | 2004-05-10 | 2006-12-21 | Harald Mischak | Method and markers for the diagnosis of renal diseases |
| JP5785355B2 (ja) * | 2004-11-24 | 2015-09-30 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 動物における生体異物物質の肝臓クリアランスを改良する方法 |
| US20090176864A1 (en) * | 2004-11-24 | 2009-07-09 | Hill's Pet Nutrition, Inc. | Methods For Improving Hepatic and Immune Function In An Animal |
| US8647660B2 (en) * | 2004-12-29 | 2014-02-11 | Hill's Pet Nutrition, Inc. | Combination of limited nutrients and enhanced dietary antioxidants to impart improved kidney health |
| US8252742B2 (en) | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| CN102907561A (zh) * | 2004-12-30 | 2013-02-06 | 希尔氏宠物营养品公司 | 提高老年动物的生活质量的方法 |
| US20060205818A1 (en) * | 2005-03-08 | 2006-09-14 | Burzynski Stanislaw R | Method for the treatment of von Hippel-Lindau (VHL) disease with phenylacetyl-derivatives |
| EP1874130A4 (en) * | 2005-04-19 | 2009-04-29 | Hills Pet Nutrition Inc | METHOD AND COMPOSITIONS FOR PREVENTING AND TREATING NURSE DISEASES |
| CA2605855A1 (en) * | 2005-04-29 | 2006-11-09 | Hill's Pet Nutrition, Inc. | Methods for prolonging feline life |
| CA2608670C (en) * | 2005-05-20 | 2019-03-05 | Hill's Pet Nutrition, Inc. | Methods for promoting health or wellness in adult animals |
| WO2007002836A2 (en) * | 2005-06-29 | 2007-01-04 | Hill's Pet Nutrition, Inc. | Methods and compositions for the prevention and treatment of kidney disease |
| CA2619042C (en) * | 2005-08-17 | 2011-03-15 | Hill's Pet Nutrition, Inc. | Methods and compositions for the prevention and treatment of kidney disease |
| AU2008223791B2 (en) * | 2007-03-07 | 2013-10-03 | Mosaiques Diagnostics And Therapeutics Ag | Method for the standardization of the concentration of analytes in a urine sample |
| EP1972940A1 (de) * | 2007-03-14 | 2008-09-24 | mosaiques diagnostics and therapeutics AG | Verfahren und Marker zur Diagnose von Nierenerkrankungen |
| EP2535718B1 (en) * | 2007-05-11 | 2014-07-09 | The Institutes for Pharmaceutical Discovery, LLC | Methods for early diagnosis of kidney disease |
| AU2008309605A1 (en) * | 2007-10-09 | 2009-04-16 | Mosaiques Diagnostics And Therapeutics Ag | Polypeptide marker for the diagnosis of prostate cancer |
| EP2051078A1 (de) * | 2007-10-19 | 2009-04-22 | mosaiques diagnostics and therapeutics AG | Verfahren und Marker zur Diagnose von Diabetes Mellitus |
| JP2011515672A (ja) * | 2008-03-19 | 2011-05-19 | モザイクス ダイアグノスティクス アンド セラピューティクス アーゲー | 腎尿細管の損傷および疾患の診断のための方法およびマーカー |
| EP2313778B1 (en) * | 2008-07-18 | 2015-01-28 | Boston Medical Center Corporation | Diagnostics for membranous nephropathy |
| NZ610356A (en) * | 2008-08-28 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US9057735B2 (en) * | 2008-08-29 | 2015-06-16 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2338054A1 (de) * | 2008-09-17 | 2011-06-29 | Mosaiques Diagnostics And Therapeutics AG | Nierenzellkarzinom |
| CN104020284B (zh) * | 2008-10-21 | 2016-08-24 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| NZ628843A (en) * | 2008-10-21 | 2016-02-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2913676A1 (en) | 2008-11-10 | 2015-09-02 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| ES2528799T3 (es) * | 2008-11-22 | 2015-02-12 | Astute Medical, Inc. | Métodos para el pronóstico de insuficiencia renal aguda |
| WO2010064239A1 (en) | 2008-12-04 | 2010-06-10 | Technion Research And Development Foundation Ltd. | Apparatus and methods for diagnosing renal disorders |
| BRPI1007483B1 (pt) * | 2009-01-28 | 2021-11-30 | Bio Preventive Medicine Corporation | Método de diagnóstico de nefropatia in vitro, método in vitro para o monitoramento de progresso de nefropatia, método in vitro para o monitoramento da eficácia de um tratamento de nefropatia, método in vitro de avaliação de toxicidade renal de um agente e kit para diagnóstico de nefropatia |
| US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP5827226B2 (ja) * | 2009-08-07 | 2015-12-02 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| CN102792161B (zh) * | 2009-08-28 | 2014-11-12 | 阿斯图特医药公司 | 肾损伤和肾衰竭的诊断及预后的方法及组合物 |
| EA201290192A1 (ru) | 2009-11-07 | 2013-02-28 | Астьют Медикал, Инк. | Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности |
| MX2012005210A (es) * | 2009-11-07 | 2012-08-03 | Astute Medical Inc | Metodos y composiciones para diagnostico y pronostico de lesion renal y falla renal. |
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| DK2666872T3 (en) | 2010-02-05 | 2016-07-25 | Astute Medical Inc | Methods and compositions for the diagnosis and prognosis of renal injury and renal insufficiency |
| EP2539712A4 (en) | 2010-02-26 | 2013-09-18 | Astute Medical Inc | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE |
| CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| WO2011162821A1 (en) | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20130203074A1 (en) | 2010-06-23 | 2013-08-08 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2012019110A1 (en) * | 2010-08-05 | 2012-02-09 | Abbott Laboratories | Method and system for managing patient healthcare |
| DE102010038014B4 (de) * | 2010-10-06 | 2021-10-07 | Numares Ag | Verwendung spezifischer Substanzen als Marker zur Bestimmung des Risikos einer Nierenabstoßung |
| KR101215759B1 (ko) | 2010-11-01 | 2012-12-26 | 서울대학교산학협력단 | 오로소뮤코이드를 포함하는 조성물의 용도 |
| PT2691530T (pt) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Glicoproteínas e vectores recombinantes cmv |
| CN102854325B (zh) * | 2011-07-01 | 2015-01-07 | 复旦大学 | 胰岛素与血清蛋白可逆性结合的亲和力指标测定方法及应用 |
| EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
| US20130115640A1 (en) * | 2011-11-03 | 2013-05-09 | James A. Tumlin | ACTH for Treatment of Kidney Disease |
| WO2013086359A1 (en) | 2011-12-08 | 2013-06-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US9689826B2 (en) | 2012-03-11 | 2017-06-27 | Technion Research And Development Foundation Ltd. | Detection of chronic kidney disease and disease progression |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| CA3158996C (en) | 2013-01-17 | 2024-06-04 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP2016188761A (ja) * | 2013-08-23 | 2016-11-04 | 国立研究開発法人国立国際医療研究センター | 糖尿病腎症の発症または発症リスクの検出方法及びキット |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| CN104007258B (zh) * | 2013-09-30 | 2016-07-06 | 中国医学科学院基础医学研究所 | 局灶性节段性肾小球硬化的蛋白标志物 |
| EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| CN105917229B (zh) | 2013-12-03 | 2019-04-26 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| CN104849466A (zh) * | 2014-02-14 | 2015-08-19 | 张曼 | 尿液玻璃体结合蛋白在2型糖尿病合并早期肾损伤诊治中的应用 |
| US20170205427A1 (en) * | 2014-07-23 | 2017-07-20 | University Of British Columbia | Biomarkers for anderson-fabry disease |
| US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| WO2016164854A1 (en) | 2015-04-09 | 2016-10-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2017277305A1 (en) | 2016-06-06 | 2018-12-20 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
| US11026625B2 (en) | 2017-08-08 | 2021-06-08 | Fresenius Medical Care Holdings, Inc. | Systems and methods for treating and estimating progression of chronic kidney disease |
| CN107561175A (zh) * | 2017-08-10 | 2018-01-09 | 武汉大学 | 一种肾小球硬化大鼠模型的评价方法 |
| RU2697722C1 (ru) * | 2018-12-06 | 2019-08-19 | Ирина Сергеевна Шатохина | Способ диагностики активности воспалительного процесса при латентном течении хронического пиелонефрита |
| CN110632229A (zh) * | 2019-09-24 | 2019-12-31 | 华兰生物工程重庆有限公司 | 高效液相色谱仪检测静注人免疫球蛋白(pH4)蛋白质含量的方法 |
| CN111714517A (zh) * | 2020-04-14 | 2020-09-29 | 南开大学 | 一种溶酶体作为制备药物领域的应用 |
| RU2768464C1 (ru) * | 2021-04-27 | 2022-03-24 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ диагностики мембранозной нефропатии как одной из форм хронического гломерулонефрита |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994165A (en) * | 1989-02-16 | 1991-02-19 | Cornell Research Foundation, Inc. | Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry |
| DE69221666T2 (de) | 1991-05-24 | 1998-01-15 | Wakamoto Pharma Co Ltd | Verfahren zur Diagnose von Nierenkrankheiten durch Nachweisung von Albuminfragmenten |
| JPH0682446A (ja) * | 1992-08-31 | 1994-03-22 | Wakamoto Pharmaceut Co Ltd | 腎疾患の診断法 |
| DE4336498A1 (de) * | 1993-10-26 | 1995-04-27 | Bender & Co Gmbh | Verfahren zur Diagnose von Nieren- und Gefäßerkrankungen |
| US5534431A (en) | 1994-02-28 | 1996-07-09 | The Board Of Regents Of The University Of Nebraska | Hybridomas and monoclonal antibodies specific for unique determinants of nephropathy-related immunoglobulin G and complexes thereof |
| US5908925A (en) | 1996-06-27 | 1999-06-01 | Exocell, Inc. | Genetically engineered immunoglobulins with specificity for glycated albumin |
| US5800998A (en) * | 1996-11-12 | 1998-09-01 | Millennium Pharmaceuticals, Inc. | Assays for diagnosing type II diabetes in a subject |
| AU1674400A (en) | 1998-12-21 | 2000-07-12 | Monash University | Kidney disease detection and treatment |
-
1999
- 1999-12-20 AU AU16744/00A patent/AU1674400A/en not_active Abandoned
- 1999-12-20 JP JP2000589950A patent/JP4160263B2/ja not_active Expired - Fee Related
- 1999-12-20 MX MXPA01006404A patent/MXPA01006404A/es not_active IP Right Cessation
- 1999-12-20 EP EP99959616A patent/EP1141728B1/en not_active Expired - Lifetime
- 1999-12-20 BR BR9916407-8A patent/BR9916407A/pt not_active Application Discontinuation
- 1999-12-20 WO PCT/IB1999/002029 patent/WO2000037944A1/en not_active Ceased
- 1999-12-20 DK DK99959616T patent/DK1141728T3/da active
- 1999-12-20 IL IL14389299A patent/IL143892A0/xx unknown
- 1999-12-20 CN CN99814862A patent/CN1331801A/zh active Pending
- 1999-12-20 AT AT99959616T patent/ATE376187T1/de not_active IP Right Cessation
- 1999-12-20 CA CA002356174A patent/CA2356174A1/en not_active Abandoned
- 1999-12-20 DE DE69937368T patent/DE69937368T2/de not_active Expired - Lifetime
-
2001
- 2001-06-28 US US09/893,346 patent/US20020012906A1/en not_active Abandoned
- 2001-06-28 US US09/892,797 patent/US6589748B2/en not_active Expired - Fee Related
-
2003
- 2003-11-26 US US10/721,351 patent/US20040106155A1/en not_active Abandoned
-
2005
- 2005-09-16 JP JP2005270160A patent/JP4388515B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006038877A (ja) | 2006-02-09 |
| EP1141728B1 (en) | 2007-10-17 |
| US20020022236A1 (en) | 2002-02-21 |
| JP2002533680A (ja) | 2002-10-08 |
| BR9916407A (pt) | 2001-09-25 |
| AU1674400A (en) | 2000-07-12 |
| IL143892A0 (en) | 2002-04-21 |
| JP4160263B2 (ja) | 2008-10-01 |
| DE69937368T2 (de) | 2008-07-17 |
| US20020012906A1 (en) | 2002-01-31 |
| EP1141728A4 (en) | 2005-01-12 |
| DK1141728T3 (da) | 2008-02-04 |
| ATE376187T1 (de) | 2007-11-15 |
| US20040106155A1 (en) | 2004-06-03 |
| WO2000037944A1 (en) | 2000-06-29 |
| EP1141728A1 (en) | 2001-10-10 |
| DE69937368D1 (de) | 2007-11-29 |
| JP4388515B2 (ja) | 2009-12-24 |
| US6589748B2 (en) | 2003-07-08 |
| MXPA01006404A (es) | 2003-06-06 |
| CN1331801A (zh) | 2002-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1141728B1 (en) | Kidney disease detection and treatment | |
| US6447989B1 (en) | Kidney disease detection and treatment | |
| US20030003588A1 (en) | Method for kidney disease detection by protein profiling | |
| EP1591789B1 (en) | Method for improving the recovery of Troponin I and T | |
| EP0802411A2 (en) | Measurement method and kit for hemoglobin A1c | |
| US20050191664A1 (en) | Method for kidney disease detection | |
| US5246835A (en) | Method of diagnosing renal diseases | |
| EP1238284B1 (en) | Diagnostic assay for stroke | |
| US7202042B2 (en) | Rapid evaluation of the ratio of biological molecules | |
| Arendt et al. | Increased endothelin plasma concentrations in patients with coronary artery disease or hyperlipoproteinemia without coronary events | |
| CA2393004A1 (en) | Method of diagnosing neurodegenerative disease | |
| WO1993025911A1 (en) | Diagnosing alzheimer's disease and schizophrenia | |
| JPH0580053A (ja) | ヒト子宮体癌細胞の免疫化学的検出方法 | |
| Liu et al. | Immunochemical determination of LDH-1 | |
| JP3998245B2 (ja) | 酸化アポリポタンパク質ａｉ及びそれを含有する酸化リポタンパク質の測定法及びキット | |
| WO2002022165A9 (en) | Non-genetic based protein disease markers | |
| EP0100395B1 (en) | Reagent for determination of human urine kallikrein | |
| JPH0690203B2 (ja) | 前立腺特異抗原とα▲下１▼−アンチトリプシン複合体の定量方法 | |
| ZA200309593B (en) | Method for kidney disease detection by protein profiling. | |
| WO2021216585A1 (en) | Methods for prediction, detection and monitoring of substance use disorders and/or an infection | |
| JPH09318627A (ja) | 腎不全またはバセドウ病における骨組織の代謝異常をスクリーニングする方法 | |
| JP2007279066A (ja) | 酸化アポリポタンパク質ａｉ及びそれを含有する酸化リポタンパク質の測定法及びキット | |
| JPH0833398B2 (ja) | ヒト組織プラスミノーゲンアクチベーター・ヒトプラスミノーゲンアクチベーターインヒビター複合体の測定方法及び測定キット |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |