DE69937368T2 - Nachweis von erkrankungen der nieren und behandlung - Google Patents
Nachweis von erkrankungen der nieren und behandlung Download PDFInfo
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- DE69937368T2 DE69937368T2 DE69937368T DE69937368T DE69937368T2 DE 69937368 T2 DE69937368 T2 DE 69937368T2 DE 69937368 T DE69937368 T DE 69937368T DE 69937368 T DE69937368 T DE 69937368T DE 69937368 T2 DE69937368 T2 DE 69937368T2
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| AUPP784398 | 1998-12-21 | ||
| AUPP7843A AUPP784398A0 (en) | 1998-12-21 | 1998-12-21 | Kidney disease detection and treatment |
| US415217 | 1999-10-12 | ||
| US09/415,217 US6447989B1 (en) | 1998-12-21 | 1999-10-12 | Kidney disease detection and treatment |
| PCT/IB1999/002029 WO2000037944A1 (en) | 1998-12-21 | 1999-12-20 | Kidney disease detection and treatment |
Publications (2)
| Publication Number | Publication Date |
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| DE69937368D1 DE69937368D1 (de) | 2007-11-29 |
| DE69937368T2 true DE69937368T2 (de) | 2008-07-17 |
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| DE69937368T Expired - Lifetime DE69937368T2 (de) | 1998-12-21 | 1999-12-20 | Nachweis von erkrankungen der nieren und behandlung |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010038014A1 (de) * | 2010-10-06 | 2012-04-12 | Lipofit Analytic Gmbh | Verfahren zur Charakterisierung einer Probe und eines Systems |
Families Citing this family (77)
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| AUPP784398A0 (en) | 1998-12-21 | 1999-01-21 | Monash University | Kidney disease detection and treatment |
| AU1674400A (en) | 1998-12-21 | 2000-07-12 | Monash University | Kidney disease detection and treatment |
| US7250294B2 (en) * | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| AU2002305159B2 (en) * | 2001-03-28 | 2007-12-13 | Heska Corporation | Methods of detecting early renal disease in animals |
| US20030003588A1 (en) * | 2001-06-28 | 2003-01-02 | Comper Wayne D. | Method for kidney disease detection by protein profiling |
| CN100556546C (zh) * | 2003-02-13 | 2009-11-04 | 贝克顿·迪金森公司 | 在血液收集过程中去除成分的装置及其使用 |
| US7482128B2 (en) | 2003-03-27 | 2009-01-27 | Heska Corporation | Anti-feline albumin antibodies |
| JP2007521232A (ja) | 2003-08-08 | 2007-08-02 | アブジェニックス・インコーポレーテッド | 副甲状腺ホルモン（ｐｔｈ）に対する抗体およびその使用 |
| US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| US20050112123A1 (en) * | 2003-10-06 | 2005-05-26 | Vaughan Michael R. | Methods of treating proteinuria |
| US20060286602A1 (en) * | 2004-05-10 | 2006-12-21 | Harald Mischak | Method and markers for the diagnosis of renal diseases |
| JP5785355B2 (ja) * | 2004-11-24 | 2015-09-30 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 動物における生体異物物質の肝臓クリアランスを改良する方法 |
| US20090176864A1 (en) * | 2004-11-24 | 2009-07-09 | Hill's Pet Nutrition, Inc. | Methods For Improving Hepatic and Immune Function In An Animal |
| US8647660B2 (en) * | 2004-12-29 | 2014-02-11 | Hill's Pet Nutrition, Inc. | Combination of limited nutrients and enhanced dietary antioxidants to impart improved kidney health |
| US8252742B2 (en) | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| CN102907561A (zh) * | 2004-12-30 | 2013-02-06 | 希尔氏宠物营养品公司 | 提高老年动物的生活质量的方法 |
| US20060205818A1 (en) * | 2005-03-08 | 2006-09-14 | Burzynski Stanislaw R | Method for the treatment of von Hippel-Lindau (VHL) disease with phenylacetyl-derivatives |
| EP1874130A4 (en) * | 2005-04-19 | 2009-04-29 | Hills Pet Nutrition Inc | METHOD AND COMPOSITIONS FOR PREVENTING AND TREATING NURSE DISEASES |
| CA2605855A1 (en) * | 2005-04-29 | 2006-11-09 | Hill's Pet Nutrition, Inc. | Methods for prolonging feline life |
| CA2608670C (en) * | 2005-05-20 | 2019-03-05 | Hill's Pet Nutrition, Inc. | Methods for promoting health or wellness in adult animals |
| WO2007002836A2 (en) * | 2005-06-29 | 2007-01-04 | Hill's Pet Nutrition, Inc. | Methods and compositions for the prevention and treatment of kidney disease |
| CA2619042C (en) * | 2005-08-17 | 2011-03-15 | Hill's Pet Nutrition, Inc. | Methods and compositions for the prevention and treatment of kidney disease |
| AU2008223791B2 (en) * | 2007-03-07 | 2013-10-03 | Mosaiques Diagnostics And Therapeutics Ag | Method for the standardization of the concentration of analytes in a urine sample |
| EP1972940A1 (de) * | 2007-03-14 | 2008-09-24 | mosaiques diagnostics and therapeutics AG | Verfahren und Marker zur Diagnose von Nierenerkrankungen |
| EP2535718B1 (en) * | 2007-05-11 | 2014-07-09 | The Institutes for Pharmaceutical Discovery, LLC | Methods for early diagnosis of kidney disease |
| AU2008309605A1 (en) * | 2007-10-09 | 2009-04-16 | Mosaiques Diagnostics And Therapeutics Ag | Polypeptide marker for the diagnosis of prostate cancer |
| EP2051078A1 (de) * | 2007-10-19 | 2009-04-22 | mosaiques diagnostics and therapeutics AG | Verfahren und Marker zur Diagnose von Diabetes Mellitus |
| JP2011515672A (ja) * | 2008-03-19 | 2011-05-19 | モザイクス ダイアグノスティクス アンド セラピューティクス アーゲー | 腎尿細管の損傷および疾患の診断のための方法およびマーカー |
| EP2313778B1 (en) * | 2008-07-18 | 2015-01-28 | Boston Medical Center Corporation | Diagnostics for membranous nephropathy |
| NZ610356A (en) * | 2008-08-28 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US9057735B2 (en) * | 2008-08-29 | 2015-06-16 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2338054A1 (de) * | 2008-09-17 | 2011-06-29 | Mosaiques Diagnostics And Therapeutics AG | Nierenzellkarzinom |
| CN104020284B (zh) * | 2008-10-21 | 2016-08-24 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| NZ628843A (en) * | 2008-10-21 | 2016-02-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2913676A1 (en) | 2008-11-10 | 2015-09-02 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| ES2528799T3 (es) * | 2008-11-22 | 2015-02-12 | Astute Medical, Inc. | Métodos para el pronóstico de insuficiencia renal aguda |
| WO2010064239A1 (en) | 2008-12-04 | 2010-06-10 | Technion Research And Development Foundation Ltd. | Apparatus and methods for diagnosing renal disorders |
| BRPI1007483B1 (pt) * | 2009-01-28 | 2021-11-30 | Bio Preventive Medicine Corporation | Método de diagnóstico de nefropatia in vitro, método in vitro para o monitoramento de progresso de nefropatia, método in vitro para o monitoramento da eficácia de um tratamento de nefropatia, método in vitro de avaliação de toxicidade renal de um agente e kit para diagnóstico de nefropatia |
| US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP5827226B2 (ja) * | 2009-08-07 | 2015-12-02 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| CN102792161B (zh) * | 2009-08-28 | 2014-11-12 | 阿斯图特医药公司 | 肾损伤和肾衰竭的诊断及预后的方法及组合物 |
| EA201290192A1 (ru) | 2009-11-07 | 2013-02-28 | Астьют Медикал, Инк. | Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности |
| MX2012005210A (es) * | 2009-11-07 | 2012-08-03 | Astute Medical Inc | Metodos y composiciones para diagnostico y pronostico de lesion renal y falla renal. |
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| DK2666872T3 (en) | 2010-02-05 | 2016-07-25 | Astute Medical Inc | Methods and compositions for the diagnosis and prognosis of renal injury and renal insufficiency |
| EP2539712A4 (en) | 2010-02-26 | 2013-09-18 | Astute Medical Inc | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE |
| CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| WO2011162821A1 (en) | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20130203074A1 (en) | 2010-06-23 | 2013-08-08 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2012019110A1 (en) * | 2010-08-05 | 2012-02-09 | Abbott Laboratories | Method and system for managing patient healthcare |
| KR101215759B1 (ko) | 2010-11-01 | 2012-12-26 | 서울대학교산학협력단 | 오로소뮤코이드를 포함하는 조성물의 용도 |
| PT2691530T (pt) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Glicoproteínas e vectores recombinantes cmv |
| CN102854325B (zh) * | 2011-07-01 | 2015-01-07 | 复旦大学 | 胰岛素与血清蛋白可逆性结合的亲和力指标测定方法及应用 |
| EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
| US20130115640A1 (en) * | 2011-11-03 | 2013-05-09 | James A. Tumlin | ACTH for Treatment of Kidney Disease |
| WO2013086359A1 (en) | 2011-12-08 | 2013-06-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US9689826B2 (en) | 2012-03-11 | 2017-06-27 | Technion Research And Development Foundation Ltd. | Detection of chronic kidney disease and disease progression |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| CA3158996C (en) | 2013-01-17 | 2024-06-04 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP2016188761A (ja) * | 2013-08-23 | 2016-11-04 | 国立研究開発法人国立国際医療研究センター | 糖尿病腎症の発症または発症リスクの検出方法及びキット |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| CN104007258B (zh) * | 2013-09-30 | 2016-07-06 | 中国医学科学院基础医学研究所 | 局灶性节段性肾小球硬化的蛋白标志物 |
| EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| CN105917229B (zh) | 2013-12-03 | 2019-04-26 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| CN104849466A (zh) * | 2014-02-14 | 2015-08-19 | 张曼 | 尿液玻璃体结合蛋白在2型糖尿病合并早期肾损伤诊治中的应用 |
| US20170205427A1 (en) * | 2014-07-23 | 2017-07-20 | University Of British Columbia | Biomarkers for anderson-fabry disease |
| US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| WO2016164854A1 (en) | 2015-04-09 | 2016-10-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2017277305A1 (en) | 2016-06-06 | 2018-12-20 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
| US11026625B2 (en) | 2017-08-08 | 2021-06-08 | Fresenius Medical Care Holdings, Inc. | Systems and methods for treating and estimating progression of chronic kidney disease |
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| CN111714517A (zh) * | 2020-04-14 | 2020-09-29 | 南开大学 | 一种溶酶体作为制备药物领域的应用 |
| RU2768464C1 (ru) * | 2021-04-27 | 2022-03-24 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ диагностики мембранозной нефропатии как одной из форм хронического гломерулонефрита |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994165A (en) * | 1989-02-16 | 1991-02-19 | Cornell Research Foundation, Inc. | Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry |
| DE69221666T2 (de) | 1991-05-24 | 1998-01-15 | Wakamoto Pharma Co Ltd | Verfahren zur Diagnose von Nierenkrankheiten durch Nachweisung von Albuminfragmenten |
| JPH0682446A (ja) * | 1992-08-31 | 1994-03-22 | Wakamoto Pharmaceut Co Ltd | 腎疾患の診断法 |
| DE4336498A1 (de) * | 1993-10-26 | 1995-04-27 | Bender & Co Gmbh | Verfahren zur Diagnose von Nieren- und Gefäßerkrankungen |
| US5534431A (en) | 1994-02-28 | 1996-07-09 | The Board Of Regents Of The University Of Nebraska | Hybridomas and monoclonal antibodies specific for unique determinants of nephropathy-related immunoglobulin G and complexes thereof |
| US5908925A (en) | 1996-06-27 | 1999-06-01 | Exocell, Inc. | Genetically engineered immunoglobulins with specificity for glycated albumin |
| US5800998A (en) * | 1996-11-12 | 1998-09-01 | Millennium Pharmaceuticals, Inc. | Assays for diagnosing type II diabetes in a subject |
| AU1674400A (en) | 1998-12-21 | 2000-07-12 | Monash University | Kidney disease detection and treatment |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010038014A1 (de) * | 2010-10-06 | 2012-04-12 | Lipofit Analytic Gmbh | Verfahren zur Charakterisierung einer Probe und eines Systems |
| US10497465B2 (en) | 2010-10-06 | 2019-12-03 | Numares Ag | Method for characterizing a sample by data analysis |
| DE102010038014B4 (de) | 2010-10-06 | 2021-10-07 | Numares Ag | Verwendung spezifischer Substanzen als Marker zur Bestimmung des Risikos einer Nierenabstoßung |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006038877A (ja) | 2006-02-09 |
| EP1141728B1 (en) | 2007-10-17 |
| US20020022236A1 (en) | 2002-02-21 |
| JP2002533680A (ja) | 2002-10-08 |
| CA2356174A1 (en) | 2000-06-29 |
| BR9916407A (pt) | 2001-09-25 |
| AU1674400A (en) | 2000-07-12 |
| IL143892A0 (en) | 2002-04-21 |
| JP4160263B2 (ja) | 2008-10-01 |
| US20020012906A1 (en) | 2002-01-31 |
| EP1141728A4 (en) | 2005-01-12 |
| DK1141728T3 (da) | 2008-02-04 |
| ATE376187T1 (de) | 2007-11-15 |
| US20040106155A1 (en) | 2004-06-03 |
| WO2000037944A1 (en) | 2000-06-29 |
| EP1141728A1 (en) | 2001-10-10 |
| DE69937368D1 (de) | 2007-11-29 |
| JP4388515B2 (ja) | 2009-12-24 |
| US6589748B2 (en) | 2003-07-08 |
| MXPA01006404A (es) | 2003-06-06 |
| CN1331801A (zh) | 2002-01-16 |
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